Thymulin gene therapy prevents the histomorphometric changes induced by thymulin deficiency in the thyrotrope population of mice

Cells Tissues Organs

Volumn 194, Issue 1, 2011, Pages 67-75

  Martines, Eliana V ^a,d   Reggiani, Paula C ^a,b   Schwerdt, José I ^a,b   Goya, Rodolfo G ^a,b   Cónsole, Gloria M ^a,c  

^a FACULTAD DE CIENCIAS MÉDICAS   (Argentina)

^b INSTITUTO DE INVESTIGACIONES BIOQUÍMICAS DE LA PLATA INIBIOLP   (Argentina)

^c Universidad Provincial del Sudoeste   (Argentina)

^d Universidad Adventista del Plata   (Argentina)

Author keywords

Hypophysiotropic activity; Nude mice; RAd FTS; Thymulin gene therapy; Thymus pituitary axis

Indexed keywords

ADENOVIRUS VECTOR; GREEN FLUORESCENT PROTEIN; THYMULIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DENSITY; CELL POPULATION; CELL SIZE; CONTROLLED STUDY; DRUG MECHANISM; FEMALE; GENE EXPRESSION; HORMONE BLOOD LEVEL; HORMONE DEFICIENCY; HYPOPHYSIS; IMMUNOHISTOCHEMISTRY; MALE; MORPHOMETRICS; MOUSE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; THYMULIN DEFICIENCY; TSH SECRETING CELL; VIRAL GENE THERAPY;

ANIMALS; CELL COUNT; FEMALE; GENE THERAPY; GENETIC VECTORS; MALE; MICE; MICE, INBRED C57BL; MICE, NUDE; THYMIC FACTOR, CIRCULATING; THYMUS GLAND; THYROTROPHS;

MUS; MUS MUSCULUS; ORYCTOLAGUS CUNICULUS;

EID: 79959376731     PISSN: 14226405     EISSN: 14226421     Source Type: Journal    
DOI: 10.1159/000322583     Document Type: Article

References (21)

1. Bach, J.F. (1983) Thymulin (FTS-Zn). Clin Immunol Allergy 3: 133-156. (Pubitemid 13063449)
2. Brown, O.A., Y.E. Sosa, F. Bolognani, R.G. Goya (1998) Thymulin stimulates prolactin and thyrotropin release in an age-related manner. Mech Ageing Dev 104: 249-262. (Pubitemid 28472899)
3. Camihort, G., G. Luna, S. Vesenbeckh, C. Ferese, M. Dardenne, R. Goya, G. Cónsole (2006) Serum thymulin immunoneutralization on pituitary cell populations in peripubertal mice. Cells Tissues Organs 18: 23-30. (Pubitemid 46018613)
4. Cónsole, G.M., S.B. Jurado, M. Petruccelli, M. Carino, R.S. Calandra, C.L. Gómez Dumm (2002) Influence of photoinhibition on the morphology and function of pituitary lacto-tropes in male golden hamsters. Neuroendocrinology 75: 316-325. (Pubitemid 34518769)
5. Cónsole, G.M., S.B. Jurado, S.B. Rulli, R.S. Ca-landra, C.L. Gómez Dumm (2001) Ultra-structural and quantitative immunohisto-chemical changes induced by nonsteroid an-tiandrogens on pituitary gonadotroph population of prepubertal male rats. Cells Tissues Organs 169: 64-72. (Pubitemid 32437046)
6. Dardenne, M., J.F. Bach (1975) The sheep cell rosette assay for the evaluation of thymic hormones; in Van Bekkum, D.W., A.M. Kruis-beek (eds): Biological Activity of Thymic Hormones: International Workshop and Symposium. Rotterdam, Kooyker, pp. 235-243.
7. Dardenne, M., M. Papiernik, J.F. Bach, O. Stut-man (1974) Studies on thymus products. 3. Epithelial origin of the serum thymic factor. Immunology 27: 299-304.
8. Dardenne, M., J.M. Pléau, B. Nabarra, P. Lefrancier, M. Derrien, J. Choay, J.F. Bach (1982) Contribution of zinc and other metals to the biological activity of serum thymic factor (FTS). Proc Nat l Acad Sci USA 79: 5370-5373. (Pubitemid 13233739)
9. Fabris, N. (1973) Immunodepression in thyroid-deprived animals. Clin Exp Immunol 15: 601-611.
10. Fabris, N., E. Mocchegiani (1985) Endocrine control of thymic serum factor production in young-adult and old mice. Cell Immunol 91: 325-335. (Pubitemid 15087171)
11. Fabris, N., E. Mocchegiani, S. Mariotti, F. Pacine, A. Pinchera (1986) Thyroid function modulates thymic endocrine activity. J Clin Endocrinol Metab 62: 474-478. (Pubitemid 16138162)
12. Gastinel L.N., M. Dardenne, J.M. Pléau, J.F. Bach (1984) Studies on the zinc-binding site to the serum thymic factor. Biochim Biophys Acta 797: 147-155. (Pubitemid 14197627)
13. Goya, R.G., P.C. Reggiani, S.M. Vesenbeckh, J.M. Pléau, Y.E. Sosa, G.M. Cónsole, R. Schade, P. Henklein, M. Dardenne (2007). Thymulin gene therapy prevents the reduction in circulating gonadotropins induced by thymulin deficiency in mice. Am J Physiol Endocrinol Metab 293: E182-E187. (Pubitemid 47108168)
14. Goya R.G., Y.E. Sosa, G.M. Cónsole (1995) Altered thyrotropic and somatotropic responses to environmental challenges in congenitally athymic mice. Brain Behav Immun 9: 79-86.
15. Mocchegiani E., L. Amadio, N. Fabris (1990) Neuroendocrine-thymus interactions. 1. In vitro modulation of thymic factor secretion by thyroid hormones. J Endocrinol Invest 13: 139-147. (Pubitemid 20111829)
16. Morel G.R., P.C. Reggiani, G.M. Cónsole, O.J. Rimoldi, S.M. Vesenbeckh, M.M. Garcia-Bravo, S.S. Rodriguez, O.A. Brown, R.G. Goya (2008) Potential of gene therapy for restoration of endocrine thymic function in thymusdeficient animal models. Curr Gene Ther 8: 49-53. (Pubitemid 351485840)
17. Pierpaoli W., E. Sorkin (1972) Alterations of adrenal cortex and thyroid in mice with congenital absence of the thymus. Nat New Biol 238: 282-285.
18. Reggiani P.C., C.B. Hereñú, O.J. Rimoldi, O.A. Brown, J.M. Pléau, M. Dardenne, R.G. Goya (2006) Gene therapy for long-term restoration of circulating thymulin in thymecto-mized mice and rats. Gene Ther 13: 1214-1221. (Pubitemid 44184715)
19. Ruitenberg E.J., J.M. Berkvens (1977) The morphology of the endocrine system in congenitally athymic (nude) mice. J Pathol 121: 225-231. (Pubitemid 8083231)
20. Savino W., B. Wolf, S. Aratan-Spire, M. Dardenne (1984) Thymic hormone containing cells. 4. Fluctuations in the thyroid hormone levels in vivo can modulate the secretion of thymu-lin by the epithelial cells of young mouse thy-mus. Clin Exp Immunol 55: 629-635. (Pubitemid 14185823)
21. Villa-Verde D.M., V. Mello-Coelho, D.A. Farias de Oliveira, M. Dardenne, W. Savino (1993) Pleiotropic influence of triiodothyronine on thymus physiology. Endocrinology 133: 867-875. (Pubitemid 23238904)