Hemin binding and oxidation of lipoproteins in serum: Mechanisms and effect on the interaction of LDL with human macrophages

Journal of Lipid Research

Volumn 39, Issue 4, 1998, Pages 755-766

  Camejo, Germán ^a,b   Halberg, Carina ^a   Manschik Lundin, Angela ^a   Hurt Camejo, Eva ^b   Rosengren, Birgitta ^b   Olsson, Helena ^a   Hansson, Göran I ^a   Forsberg, Gun Britt ^a   Ylhen, Britt ^a  

^a ASTRAZENECA R AND D   (Sweden)

^b UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

Conjugated dienes; Hemin binding; Lipoprotein degradation; Lipoprotein oxidation; Macrophages; Serum components

Indexed keywords

ALKADIENE; FERRIC ION; FREE RADICAL; HEMIN; HEMOGLOBIN; HIGH DENSITY LIPOPROTEIN; HYDROGEN PEROXIDE; LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; PORPHYRIN; PROSTAGLANDIN F2; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ARTICLE; ATHEROGENESIS; CONTROLLED STUDY; ELECTROPHORESIS; EXTRACELLULAR FLUID; FLUORESCENCE; HUMAN; HUMAN CELL; INTIMA; LIPOPROTEIN METABOLISM; MACROPHAGE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN PROCESSING; SPECTROPHOTOMETRY; ULTRAFILTRATION;

BIOLOGICAL TRANSPORT; BLOOD; HEMIN; HUMANS; LIPOPROTEINS; LIPOPROTEINS, HDL; LIPOPROTEINS, LDL; MACROPHAGES; MODELS, STRUCTURAL; OXIDATION-REDUCTION; PORPHYRINS;

EID: 0031965781     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (57)

1. Berliner, J., and J. Heinecke. 1996. The role of oxidized lipoproteins in atherogenesis. Free Radical Biol. Med. 20: 707-727.
2. Esterbauer, H., J. Gebicki, H. Puhl, and G. Jürgens. 1992. The role of lipid peroxidation and antioxidants in oxidative modification of LDL. Free Radical Biol. Med. 13: 341-390.
3. Navab, M., J. Berliner, A. Watson, S. Hama, M. Territo, A. Lusis, D. Shih, B. Van Lenten, J. Frank, L. Demer, P. Edwards, and A. Fogelman. 1996. The Ym and Yang of oxidation in the development of the fatty streak. Arterioscler. Thromb. Vasc. Biol. 16: 831-842.
4. Leeuwenburgh, C., J. Rasmussen, F. Hsu, D. Mueller, P. Subramanian, and J. Heinecke. 1997. Mass spectrometric quantification of markers for protein oxidation by tyrosyl radical, copper, and hydroxyl radical in low density lipoprotein isolated from human atherosclerotic plaques. J. Biol. Chem. 272: 3520-3526.
5. Camejo, G., E. Hurt-Camejo, B. Rosengren, O. Wiklund, F. López, and G. Bondjers. 1991. Modification of copper-catalyzed oxidation of low density lipoprotein by proteoglycans and glycosaminoglycans. J. Lipid Res. 32: 1983-1991.
6. Hurt-Camejo, E., G. Camejo, B. Rosengren, F. López, A. C., G. Fager, and G. Bondjers. 1992. Effect of arterial proteoglycans and glycosaminoglycans on low density lipoprotein oxidation and its uptake by human macrophages and arterial smooth muscle cells. Arterioscler. Thromb. 12: 569-583.
7. Williams, K. J., and I. Tabas. 1995. The response-to-retention hypothesis of early atherogenesis. Arterioscler. Thromb. Vasc. Biol. 15: 551-561.
8. Hurt-Camejo, E., U. Olsson, O. Wiklund, G. Bondjers, and G. Camejo. 1997. Cellular consequences of the association of apoB lipoproteins with proteoglycans: potential contribution to atherogenesis. Arterioscler. Thromb. Vasc. Biol. 17: 1011-1017.
9. Jacob, H. S. 1994. Vascular shear forces and atherogenesis: role of shear-provoked endothelial viral infection and heme iron accumulation. Perspect. Biol. Med. 38: 114-124.
10. Miller, Y., Y. Felikman, and N. Shaklai. 1995. The involvement of low density lipoprotein in hemin transport potentiates peroxidative damage. Biochim. Biophys. Acta. 1272: 119-127.
11. Miller, Y., Y. Felikman, and N. Shaklai. 1996. Hemoglobin induced apolipoprotein B crosslinking in low density lipoprotein oxidation. Arch. Biochem. Biophys. 326: 252-260.
12. Miller, Y., S. Altamentova, and N. Shaklai. 1997. Oxidation of low density lipoprotein by hemoglobin stems from a heme-initiated globin radical: antioxidant role of haptoglobin. Biochemistry. 36: 12189-12198.
13. Balla, G., H. S. Jacob, J. Eaton, J. Belcher, and G. Vercellotti. 1991. Hemin: a possible physiological mediator of low density lipoprotein oxidation and endothelial injury. Arterioscler. Thromb. 11: 1700-1711.
14. Balla, G., G. Vercellotti, U. Muller-Eberhard, J. Eaton, and H. Jacob. 1991. Exposure of endothelial cells to free heme potentiates damage mediated by granulocytes and toxic oxygen species. Lab. Invest. 64: 648-655.
15. Tribble, D., R. M. Krauss, M. Langsberg, P. M. Thiel, and J. van den Berg. 1995. Greater oxidative susceptibility of the surface monolayer in small dense LDL may contribute to differences in copper-induced oxidation among LDL subfractions. J. Lipid Res. 36: 662-671.
16. Tribble, D., M. Chu, G. Levine, R. Kraus, and E. Gong. 1996. Selective resistance of LDL core lipids to iron-mediated oxidation: implications for the biological properties of iron-oxidized LDL. Arteriosder. Thromb. Vasc. Biol. 16: 1580-1587.
17. Smith, E. B., and E. M. Staples. 1980. Distribution of plasma proteins across the human aortic wall: barrier functions and endothelium and internal elastic lamina. Atherosclerosis. 37: 579-590.
18. Luc, G., Z. Majd, P. Poulain, L. Elkhalil, and J-C. Fruchart. 1996. Interstitial fluid apolipoprotein A-II: an association with the occurrence of myocardial infarction. Atherosclerosis. 127: 131-137.
19. Nielsen, L., S. Slender, M. Jauhianien, and B. Nordestgaard. 1996. Preferential influx and decreased fractional loss of lipoprotein[a] in atherosclerosis compared with non-lesioned rabbit aorta. J. Clin. Invest. 98: 563-571.
20. Collins, E., and T. Carew. 1997. Residence time of low-density lipoprotein in the normal and atherosclerotic rabbit aorta. Circ. Res. 80: 208-218.
21. Halliwell, B. 1988. Albumin - an important extracellular antioxidant? Biochem. Pharmacol. 37: 569-571.
22. Jessup, W., and D. Leake. 1995. Cell-mediated oxidation of lipoproteins. In Oxidative Stress, Lipoproteins and Cardiovascular Dysfunction. C. Rice-Evans and K. Bruckdorfer, editors. Vol. VII. Portland Press, London. 99-129.
23. Ehrenwald, E., G. M. Chisolm, and P. L. Fox. 1994. Intact human ceruloplasmin oxidatively modifies low density lipoprotein. J. Clin. Invest. 93: 1493-1501.
24. Cannon, J., M. Yunker, and N. Luoma. 1995. The effect of aggregation inhibitors and antioxidants on the stability of hemin solutions. J. Pharm. Sci. Technol. 40: 77-82.
25. Gutteridge, J., and A. Smith. 1988. Antioxidant protection by haemopexin of haem-stimulated lipid peroxidation. Biochem. J. 256: 861-865.
26. Kongshaug, M. 1992. Distribution of tetrapyrrole photo-sensitizers among human plasma proteins. Int. J. Biochem. Cell Biol. 24: 1239-1265.
27. Spokojny, A., J. Serur, J. Skillman, and J. R. Spears. 1986. Uptake of hematoporphyrin derivative by atheromatous plaques: studies in human in vitro and rabbit in vitro. J. Am. Coll. Cardiol. 8: 1387-1392.
28. Hamblin, M., and L. Newman. 1994. On the mechanism of the tumour-localizing effect in photodynamic therapy. J. Photochem. Photobiol. B. 23: 3-8.
29. Rice-Evans, C. 1995. Free radicals and antioxidants in normal and pathological processes. In Oxidative Stress, Lipoproteins and Cardiovascular Dysfunction. C. Rice-Evans and K. Bruckdorfer, editors. Vol. VII. Portland Press, London.
30. Ishikawa, K., X-P. Wang, J-H. Qiao, M. Navab, and A. Fogelman. 1997. Heine oxygenase-1 inhibits atherosclerotic lesion formation in LDL receptor knockout mice. Circulation. 96 (Suppl): 1-111.
31. Olsson, U., G. Camejo, E. Hurt-Camejo, K. Elfsber, O. Wiklund, and G. Bondjers. 1997. Possible functional interactions of apolipoprotein B-100 segments that associate with cell proteoglycans and the apoB/E receptor. Arterioscler. Thromb. Vasc. Biol. 17: 149-155.
32. Hallberg, C., M. Håden, G. Hanson, K. Pettersson, C. Westerlund, G. Bondjers, A-M. Östlund-Linqvist, and G. Camejo. 1994. Lipoprotein fractionation in deuterium oxide gradients: a procedure for evaluation of antioxidant binding and susceptibility to oxidation. J. Lipid Res. 35: 1-9.
33. Redgrave, T., D. Roberts, and C. West. 1975. Separation of plasma lipoproteins by density gradient centrifugation. Anal. Biochem. 65: 42-49.
34. Domingo, A. 1990. Exponential gradient maker using a disposable syringe. Anal. Biochem. 189: 88-90.
35. Epps, D. E., T. Raub, and F. Kezdy. 1995. A general, wide range spectrofluorometric method for measuring the site-specific affinities of drugs toward human serum albumin. Anal Biochem. 227: 324-350.
36. Riccheli, F., S. Gobbo, G. Jori, G. Moreno, and C. Salet. 1995. Temperature-induced changes in fluorescent properties as a probe of porphyrin microenvironment in lipid membranes. 1. The partition of hematoporphyrin and protoporphyrin in liposomes. Eur. J. Biochem. 233: 159-164.
37. Ricchelli, F., and S. Gobbo. 1995. Porphyrins as fluorescent probes for monitoring phase transitions of lipid domains in biological membranes. Factors influencing the microenvironment of hematoporphyrin and protoporphyrin in liposomes. J. Photochem. Photobiol. B. 29: 65-70.
38. Ricchelli, F., S. Gobbo, G. Jori, C. Salet, and G. Moreno. 1995. Temperature-induced changes in fluorescent properties as a probe of porphyrin microenvironment in lipid membranes. 2. The partition of hematoporphyrin and pro toporphyrin in mitochondria. Eur. J. Biochem. 233: 165-170.
39. Wallin, B., B. Rosengren, H. Shertzer, and G. Camejo. 1993. Lipoprotein oxidation and measurements of thiobarbituric acid reacting substances formation in a single microtiter plate: its use for evaluation of antioxidants. Anal. Biochem. 208: 10-15.
40. 2-isoprostanes as indicators of nonenzymatic lipid peroxidation in vivo by gas chromatography-mass spectrometry: development of a solid-phase extraction procedure. J. Chromatogr. B Biomed. Appl. 667: 199-208.
41. Sakai, M., A. Miyazaki, H. Hakamata, T. Kodama, H. Szuki, S. Kobori, M. Shichiri, and S. Horiuchi. 1996. The scavenger receptor serves as a route for internalization of lysophosphatidylcholine in oxidized low density lipoprotein-induced macrophage proliferation. J. Biol. Chem. 271: 27346-27352.
42. Berger, T., M. Polidori, A. Dabbagh, P. Evans, B. Halliwell, J. Morrow, J. Roberts, and B. Frei. 1997. Antioxidant activity of vitamin G in iron overloaded plasma. J. Biol. Chem. 272: 15656-15660.
43. Paganga, G., C. Rice-Evans, R. Rule, and D. Leake. 1992. The interaction between ruptured erythrocytes and low-density lipoproteins. FEBS Lett. 303: 154-158.
44. Sarti, P., N. Hogg, V. Darley-Usmar, M. Sanna, and M. Wilson. 1994. The oxidation of cytochrome-c oxidase vesicles. Biochim. Biophys. Acta. 1208: 38-44.
45. Patel, R., U. Diczfaluzy, S. Dzeletovic, M. Wilson, and V. Darley-Usmar. 1996. Formation of oxysterols during oxidation of low density lipoprotein by peroxynitrite, myoglobin, and copper. J. Lipid Res. 37: 2361-2371.
46. Jori, G., and E. Reddi. 1993. The role of lipoproteins in the delivery of tumor-targeting photosensitizers. Int. J. Biochem. Cell Biol. 25: 1369-1375.
47. Wu, M., and W. Morgan. 1993. Characterization of hemopexin and its interaction with heme by differential scanning calorimetry and circular dichroism. Biochemistry. 32: 7216-7222.
48. Morrow, J., J. Awad, A. Wu, W. Zackert, V. Daniel, and J. Roberts. 1996. Nonenzymatic free radical-catalyzed generation of thromboxane-like compounds (isothromboxanes) in vivo. J. Biol. Chem. 271: 23185-23190.
49. 2α, a product of lipid peroxidation, increases portal pressure in normal and cirrothic rats. Gastroenterology. 112: 208-213.
50. 2-isoprostanes in human atherosclerotic lesions. J. Clin. Invest. 100: 2028-2034.
51. Ricchelli, F. 1995. Photophysical properties of porphyrins in biological membranes. J. Photochem. Photobiol. B.29: 109-118.
52. Morriset, J., R. Jackson, and A. Gotto. 1977. Lipid-protein interactions in the plasma lipoproteins. Biochim. Biophys. Acta. 472: 94-133.
53. Camejo, G., S-O. Olofsson, F. López, P. Carlsson, and G. Bondjers. 1988. Identification of apoB-100 segments mediating the interaction of low density lipoproteins with arterial proteoglycans. Arteriosclerosis. 8: 368-377.
54. Olsson, U., G. Camejo, and G. Bondjers. 1993. Binding of a synthetic apolipoprotein B-100 peptide and peptide analogues to chondroitin 6-sulfate: effects of the lipid environment. Biochemistry. 32: 1858-1865.
55. Börchers, T., and F. Spener. 1993. Involvement of arginine in the binding of heme and fatty acid-binding protein from bovine liver. Mol. Cell. Biochem. 123: 23-77.
56. Beltramini, M., P. Firey, F. Ricchelli, M. Rodgers, and G. Jori. 1987. Steady-state and time-resolved spectroscopic studies on the hematoporphyrin-lipoprotein complex. Biochemistry 26: 6852-6858.
57. Yuan, X. M., U. T. Brunk, and A. G. Olsson. 1995. Effects of iron- and hemoglobin-loaded human monocyte-derived macrophages on oxidation and uptake of LDL. Arterioscler. Thromb. Vasc. Biol. 15: 1345-1351.