Determination of ligand-protein dissociation constants by electrospray mass spectrometry-based diffusion measurements

Analytical Chemistry

Volumn 76, Issue 23, 2005, Pages 7077-7083

  Clark, Sonya M ^a   Konermann, Lars ^a  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL BONDS; DIFFUSION; DISSOCIATION; IONIZATION; MASS SPECTROMETRY;

DISSOCIATION CONSTANTS; ELECTROSPRAY IONIZATION MASS SPECTROMETRY (ESI-MS); LIGAND-PROTEIN INTERACTIONS;

PROTEINS;

ENZYME INHIBITOR; LIGAND; PROTEIN DERIVATIVE;

ACCURACY; AQUEOUS SOLUTION; ARTICLE; CONCENTRATION RESPONSE; DIFFUSION COEFFICIENT; DISSOCIATION CONSTANT; ELECTROSPRAY MASS SPECTROMETRY; INTERMETHOD COMPARISON; LIGAND BINDING; MATHEMATICAL COMPUTING; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; MOLECULAR MECHANICS; PROTEIN BINDING;

BENZAMIDINES; DIFFUSION; ENZYME INHIBITORS; LIGANDS; MURAMIDASE; PROTEIN BINDING; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; STRUCTURE-ACTIVITY RELATIONSHIP; TIME FACTORS; TRISACCHARIDES; TRYPSIN;

EID: 10044271179     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac049344o     Document Type: Article

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