메뉴 건너뛰기




Volumn 14, Issue 9, 2014, Pages 2023-2036

Mesenchymal stem cell therapy promotes corneal allograft survival in rats by local and systemic immunomodulation

Author keywords

Basic (laboratory) research science; corneal transplantation ophthalmology; immune regulation; immunosuppression immune modulation; regenerative medicine; stem cells; translational research science

Indexed keywords

ALLOANTIBODY; ALLOANTIGEN; CD161 ANTIGEN; CD3 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; GAMMA INTERFERON; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2; INTERLEUKIN 1BETA; INTERLEUKIN 6; TRANSCRIPTION FACTOR FOXP3; IMMUNOLOGICAL ADJUVANT; PRIMER DNA;

EID: 84906214083     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/ajt.12828     Document Type: Article
Times cited : (41)

References (43)
  • 1
    • 77949811286 scopus 로고    scopus 로고
    • Novel gene therapeutic strategies for the induction of tolerance in cornea transplantation
    • Ritter T, Pleyer U., Novel gene therapeutic strategies for the induction of tolerance in cornea transplantation. Expert Rev Clin Immunol 2009; 5: 749-764.
    • (2009) Expert Rev Clin Immunol , vol.5 , pp. 749-764
    • Ritter, T.1    Pleyer, U.2
  • 2
    • 0032855582 scopus 로고    scopus 로고
    • Immunobiology and immunopathology of corneal transplantation
    • Streilein JW., Immunobiology and immunopathology of corneal transplantation. Chem Immunol 1999; 73: 186-206.
    • (1999) Chem Immunol , vol.73 , pp. 186-206
    • Streilein, J.W.1
  • 3
    • 2442674323 scopus 로고    scopus 로고
    • Corneal transplantation: The forgotten graft
    • George AJ, Larkin DF., Corneal transplantation: The forgotten graft. Am J Transplant 2004; 4: 678-685.
    • (2004) Am J Transplant , vol.4 , pp. 678-685
    • George, A.J.1    Larkin, D.F.2
  • 4
    • 29244455283 scopus 로고    scopus 로고
    • The impact of corneal allograft rejection on the long-term outcome of corneal transplantation
    • Coster DJ, Williams KA., The impact of corneal allograft rejection on the long-term outcome of corneal transplantation. Am J Ophthalmol 2005; 140: 1112-1122.
    • (2005) Am J Ophthalmol , vol.140 , pp. 1112-1122
    • Coster, D.J.1    Williams, K.A.2
  • 5
    • 38449117237 scopus 로고    scopus 로고
    • The immunobiology of corneal transplantation
    • Williams KA, Coster DJ., The immunobiology of corneal transplantation. Transplantation 2007; 84: 806-813.
    • (2007) Transplantation , vol.84 , pp. 806-813
    • Williams, K.A.1    Coster, D.J.2
  • 7
    • 79959972186 scopus 로고    scopus 로고
    • Cornea: Window to ocular immunology
    • Niederkorn JY., Cornea: Window to ocular immunology. Curr Immunol Rev 2012; 7: 328-335.
    • (2012) Curr Immunol Rev , vol.7 , pp. 328-335
    • Niederkorn, J.Y.1
  • 8
    • 1542286220 scopus 로고    scopus 로고
    • Mesenchymal stem cells: Clinical applications and biological characterization
    • Barry FP, Murphy JM., Mesenchymal stem cells: Clinical applications and biological characterization. Int J Biochem Cell Biol 2004; 36: 568-584.
    • (2004) Int J Biochem Cell Biol , vol.36 , pp. 568-584
    • Barry, F.P.1    Murphy, J.M.2
  • 9
    • 33748160964 scopus 로고    scopus 로고
    • Mesenchymal stem cells for bone, cartilage, tendon and skeletal muscle repair
    • Krampera M, Pizzolo G, Aprili G, Franchini M., Mesenchymal stem cells for bone, cartilage, tendon and skeletal muscle repair. Bone 2006; 39: 678-683.
    • (2006) Bone , vol.39 , pp. 678-683
    • Krampera, M.1    Pizzolo, G.2    Aprili, G.3    Franchini, M.4
  • 10
    • 84872139846 scopus 로고    scopus 로고
    • Anti-donor immune responses elicited by allogeneic mesenchymal stem cells: What have we learned so far
    • Griffin MD, Ryan AE, Alagesan S, Lohan P, Treacy O, Ritter T., Anti-donor immune responses elicited by allogeneic mesenchymal stem cells: What have we learned so far ? Immunol Cell Biol 2013; 91: 40-51.
    • (2013) Immunol Cell Biol , vol.91 , pp. 40-51
    • Griffin, M.D.1    Ryan, A.E.2    Alagesan, S.3    Lohan, P.4    Treacy, O.5    Ritter, T.6
  • 11
    • 78649374199 scopus 로고    scopus 로고
    • Immunological aspects of allogeneic mesenchymal stem cell therapy
    • Griffin MD, Ritter T, Mahon B., Immunological aspects of allogeneic mesenchymal stem cell therapy. Hum Gene Ther 2010; 21: 1641-1655.
    • (2010) Hum Gene Ther , vol.21 , pp. 1641-1655
    • Griffin, M.D.1    Ritter, T.2    Mahon, B.3
  • 12
    • 77952319188 scopus 로고    scopus 로고
    • Mesenchymal stem cell therapy: Two steps forward, one step back
    • Ankrum J, Karp JM., Mesenchymal stem cell therapy: Two steps forward, one step back. Trends Mol Med 2010; 16: 203-209.
    • (2010) Trends Mol Med , vol.16 , pp. 203-209
    • Ankrum, J.1    Karp, J.M.2
  • 13
    • 58449135981 scopus 로고    scopus 로고
    • Why are MSCs therapeutic? New data: New insight
    • Caplan AI., Why are MSCs therapeutic? New data: New insight. J Pathol 2009; 217: 318-324.
    • (2009) J Pathol , vol.217 , pp. 318-324
    • Caplan, A.I.1
  • 14
    • 84866859990 scopus 로고    scopus 로고
    • Mesenchymal stromal cells: A key player in 'innate tolerance'
    • Dazzi F, Lopes L, Weng L., Mesenchymal stromal cells: A key player in 'innate tolerance' ? Immunology 2012; 137: 206-213.
    • (2012) Immunology , vol.137 , pp. 206-213
    • Dazzi, F.1    Lopes, L.2    Weng, L.3
  • 15
    • 36348977575 scopus 로고    scopus 로고
    • Immunomodulatory properties of mesenchymal stromal cells
    • Nauta AJ, Fibbe WE., Immunomodulatory properties of mesenchymal stromal cells. Blood 2007; 110: 3499-3506.
    • (2007) Blood , vol.110 , pp. 3499-3506
    • Nauta, A.J.1    Fibbe, W.E.2
  • 16
    • 84856973179 scopus 로고    scopus 로고
    • Mesenchymal stem/stromal cells (MSCs): Role as guardians of inflammation
    • Prockop DJ, Oh JY., Mesenchymal stem/stromal cells (MSCs): Role as guardians of inflammation. Mol Ther 2012; 20: 14-20.
    • (2012) Mol Ther , vol.20 , pp. 14-20
    • Prockop, D.J.1    Oh, J.Y.2
  • 17
    • 0037093058 scopus 로고    scopus 로고
    • Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli
    • Di Nicola M, Carlo-Stella C, Magni M, et al. Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli. Blood 2002; 99: 3838-3843.
    • (2002) Blood , vol.99 , pp. 3838-3843
    • Di Nicola, M.1    Carlo-Stella, C.2    Magni, M.3
  • 18
    • 58149326737 scopus 로고    scopus 로고
    • Bone marrow stromal cells attenuate sepsis via prostaglandin E(2)-dependent reprogramming of host macrophages to increase their interleukin-10 production
    • Nemeth K, Leelahavanichkul A, Yuen PS, et al. Bone marrow stromal cells attenuate sepsis via prostaglandin E(2)-dependent reprogramming of host macrophages to increase their interleukin-10 production. Nat Med 2009; 15: 42-49.
    • (2009) Nat Med , vol.15 , pp. 42-49
    • Nemeth, K.1    Leelahavanichkul, A.2    Yuen, P.S.3
  • 19
    • 77957338676 scopus 로고    scopus 로고
    • Mesenchymal stromal cells: Facilitators of successful transplantation
    • English K, French A, Wood KJ., Mesenchymal stromal cells: Facilitators of successful transplantation ? Cell Stem Cell 2010; 7: 431-442.
    • (2010) Cell Stem Cell , vol.7 , pp. 431-442
    • English, K.1    French, A.2    Wood, K.J.3
  • 20
    • 49249129381 scopus 로고    scopus 로고
    • The anti-inflammatory and anti-angiogenic role of mesenchymal stem cells in corneal wound healing following chemical injury
    • Oh JY, Kim MK, Shin MS, et al. The anti-inflammatory and anti-angiogenic role of mesenchymal stem cells in corneal wound healing following chemical injury. Stem Cells 2008; 26: 1047-1055.
    • (2008) Stem Cells , vol.26 , pp. 1047-1055
    • Oh, J.Y.1    Kim, M.K.2    Shin, M.S.3
  • 21
    • 79954986522 scopus 로고    scopus 로고
    • Corneal surface reconstruction using adult mesenchymal stem cells in experimental limbal stem cell deficiency in rabbits
    • Reinshagen H, Auw-Haedrich C, Sorg RV, et al. Corneal surface reconstruction using adult mesenchymal stem cells in experimental limbal stem cell deficiency in rabbits. Acta Ophthalmol 2009; 89: 741-748.
    • (2009) Acta Ophthalmol , vol.89 , pp. 741-748
    • Reinshagen, H.1    Auw-Haedrich, C.2    Sorg, R.V.3
  • 22
    • 84869080677 scopus 로고    scopus 로고
    • Intravenous mesenchymal stem cells prevented rejection of allogeneic corneal transplants by aborting the early inflammatory response
    • Oh JY, Lee RH, Yu JM, et al. Intravenous mesenchymal stem cells prevented rejection of allogeneic corneal transplants by aborting the early inflammatory response. Mol Ther 2012; 20: 2143-2152.
    • (2012) Mol Ther , vol.20 , pp. 2143-2152
    • Oh, J.Y.1    Lee, R.H.2    Yu, J.M.3
  • 23
    • 84860492238 scopus 로고    scopus 로고
    • Role of lentivirus-mediated overexpression of programmed death-ligand 1 on corneal allograft survival
    • Nosov M, Wilk M, Morcos M, et al. Role of lentivirus-mediated overexpression of programmed death-ligand 1 on corneal allograft survival. Am J Transplant 2012; 12: 1313-1322.
    • (2012) Am J Transplant , vol.12 , pp. 1313-1322
    • Nosov, M.1    Wilk, M.2    Morcos, M.3
  • 24
    • 84865412756 scopus 로고    scopus 로고
    • Immunogenicity of allogeneic mesenchymal stem cells
    • Schu S, Nosov M, O'Flynn L, et al. Immunogenicity of allogeneic mesenchymal stem cells. J Cell Mol Med 2012; 16: 2094-2103.
    • (2012) J Cell Mol Med , vol.16 , pp. 2094-2103
    • Schu, S.1    Nosov, M.2    O'Flynn, L.3
  • 25
    • 38649105374 scopus 로고    scopus 로고
    • Mesenchymal stem cell-mediated immunosuppression occurs via concerted action of chemokines and nitric oxide
    • Ren G, Zhang L, Zhao X, et al. Mesenchymal stem cell-mediated immunosuppression occurs via concerted action of chemokines and nitric oxide. Cell Stem Cell 2008; 2: 141-150.
    • (2008) Cell Stem Cell , vol.2 , pp. 141-150
    • Ren, G.1    Zhang, L.2    Zhao, X.3
  • 26
    • 69249119079 scopus 로고    scopus 로고
    • Species variation in the mechanisms of mesenchymal stem cell-mediated immunosuppression
    • Ren G, Su J, Zhang L, et al. Species variation in the mechanisms of mesenchymal stem cell-mediated immunosuppression. Stem Cells 2009; 27: 1954-1962.
    • (2009) Stem Cells , vol.27 , pp. 1954-1962
    • Ren, G.1    Su, J.2    Zhang, L.3
  • 27
    • 77951889580 scopus 로고    scopus 로고
    • Inflammatory cytokine-induced intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 in mesenchymal stem cells are critical for immunosuppression
    • Ren G, Zhao X, Zhang L, et al. Inflammatory cytokine-induced intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 in mesenchymal stem cells are critical for immunosuppression. J Immunol 2010; 184: 2321-2328.
    • (2010) J Immunol , vol.184 , pp. 2321-2328
    • Ren, G.1    Zhao, X.2    Zhang, L.3
  • 28
    • 80053221596 scopus 로고    scopus 로고
    • Pretreatment with interferon-γ enhances the therapeutic activity of mesenchymal stromal cells in animal models of colitis
    • Duijvestein M, Wildenberg ME, Welling MM, et al. Pretreatment with interferon-γ enhances the therapeutic activity of mesenchymal stromal cells in animal models of colitis. Stem Cells 2011; 29: 1549-1558.
    • (2011) Stem Cells , vol.29 , pp. 1549-1558
    • Duijvestein, M.1    Wildenberg, M.E.2    Welling, M.M.3
  • 29
    • 84856960632 scopus 로고    scopus 로고
    • Human MSC suppression correlates with cytokine induction of indoleamine 2,3-dioxygenase and bystander M2 macrophage differentiation
    • François M, Romieu-Mourez R, Li M, Galipeau J., Human MSC suppression correlates with cytokine induction of indoleamine 2,3-dioxygenase and bystander M2 macrophage differentiation. Mol Ther 2012; 20: 187-195.
    • (2012) Mol Ther , vol.20 , pp. 187-195
    • François, M.1    Romieu-Mourez, R.2    Li, M.3    Galipeau, J.4
  • 30
    • 84865184497 scopus 로고    scopus 로고
    • Mesenchymal stem cells: A double-edged sword in regulating immune responses
    • Li W, Ren G, Huang Y, et al. Mesenchymal stem cells: A double-edged sword in regulating immune responses. Cell Death Differ 2012; 19: 1505-1513.
    • (2012) Cell Death Differ , vol.19 , pp. 1505-1513
    • Li, W.1    Ren, G.2    Huang, Y.3
  • 31
    • 59849093427 scopus 로고    scopus 로고
    • Levels of Foxp3 in regulatory T cells reflect their functional status in transplantation
    • Chauhan SK, Saban DR, Lee HK, Dana R., Levels of Foxp3 in regulatory T cells reflect their functional status in transplantation. J Immunol 2009; 182: 148-153.
    • (2009) J Immunol , vol.182 , pp. 148-153
    • Chauhan, S.K.1    Saban, D.R.2    Lee, H.K.3    Dana, R.4
  • 33
    • 54949139152 scopus 로고    scopus 로고
    • CD4+CD25+Foxp3+ regulatory T cells suppress anti-tumor immune responses in patients with colorectal cancer
    • Clarke SL, Betts GJ, Plant A, et al. CD4+CD25+Foxp3+ regulatory T cells suppress anti-tumor immune responses in patients with colorectal cancer. PLoS ONE 2006; 1: e129.
    • (2006) PLoS ONE , vol.1
    • Clarke, S.L.1    Betts, G.J.2    Plant, A.3
  • 34
    • 56149110595 scopus 로고    scopus 로고
    • Pretransplant infusion of mesenchymal stem cells prolongs the survival of a semiallogeneic heart transplant through the generation of regulatory T cells
    • Casiraghi F, Azzollini N, Cassis P, et al. Pretransplant infusion of mesenchymal stem cells prolongs the survival of a semiallogeneic heart transplant through the generation of regulatory T cells. J Immunol 2008; 181: 3933-3946.
    • (2008) J Immunol , vol.181 , pp. 3933-3946
    • Casiraghi, F.1    Azzollini, N.2    Cassis, P.3
  • 35
    • 84865578483 scopus 로고    scopus 로고
    • Localization of mesenchymal stromal cells dictates their immune or proinflammatory effects in kidney transplantation
    • Casiraghi F, Azzollini N, Todeschini M, et al. Localization of mesenchymal stromal cells dictates their immune or proinflammatory effects in kidney transplantation. Am J Transplant 2012; 12: 2373-2383.
    • (2012) Am J Transplant , vol.12 , pp. 2373-2383
    • Casiraghi, F.1    Azzollini, N.2    Todeschini, M.3
  • 36
    • 33645759735 scopus 로고    scopus 로고
    • Mesenchymal stem cell transplantation in a rabbit corneal alkali burn model: Engraftment and involvement in wound healing
    • Ye J, Kao K, Kim JC., Mesenchymal stem cell transplantation in a rabbit corneal alkali burn model: Engraftment and involvement in wound healing. Eye 2006; 20: 482-490.
    • (2006) Eye , vol.20 , pp. 482-490
    • Ye, J.1    Kao, K.2    Kim, J.C.3
  • 37
    • 33746108235 scopus 로고    scopus 로고
    • Reconstruction of chemically burned rat corneal surface by bone marrow-derived human mesenchymal stem cells
    • Ma Y, Xu Y, Xiao Z, et al. Reconstruction of chemically burned rat corneal surface by bone marrow-derived human mesenchymal stem cells. Stem Cells 2006; 24: 315-321.
    • (2006) Stem Cells , vol.24 , pp. 315-321
    • Ma, Y.1    Xu, Y.2    Xiao, Z.3
  • 38
    • 38549143756 scopus 로고    scopus 로고
    • Bone marrow-derived progenitor cells promote corneal wound healing following alkali injury
    • Ye J, Lee SY, Kook KH, Yao K., Bone marrow-derived progenitor cells promote corneal wound healing following alkali injury. Graefes Arch Clin Exp Ophthalmol 2008; 246: 217-222.
    • (2008) Graefes Arch Clin Exp Ophthalmol , vol.246 , pp. 217-222
    • Ye, J.1    Lee, S.Y.2    Kook, K.H.3    Yao, K.4
  • 39
    • 84865603599 scopus 로고    scopus 로고
    • Immunomodulatory effects of mesenchymal stem cells in a rat corneal allograft rejection model
    • Jia Z, Jiao C, Zhao S, et al. Immunomodulatory effects of mesenchymal stem cells in a rat corneal allograft rejection model. Exp Eye Res 2012; 102: 44-49.
    • (2012) Exp Eye Res , vol.102 , pp. 44-49
    • Jia, Z.1    Jiao, C.2    Zhao, S.3
  • 41
    • 84885099905 scopus 로고    scopus 로고
    • Mesenchymal stromal cells: Sensors and switchers of inflammation
    • Bernardo ME, Fibbe WE., Mesenchymal stromal cells: Sensors and switchers of inflammation. Cell Stem Cell 2013; 13: 392-402.
    • (2013) Cell Stem Cell , vol.13 , pp. 392-402
    • Bernardo, M.E.1    Fibbe, W.E.2
  • 42
    • 84887464321 scopus 로고    scopus 로고
    • Donor bone marrow-derived dendritic cells prolong corneal allograft survival and promote an intragraft immunoregulatory milieu
    • O'Flynn L, Treacy O, Ryan AE, et al. Donor bone marrow-derived dendritic cells prolong corneal allograft survival and promote an intragraft immunoregulatory milieu. Mol Ther 2013; 21: 2102-2112.
    • (2013) Mol Ther , vol.21 , pp. 2102-2112
    • O'Flynn, L.1    Treacy, O.2    Ryan, A.E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.