Activation of peroxisome proliferator-Activated receptor δ inhibits angiotensin II-induced activation of matrix metalloproteinase-2 in vascular smooth muscle cells

Journal of Vascular Research

Volumn 51, Issue 3, 2014, Pages 221-230

  Ham, Sun Ah ^a   Lee, Hanna ^a   Hwang, Jung Seok ^a   Kang, Eun Sil ^a   Yoo, Taesik ^a   Paek, Kyung Shin ^b   Do, Jeong Tae ^a   Park, Chankyu ^a   Oh, Jae Wook ^a   Kim, Jin Hoi ^a   Han, Chang Woo ^c   Seo, Han Geuk ^a  

^a Konkuk University   (South Korea)

^b Semyung University   (South Korea)

^c Pusan National University   (South Korea)

Author keywords

Angiotensin II; Cell migration; Matrix metalloproteinases; Peroxisome proliferator Activated receptor; Tissue inhibitor of metalloproteinases

Indexed keywords

ANGIOTENSIN II; GELATINASE A; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; [2 METHYL 4 [4 METHYL 2 (4 TRIFLUOROMETHYLPHENYL) 5 THIAZOLYLMETHYLTHIO]PHENOXY]ACETIC ACID; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PROTEIN KINASE; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TISSUE INHIBITOR OF METALLOPROTEINASE 3;

ANIMAL CELL; ARTICLE; CELL MIGRATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; EXTRACELLULAR MATRIX; GENETIC TRANSFECTION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; UPREGULATION; VASCULAR SMOOTH MUSCLE; BLOOD VESSEL TONE; DRUG EFFECT; GENE REPRESSION; IN VITRO STUDY; MEDIATOR; PROTEIN DEGRADATION; PROTEIN EXPRESSION; RECEPTOR UPREGULATION; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE CELL;

ANGIOTENSIN II; ANIMALS; CELLS, CULTURED; ENZYME ACTIVATION; MALE; MATRIX METALLOPROTEINASE 2; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; PHOSPHATIDYLINOSITOL 3-KINASES; PPAR DELTA; PROTO-ONCOGENE PROTEINS C-AKT; RATS; SIGNAL TRANSDUCTION; THIAZOLES;

EID: 84906041607     PISSN: 10181172     EISSN: 14230135     Source Type: Journal    
DOI: 10.1159/000365250     Document Type: Article

References (35)

1. Issemann I, Green S: Activation of a memberof the steroid hormone receptor superfamilyby peroxisome proliferators. Nature 1990;347: 645-650.
2. Kersten S, Desvergne B, Wahli W: Roles ofPPARs in health and disease. Nature 2000;405: 421-424.
3. Tugwood JD, Issemann I, Anderson RG, BundellKR, McPheat WL, Green S: The mouseperoxisome proliferator activated receptorrecognizes a response element in the 5 ′ flankingsequence of the rat acyl CoA oxidase gene. EMBO J 1992; 11: 433-439.
4. Kim HJ, Ham SA, Kim MY, Hwang JS, Lee H,Kang ES, Yoo T, Woo IS, Yabe-Nishimura C,Paek KS, Kim JH, Seo HG: PPARδ coordinatesangiotensin II-induced senescence invascular smooth muscle cells through PTENmediatedinhibition of superoxide generation. J Biol Chem 2011; 286: 44585-44593.
5. Lee CH, Chawla A, Urbiztondo N, Liao D,Boisvert WA, Evans RM, Curtiss LK: Transcriptionalrepression of atherogenic inflammation:modulation by PPARdelta. Science2003; 302: 453-457.
6. Marx N, Duez H, Fruchart JC, Staels B: Peroxisomeproliferator-Activated receptors andatherogenesis: regulators of gene expressionin vascular cells. Circ Res 2004; 94: 1168-1178.
7. Kim HJ, Kim MY, Jin H, Kim HJ, Kang SS,Kim HJ, Lee JH, Chang KC, Hwang JY, Yabe-Nishimura C, Kim JH, Seo HG: Peroxisomeproliferator-Activated receptor {delta} regulatesextracellular matrix and apoptosis ofvascular smooth muscle cells through the activationof transforming growth factor-{beta}1/Smad3. Circ Res 2009; 105: 16-24.
8. Kim HJ, Ham SA, Paek KS, Hwang JS, JungSY, Kim MY, Jin H, Kang ES, Woo IS, Kim HJ,Lee JH, Chang KC, Han CW, Seo HG: Transcriptionalup-regulation of antioxidantgenes by PPARδ inhibits angiotensin II-inducedpremature senescence in vascularsmooth muscle cells. Biochem Biophys ResCommun 2011; 406: 564-569.
9. Kim MY, Kang ES, Ham SA, Hwang JS, YooTS, Lee H, Paek KS, Park C, Lee HT, Kim JH,Han CW, Seo HG: The PPARδ-mediated inhibitionof angiotensin II-induced prematuresenescence in human endothelial cells isSIRT1-dependent. Biochem Pharmacol 2012;84: 1627-1634.
10. Kim HJ, Kim MY, Hwang JS, Kim HJ, LeeJH, Chang KC, Kim JH, Han CW, Kim JH,Seo HG: PPARdelta inhibits IL-1beta-stimulatedproliferation and migration of vascularsmooth muscle cells via up-regulation ofIL-1Ra. Cell Mol Life Sci 2010; 67: 2119-2130.
11. Visse R, Nagase H: Matrix metalloproteinasesand tissue inhibitors of metalloproteinases:structure, function, and biochemistry. CircRes 2003; 92: 827-839.
12. Raffetto JD, Khalil RA: Matrix metalloproteinasesand their inhibitors in vascular remodelingand vascular disease. BiochemPharmacol 2008; 75: 346-359.
13. Yasumitsu H, Miyazaki K, Umenishi F, KoshikawaN, Umeda M: Comparison of extracellularmatrix-degrading activities between64-kDa and 90-kDa gelatinases purified ininhibitor-free forms from human schwannomacells. J Biochem 1992; 111: 74-80.
14. Kuzuya M, Kanda S, Sasaki T, Tamaya-MoriN, Cheng XW, Itoh T, Itohara S, Iguchi A: Deficiencyof gelatinase a suppresses smoothmuscle cell invasion and development of experimentalintimal hyperplasia. Circulation2003; 108: 1375-1381.
15. Cho A, Reidy MA: Matrix metalloproteinase-9 is necessary for the regulation of smoothmuscle cell replication and migration after arterialinjury. Circ Res 2002; 91: 845-851.
16. Mason DP, Kenagy RD, Hasenstab D, Bowen-Pope DF, Seifert RA, Coats S, Hawkins SM,Clowes AW: Matrix metalloproteinase-9overexpression enhances vascular smoothmuscle cell migration and alters remodelingin the injured rat carotid artery. Circ Res 1999;85: 1179-1185.
17. Arenas IA, Xu Y, Lopez-Jaramillo P, DavidgeST: Angiotensin II-induced MMP-2 releasefrom endothelial cells is mediated by TNFalpha. Am J Physiol Cell Physiol 2004;286:C779-C784.
18. Luchtefeld M, Grote K, Grothusen C, Bley S,Bandlow N, Selle T, Struber M, Haverich A,Bavendiek U, Drexler H, Schieffer B: AngiotensinII induces MMP-2 in a p47phox-dependentmanner. Biochem Biophys Res Commun2005; 328: 183-188.
19. Susa S, Wakabayashi I: Extracellular alkalosisactivates ERK mitogen-Activated protein kinaseof vascular smooth muscle cells throughNADPH-mediated formation of reactive oxygenspecies. FEBS Lett 2003; 554: 399-402.
20. Baumer AT, Ten Freyhaus H, Sauer H, WartenbergM, Kappert K, Schnabel P, Konkol C, HeschelerJ, Vantler M, Rosenkranz S: Phosphatidylinositol3-kinase- dependent membrane recruitmentof Rac-1 and p47phox is critical foralpha-platelet-derived growth factor receptorinducedproduction of reactive oxygen species. J Biol Chem 2008; 283: 7864-7876.
21. Ham SA, Kang ES, Lee H, Hwang JS, Yoo T,Paek KS, Park C, Kim JH, Lim DS, Seo HG:PPARδ inhibits UVB-induced secretion ofMMP-1 through MKP-7-mediated suppressionof JNK signaling. J Invest Dermatol 2013;133: 2593-2600.
22. Meissner M, Berlinski B, Doll M, Hrgovic I,Laubach V, Reichenbach G, Kippenberger S,Gille J, Kaufmann R: AP1-dependent repressionof TGFα-mediated MMP9 upregulationby PPARδ agonists in keratinocytes. Exp Dermatol2011; 20: 425-429.
23. Nguyen Dinh Cat A, Touyz RM: Cell signalingof angiotensin II on vascular tone: novelmechanisms. Curr Hypertens Rep 2011; 13:122-128.
24. Livak KJ, Schmittgen TD: Analysis of relativegene expression data using real-time quantitativePCR and the 2(-Delta Delta C(T))method. Methods 2001; 25: 402-408.
25. Ahmed SH, Clark LL, Pennington WR, WebbCS, Bonnema DD, Leonardi AH, McClureCD, Spinale FG, Zile MR: Matrix metalloproteinases/tissue inhibitors of metalloproteinases:relationship between changes in proteolyticdeterminants of matrix composition andstructural, functional, and clinical manifestationsof hypertensive heart disease. Circulation2006; 113: 2089-2096.
26. Vigetti D, Moretto P, Viola M, Genasetti A,Rizzi M, Karousou E, Pallotti F, De Luca G, PassiA: Matrix metalloproteinase 2 and tissue inhibitorsof metalloproteinases regulate humanaortic smooth muscle cell migration during invitro aging. FASEB J 2006; 20: 1118-1130.
27. Rosenberg GA, Estrada EY, Dencoff JE: Matrixmetalloproteinases and TIMPs are associatedwith blood-brain barrier opening afterreperfusion in rat brain. Stroke 1998; 29:2189-2195.
28. Yin KJ, Deng Z, Hamblin M, Zhang J, ChenYE: Vascular PPARdelta protects againststroke-induced brain injury. ArteriosclThromb Vasc Biol 2011; 31: 574-581.
29. Ehrenborg E, Krook A: Regulation of skeletalmuscle physiology and metabolism by peroxisomeproliferator-Activated receptor delta. Pharmacol Rev 2009; 61: 373-393.
30. Lim HJ, Lee S, Park JH, Lee KS, Choi HE,Chung KS, Lee HH, Park HY: PPAR delta agonistl-165041 inhibits rat vascular smoothmuscle cell proliferation and migration via inhibitionof cell cycle. Atherosclerosis 2009;202: 446-454.
31. Jimenez E, Perez de la Blanca E, Urso L,Gonzalez I, Salas J, Montiel M: Angiotensin iiinduces MMP 2 activity via FAK/JNK pathwayin human endothelial cells. Biochem BiophysRes Commun 2009; 380: 769-774.
32. Lee H, Ham SA, Kim MY, Kim JH, Paek KS,Kang ES, Kim HJ, Hwang JS, Yoo T, Park C,Kim JH, Lim DS, Han CW, Seo HG: Activationof PPARδ counteracts angiotensin II-inducedROS generation by inhibiting rac1translocation in vascular smooth muscle cells. Free Radic Res 2012; 46: 912-919.
33. Dollery CM, McEwan JR, Henney AM: Matrixmetalloproteinases and cardiovasculardisease. Circ Res 1995; 77: 863-868.
34. Forough R, Koyama N, Hasenstab D, Lea H,Clowes M, Nikkari ST, Clowes AW: Overexpressionof tissue inhibitor of matrix metalloproteinase-1 inhibits vascular smooth musclecell functions in vitro and in vivo. Circ Res1996; 79: 812-820.
35. Zempo N, Koyama N, Kenagy RD, Lea HJ,Clowes AW: Regulation of vascular smoothmuscle cell migration and proliferation in vitroand in injured rat arteries by a syntheticmatrix metalloproteinase inhibitor. ArteriosclThromb Vasc Biol 1996; 16: 28-33.