-
1
-
-
70149105476
-
Ewing's sarcoma: Standard and experimental treatment options
-
Subbiah V, Anderson P, Lazar AJ, Burdett E, Raymond K, et al. (2009) Ewing's sarcoma: standard and experimental treatment options. Curr Treat Options Oncol 10: 126-140.
-
(2009)
Curr Treat Options Oncol
, vol.10
, pp. 126-140
-
-
Subbiah, V.1
Anderson, P.2
Lazar, A.J.3
Burdett, E.4
Raymond, K.5
-
2
-
-
0026686674
-
Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours
-
Delattre O, Zucman J, Plougastel B, Desmaze C, Melot T, et al. (1992) Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours. Nature 359: 162-165.
-
(1992)
Nature
, vol.359
, pp. 162-165
-
-
Delattre, O.1
Zucman, J.2
Plougastel, B.3
Desmaze, C.4
Melot, T.5
-
3
-
-
0026520801
-
A novel reciprocal chromosome translocation t(11;22)(p13;q12) in an intraabdominal desmoplastic small round-cell tumor
-
Sawyer JR, Tryka AF, Lewis JM (1992) A novel reciprocal chromosome translocation t(11;22)(p13;q12) in an intraabdominal desmoplastic small round-cell tumor. Am J Surg Pathol 16: 411-416.
-
(1992)
Am J Surg Pathol
, vol.16
, pp. 411-416
-
-
Sawyer, J.R.1
Tryka, A.F.2
Lewis, J.M.3
-
4
-
-
0028799662
-
Characterization of the genomic breakpoint and chimeric transcripts in the EWS-WT1 gene fusion of desmoplastic small round cell tumor
-
Gerald WL, Rosai J, Ladanyi M (1995) Characterization of the genomic breakpoint and chimeric transcripts in the EWS-WT1 gene fusion of desmoplastic small round cell tumor. Proc Natl Acad Sci U S A 92: 1028-1032.
-
(1995)
Proc Natl Acad Sci U S a
, vol.92
, pp. 1028-1032
-
-
Gerald, W.L.1
Rosai, J.2
Ladanyi, M.3
-
5
-
-
0030341370
-
Specificity of the EWS/WT1 gene fusion for desmoplastic small round cell tumour
-
Ladanyi M, Gerald WL (1996) Specificity of the EWS/WT1 gene fusion for desmoplastic small round cell tumour. J Pathol 180: 462.
-
(1996)
J Pathol
, vol.180
, pp. 462
-
-
Ladanyi, M.1
Gerald, W.L.2
-
6
-
-
0037456435
-
Addition of ifosfamide and etoposide to standard chemotherapy for Ewing's sarcoma and primitive neuroectodermal tumor of bone
-
DOI 10.1056/NEJMoa020890
-
Grier HE, Krailo MD, Tarbell NJ, Link MP, Fryer CJ, et al. (2003) Addition of ifosfamide and etoposide to standard chemotherapy for Ewing's sarcoma and primitive neuroectodermal tumor of bone. N Engl J Med 348: 694-701. (Pubitemid 36237038)
-
(2003)
New England Journal of Medicine
, vol.348
, Issue.8
, pp. 694-701
-
-
Grier, H.E.1
Krailo, M.D.2
Tarbell, N.J.3
Link, M.P.4
Fryer, C.J.H.5
Pritchard, D.J.6
Gebhardt, M.C.7
Dickman, P.S.8
Perlman, E.J.9
Meyers, P.A.10
Donaldson, S.S.11
Moore, S.12
Rausen, A.R.13
Vietti, T.J.14
Miser, J.S.15
-
7
-
-
4344571848
-
Treatment of metastatic Ewing's sarcoma or primitive neuroectodermal tumor of bone: Evaluation of combination ifosfamide and etoposide - A children's cancer group and pediatric oncology group study
-
DOI 10.1200/JCO.2004.01.041
-
Miser JS, Krailo MD, Tarbell NJ, Link MP, Fryer CJ, et al. (2004) Treatment of metastatic Ewing's sarcoma or primitive neuroectodermal tumor of bone: evaluation of combination ifosfamide and etoposide-a Children's Cancer Group and Pediatric Oncology Group study. J Clin Oncol 22: 2873-2876. (Pubitemid 41079906)
-
(2004)
Journal of Clinical Oncology
, vol.22
, Issue.14
, pp. 2873-2876
-
-
Miser, J.S.1
Krailo, M.D.2
Tarbell, N.J.3
Link, M.P.4
Fryer, C.J.H.5
Pritchard, D.J.6
Gebhardt, M.C.7
Dickman, P.S.8
Perhnan, E.J.9
Meyers, P.A.10
Donaldson, S.S.11
Moore, S.12
Rausen, A.R.13
Vietti, T.J.14
Grier, H.E.15
-
8
-
-
77950809826
-
Chemotherapy resistance and retreatment: A dogma revisited
-
Naing A, Kurzrock R (2010) Chemotherapy resistance and retreatment: a dogma revisited. Clin Colorectal Cancer 9: E1-4.
-
(2010)
Clin Colorectal Cancer
, vol.9
-
-
Naing, A.1
Kurzrock, R.2
-
9
-
-
80052831572
-
Phase I trial of cixutumumab combined with temsirolimus in patients with advanced cancer
-
Naing A, Kurzrock R, Burger A, Gupta S, Lei X, et al. (2011) Phase I trial of cixutumumab combined with temsirolimus in patients with advanced cancer. Clin Cancer Res 17: 6052-6060.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 6052-6060
-
-
Naing, A.1
Kurzrock, R.2
Burger, A.3
Gupta, S.4
Lei, X.5
-
10
-
-
84860506226
-
Insulin Growth Factor-Receptor (IGF-1R) Antibody Cixutumumab Combined with the mTOR Inhibitor Temsirolimus in Patients with Refractory Ewing's Sarcoma Family Tumors
-
Naing A, Lorusso P, Fu S, Hong DS, Anderson P, et al. (2012) Insulin Growth Factor-Receptor (IGF-1R) Antibody Cixutumumab Combined with the mTOR Inhibitor Temsirolimus in Patients with Refractory Ewing's Sarcoma Family Tumors. Clin Cancer Res.
-
(2012)
Clin Cancer Res
-
-
Naing, A.1
Lorusso, P.2
Fu, S.3
Hong, D.S.4
Anderson, P.5
-
11
-
-
79953742425
-
Targeted morphoproteomic profiling of Ewing's sarcoma treated with insulin-like growth factor 1 receptor (IGF1R) inhibitors: Response/resistance signatures
-
Subbiah V, Naing A, Brown RE, Chen H, Doyle L, et al. (2011) Targeted morphoproteomic profiling of Ewing's sarcoma treated with insulin-like growth factor 1 receptor (IGF1R) inhibitors: response/resistance signatures. PLoS One 6: e18424.
-
(2011)
PLoS One
, vol.6
-
-
Subbiah, V.1
Naing, A.2
Brown, R.E.3
Chen, H.4
Doyle, L.5
-
12
-
-
84867649825
-
Ewing's sarcoma: Overcoming the therapeutic plateau
-
Subbiah V, Kurzrock R (2012) Ewing's sarcoma: overcoming the therapeutic plateau. Discov Med 13: 405-415.
-
(2012)
Discov Med
, vol.13
, pp. 405-415
-
-
Subbiah, V.1
Kurzrock, R.2
-
13
-
-
77950974697
-
A phase I study of weekly R1507, a human monoclonal antibody insulin-like growth factor-I receptor antagonist, in patients with advanced solid tumors
-
Kurzrock R, Patnaik A, Aisner J, Warren T, Leong S, et al. (2010) A phase I study of weekly R1507, a human monoclonal antibody insulin-like growth factor-I receptor antagonist, in patients with advanced solid tumors. Clin Cancer Res 16: 2458-2465.
-
(2010)
Clin Cancer Res
, vol.16
, pp. 2458-2465
-
-
Kurzrock, R.1
Patnaik, A.2
Aisner, J.3
Warren, T.4
Leong, S.5
-
14
-
-
80053994190
-
R1507, an anti-insulin-like growth factor-1 receptor (IGF-1R) antibody, and EWS/FLI-1 siRNA in Ewing's sarcoma: Convergence at the IGF/IGFR/Akt axis
-
Huang HJ, Angelo LS, Rodon J, Sun M, Kuenkele KP, et al. (2011) R1507, an anti-insulin-like growth factor-1 receptor (IGF-1R) antibody, and EWS/FLI-1 siRNA in Ewing's sarcoma: convergence at the IGF/IGFR/Akt axis. PLoS One 6: e26060.
-
(2011)
PLoS One
, vol.6
-
-
Huang, H.J.1
Angelo, L.S.2
Rodon, J.3
Sun, M.4
Kuenkele, K.P.5
-
15
-
-
84858693604
-
Desmoplastic small round cell tumors with EWS-WT1 fusion transcript in children and young adults
-
Philippe-Chomette P, Kabbara N, Andre N, Pierron G, Coulomb A, et al. (2012) Desmoplastic small round cell tumors with EWS-WT1 fusion transcript in children and young adults. Pediatr Blood Cancer 58: 891-897.
-
(2012)
Pediatr Blood Cancer
, vol.58
, pp. 891-897
-
-
Philippe-Chomette, P.1
Kabbara, N.2
Andre, N.3
Pierron, G.4
Coulomb, A.5
-
16
-
-
79958820809
-
The diagnosis and management of desmoplastic small round cell tumor: A review
-
Hayes-Jordan A, Anderson PM (2011) The diagnosis and management of desmoplastic small round cell tumor: a review. Curr Opin Oncol 23: 385-389.
-
(2011)
Curr Opin Oncol
, vol.23
, pp. 385-389
-
-
Hayes-Jordan, A.1
Anderson, P.M.2
-
17
-
-
0033678069
-
The clinical approach to desmoplastic small round cell tumor
-
Quaglia MP, Brennan MF (2000) The clinical approach to desmoplastic small round cell tumor. Surg Oncol 9: 77-81.
-
(2000)
Surg Oncol
, vol.9
, pp. 77-81
-
-
Quaglia, M.P.1
Brennan, M.F.2
-
18
-
-
79959795786
-
Improved survival with vemurafenib in melanoma with BRAF V600E mutation
-
Chapman PB, Hauschild A, Robert C, Haanen JB, Ascierto P, et al. (2011) Improved survival with vemurafenib in melanoma with BRAF V600E mutation. N Engl J Med 364: 2507-2516.
-
(2011)
N Engl J Med
, vol.364
, pp. 2507-2516
-
-
Chapman, P.B.1
Hauschild, A.2
Robert, C.3
Haanen, J.B.4
Ascierto, P.5
-
19
-
-
78049425319
-
Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer
-
Kwak EL, Bang YJ, Camidge DR, Shaw AT, Solomon B, et al. (2010) Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer. N Engl J Med 363: 1693-1703.
-
(2010)
N Engl J Med
, vol.363
, pp. 1693-1703
-
-
Kwak, E.L.1
Bang, Y.J.2
Camidge, D.R.3
Shaw, A.T.4
Solomon, B.5
-
20
-
-
84856555606
-
Oncogene mutation profiling of pediatric solid tumors reveals significant subsets of embryonal rhabdomyosarcoma and neuroblastoma with mutated genes in growth signaling pathways
-
Shukla N, Ameur N, Yilmaz I, Nafa K, Lau CY, et al. (2012) Oncogene mutation profiling of pediatric solid tumors reveals significant subsets of embryonal rhabdomyosarcoma and neuroblastoma with mutated genes in growth signaling pathways. Clin Cancer Res 18: 748-757.
-
(2012)
Clin Cancer Res
, vol.18
, pp. 748-757
-
-
Shukla, N.1
Ameur, N.2
Yilmaz, I.3
Nafa, K.4
Lau, C.Y.5
-
21
-
-
84880823765
-
Germline PTPRD mutations in Ewing sarcoma: Biologic and clinical implications
-
Jiang Y, Janku F, Subbiah V, Angelo LS, Naing A, et al. (2013) Germline PTPRD mutations in Ewing sarcoma: biologic and clinical implications. Oncotarget 4: 884-889.
-
(2013)
Oncotarget
, vol.4
, pp. 884-889
-
-
Jiang, Y.1
Janku, F.2
Subbiah, V.3
Angelo, L.S.4
Naing, A.5
-
22
-
-
84880774563
-
Morphoproteomic profiling of the mammalian target of rapamycin (mTOR) signaling pathway in desmoplastic small round cell tumor (EWS/WT1), Ewing's sarcoma (EWS/FLI1) and Wilms' tumor(WT1)
-
Subbiah V, Brown RE, Jiang Y, Buryanek J, Hayes-Jordan A, et al. (2013) Morphoproteomic profiling of the mammalian target of rapamycin (mTOR) signaling pathway in desmoplastic small round cell tumor (EWS/WT1), Ewing's sarcoma (EWS/FLI1) and Wilms' tumor(WT1). PLoS One 8: e68985.
-
(2013)
PLoS One
, vol.8
-
-
Subbiah, V.1
Brown, R.E.2
Jiang, Y.3
Buryanek, J.4
Hayes-Jordan, A.5
-
23
-
-
79958696694
-
The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling
-
Hsu PP, Kang SA, Rameseder J, Zhang Y, Ottina KA, et al. (2011) The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. Science 332: 1317-1322.
-
(2011)
Science
, vol.332
, pp. 1317-1322
-
-
Hsu, P.P.1
Kang, S.A.2
Rameseder, J.3
Zhang, Y.4
Ottina, K.A.5
-
24
-
-
79958696336
-
Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling
-
Yu Y, Yoon SO, Poulogiannis G, Yang Q, Ma XM, et al. (2011) Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling. Science 332: 1322-1326.
-
(2011)
Science
, vol.332
, pp. 1322-1326
-
-
Yu, Y.1
Yoon, S.O.2
Poulogiannis, G.3
Yang, Q.4
Ma, X.M.5
-
25
-
-
67249088143
-
The tyrosine phosphatase PTPRD is a tumor suppressor that is frequently inactivated and mutated in glioblastoma and other human cancers
-
Veeriah S, Brennan C, Meng S, Singh B, Fagin JA, et al. (2009) The tyrosine phosphatase PTPRD is a tumor suppressor that is frequently inactivated and mutated in glioblastoma and other human cancers. Proc Natl Acad Sci U S A 106: 9435-9440.
-
(2009)
Proc Natl Acad Sci U S a
, vol.106
, pp. 9435-9440
-
-
Veeriah, S.1
Brennan, C.2
Meng, S.3
Singh, B.4
Fagin, J.A.5
-
26
-
-
33645242181
-
STAT3 is activated in a subset of the Ewing sarcoma family of tumours
-
Lai R, Navid F, Rodriguez-Galindo C, Liu T, Fuller CE, et al. (2006) STAT3 is activated in a subset of the Ewing sarcoma family of tumours. J Pathol 208: 624-632.
-
(2006)
J Pathol
, vol.208
, pp. 624-632
-
-
Lai, R.1
Navid, F.2
Rodriguez-Galindo, C.3
Liu, T.4
Fuller, C.E.5
-
27
-
-
84862999938
-
Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer
-
Misale S, Yaeger R, Hobor S, Scala E, Janakiraman M, et al. (2012) Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer. Nature 486: 532-536.
-
(2012)
Nature
, vol.486
, pp. 532-536
-
-
Misale, S.1
Yaeger, R.2
Hobor, S.3
Scala, E.4
Janakiraman, M.5
-
28
-
-
84862975924
-
Cancer: Pinprick diagnostics
-
Vilar E, Tabernero J (2012) Cancer: Pinprick diagnostics. Nature 486: 482-483.
-
(2012)
Nature
, vol.486
, pp. 482-483
-
-
Vilar, E.1
Tabernero, J.2
-
29
-
-
84863000299
-
The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers
-
Diaz LA Jr, Williams RT, Wu J, Kinde I, Hecht JR, et al. (2012) The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers. Nature 486: 537-540.
-
(2012)
Nature
, vol.486
, pp. 537-540
-
-
Diaz Jr., L.A.1
Williams, R.T.2
Wu, J.3
Kinde, I.4
Hecht, J.R.5
-
30
-
-
77954668198
-
Acquired KRAS mutations during progression of colorectal cancer metastases: Possible implications for therapy and prognosis
-
Bouchahda M, Karaboue A, Saffroy R, Innominato P, Gorden L, et al. (2010) Acquired KRAS mutations during progression of colorectal cancer metastases: possible implications for therapy and prognosis. Cancer Chemother Pharmacol 66: 605-609.
-
(2010)
Cancer Chemother Pharmacol
, vol.66
, pp. 605-609
-
-
Bouchahda, M.1
Karaboue, A.2
Saffroy, R.3
Innominato, P.4
Gorden, L.5
-
31
-
-
30644467070
-
RACK1 recruits STAT3 specifically to insulin and insulin-like growth factor 1 receptors for activation, which is important for regulating anchorage-independent growth
-
DOI 10.1128/MCB.26.2.413-424.2006
-
Zhang W, Zong CS, Hermanto U, Lopez-Bergami P, Ronai Z, et al. (2006) RACK1 recruits STAT3 specifically to insulin and insulin-like growth factor 1 receptors for activation, which is important for regulating anchorage- independent growth. Mol Cell Biol 26: 413-424. (Pubitemid 43089756)
-
(2006)
Molecular and Cellular Biology
, vol.26
, Issue.2
, pp. 413-424
-
-
Zhang, W.1
Zong, C.S.2
Hermanto, U.3
Lopez-Bergami, P.4
Ronai, Z.5
Wang, L.-H.6
-
32
-
-
0141988690
-
c-MET mutational analysis in small cell lung cancer: Novel juxtamembrane domain mutations regulating cytoskeletal functions
-
Ma PC, Kijima T,Maulik G, Fox EA, Sattler M, et al. (2003) c-MET mutational analysis in small cell lung cancer: novel juxtamembrane domain mutations regulating cytoskeletal functions. Cancer Res 63: 6272-6281. (Pubitemid 37255174)
-
(2003)
Cancer Research
, vol.63
, Issue.19
, pp. 6272-6281
-
-
Ma, P.C.1
Kijima, T.2
Maulik, G.3
Fox, E.A.4
Sattler, M.5
Griffin, J.D.6
Johnson, B.E.7
Salgia, R.8
-
33
-
-
0031854558
-
The roles of hepatocyte growth factor/scatter factor and Met receptor in human cancers (Review)
-
To CT, Tsao MS (1998) The roles of hepatocyte growth factor/scatter factor and met receptor in human cancers (Review). Oncol Rep 5: 1013-1024. (Pubitemid 28372555)
-
(1998)
Oncology Reports
, vol.5
, Issue.5
, pp. 1013-1024
-
-
To, C.T.T.1
Tsao, M.S.2
-
34
-
-
34247465448
-
c-Met is a potentially new therapeutic target for treatment of human melanoma
-
DOI 10.1158/1078-0432.CCR-06-0776
-
Puri N, Ahmed S, Janamanchi V, Tretiakova M, Zumba O, et al. (2007) c-Met is a potentially new therapeutic target for treatment of human melanoma. Clin Cancer Res 13: 2246-2253. (Pubitemid 46649894)
-
(2007)
Clinical Cancer Research
, vol.13
, Issue.7
, pp. 2246-2253
-
-
Puri, N.1
Ahmed, S.2
Janamanchi, V.3
Tretiakova, M.4
Zumba, O.5
Krausz, T.6
Jagadeeswaran, R.7
Salgia, R.8
-
35
-
-
70349443680
-
Ethnic differences and functional analysis of MET mutations in lung cancer
-
Krishnaswamy S, Kanteti R, Duke-Cohan JS, Loganathan S, Liu W, et al. (2009) Ethnic differences and functional analysis of MET mutations in lung cancer. Clin Cancer Res 15: 5714-5723.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 5714-5723
-
-
Krishnaswamy, S.1
Kanteti, R.2
Duke-Cohan, J.S.3
Loganathan, S.4
Liu, W.5
-
36
-
-
37249056471
-
The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations
-
DOI 10.1126/science.1150799
-
Huang CH, Mandelker D, Schmidt-Kittler O, Samuels Y, Velculescu VE, et al. (2007) The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations. Science 318: 1744-1748. (Pubitemid 350274378)
-
(2007)
Science
, vol.318
, Issue.5857
, pp. 1744-1748
-
-
Huang, C.-H.1
Mandelker, D.2
Schmidt-Kittler, O.3
Samuels, Y.4
Velculescu, V.E.5
Kinzler, K.W.6
Vogelstein, B.7
Gabelli, S.B.8
Amzel, L.M.9
-
37
-
-
0033604577
-
Signaling by distinct classes of phosphoinositide 3-kinases
-
Vanhaesebroeck B, Waterfield MD (1999) Signaling by distinct classes of phosphoinositide 3-kinases. Exp Cell Res 253: 239-254.
-
(1999)
Exp Cell Res
, vol.253
, pp. 239-254
-
-
Vanhaesebroeck, B.1
Waterfield, M.D.2
-
38
-
-
0036632368
-
The phosphatidylinositol 3-kinase-AKT pathway in human cancer
-
Vivanco I, Sawyers CL (2002) The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat Rev Cancer 2: 489-501. (Pubitemid 37328931)
-
(2002)
Nature Reviews Cancer
, vol.2
, Issue.7
, pp. 489-501
-
-
Vivanco, I.1
Sawyers, C.L.2
-
39
-
-
20444374445
-
Mutant PIK3CA promotes cell growth and invasion of human cancer cells
-
DOI 10.1016/j.ccr.2005.05.014, PII S1535610805001601
-
Samuels Y, Diaz LA Jr, Schmidt-Kittler O, Cummins JM, Delong L, et al. (2005) Mutant PIK3CA promotes cell growth and invasion of human cancer cells. Cancer Cell 7: 561-573. (Pubitemid 40799249)
-
(2005)
Cancer Cell
, vol.7
, Issue.6
, pp. 561-573
-
-
Samuels, Y.1
Diaz Jr., L.A.2
Schmidt-Kittler, O.3
Cummins, J.M.4
DeLong, L.5
Cheong, I.6
Rago, C.7
Huso, D.L.8
Lengauer, C.9
Kinzler, K.W.10
Vogelstein, B.11
Velculescu, V.E.12
|