Quantification of the effects of ionic strength, viscosity, and hydrophobicity on protein-ligand binding affinity

ACS Medicinal Chemistry Letters

Volumn 5, Issue 8, 2014, Pages 931-936

  Papaneophytou, Christos P ^a,b   Grigoroudis, Asterios I ^a   McInnes, Campbell ^c   Kontopidis, George ^a,b  

^a UNIVERSITY OF THESSALY   (Greece)

^b INFORMATION TECHNOLOGIES INSTITUTE   (Greece)

^c UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Affinity; dissociation constant; fluorescence spectroscopy; ion strength; solvent; viscosity

Indexed keywords

SODIUM CHLORIDE;

ARTICLE; BINDING AFFINITY; BINDING SITE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DISSOCIATION CONSTANT; HYDROPHOBICITY; IONIC STRENGTH; LIGAND BINDING; MOLECULAR INTERACTION; PRIORITY JOURNAL; PROTEIN BINDING; QUANTITATIVE ANALYSIS; TEMPERATURE; VISCOSITY;

EID: 84906270193     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml500204e     Document Type: Article

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