Virtual reality exposure in anxiety disorders: Impact on psychophysiological reactivity

World Journal of Biological Psychiatry

Volumn 15, Issue 6, 2014, Pages 427-442

  Diemer, Julia ^a,b   Mühlberger, Andreas ^b   Pauli, Paul ^c   Zwanzger, Peter ^a,d  

^a UNIVERSITY HOSPITAL MÜNSTER   (Germany)

^b UNIVERSITY OF REGENSBURG   (Germany)

^c UNIVERSITY OF WÜRZBURG   (Germany)

^d Inn Salzach Hospital   (Germany)

Author keywords

Anxiety disorders; CBT; Exposure therapy; Psychophysiology; Virtual reality

Indexed keywords

ANXIETY DISORDERS; HUMAN; PATHOPHYSIOLOGY; PROCEDURES; VIRTUAL REALITY EXPOSURE THERAPY;

ANXIETY DISORDERS; HUMANS; VIRTUAL REALITY EXPOSURE THERAPY;

EID: 84905816627     PISSN: 15622975     EISSN: 18141412     Source Type: Journal    
DOI: 10.3109/15622975.2014.892632     Document Type: Review

References (70)

1. Alpers GW, Sell R. 2008. And yet they correlate: psychophysiological activation predicts self-report outcomes of exposure therapy in claustrophobia. J Anxiety Disord 22: 1101-1109.
2. Bandelow B, Zohar J, Hollander E, Kasper S, Möller H. 2008. World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for the pharmacological treatment of anxiety, obsessive-compulsive and posttraumatic stress disorders-first revision. World J Biol Psychiatry 9: 248-312.
3. Borkovec TD, Sides JK. 1979. The contribution of relaxation and expectancy to fear reduction via graded, imaginal exposure to feared stimuli. Behav Res Ther 17(6): 529-540.
4. Bouchard S, CôtéS, Richard DCS. 2007. Virtual reality applications for exposure. In: Richard DCS Lauterbach D, editors. Handbook of exposure therapies. Amsterdam: Elsevier Academy Press. p. 347-388.
5. Bradley MM, Lang PJ. 2007. Emotion and motivation. In: Cacioppo JT, Tassinary LG, Berntson GG, editors. Handbook of psychophysiology. Cambridge: Cambridge University Press. p. 581-607.
6. Bullinger AH, Roessler A, Mueller-Spahn F. 1998. Threedimensional virtual reality as a tool in cognitive-behavioral therapy of claustrophobic patients. Cyber Psychol Behav 1(2): 139-145.
7. Bullinger AH, Hemmeter UM, Stefani O, Angehrn I, Mueller-Spahn F, Bekiaris E, et al. 2005. Stimulation of cortisol during mental task performance in a provocative virtual environment. Appl Psychophysiol Biofeedback 30(3): 205-216.
8. Choy Y, Fyer AJ, Lipsitz JD. 2007. Treatment of specific phobia in adults. Clin Psychol Rev 27(3): 266-286.
9. Cleworth TW, Horslen BC, Carpenter MG. 2012. Influence of real and virtual heights on standing balance. Gait Posture 36: 172-176.
10. Cloos JM. 2005. The treatment of panic disorder. Curr Opin Psychiatry 18(1): 45-50.
11. Cornwell BR, Johnson L, Berardi L, Grillon C. 2006. Anticipation of public speaking in virtual reality reveals a relationship between trait social anxiety and startle reactivity. Biol Psychiatry 59(7): 664-666.
12. Cornwell BR, Heller R, Biggs A, Pine DS, Grillon C. 2011. Becoming the center of attention in social anxiety disorder: startle reactivity to a virtual audience during speech anticipation. J Clin Psychiatry 72(7): 942-948.
13. de Carvalho MR, Freire RC, Nardi AE. 2010. Virtual reality as a mechanism for exposure therapy. World J Biol Psychiatry 11(2 Pt 2): 220-230.
14. de Quervain DJ, Bentz D, Michael T, Bolt OC, Wiederhold BK, Margraf J, et al. 2011. Glucocorticoids enhance extinctionbased psychotherapy. Proc Natl Acad Sci USA 108(16): 6621-6625.
15. Domschke K, Reif A, Weber H, Richter J, Hohoff C, Ohrmann P, et al. 2011. Neuropeptide S receptor gene-converging evidence for a role in panic disorder. Mol Psychiatry 16: 938-948.
16. Donahue CB, Kushner MG, Thuras PD, Murphy TG, Van Demark JB, Adson DE. 2009. Effect of quetiapine vs. placebo on response to two virtual public speaking exposures in individuals with social phobia. J Anxiety Disord 23(3): 362-368.
17. Fanselow MS. 1994. Neural organization of the defensive behavior system responsible for fear. Psychon Bull Rev 1(4): 429-438.
18. Foa EB, Kozak MJ. 1986. Emotional processing of fear: exposure to corrective information. Psychol Bull 99(1): 20-35.
19. Freire RC, De Carvalho MR, Joffily M, Zin WA, Nardi AE. 2010. Anxiogenic properties of a computer simulation for panic disorder with agoraphobia. J Affect Disord 125(1-3): 301-306.
20. Gamito P, Oliveira J, Morais D, Saraiva T, Rosa J, Leal A, et al. 2007. War PTSD: a VR pre-trial case study. Annu Rev CyberTherapy Telemed 5: 191-198.
21. Garcia-Palacios A, Botella C, Hoffman H, Fabregat S. 2007. Comparing acceptance and refusal rates of virtual reality exposure vs. in vivo exposure by patients with specific phobias. CyberPsychol Behav 10(5): 722-724.
22. Gregg L, Tarrier N. 2007. Virtual reality in mental health: A review of the literature. Soc Psychiatry Psychiatr Epidemiol 42(5): 343-354.
23. Gustavsson A, Svensson M, Jacobi F, Allgulander C, Alonso J, Beghi E, et al. 2011. Cost of disorders of the brain in Europe 2010. Eur Neuropsychopharmacol 21(10): 718-779.
24. Harris SR, Kemmerling RL, North MM. 2002. Brief virtual reality therapy for public speaking anxiety. Cyberpsychol Behav 5(6): 543-550.
25. Herbelin B, Riquier F, Vexo F, Thalmann D. 2002. Virtual reality in cognitive behavioral therapy: a study on social anxiety disorder. In: 8th International Conference on Virtual Systems and Multimedia, VSMM2002. Available at: http://vrlab.epfl.ch/Publications/pdf/Herbelin-and-al-VSMM-02.pdf via theINTERNET. Accessed 16 May 2012.
26. Jang DP, Kim IY, Nam SW, Wiederhold BK, Wiederhold MD, Kim SI. 2002. Analysis of physiological response to two virtual environments: driving and flying simulation. Cyberpsychol Behav 5(1): 11-18.
27. Jönsson P, Wallergard M, Osterberg K, Hansen AM, Johansson G, Karlson B. 2010. Cardiovascular and cortisol reactivity and habituation to a virtual reality version of the trier social stress test: a pilot study. Psychoneuroendocrinology 35(9): 1397-1403.
28. Kelly O, Matheson K, Martinez A, Merali Z, Anisman H. 2007. Psychosocial stress evoked by a virtual audience: relation to neuroendocrine activity. Cyberpsychol Behav 10(5): 655-662.
29. Kotlyar M, Donahue C, Thuras P, Kushner MG, O'Gorman N, Smtih EA, Adson DE. 2008. Physiological response to a speech stressor presented in a virtual reality environment. Psychophysiology 45: 1034-1037.
30. Lang PJ, Cuthbert BN, Bradley MM. 1998. Measuring emotion in therapy: imagery, activation, and feeling. Behav Ther 29: 655-674.
31. Lang PJ, Davis M, Ohman A. 2000. Fear and anxiety: animal models and human cognitive psychophysiology. J Affect Disord 61(3): 137-159.
32. Lang PJ, Melamed BG, Hart J. 1970. A psychophysiological analysis of fear modification using an automated desensitization procedure. J Abnorm Psychol 76(2): 220-234.
33. Lang PJ, Greenwald MK, Bradley MM, Hamm AO. 1993.Looking at pictures: affective, facial, visceral, and behavioral reactions. Psychophysiology 30(3): 261-273.
34. Ling Y, Brinkman W, Nefs HT, Qu C, Heynderickx I. 2012. Effects of stereoscopic viewing on presence, anxiety, and cybersickness in a virtual reality environment for public speaking. Presence 21(3): 254-267.
35. McNally RJ. 2007. Mechanisms of exposure therapy: how neuroscience can improve psychological treatments for anxiety disorders. Clin Psychol Rev 27(6): 750-759.
36. Meehan M, Insko B, Whitton M, Brooks JP. 2002. Physiological measures of presence in stressful virtual environments. ACM Trans Graphics 21: 645-653.
37. Meyerbröker K, Emmelkamp PMG. 2010. Virtual reality exposure therapy in anxiety disorders: a systematic review of process-and-outcome studies. Depress Anxiety 27: 933-944.
38. Moore K, Wiederhold BK, Wiederhold MD, Riva G. 2002. Panic and agoraphobia in a virtual world. Cyberpsychol Behav 5(3): 197-202.
39. Mühlberger A, Herrmann MJ, Wiedemann GC, Ellgring H, Pauli P. 2001. Repeated exposure of flight phobics to flights in virtual reality. Behav Res Ther 39(9): 1033-1050.
40. Mühlberger A, Petrusek S, Herrmann MJ, Pauli P. 2005a. Biocyberpsychologie: subjektive und physiologische Reaktionen von Flugphobikern und Gesunden bei Exposition mit virtuellen Flügen. Zeitschr Klin Psychol Psychother: Forschung Praxis 34(2): 133-143.
41. Mühlberger A, Wiedemann G, Pauli P. 2005b. Subjective and physiologic reactions of flight phobics during VR exposure and treatment outcome: what adds motion simulation? Annu Rev Cyber Therapy Telemed 3: 185-192.
42. Mühlberger A, Bülthoff HH, Wiedemann G, Pauli P. 2007. Virtual reality for the psychophysiological assessment of phobic fear: responses during virtual tunnel driving. Psychol Assess 19(3): 340-346.
43. Mühlberger A, Wieser MJ, Pauli P. 2008a. Darkness-enhanced startle responses in ecologically valid environments: a virtual tunnel driving experiment. Biol Psychol 77(1): 47-52.
44. Mühlberger A, Sperber M, Wieser MJ, Pauli P. 2008b. A virtual reality avoidance test (VR-BAT) for the assessment of spider phobia. J CyperTherapy Rehabil 1(2): 147-158.
45. Opris D, Pintea S, Garcia-Palacios A, Botella C, Szamoskozi S, David D. 2012. Virtual reality exposure therapy in anxiety disorders: a quantitative meta-analysis. Depress Anxiety 29(2): 85-93.
46. Orman EK. 2003. Effect of virtual reality graded exposure on heart rate and self-reported anxiety of performing saxophonists. JRME 51(4): 302-315.
47. Orman EK. 2004. Effect of virtual reality graded exposure on anxiety levels of performing musicians: a case study. J Music Ther 41(1): 70-78.
48. Otte C. 2011. Cognitive behavioral therapy in anxiety disorders: current state of the evidence. Dialogues Clin Neurosci 13(4): 413-421.
49. Pan X, Gillies M, Barker C, Clark D, Slater M. 2012. Socially anxious men interact with a forward virtual woman: an experimental study. 2012;7:e32931.
50. Powers MB, Emmelkamp PM. 2008. Virtual reality exposure therapy for anxiety disorders: a meta-analysis. J Anxiety Disord 22(3): 561-569.
51. Pull CB. 2005. Current status of virtual reality exposure therapy in anxiety disorders. Curr Opin Psychiatry 18: 7-14.
52. Ressler KJ, Rothbaum BO, Tannenbaum L, Anderson P, Graap K, Zimand E, et al. 2004. Cognitive enhancers as adjuncts to psychotherapy: use of D-cycloserine in phobic individuals to facilitate extinction of fear. Arch Gen Psychiatry 61(11): 1136-1144.
53. Rheingold H. 1992. Virtual Reality. London: Mandarin.
54. Rothbaum BO, Ruef AM, Litz BT, Han H, Hodges L. 2003. Virtual reality exposure therapy of combat-related PTSD: a case study using psychophysiological indicators of outcome. J Cogn Psychother 17(2): 163-177.
55. Saraiva T, Gamito P, Oliveira J, Morais D, Pombal M, Gamito L et al. 2007. The use of VR exposure in the treatment of motor vehicle PTSD: a case-report. Annu Rev Cyber Therapy Telemed 5: 199-205.
56. Simeonov PI, Hsiao H, Dotson BW, Ammons DE. 2005. Height effects in real and virtual environments. Hum Factors 47(2): 430-438.
57. Slater M, Pertaub DP, Barker C, Clark DM. 2006. An experimental study on fear of public speaking using a virtual environment. Cyberpsychol Behav 9(5): 627-633.
58. Taylor S, Abramowitz JS, McKay D. 2012. Non-adherence and non-response in the treatment of anxiety disorders. J Anxiety Disord 26: 583-589.
59. Tryon WW. 2005. Possible mechanisms for why desensitization and exposure therapy work. Clin Psychol Review 25: 67-95.
60. Villani D, Repetto C, Cipresso P, Riva G. 2012. May I experience more presence in doing the same thing in virtual reality than in reality? An answer from a simulated job interview. Interacting with Computers 24(4): 265-272.
61. Walshe DG, Lewis EJ, Kim SI, O'Sullivan K, Wiederhold BK. 2003. Exploring the use of computer games and virtual reality in exposure therapy for fear of driving following a motor vehicle accident. Cyberpsychol Behav 6(3): 329-334.
62. Watson JP, Marks IM. 1971. Relevant and irrelevant fear in flooding-A crossover study of phobic patients. Behav Ther 2: 275-293.
63. Wiederhold B, Gevirtz R, Wiederhold M. 1998a. Fear of flying: a case report using virtual reality therapy with physiological monitoring. Cyberpsychol Behav 1(2): 97-103.
64. Wiederhold BK, Davis R, Wiederhold MD. 1998b. The effects of immersiveness on physiology. Stud Health Technol Inform 58: 52-60.
65. Wiederhold BK, Jang DP, Gevirtz RG, Kim SI, Kim IY, Wiederhold MD. 2002a. The treatment of fear of flying: a controlled study of imaginal and virtual reality graded exposure therapy. IEEE Trans Inf Technol Biomed 6(3): 218-223.
66. Wiederhold BK, Jang DP, Kim SI, Wiederhold MD. 2002b. Physiological monitoring as an objective tool in virtual reality therapy. Cyberpsychol Behav 5(1): 77-82.
67. Wiederhold BK, Mendoza M, Nakatani T, Bullinger AH, Wiederhold MD. 2005. VR for blood-injection-injury phobia. Annu Rev CyberTherapy Telemed 3: 109-116.
68. Wieser MJ, Pauli P, Grosseibl M, Molzow I, Mühlberger A. 2010. Virtual social interactions in social anxiety-the impact of sex, gaze, and interpersonal distance. Cyberpsychol Behav Soc Netw 13(5): 547-554.
69. Wilhelm FH, Pfaltz MC, Gross JJ, Mauss IB, Kim SI, Wiederhold BK. 2005. Mechanisms of virtual reality exposure therapy: the role of the behavioral activation and behavioral inhibition systems. Appl Psychophysiol Biofeedback 30(3): 271-284.
70. Wittchen HU, Jacobi F, Rehm J, Gustavsson A, Svensson M, Jonsson B, et al. 2011. The size and burden of mental disorders and other disorders of the brain in Europe 2010. Eur Neuropsychopharmacol 21(9): 655-679.