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Volumn 89, Issue , 2014, Pages 11-18

The flavonoid quercetin induces acute vasodilator effects in healthy volunteers: Correlation with beta-glucuronidase activity

Author keywords

Glucuronidase; Human; Metabolites; Quercetin; Vasodilation

Indexed keywords

BETA GLUCURONIDASE; DRUG METABOLITE; GLUTATHIONE; ISORHAMNETIN; NITRITE; PLACEBO; QUERCETIN;

EID: 84905820086     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2014.07.005     Document Type: Article
Times cited : (78)

References (38)
  • 1
    • 0036774226 scopus 로고    scopus 로고
    • Flavonoid antioxidants: Chemistry, metabolism and structure-activity relationships
    • DOI 10.1016/S0955-2863(02)00208-5, PII S0955286302002085
    • K.E. Heim, A.R. Tagliaferro, and D.J. Bobilya Flavonoid antioxidants: chemistry, metabolism and structure-activity relationships J Nutr Biochem 13 2002 572 584 (Pubitemid 35246546)
    • (2002) Journal of Nutritional Biochemistry , vol.13 , Issue.10 , pp. 572-584
    • Heim, K.E.1    Tagliaferro, A.R.2    Bobilya, D.J.3
  • 2
    • 0042524621 scopus 로고    scopus 로고
    • The relation between dietary flavonol intake and coronary heart disease mortality: A meta-analysis of prospective cohort studies
    • DOI 10.1038/sj.ejcn.1601624
    • R.R. Huxley, and H.A. Neil The relation between dietary flavonol intake and coronary heart disease mortality: a meta-analysis of prospective cohort studies Eur J Clin Nutr 57 2003 904 908 (Pubitemid 36987238)
    • (2003) European Journal of Clinical Nutrition , vol.57 , Issue.8 , pp. 904-908
    • Huxley, R.R.1    Neil, H.A.W.2
  • 3
    • 77249110336 scopus 로고    scopus 로고
    • Dietary flavonol intake may lower stroke risk in men and women
    • P.C. Hollman, A. Geelen, and D. Kromhout Dietary flavonol intake may lower stroke risk in men and women J Nutr 140 2010 600 604
    • (2010) J Nutr , vol.140 , pp. 600-604
    • Hollman, P.C.1    Geelen, A.2    Kromhout, D.3
  • 4
    • 84884398142 scopus 로고    scopus 로고
    • Dietary flavonoid intake and smoking-related cancer risk: A meta-analysis
    • H.D. Woo, and J. Kim Dietary flavonoid intake and smoking-related cancer risk: a meta-analysis PLoS ONE 8 2013 e75604
    • (2013) PLoS ONE , vol.8 , pp. 75604
    • Woo, H.D.1    Kim, J.2
  • 5
    • 13844271387 scopus 로고    scopus 로고
    • Bioavailability and bioefficacy of polyphenols in humans. II. Review of 93 intervention studies
    • G. Williamson, and C. Manach Bioavailability and bioefficacy of polyphenols in humans. II. Review of 93 intervention studies Am J Clin Nutr 81 2005 243S 255S
    • (2005) Am J Clin Nutr , vol.81
    • Williamson, G.1    Manach, C.2
  • 6
    • 78649635059 scopus 로고    scopus 로고
    • Flavonols and cardiovascular disease
    • F. Perez-Vizcaino, and J. Duarte Flavonols and cardiovascular disease Mol Aspects Med 31 2010 478 494
    • (2010) Mol Aspects Med , vol.31 , pp. 478-494
    • Perez-Vizcaino, F.1    Duarte, J.2
  • 11
    • 84865567726 scopus 로고    scopus 로고
    • Acute, quercetin-induced reductions in blood pressure in hypertensive individuals are not secondary to lower plasma angiotensin-converting enzyme activity or endothelin-1: Nitric oxide
    • A. Larson, M.A. Witman, Y. Guo, S. Ives, R.S. Richardson, and R.S. Bruno et al. Acute, quercetin-induced reductions in blood pressure in hypertensive individuals are not secondary to lower plasma angiotensin-converting enzyme activity or endothelin-1: nitric oxide Nutr Res 32 2012 557 564
    • (2012) Nutr Res , vol.32 , pp. 557-564
    • Larson, A.1    Witman, M.A.2    Guo, Y.3    Ives, S.4    Richardson, R.S.5    Bruno, R.S.6
  • 12
    • 84871055775 scopus 로고    scopus 로고
    • A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990-2010: A systematic analysis for the Global Burden of Disease Study 2010
    • S.S. Lim, T. Vos, A.D. Flaxman, G. Danaei, K. Shibuya, and H. Adair-Rohani et al. A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010 Lancet 380 2012 2224 2260
    • (2012) Lancet , vol.380 , pp. 2224-2260
    • Lim, S.S.1    Vos, T.2    Flaxman, A.D.3    Danaei, G.4    Shibuya, K.5    Adair-Rohani, H.6
  • 13
  • 14
    • 0036257545 scopus 로고    scopus 로고
    • Cardiovascular effects of isorhamnetin and quercetin in isolated rat and porcine vascular smooth muscle and isolated rat atria
    • DOI 10.1055/s-2002-26752
    • M. Ibarra, F. Pérez-Vizcaíno, A. Cogolludo, J. Duarte, F. Zaragozá-Arnáez, and J.G. López-López et al. Cardiovascular effects of isorhamnetin and quercetin in isolated rat and porcine vascular smooth muscle and isolated rat atria Planta Med 68 2002 307 310 (Pubitemid 34494039)
    • (2002) Planta Medica , vol.68 , Issue.4 , pp. 307-310
    • Ibarra, M.1    Perez-Vizcaino, F.2    Cogolludo, A.3    Duarte, J.4    Zaragoza-Arnaez, F.5    Lopez-Lopez, J.G.6    Tamargo, J.7
  • 15
    • 13844281685 scopus 로고    scopus 로고
    • Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies
    • C. Manach, G. Williamson, C. Morand, A. Scalbert, and C. Rémésy Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies Am J Clin Nutr 81 2005 230S 242S
    • (2005) Am J Clin Nutr , vol.81
    • Manach, C.1    Williamson, G.2    Morand, C.3    Scalbert, A.4    Rémésy, C.5
  • 16
    • 0035692180 scopus 로고    scopus 로고
    • Human metabolism of dietary flavonoids: Identification of plasma metabolites of quercetin
    • A.J. Day, F. Mellon, D. Barron, G. Sarrazin, M.R. Morgan, and G. Williamson Human metabolism of dietary flavonoids: identification of plasma metabolites of quercetin Free Radic Res 35 2001 941 952 (Pubitemid 34065683)
    • (2001) Free Radical Research , vol.35 , Issue.6 , pp. 941-952
    • Day, A.J.1    Mellon, F.2    Barron, D.3    Sarrazin, G.4    Morgan, M.R.A.5    Williamson, G.6
  • 17
    • 67349151315 scopus 로고    scopus 로고
    • Glucuronidated and sulfated metabolites of the flavonoid quercetin prevent endothelial dysfunction but lack direct vasorelaxant effects in rat aorta
    • F. Lodi, R. Jimenez, L. Moreno, P.A. Kroon, P.W. Needs, and D.A. Hughes et al. Glucuronidated and sulfated metabolites of the flavonoid quercetin prevent endothelial dysfunction but lack direct vasorelaxant effects in rat aorta Atherosclerosis 204 2009 34 39
    • (2009) Atherosclerosis , vol.204 , pp. 34-39
    • Lodi, F.1    Jimenez, R.2    Moreno, L.3    Kroon, P.A.4    Needs, P.W.5    Hughes, D.A.6
  • 18
    • 0035839129 scopus 로고    scopus 로고
    • Flavonoid glucuronides are substrates for human liver β-glucuronidase
    • DOI 10.1016/S0014-5793(01)02684-9, PII S0014579301026849
    • K.A. O'Leary, A.J. Day, P.W. Needs, W.S. Sly, N.M. O'Brien, and G. Williamson Flavonoid glucuronides are substrates for human liver beta-glucuronidase FEBS Lett 503 2001 103 106 (Pubitemid 32769964)
    • (2001) FEBS Letters , vol.503 , Issue.1 , pp. 103-106
    • O'Leary, K.A.1    Day, A.J.2    Needs, P.W.3    Sly, W.S.4    O'Brien, N.M.5    Williamson, G.6
  • 19
    • 49449084484 scopus 로고    scopus 로고
    • Tissue distribution of quercetin in pigs after long-term dietary supplementation
    • J. Bieger, R. Cermak, R. Blank, V.C. de Boer,.P.C. Hollman, and J. Kamphues et al. Tissue distribution of quercetin in pigs after long-term dietary supplementation J Nutr 138 2008 1417 1420
    • (2008) J Nutr , vol.138 , pp. 1417-1420
    • Bieger, J.1    Cermak, R.2    Blank, R.3    De Boer, V.C.4    Hollman, P.C.5    Kamphues, J.6
  • 20
    • 44049084958 scopus 로고    scopus 로고
    • Macrophage as a target of quercetin glucuronides in human atherosclerotic arteries: Implication in the anti-atherosclerotic mechanism of dietary flavonoids
    • Y. Kawai, T. Nishikawa, Y. Shiba, S. Saito, K. Murota, and N. Shibata et al. Macrophage as a target of quercetin glucuronides in human atherosclerotic arteries: implication in the anti-atherosclerotic mechanism of dietary flavonoids J Biol Chem 283 2008 9424 9434
    • (2008) J Biol Chem , vol.283 , pp. 9424-9434
    • Kawai, Y.1    Nishikawa, T.2    Shiba, Y.3    Saito, S.4    Murota, K.5    Shibata, N.6
  • 22
    • 79952012081 scopus 로고    scopus 로고
    • Conjugated quercetin glucuronides as bioactive metabolites and precursors of aglycone in vivo
    • J. Terao, K. Murota, and Y. Kawai Conjugated quercetin glucuronides as bioactive metabolites and precursors of aglycone in vivo Food Funct 2 2011 11 17
    • (2011) Food Funct , vol.2 , pp. 11-17
    • Terao, J.1    Murota, K.2    Kawai, Y.3
  • 24
    • 85027942097 scopus 로고    scopus 로고
    • The flavonoid paradox: Conjugation and deconjugation as key steps for the biological activity of flavonoids
    • F. Perez-Vizcaino, J. Duarte, and C. Santos-Buelga The flavonoid paradox: conjugation and deconjugation as key steps for the biological activity of flavonoids J Sci Food Agric 92 2012 1822 1825
    • (2012) J Sci Food Agric , vol.92 , pp. 1822-1825
    • Perez-Vizcaino, F.1    Duarte, J.2    Santos-Buelga, C.3
  • 26
    • 33746698897 scopus 로고    scopus 로고
    • Absorption, excretion and metabolite profiling of methyl-, glucuronyl-, glucosyl- and sulpho-conjugates of quercetin in human plasma and urine after ingestion of onions
    • DOI 10.1079/BJN20061809
    • W. Mullen, C.A. Edwards, and A. Crozier Absorption, excretion and metabolite profiling of methyl-, glucuronyl-, glucosyl- and sulpho-conjugates of quercetin in human plasma and urine after ingestion of onions Br J Nutr 96 2006 107 116 (Pubitemid 44160903)
    • (2006) British Journal of Nutrition , vol.96 , Issue.1 , pp. 107-116
    • Mullen, W.1    Edwards, C.A.2    Crozier, A.3
  • 27
    • 51049095905 scopus 로고    scopus 로고
    • Daily quercetin supplementation dose-dependently increases plasma quercetin concentrations in healthy humans
    • S. Egert, S. Wolffram, A. Bosy-Westphal, C. Boesch-Saadatmandi, A.E. Wagner, and J. Frank et al. Daily quercetin supplementation dose-dependently increases plasma quercetin concentrations in healthy humans J Nutr 138 2008 1615 1621
    • (2008) J Nutr , vol.138 , pp. 1615-1621
    • Egert, S.1    Wolffram, S.2    Bosy-Westphal, A.3    Boesch-Saadatmandi, C.4    Wagner, A.E.5    Frank, J.6
  • 29
    • 53549117737 scopus 로고    scopus 로고
    • Serum beta-glucuronidase activity in response to fruit and vegetable supplementation: A controlled feeding study
    • S.S. Maruti, J.L. Chang, J.A. Prunty, J. Bigler, Y. Schwarz, and S.S. Li et al. Serum beta-glucuronidase activity in response to fruit and vegetable supplementation: a controlled feeding study Cancer Epidemiol Biomarkers Prev 17 2008 1808 1812
    • (2008) Cancer Epidemiol Biomarkers Prev , vol.17 , pp. 1808-1812
    • Maruti, S.S.1    Chang, J.L.2    Prunty, J.A.3    Bigler, J.4    Schwarz, Y.5    Li, S.S.6
  • 30
    • 0029840830 scopus 로고    scopus 로고
    • Measurement of nitrate and nitrite in biological samples using nitrate reductase and Griess reaction
    • D.L. Granger, R.R. Taintor, K.S. Boockvar, and J.B. Hibbs Jr. Measurement of nitrate and nitrite in biological samples using nitrate reductase and Griess reaction Methods Enzymol 268 1996 142 151 (Pubitemid 26286356)
    • (1996) Methods in Enzymology , vol.268 , pp. 142-151
    • Granger, D.L.1    Taintor, R.R.2    Boockvar, K.S.3    Hibbs Jr., J.B.4
  • 31
    • 84902174334 scopus 로고    scopus 로고
    • Effect of maternal nutrient restriction and melatonin supplementation from mid to late gestation on vascular reactivity of maternal and fetal placental arteries
    • P. Shukla, C.O. Lemley, N. Dubey, A.M. Meyer, S.T. O'Rourke, and K.A. Vonnahme Effect of maternal nutrient restriction and melatonin supplementation from mid to late gestation on vascular reactivity of maternal and fetal placental arteries Placenta 35 2014 461 466
    • (2014) Placenta , vol.35 , pp. 461-466
    • Shukla, P.1    Lemley, C.O.2    Dubey, N.3    Meyer, A.M.4    O'Rourke, S.T.5    Vonnahme, K.A.6
  • 32
    • 45849151306 scopus 로고    scopus 로고
    • Systolic pressure is all that matters
    • B. Williams, L.H. Lindholm, and P. Sever Systolic pressure is all that matters Lancet 371 2008 2219 2221
    • (2008) Lancet , vol.371 , pp. 2219-2221
    • Williams, B.1    Lindholm, L.H.2    Sever, P.3
  • 34
    • 0027306056 scopus 로고
    • Vasodilatory effects of flavonoids in rat aortic smooth muscle. Structure-activity relationships
    • DOI 10.1016/0306-3623(93)90159-U
    • J. Duarte, F. Pérez Vizcaíno, P. Utrilla, J. Jiménez, J. Tamargo, and A. Zarzuelo Vasodilatory effects of flavonoids in rat aortic smooth muscle. Structure-activity relationships Gen Pharmacol 24 1993 857 862 (Pubitemid 23231766)
    • (1993) General Pharmacology , vol.24 , Issue.4 , pp. 857-862
    • Duarte, J.1    Perez Vizcaino, F.2    Utrilla, P.3    Jimenez, J.4    Tamargo, J.5    Zarzuelo, A.6
  • 35
    • 53849146739 scopus 로고    scopus 로고
    • Pure dietary flavonoids quercetin and (-)-epicatechin augment nitric oxide products and reduce endothelin-1 acutely in healthy men
    • W.M. Loke, J.M. Hodgson, J.M. Proudfoot, A.J. McKinley, I.B. Puddey, and K.D. Croft Pure dietary flavonoids quercetin and (-)-epicatechin augment nitric oxide products and reduce endothelin-1 acutely in healthy men Am J Clin Nutr 88 2008 1018 1025
    • (2008) Am J Clin Nutr , vol.88 , pp. 1018-1025
    • Loke, W.M.1    Hodgson, J.M.2    Proudfoot, J.M.3    McKinley, A.J.4    Puddey, I.B.5    Croft, K.D.6
  • 36
    • 84865662470 scopus 로고    scopus 로고
    • UHPLC-(ESI)QTOF MS/MS profiling of quercetin metabolites in human plasma postconsumption of applesauce enriched with apple peel and onion
    • J. Lee, S.E. Ebeler, J.A. Zweigenbaum, and A.E. Mitchell UHPLC-(ESI)QTOF MS/MS profiling of quercetin metabolites in human plasma postconsumption of applesauce enriched with apple peel and onion J Agric Food Chem 60 2012 8510 8520
    • (2012) J Agric Food Chem , vol.60 , pp. 8510-8520
    • Lee, J.1    Ebeler, S.E.2    Zweigenbaum, J.A.3    Mitchell, A.E.4
  • 37
    • 65349188107 scopus 로고    scopus 로고
    • Different profiles of quercetin metabolites in rat plasma: Comparison of two administration methods
    • Y. Kawai, S. Saito, T. Nishikawa, A. Ishisaka, K. Murota, and J. Terao Different profiles of quercetin metabolites in rat plasma: comparison of two administration methods Biosci Biotechnol Biochem 73 2009 517 523
    • (2009) Biosci Biotechnol Biochem , vol.73 , pp. 517-523
    • Kawai, Y.1    Saito, S.2    Nishikawa, T.3    Ishisaka, A.4    Murota, K.5    Terao, J.6
  • 38
    • 27944465716 scopus 로고    scopus 로고
    • Identification and functional analysis of genetic variants of the human β-glucuronidase in a German population sample
    • M. Gratz, C. Kunert-Keil, U. John, I. Cascorbi, and H.K. Kroemer Identification and functional analysis of genetic variants of the human beta-glucuronidase in a German population sample Pharmacogenet Genomics 15 2005 875 881 (Pubitemid 41666769)
    • (2005) Pharmacogenetics and Genomics , vol.15 , Issue.12 , pp. 875-881
    • Gratz, M.1    Kunert-Keil, C.2    John, U.3    Cascorbi, I.4    Kroemer, H.K.5


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