Cold temperature improves mobility and survival in Drosophila models of autosomal-dominant hereditary spastic paraplegia (AD-HSP)

DMM Disease Models and Mechanisms

Volumn 7, Issue 8, 2014, Pages 1005-1012

  Baxter, Sally L ^a   Allard, Denise E ^b   Crowl, Christopher ^c   Sherwood, Nina Tang ^c  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

^c DUKE UNIVERSITY   (United States)

Author keywords

AD HSP; Cold treatment; Drosophila disease model; Hereditary spastic paraplegia; Microtubule severing; Spastin; Therapeutic hypothermia

Indexed keywords

ADENOSINE TRIPHOSPHATASE; CALCIUM CHANNEL; DROSOPHILA PROTEIN; FLOWER PROTEIN, DROSOPHILA; KATANIN P60-LIKE 1 PROTEIN, DROSOPHILA; SPASTIN PROTEIN, DROSOPHILA;

ANIMAL; COLD; DISEASE MODEL; DROSOPHILA MELANOGASTER; GENETICS; GENOTYPE; HEREDITARY MOTOR SENSORY NEUROPATHY; INSECT; LARVA; LONGEVITY; METABOLISM; MOTOR ACTIVITY; MOVEMENT (PHYSIOLOGY); MUTATION; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; SURVIVAL; SYNAPSE; TRANSGENIC ANIMAL;

ADENOSINE TRIPHOSPHATASES; ANIMALS; ANIMALS, GENETICALLY MODIFIED; CALCIUM CHANNELS; COLD TEMPERATURE; DISEASE MODELS, ANIMAL; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; GENOTYPE; LARVA; LONGEVITY; MOTOR ACTIVITY; MOVEMENT; MUTATION; PUPA; SPASTIC PARAPLEGIA, HEREDITARY; SURVIVAL ANALYSIS; SYNAPSES;

EID: 84905868503     PISSN: 17548403     EISSN: 17548411     Source Type: Journal    
DOI: 10.1242/dmm.013987     Document Type: Article

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