Rapid optimization of a peptide inhibitor of malaria parasite invasion by comprehensive N-methyl scanning

Journal of Biological Chemistry

Volumn 284, Issue 14, 2009, Pages 9361-9371

  Harris, Karen S ^a   Casey, Joanne L ^a,b   Coley, Andrew M ^a   Karas, John A ^c   Sabo, Jennifer K ^d   Tan, Yen Yee ^d   Dolezal, Olan ^e   Norton, Raymond S ^d   Hughes, Andrew B ^a   Scanlon, Denis ^c   Foley, Michael ^a,b  

^a LA TROBE UNIVERSITY   (Australia)

^b AdAlta Pty Ltd   (Australia)

^c UNIVERSITY OF MELBOURNE   (Australia)

^d WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^e CSIRO   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

APICAL MEMBRANES; BINDING PROPERTIES; BIOLOGICALLY ACTIVE PEPTIDES; DRUG DEVELOPMENT; MALARIA PARASITE; METHYL GROUP; METHYL SCANNING; N-METHYLATION; PARASITE-; PEPTIDE BACKBONES; PEPTIDE INHIBITORS; PEPTIDE THERAPEUTICS; PLASMODIUM FALCIPARUM; PROTEOLYTIC DEGRADATION; PROTEOLYTIC STABILITY; RAPID OPTIMIZATION; STRUCTURAL ALTERATIONS;

ALKYLATION; AMIDES; BINDING ENERGY; HYDROCARBONS; LEAD COMPOUNDS; METHYLATION;

AMINES;

AMIDE; APICAL MEMBRANE ANTIGEN 1; MALARIA VACCINE; PEPTIDE DERIVATIVE; PEPTIDE INHIBITOR; PROTEIN INHIBITOR; R1 PEPTIDE; UNCLASSIFIED DRUG; ANTIMALARIAL AGENT; PEPTIDE;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; MALARIA FALCIPARUM; METHYLATION; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PEPTIDE SYNTHESIS; PHAGE DISPLAY; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN MODIFICATION; PROTEIN STABILITY; SOLID PHASE SYNTHESIS; AMINO ACID SEQUENCE; ANIMAL; CHEMISTRY; DRUG EFFECT; ENZYME SPECIFICITY; MOLECULAR GENETICS; NUCLEAR MAGNETIC RESONANCE; SURFACE PLASMON RESONANCE; TIME;

PLASMODIUM FALCIPARUM;

AMINO ACID SEQUENCE; ANIMALS; ANTIMALARIALS; METHYLATION; MOLECULAR SEQUENCE DATA; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PEPTIDES; PLASMODIUM FALCIPARUM; SUBSTRATE SPECIFICITY; SURFACE PLASMON RESONANCE; TIME FACTORS;

EID: 66149111751     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M808762200     Document Type: Article

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