Vitamin D deficiency is associated with orthostatic hypotension in oldest-old women

Journal of Internal Medicine

Volumn 276, Issue 3, 2014, Pages 285-295

  Annweiler, C ^a,b,c   Schott, A M ^d   Rolland, Y ^e,f   Beauchet, O ^a  

^a ANGERS UNIVERSITY HOSPITAL   (France)

^b UNIVERSITÉ D'ANGERS   (France)

^c ROBARTS RESEARCH INSTITUTE   (Canada)

^d HOSPICES CIVILS DE LYON   (France)

^e TOULOUSE UNIVERSITY HOSPITAL   (France)

^f INSERM   (France)

Author keywords

Older adults; Orthostatic hypotension; Vitamin D

Indexed keywords

OLDER ADULTS; ORTHOSTATIC HYPOTENSION; VITAMIN D;

AGED, 80 AND OVER; BLOOD PRESSURE; CROSS-SECTIONAL STUDIES; FEMALE; HUMANS; HYPOTENSION, ORTHOSTATIC; PROSPECTIVE STUDIES; VITAMIN D; VITAMIN D DEFICIENCY;

EID: 84905754114     PISSN: 09546820     EISSN: 13652796     Source Type: Journal    
DOI: 10.1111/joim.12201     Document Type: Article

References (34)

1. Soldo BJ, Hurd MD, Rodgers WL, Wallace RB. Asset and Health Dynamics Among the Oldest Old: an overview of the AHEAD Study. J Gerontol B Psychol Sci Soc Sci 1997; 52: 1-20.
2. Davidson S, Goodwin J, Rossall P, eds. Improving Later Life: Understanding the Oldest old. London: Age UK, 2013.
3. Belmin J, Abderrhamane M, Medjahed S et al. Variability of blood pressure response to orthostatism and reproducibility of the diagnosis of orthostatic hypotension in elderly subjects. J Gerontol A Biol Sci Med Sci 2000; 55: M667-71.
4. Gupta V, Lipsitz LA. Orthostatic hypotension in the elderly: diagnosis and treatment. Am J Med 2007; 120: 841-7.
5. Kawaguchi T, Uyama O, Konishi M, Nishiyama T, Iida T. Orthostatic hypotension in elderly persons during passive standing: a comparison with young persons. J Gerontol A Biol Sci Med Sci 2001; 56: M273-80.
6. Luukinen H, Koski K, Laippala P, Kivelä SL. Prognosis of diastolic and systolic orthostatic hypotension in older persons. Arch Intern Med 1999; 159: 273-80.
7. Duron E, Lenoir H, Pequignot R, Lefèvre M, Rigaud AS, Hanon O. What is the most relevant definition of orthostatic hypotension: systolic blood pressure drop, diastolic blood pressure drop, or both? Arch Mal Coeur Vaiss 2007; 100: 689-94.
8. Lewis A, Lipsitz LA. Dynamics of stability: the physiologic basis of functional health and frailty. J Gerontol A Biol Sci Med Sci 2002; 57: B115-25.
9. Annweiler C, Souberbielle JC, Schott AM, de Decker L, Berrut G, Beauchet O. Vitamin D in the elderly: 5 points to remember. Geriatr Psychol Neuropsychiatr Vieil 2011; 9: 259-67.
10. Dawson-Hughes B, Heaney R, Holick M, Lips P, Meunier PJ, Vieth R. Estimates of optimal vitamin D status. Osteoporos Int 2005; 16: 713-6.
11. Zehnder D, Bland R, Chana RS et al. Synthesis of 1, 25-dihydroxyvitamin D(3) by human endothelial cells is regulated by inflammatory cytokines: a novel autocrine determinant of vascular cell adhesion. J Am Soc Nephrol 2002; 13: 621-9.
12. Somjen D, Weisman Y, Kohen F et al. 25-hydroxyvitamin D3-1alpha-hydroxylase is expressed in human vascular smooth muscle cells and is upregulated by parathyroid hormone and estrogenic compounds. Circulation 2005; 111: 1666-71.
13. Li YC, Kong J, Wei M, Chen ZF, Liu SQ, Cao LP. 1, 25-Dihydroxyvitamin D3 is a negative endocrine regulator of the renin-angiotensin system. J Clin Invest 2002; 110: 229-38.
14. Rebsamen MC, Sun J, Norman AW, Liao JK. 1alpha, 25-dihydroxyvitamin D3 induces vascular smooth muscle cell migration via activation of phosphatidylinositol 3-kinase. Circ Res 2002; 91: 17-24.
15. Yamamoto T, Kozawa O, Tanabe K et al. 1, 25-dihydroxyvitamin D3 stimulates vascular endothelial growth factor release in aortic smooth muscle cells: role of p38 mitogen-activated protein kinase. Arch Biochem Biophys 2002; 398: 1-6.
16. Braam LA, Hoeks AP, Brouns F, Hamulyak K, Gerichhausen MJ, Vermeer C. Beneficial effects of vitamins D and K on the elastic properties of the vessel wall in postmenopausal women: a follow-up study. Thromb Haemost 2004; 91: 373-80.
17. Kalueff AV, Tuohimaa P. Neurosteroid hormone vitamin D and its utility in clinical nutrition. Curr Opin Clin Nutr Metab Care 2007; 10: 12-9.
18. Annweiler C, Schott AM, Berrut G et al. Vitamin D and ageing: neurological issues. Neuropsychobiology 2010; 62: 139-50.
19. Dargent-Molina P, Favier F, Grandjean H et al. Fall-related factors and risk of hip fracture: the EPIDOS prospective study. Lancet 1996; 348: 145-9.
20. Annweiler C, Schott AM, Montero-Odasso M et al. Cross-sectional association between serum vitamin D concentration and walking speed measured at usual and fast pace among older women: the EPIDOS study. J Bone Miner Res 2010; 25: 1858-66.
21. Pickering TG, Hall JE, Appel LJ et al. Recommendations for blood pressure measurment in humans and experimental animals: part 1: blood pressure measurement in humans: a statement for professionals from the Subcommittee of Professional and Public Education of the American Heart Association Council on High Blood Pressure Research. Circulation 2005; 111: 697-716.
22. Izzo Jr JL, Sica DA, Black HR, eds. Hypertension Primer: The Essentials of High Blood Pressure. Basic Science, Population Science, and Clinical Management, 4th edn. Dallas: American Heart Association, 2008.
23. Annweiler C, Rolland Y, Schott AM et al. Higher vitamin D dietary intake is associated with lower risk of alzheimer's disease: a 7-year follow-up. J Gerontol A Biol Sci Med Sci 2012; 67: 1205-11.
24. Pfeiffer EA. A short portable mental state questionnaire for the assessment of organic brain deficit in elderly patients. J Am Geriatr Soc 1975; 50: 1996-2002.
25. Rosenthal T. Seasonal variations in blood pressure. Am J Geriatr Cardiol 2004; 13: 267-72.
26. Forman JP, Giovannucci E, Holmes MD et al. Plasma 25-hydroxyvitamin D levels and risk of incident hypertension. Hypertension 2007; 49: 1063-9.
27. Mateus-Hamdan L, Beauchet O, Bouvard B, Legrand E, Fantino B, Annweiler C. High parathyroid hormone, but not low vitamin D concentrations, expose elderly inpatients to hypertension. Geriatr Gerontol Int 2013; 13: 783-91.
28. Pfeifer M, Begerow B, Minne HW, Nachtigall D, Hansen C. Effects of a short term vitamin D3 and calcium supplementation on blood pressure and parathyroid hormone levels in elderly women. J Clin Endocrinol Metab 2001; 86: 1633-7.
29. McCarroll KG, Robinson DJ, Coughlan A, Healy M, Kenny RA, Cunningham C. Vitamin D and orthostatic hypotension. Age Ageing 2012; 41: 810-3.
30. Bischoff-Ferrari HA, Dawson-Hughes B, Staehelin HB et al. Fall prevention with supplemental and active forms of vitamin D: a meta-analysis of randomised controlled trials. BMJ 2009; 339: b3692.
31. Houston DK, Cesari M, Ferrucci L et al. Association between vitamin D status and physical performance: the InCHIANTI study. J Gerontol A Biol Sci Med Sci 2007; 62: 440-6.
32. Annweiler C, Schott AM, Berrut G, Fantino B, Beauchet O. Vitamin D-related changes in physical performance: a systematic review. J Nutr Health Aging 2009; 13: 893-8.
33. Annweiler C, Montero-Odasso M, Schott AM, Berrut G, Fantino B, Beauchet O. Fall prevention and vitamin D in the elderly: an overview of the key role of the non-bone effects. J Neuroeng Rehabil 2010; 7: 50.
34. Gloth FM 3rd, Tobin JD. Vitamin D deficiency in older people. J Am Geriatr Soc 1995; 43: 822-8.