Conformational changes in the human estrogen receptor observed by 19F NMR

Biochemical and Biophysical Research Communications

Volumn 270, Issue 3, 2000, Pages 988-991

  Luck, Linda A ^a   Barse, Jessica L ^a   Luck, Amanda M ^a   Peck, Colleen H ^a  

^a CLARKSON UNIVERSITY   (United States)

Author keywords

19F NMR; Conformational change; Estradiol; Estrogen receptor; Hormone binding domain; Nuclear receptors

Indexed keywords

ESTRADIOL; ESTROGEN RECEPTOR; FLUORINE; GLUTATHIONE TRANSFERASE; TRYPTOPHAN;

ARTICLE; CONFORMATIONAL TRANSITION; HUMAN; LIGAND BINDING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL;

EID: 0034696773     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2000.2526     Document Type: Article

References (26)

1. Tsai M. J., O'Malley B. W. Molecular mechanisms of action of steroid/thyroid receptor superfamily members. Annu. Rev. Biochem. 63:1994;451-486.
2. Beato M., Herrlich P., Schutz G. Steroid hormone receptors: Many actors in search of a plot. Cell. 83:1995;851-857.
3. Kumar V., Green S., Stack G., Berry M., Jin J. R., Chambon P. Functional domains of the human estrogen receptor. Cell. 51:1987;941-951.
4. Beekman J. M., Allan G. F., Tsai S. Y., Tsai M.-J., O'Malley B. W. Transcriptional activity of the estrogen receptor requires a conformational change in the ligand binding domain. Mol. Endocrinol. 71:1993;266-274.
5. Fritsch M., Leary C. M., Furlow D., Ahrens H., Schuh T. J., Mueller G. C., Gorski J. A ligand-induced conformational change in the estrogen receptor is localized in the steroid binding domain. Biochemistry. 31:1992;5303-5311.
6. Moras D., Gronemeyer H. The nuclear receptor ligand-binding domain: Structure and function. Curr. Opin. Cell Biol. 10:1998;384-391.
7. Berry M., Metzger D., Chambon P. Role of the two activating domains of the estrogen receptor in cell-type and promoter context dependent antagonistic activity of the anti-estrogen 4-hydroxytamoxifen. EMBO J. 9:1990;2811-2818.
8. Carlson K. E., Choi I., Gee A., Katzenellenbogen B. S., Katzenellenbogen J. A. Altered ligand binding properties and enhanced stability of a constitutively active estrogen receptor: Evidence that an open pocket conformation is required for ligand interaction. Biochemistry. 36:1997;14897-14905.
9. Bourguet W., Ruff M., Chambon P., Gronemeyer H., Moras D. Crystal structure of the ligand-binding domain of the human nuclear RXR-alpha. Nature. 375:1995;377-382.
10. Wagner R. L., Apriletti J. W., McGrath M. E., West B. L., Baxter J. D., Fletterick R. J. A structural role for hormone in the thyroid hormone receptor. Nature. 378:1995;690-697.
11. Renaud J. P., Rochel N., Ruff M., Vivat V., Chambone P., Gronemeyer H., Moras D. Crystal structure of the RAR-gamma ligand-binding domain bound to all-trans retinoic acid. Nature. 378:1995;681-689.
12. Brzozowski A. M., Pike A. C. W., Dauter Z., Hubbard R. E., Bonn T., Engstrom O., Ohman L., Greene G. L., Gustafsson J., Carlquist M. Molecular basis of agonism and antagonism in the estrogen receptor. Nature. 389:1997;753-757.
13. Shiau A. K., Barstad D., Loria P. M., Cheng L. Kushner, P. J. Agard, D. A., Greene G. L. The structural basis of estrogen receptor/coactivator recognition and the antagonism of the interaction by tamoxifen. Cell. 95:1998;927-937.
14. Tanenbaum D. M., Wang Y., Williams S. P., Sigler P. B. Crystallographic comparison of the estrogen and progesterone receptor's ligand binding domains. Proc. Natl. Acad. Sci. USA. 95:1998;5998-6003.
15. 19F NMR studies of fluorinated sugars binding to the glucose and galactose receptor protein. Tech. Protein Chem. 6:1995;487-494.
16. 19F NMR. Magn. Reson. Chem. 35:1997;477-481.
17. Crabb J. W., Carlson A., Chen Y., Goldflam S. Intres, R. West, K. A. Hulmes, J. D. Kapron, J. T. Luck, L. A. Horwitz, J., Bok D. Structural and functional characterization of recombinant human cellular retinaldehyde-binding protein. Protein Sci. 7:1998;746-757.
18. 19F NMR results with the intrinsic fluorescence of soluble tissue factor. Proteins: Struct. Funct. Genet. 37:1999;709-716.
19. 19F NMR study of the binding of fluorinated diethylstilbestrol to the human estrogen receptor. Protein Peptide Lett. 6:1999;149-152.
20. 19F NMR to probe protein structure and conformational changes. Annu. Rev. Biophys. Biomol. Struct. 25:1996;163-195.
21. Doolittle W. F., Yanofsky C. Mutants of Escherichia coli with an altered trptophanyl-transfer ribonucleic acid synthetase. J. Bacteriol. 95:1968;1283-1294.
22. 19F NMR Studies of the d-galactose chemosensory receptor. 1. Sugar binding yields a global structural change. Biochemistry. 30:1991;4248-4252.
23. Scatchard G. The attractions of proteins for small molecules and ions. Ann. NY Acad. Sci. 51:1949;660-672.
24. Landel C., Kushner P., Greene G. The interaction of the human estrogen receptor with DNA is modulated by receptor-associated proteins. Mol. Endocrinol. 8:1994;1407-1419.
25. Seielstad D. A., Carlson K. E., Kushner P. J., Greene G. L., Katzenellenbogen J. A. Analysis of the structural core of the human estrogen receptor ligand binding domain by proteolysis/mass spectrometric analysis. Biochemistry. 34:1995;12605-12615.
26. Wagner G., Wuthrich K. Observation of internal motility of proteins by nuclear magnetic resonance. Methods Enzymol. 131:1986;307-326.