Target enzyme mutations confer differential echinocandin susceptibilities in Candida kefyr

Antimicrobial Agents and Chemotherapy

Volumn 58, Issue 9, 2014, Pages 5421-5427

  Staab, Janet F ^a   Neofytos, Dionysios ^a   Rhee, Peter ^a   Jimeńez Ortigosa, Cristina ^b   Zhang, Sean X ^a   Perlin, David S ^b   Marr, Kieren A ^a,c  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b PUBLIC HEALTH RESEARCH INSTITUTE   (United States)

^c JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHOTERICIN B LIPID COMPLEX; ANIDULAFUNGIN; CASPOFUNGIN; ECHINOCANDIN; FLUCONAZOLE; GLUCAN SYNTHASE; MICAFUNGIN; VORICONAZOLE; ANTIFUNGAL AGENT; FUNGAL PROTEIN; GLUCOSYLTRANSFERASE; LIPOPEPTIDE;

ANTIFUNGAL SUSCEPTIBILITY; ARTICLE; CANDIDA KEFYR INFECTION; CANDIDIASIS; CLINICAL ARTICLE; ENZYME INHIBITION; ENZYME KINETICS; FUNGAL STRAIN; GENETIC SIMILARITY; HUMAN; KLUYVEROMYCES MARXIANUS; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR TYPING; MUTATION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; AMINO ACID SEQUENCE; ANTIFUNGAL RESISTANCE; CANDIDA; DRUG EFFECTS; GENETICS; MICROBIAL SENSITIVITY TEST; MOLECULAR GENETICS; PROCEDURES; SEQUENCE ANALYSIS;

AMINO ACID SEQUENCE; ANTIFUNGAL AGENTS; CANDIDA; DRUG RESISTANCE, FUNGAL; ECHINOCANDINS; FUNGAL PROTEINS; GLUCOSYLTRANSFERASES; HUMANS; LIPOPEPTIDES; MICROBIAL SENSITIVITY TESTS; MOLECULAR SEQUENCE DATA; MUTATION; SEQUENCE ANALYSIS, PROTEIN;

EID: 84906089917     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.00096-14     Document Type: Article

References (37)

1. Corpus K, Hegeman-Dingle R, Bajjoka I. 2004. Candida kefyr, an uncommon but emerging fungal pathogen: report of two cases. Pharmacotherapy 24:1084-1088. http://dx.doi.org/10.1592/phco.24.11.1084.36140. (Pubitemid 39025207)
2. Reuter CW, Morgan MA, Bange FC, Gunzer F, Eder M, Hertenstein B, Ganser A. 2005. Candida kefyr as an emerging pathogen causing nosocomial bloodstream infections in neutropenic leukemia patients. Clin. Infect. Dis. 41:1365-1366. http://dx.doi.org/10.1086/497079. (Pubitemid 41532689)
3. Sendid B, Lacroix C, Bougnoux ME. 2006. Is Candida kefyr an emerging pathogen in patients with oncohematological diseases? Clin. Infect. Dis. 43:666-667. http://dx.doi.org/10.1086/506573. (Pubitemid 44267134)
4. Borg-von Zepelin M, Kunz L, Ruchel R, Reichard U, Weig M, Gross U. 2007. Epidemiology and antifungal susceptibilities of Candida spp. to six antifungal agents: results from a surveillance study on fungaemia in Germany from July 2004 to August 2005. J. Antimicrob. Chemother. 60:424-428. http://dx.doi.org/10. 1093/jac/dkm145. (Pubitemid 47243899)
5. Gomez-Lopez A, Pan D, Cuesta I, Alastruey-Izquierdo A, Rodriguez-Tudela JL, Cuenca-Estrella M. 2010. Molecular identification and susceptibility profile in vitro of the emerging pathogen Candida kefyr. Diagn. Microbiol. Infect. Dis. 66:116-119. http://dx.doi.org/10.1016/j.diagmicrobio.2009.06.007.
6. Pfaller MA, Diekema DJ. 2010. Epidemiology of invasive mycoses in North America. Crit. Rev. Microbiol. 36:1-53. http://dx.doi.org/10.3109/ 10408410903241444.
7. Pfaller MA, Boyken L, Hollis RJ, Kroeger J, Messer SA, Tendolkar S, Jones RN, Turnidge J, Diekema DJ. 2010. Wild-type MIC distributions and epidemiological cutoff values for the echinocandins and Candida spp. J. Clin. Microbiol. 48:52-56. http://dx.doi.org/10.1128/JCM.01590-09.
8. Balashov SV, Park S, Perlin DS. 2006. Assessing resistance to the echinocandin antifungal drug caspofungin in Candida albicans by profiling mutations in FKS1. Antimicrob. Agents Chemother. 50:2058-2063. http://dx.doi.org/10.1128/AAC.01653-05. (Pubitemid 43807526)
9. Douglas CM, D'Ippolito JA, Shei GJ, Meinz M, Onishi J, Marrinan JA, Li W, Abruzzo GK, Flattery A, Bartizal K, Mitchell A, Kurtz MB. 1997. Identification of the FKS1 gene of Candida albicans as the essential target of 1,3-beta-D-glucan synthase inhibitors. Antimicrob. Agents Chemother. 41:2471-2479. (Pubitemid 27467559)
10. Katiyar S, Pfaller M, Edlind T. 2006. Candida albicans and Candida glabrata clinical isolates exhibiting reduced echinocandin susceptibility. Antimicrob. Agents Chemother. 50:2892-2894. http://dx.doi.org/10.1128/AAC.00349- 06. (Pubitemid 44198725)
11. Park S, Kelly R, Kahn JN, Robles J, Hsu MJ, Register E, Li W, Vyas V, Fan H, Abruzzo G, Flattery A, Gill C, Chrebet G, Parent SA, Kurtz M, Teppler H, Douglas CM, Perlin DS. 2005. Specific substitutions in the echinocandin target Fks1p account for reduced susceptibility of rare laboratory and clinical Candida sp. isolates. Antimicrob. Agents Chemother. 49:3264-3273. http://dx.doi.org/10. 1128/AAC.49.8.3264-3273.2005. (Pubitemid 41060570)
12. Perlin DS. 2007. Resistance to echinocandin-class antifungal drugs. Drug Resist. Updat. 10:121-130. http://dx.doi.org/10.1016/j.drup.2007.04.002. (Pubitemid 47031054)
13. Perlin DS. 2011. Current perspectives on echinocandin class drugs. Future Microbiol. 6:441-457. http://dx.doi.org/10.2217/fmb.11.19.
14. Fekkar A, Meyer I, Brossas JY, Dannaoui E, Palous M, Uzunov M, Nguyen S, Leblond V, Mazier D, Datry A. 2013. Rapid emergence of echinocandin resistance during Candida kefyr fungemia treated with caspofungin. Antimicrob. Agents Chemother. 57:2380-2382. http://dx.doi.org/10.1128/AAC.02037-12.
15. Johnson ME, Edlind TD. 2012. Topological and mutational analysis of Saccharomyces cerevisiae Fks1. Eukaryot. Cell 11:952-960. http://dx.doi.org/10. 1128/EC.00082-12.
16. Delley PA, Hall MN. 1999. Cell wall stress depolarizes cell growth via hyperactivation of RHO1. J. Cell Biol. 147:163-174. http://dx.doi.org/10.1083/ jcb.147.1.163. (Pubitemid 30211804)
17. Mazur P, Baginsky W. 1996. In vitro activity of 1,3-beta-D-glucan synthase requires the GTP-binding protein Rho1. J. Biol. Chem. 271:14604-14609. http://dx.doi.org/10.1074/jbc.271.24.14604. (Pubitemid 26190367)
18. Johnson ME, Katiyar SK, Edlind TD. 2011. New Fks hot spot for acquired echinocandin resistance in Saccharomyces cerevisiae and its contribution to intrinsic resistance of Scedosporium species. Antimicrob. Agents Chemother. 55:3774-3781. http://dx.doi.org/10.1128/AAC.01811-10.
19. Dufresne SF, Marr KA, Sydnor E, Staab JF, Karp JE, Lu K, Zhang SX, Lavallee C, Perl TM, Neofytos D. 2014. Epidemiology of Candida kefyr in patients with hematologic malignancies. J. Clin. Microbiol. 52: 1830-1837. http://dx.doi.org/10.1128/JCM.00131-14.
20. Harrison FC. 1928. A systematic study of some Torulas. Trans. R. Soc. Can. 22:187-225.
21. Gillum AM, Tsay EY, Kirsch DR. 1984. Isolation of the Candida albicans gene for orotidine-5′-phosphate decarboxylase by complementation of S. cerevisiae ura3 and E. coli pyrF mutations. Mol. Gen. Genet. 198:179-182. http://dx.doi.org/10.1007/BF00328721. (Pubitemid 15180998)
22. Clinical and Laboratory Standards Institute. 2008. Reference method for broth dilution antifungal susceptibility testing of yeasts; approved standard-3rd ed. CLSI document M27-A3. Clinical and Laboratory Standards Institute, Wayne, PA.
23. Pfaller MA, Castanheira M, Diekema DJ, Messer SA, Jones RN. 2011. Triazole and echinocandin MIC distributions with epidemiological cutoff values for differentiation of wild-type strains from non-wild-type strains of six uncommon species of Candida. J. Clin. Microbiol. 49:3800-3804. http://dx.doi.org/10.1128/JCM.05047-11.
24. Redkar RJ, Dube MP, McCleskey FK, Rinaldi MG, Del Vecchio VG. 1996.DNAfingerprinting of Candida rugosa via repetitive sequence-based PCR. J. Clin. Microbiol. 34:1677-1681. (Pubitemid 26190396)
25. Pavel AB, Vasile CI. 2012. PyElph-a software tool for gel images analysis and phylogenetics. BMC Bioinformatics 13:9. http://dx.doi.org/10.1186/1471- 2105-13-9.
26. Garcia-Effron G, Katiyar SK, Park S, Edlind TD, Perlin DS. 2008. A naturally occurring proline-to-alanine amino acid change in Fks1p in Candida parapsilosis, Candida orthopsilosis, and Candida metapsilosis accounts for reduced echinocandin susceptibility. Antimicrob. Agents Chemother. 52:2305-2312. http://dx.doi.org/10.1128/AAC.00262-08. (Pubitemid 351915657)
27. Garcia-Effron G, Lee S, Park S, Cleary JD, Perlin DS. 2009. Effect of Candida glabrata FKS1 and FKS2 mutations on echinocandin sensitivity and kinetics of 1,3-beta-D-glucan synthase: implication for the existing susceptibility breakpoint. Antimicrob. Agents Chemother. 53:3690-3699. http://dx.doi.org/10.1128/AAC.00443-09.
28. Staab JF, Kahn JN, Marr KA. 2010. Differential Aspergillus lentulus echinocandin susceptibilities are Fksp independent. Antimicrob. Agents Chemother. 54:4992-4998. http://dx.doi.org/10.1128/AAC.00774-10.
29. Stevens DA. 2009. Frequency of paradoxical effect with caspofungin in Candida albicans. Eur. J. Clin. Microbiol. Infect. Dis. 28:717. http://dx.doi.org/10.1007/s10096-008-0688-y.
30. Stevens DA, White TC, Perlin DS, Selitrennikoff CP. 2005. Studies of the paradoxical effect of caspofungin at high drug concentrations. Diagn. Microbiol. Infect. Dis. 51:173-178. http://dx.doi.org/10.1016/j.diagmicrobio.2004.10.006. (Pubitemid 40568760)
31. Walker LA, Munro CA, de Bruijn I, Lenardon MD, McKinnon A, Gow NA. 2008. Stimulation of chitin synthesis rescues Candida albicans from echinocandins. PLoS Pathog. 4:e1000040. http://dx.doi.org/10.1371/journal.ppat.1000040.
32. Costa-de-Oliveira S, Marcos Miranda I, Silva RM, Pinto ESA, Rocha R, Amorim A, Goncalves Rodrigues A, Pina-Vaz C. 2011. FKS2 mutations associated with decreased echinocandin susceptibility of Candida glabrata following anidulafungin therapy. Antimicrob. Agents Chemother. 55:1312-1314. http://dx.doi.org/10.1128/AAC.00589-10.
33. Garcia-Effron G, Park S, Perlin DS. 2009. Correlating echinocandin MIC and kinetic inhibition of fks1 mutant glucan synthases for Candida albicans: implications for interpretive breakpoints. Antimicrob. Agents Chemother. 53:112-122. http://dx.doi.org/10.1128/AAC.01162-08.
34. Parmeland L, Gazon M, Guerin C, Argaud L, Lehot JJ, Bastien O, Allaouchiche B, Michallet M, Picot S, Bienvenu AL. 2013. Candida albicans and non-Candida albicans fungemia in an institutional hospital during a decade. Med. Mycol. 51:33-37. http://dx.doi.org/10.3109/13693786.2012.686673.
35. Murtagh F. 1984. Complexities of hierarchic clustering algorithms: the state of the art. Comput. Stat. 1:101-113.
36. Di Tommaso P, Moretti S, Xenarios I, Orobitg M, Montanyola A, Chang JM, Taly JF, Notredame C. 2011. T-Coffee: a web server for the multiple sequence alignment of protein and RNA sequences using structural information and homology extension. Nucleic Acids Res. 39:W13-W17. http://dx.doi.org/10.1093/nar/gkr245.
37. Taly JF, Magis C, Bussotti G, Chang JM, Di Tommaso P, Erb I, Espinosa-Carrasco J, Kemena C, Notredame C. 2011. Using the T-Coffee package to build multiple sequence alignments of protein, RNA, DNA sequences and 3D structures. Nat. Protoc. 6:1669-1682. http://dx.doi.org/10.1038/nprot.2011.393.