Disease-related phenotypes in a Drosophila model of hereditary spastic paraplegia are ameliorated by treatment with vinblastine

Journal of Clinical Investigation

Volumn 115, Issue 11, 2005, Pages 3026-3034

  Orso, Genny ^a   Martinuzzi, Andrea ^b   Rossetto, Maria Giovanna ^a,b   Sartori, Elena ^a,b   Feany, Mel ^c   Daga, Andrea ^a,b  

^a UNIVERSITY OF PADOVA   (Italy)

^b SCIENTIFIC INSTITUTE   (Italy)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE; DSPASTIN; SPASTIN; UNCLASSIFIED DRUG; VINBLASTINE; VINCA ALKALOID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEGENERATIVE DISEASE; DROSOPHILA; EMBRYO; GENE; GENE MUTATION; HEREDITARY MOTOR SENSORY NEUROPATHY; IN VIVO STUDY; LOCOMOTION; MAMMAL CELL; MICROTUBULE; MUSCLE WEAKNESS; NERVE FIBER; NEUROMUSCULAR SYNAPSE; NONHUMAN; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RNA INTERFERENCE; SPASTICITY; SPG4 GENE; SPINDLE POLE BODY; TREATMENT OUTCOME;

ADENOSINE TRIPHOSPHATASES; ANIMALS; ANIMALS, GENETICALLY MODIFIED; DISEASE MODELS, ANIMAL; DROSOPHILA; DROSOPHILA PROTEINS; HUMANS; MUTAGENESIS, SITE-DIRECTED; PHENOTYPE; RNA INTERFERENCE; SPASTIC PARAPLEGIA, HEREDITARY; VINBLASTINE;

EID: 27644498533     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI24694     Document Type: Article

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