Blood-brain barrier dysfunction can contribute to pharmacoresistance of seizures

Epilepsia

Volumn 55, Issue 8, 2014, Pages 1255-1263

  Salar, Seda ^a   Maslarova, Anna ^a   Lippmann, Kristina ^a   Nichtweiss, Julia ^a   Weissberg, Itai ^b   Sheintuch, Liron ^b   Kunz, Wolfram S ^c   Shorer, Zamir ^b   Friedman, Alon ^b   Heinemann, Uwe ^a,d  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^c UNIVERSITY HOSPITAL BONN   (Germany)

^d Neurocure Cluster of Excellence   (Germany)

Author keywords

4 Aminopyridine; Albumin; BBB disruption; Entorhinal Cortex; Pharmacoresistance; Rats

Indexed keywords

4 AMINOPYRIDINE; ALBUMIN; CALCIUM; CARBAMAZEPINE; DRUG BINDING PROTEIN; ELECTROLYTE; GABAPENTIN; MAGNESIUM; PHENOBARBITAL; PHENYTOIN; POTASSIUM ION; SERUM ALBUMIN; TOPIRAMATE; TRANSFORMING GROWTH FACTOR BETA; VALPROIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTICONVULSANT THERAPY; ARTICLE; BINDING AFFINITY; BLOOD BRAIN BARRIER; BLOOD BRAIN BARRIER DYSFUNCTION; BLOOD LEVEL; BRAIN DYSFUNCTION; BRAIN LEVEL; CONTROLLED STUDY; DISEASE COURSE; DRUG EFFICACY; DRUG EXPOSURE; ELECTRIC POTENTIAL; ELECTROLYTE DISTURBANCE; ENTORHINAL CORTEX; EPILEPTIC DISCHARGE; EXPERIMENTAL EXTRAVASATION; EXTRACELLULAR SPACE; FOCAL EPILEPSY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIPPOCAMPUS; HUMAN; LATE RECURRENT DISCHARGE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SEIZURE; ULTRAFILTRATION;

4-AMINOPYRIDINE; ALBUMIN; BBB DISRUPTION; ENTORHINAL CORTEX; PHARMACORESISTANCE; RATS;

4-AMINOPYRIDINE; ANIMALS; ANTICONVULSANTS; BLOOD-BRAIN BARRIER; DRUG RESISTANCE; HIPPOCAMPUS; INJECTIONS, INTRAVENTRICULAR; MALE; ORGAN CULTURE TECHNIQUES; RATS; RATS, WISTAR; SEIZURES; SERUM ALBUMIN, BOVINE;

EID: 84906101566     PISSN: 00139580     EISSN: 15281167     Source Type: Journal    
DOI: 10.1111/epi.12713     Document Type: Article

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