The Drosophila homologue of the hereditary spastic paraplegia protein, spastin, severs and disassembles microtubules

Current Biology

Volumn 15, Issue 7, 2005, Pages 650-655

  Roll Mecak, Antonina ^a   Vale, Ronald D ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 17144424690     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cub.2005.02.029     Document Type: Article

References (18)

1. J. Hazan, N. Fonknechten, D. Mavel, C. Paternotte, D. Samson, F. Artiguenave, C.S. Davoine, C. Cruaud, A. Durr, and P. Wincker Spastin, a new AAA protein, is altered in the most frequent form of autosomal dominant spastic paraplegia Nat. Genet. 23 1999 296 303
2. J.K. Fink, and S. Rainier Hereditary spastic paraplegia: Spastin phenotype and function Arch. Neurol. 61 2004 830 833
3. T. Frickey, and A.N. Lupas Phylogenetic analysis of AAA proteins J. Struct. Biol. 146 2004 2 10
4. L. Kammermeier, J. Spring, M. Stierwald, J.M. Burgunder, and H. Reichert Identification of the Drosophila melanogaster homolog of the human spastin gene Dev. Genes Evol. 213 2003 412 415
5. N. Trotta, G. Orso, M.G. Rossetto, A. Daga, and K. Broadie The hereditary spastic paraplegia gene, spastin, regulates microtubule stability to modulate synaptic structure and function Curr. Biol. 14 2004 1135 1147
6. N.T. Sherwood, Q. Sun, M. Xue, B. Zhang, and K. Zinn Drosophila spastin regulates synaptic microtubule networks and is required for normal motor function PLoS Biol. 2 2004 e429 10.1371/journal.pbio.0020429
7. D. Charvin, C. Cifuentes-Diaz, N. Fonknechten, V. Joshi, J. Hazan, J. Melki, and S. Betuing Mutations of SPG4 are responsible for a loss of function of spastin, an abundant neuronal protein localized in the nucleus Hum. Mol. Genet. 12 2003 71 78
8. A. Errico, P. Claudiani, M. D'Addio, and E.I. Rugarli Spastin interacts with the centrosomal protein NA14, and is enriched in the spindle pole, the midbody and the distal axon Hum. Mol. Genet. 13 2004 2121 2132
9. C. Beetz, M. Brodhun, K. Moutzouris, M. Kiehntopf, A. Berndt, D. Lehnert, T. Deufel, M. Bastmeyer, and J. Schickel Identification of nuclear localisation sequences in spastin (SPG4) using a novel Tetra-GFP reporter system Biochem. Biophys. Res. Commun. 318 2004 1079 1084
10. S.B. Wharton, C.J. McDermott, A.J. Grierson, J.D. Wood, C. Gelsthorpe, P.G. Ince, and P.J. Shaw The cellular and molecular pathology of the motor system in hereditary spastic paraparesis due to mutation of the spastin gene J. Neuropathol. Exp. Neurol. 62 2003 1166 1177
11. E. Reid, J. Connell, T.L. Edwards, S. Duley, S.E. Brown, and C.M. Sanderson The hereditary spastic paraplegia protein spastin interacts with the ESCRT-III complex-associated endosomal protein CHMP1B Hum. Mol. Genet. 14 2005 19 38
12. A. Errico, A. Ballabio, and E.I. Rugarli Spastin, the protein mutated in autosomal dominant hereditary spastic paraplegia, is involved in microtubule dynamics Hum. Mol. Genet. 11 2002 153 163
13. C.J. McDermott, A.J. Grierson, J.D. Wood, M. Bingley, S.B. Wharton, K.M. Bushby, and P.J. Shaw Hereditary spastic paraparesis: Disrupted intracellular transport associated with spastin mutation Ann. Neurol. 54 2003 748 759
14. A. Molon, S. Di Giovanni, Y.W. Chen, P.M. Clarkson, C. Angelini, E. Pegoraro, and E.P. Hoffman Large-scale disruption of microtubule pathways in morphologically normal human spastin muscle Neurology 62 2004 1097 1104
15. J.J. Hartman, and R.D. Vale Microtubule disassembly by ATP-dependent oligomerization of the AAA enzyme katanin Science 286 1999 782 785
16. F.J. McNally, and R.D. Vale Identification of katanin, an ATPase that severs and disassembles stable microtubules Cell 75 1993 419 429
17. N. Fonknechten, D. Mavel, P. Byrne, C.S. Davoine, C. Cruaud, D. Boentsch, D. Samson, P. Coutinho, M. Hutchinson, and P. McMonagle Spectrum of SPG4 mutations in autosomal dominant spastic paraplegia Hum. Mol. Genet. 9 2000 637 644
18. T. Ogura, and A.J. Wilkinson AAA+ superfamily ATPases: Common structure - diverse function Genes Cells 6 2001 575 597