Glandular Odontogenic Cysts (GOCs) Lack MAML2 Rearrangements: A Finding to Discredit the Putative Nature of GOC as a Precursor to Central Mucoepidermoid Carcinoma

Head and Neck Pathology

Volumn 8, Issue 3, 2014, Pages 287-290

  Bishop, Justin A ^a,b   Yonescu, Raluca ^a   Batista, Denise ^a   Warnock, Gary R ^a   Westra, William H ^a  

^a DEPARTMENT OF PATHOLOGY   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Central mucoepidermoid carcinoma; Glandular odontogenic cyst; MAML2

Indexed keywords

DNA BINDING PROTEIN; MAML2 PROTEIN, HUMAN; NUCLEAR PROTEIN; TRANSCRIPTION FACTOR; TUMOR MARKER;

ADENOSQUAMOUS CARCINOMA; FLUORESCENCE IN SITU HYBRIDIZATION; GENE REARRANGEMENT; GENETICS; HUMAN; JAW DISEASE; JAW TUMOR; ODONTOGENIC CYST; SENSITIVITY AND SPECIFICITY;

BIOMARKERS, TUMOR; CARCINOMA, MUCOEPIDERMOID; DNA-BINDING PROTEINS; GENE REARRANGEMENT; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; JAW DISEASES; JAW NEOPLASMS; NUCLEAR PROTEINS; ODONTOGENIC CYSTS; SENSITIVITY AND SPECIFICITY; TRANSCRIPTION FACTORS;

EID: 84905731503     PISSN: 1936055X     EISSN: 19360568     Source Type: Journal    
DOI: 10.1007/s12105-014-0534-8     Document Type: Article

References (35)

1. Ellis G, Auclair PL. Central (primary intraosseous) mucoepidermoid carcinoma. AFIP atlas of tumor pathology: tumors of the salivary glands. Silver Spring, MD: ARP Press; 2008. p. 193-6.
2. Waldron CA, Koh ML. Central mucoepidermoid carcinoma of the jaws: report of four cases with analysis of the literature and discussion of the relationship to mucoepidermoid, sialodontogenic, and glandular odontogenic cysts. J Oral Maxillofac Surg. 1990;48: 871-7.
3. Browand BC, Waldron CA. Central mucoepidermoid tumors of the jaws. Report of nine cases and review of the literature. Oral Surg Oral Med Oral Pathol. 1975;40: 631-43.
4. Brookstone MS, Huvos AG. Central salivary gland tumors of the maxilla and mandible: a clinicopathologic study of 11 cases with an analysis of the literature. J Oral Maxillofac Surg. 1992;50: 229-36.
5. Martinez-Madrigal F, Pineda-Daboin K, Casiraghi O, Luna MA. Salivary gland tumors of the mandible. Ann Diagn Pathol. 2000;4: 347-53.
6. Sadeghi EM, Weldon LL, Kwon PH, Sampson E. Mucoepidermoid odontogenic cyst. Int J Oral Maxillofac Surg. 1991;20: 142-3.
7. Kaplan I, Anavi Y, Hirshberg A. Glandular odontogenic cyst: a challenge in diagnosis and treatment. Oral Dis. 2008;14: 575-81.
8. Araujo de Morais HH, Jose de Holanda Vasconcellos R, de Santana Santos T, Guedes Queiroz LM, Dantas da Silveira EJ. Glandular odontogenic cyst: case report and review of diagnostic criteria. J Craniomaxillofac Surg. 2012;40: e46-50.
9. Robinson RA, Vincent SD. Glandular odontogenic cyst. AFIP atlas of tumor pathology: tumors and cysts of the jaws. Silver Spring, MD: ARP Press; 2012. p. 26-30.
10. Fowler CB, Brannon RB, Kessler HP, Castle JT, Kahn MA. Glandular odontogenic cyst: analysis of 46 cases with special emphasis on microscopic criteria for diagnosis. Head Neck Pathol. 2011;5: 364-75.
11. Shen J, Fan M, Chen X, Wang S, Wang L, Li Y. Glandular odontogenic cyst in China: report of 12 cases and immunohistochemical study. J Oral Pathol Med. 2006;35: 175-82.
12. Noffke C, Raubenheimer EJ. The glandular odontogenic cyst: clinical and radiological features; review of the literature and report of nine cases. Dentomaxillofac Radiol. 2002;31: 333-8.
13. Gardner DG, Kessler HP, Morency R, Schaffner DL. The glandular odontogenic cyst: an apparent entity. J Oral Pathol. 1988;17: 359-66.
14. Patron M, Colmenero C, Larrauri J. Glandular odontogenic cyst: clinicopathologic analysis of three cases. Oral Surg Oral Med Oral Pathol. 1991;72: 71-4.
15. Semba I, Kitano M, Mimura T, Sonoda S, Miyawaki A. Glandular odontogenic cyst: analysis of cytokeratin expression and clinicopathological features. J Oral Pathol Med. 1994;23: 377-82.
16. Padayachee A, van Wyk CW. Two cystic lesions with features of both the botryoid odontogenic cyst and the central mucoepidermoid tumour: sialo-odontogenic cyst? J Oral Pathol. 1987;16: 499-504.
17. Prabhu S, Rekha K, Kumar G. Glandular odontogenic cyst mimicking central mucoepidermoid carcinoma. J Oral Maxillofac Pathol. 2010;14: 12-5.
18. Manojlovic S, Grgurevic J, Knezevic G, Kruslin B. Glandular odontogenic cyst: a case report and clinicopathologic analysis of the relationship to central mucoepidermoid carcinoma. Head Neck. 1997;19: 227-31.
19. Pires FR, Chen SY, da Cruz Perez DE, de Almeida OP, Kowalski LP. Cytokeratin expression in central mucoepidermoid carcinoma and glandular odontogenic cyst. Oral Oncol. 2004;40: 545-51.
20. Vered M, Allon I, Buchner A, Dayan D. Is maspin immunolocalization a tool to differentiate central low-grade mucoepidermoid carcinoma from glandular odontogenic cyst? Acta Histochem. 2010;112: 161-8.
21. Eversole LR, Sabes WR, Rovin S. Aggressive growth and neoplastic potential of odontogenic cysts: with special reference to central epidermoid and mucoepidermoid carcinomas. Cancer. 1975;35: 270-82.
22. Bruner JM, Batsakis JG. Salivary neoplasms of the jaw bones with particular reference to central mucoepidermoid carcinomas. Ann Otol Rhinol Laryngol. 1991;100: 954-5.
23. Behboudi A, Enlund F, Winnes M, Andren Y, Nordkvist A, Leivo I, et al. Molecular classification of mucoepidermoid carcinomas-prognostic significance of the MECT1-MAML2 fusion oncogene. Genes Chromosomes Cancer. 2006;45: 470-81.
24. Chiosea SI, Dacic S, Nikiforova MN, Seethala RR. Prospective testing of mucoepidermoid carcinoma for the MAML2 translocation: clinical implications. Laryngoscope. 2012;122: 1690-4.
25. Seethala RR, Dacic S, Cieply K, Kelly LM, Nikiforova MN. A reappraisal of the MECT1/MAML2 translocation in salivary mucoepidermoid carcinomas. Am J Surg Pathol. 2010;34: 1106-21.
26. Garcia JJ, Hunt JL, Weinreb I, McHugh JB, Barnes EL, Cieply K, et al. Fluorescence in situ hybridization for detection of MAML2 rearrangements in oncocytic mucoepidermoid carcinomas: utility as a diagnostic test. Hum Pathol. 2011;42: 2001-9.
27. Okabe M, Miyabe S, Nagatsuka H, Terada A, Hanai N, Yokoi M, et al. MECT1-MAML2 fusion transcript defines a favorable subset of mucoepidermoid carcinoma. Clin Cancer Res. 2006;12: 3902-7.
28. El-Naggar AK, Lovell M, Killary AM, Clayman GL, Batsakis JG. A mucoepidermoid carcinoma of minor salivary gland with t(11;19)(q21;p13. 1) as the only karyotypic abnormality. Cancer Genet Cytogenet. 1996;87: 29-33.
29. Bell D, Holsinger CF, El-Naggar AK. CRTC1/MAML2 fusion transcript in central mucoepidermoid carcinoma of mandible-diagnostic and histogenetic implications. Ann Diagn Pathol. 2010;14: 396-401.
30. Khan HA, Loya A, Azhar R, Din NU, Bell D. Central mucoepidermoid carcinoma, a case report with molecular analysis of the TORC1/MAML2 gene fusion. Head Neck Pathol. 2010;4: 261-4.
31. Seethala RR, Dacic S, Cieply K, Kelly LM, Nikiforova MN. A reappraisal of the MECT1/MAML2 translocation in salivary mucoepidermoid carcinomas. Am J Surg Pathol. 2010;34: 1106-21.
32. Achcar Rde O, Nikiforova MN, Dacic S, Nicholson AG, Yousem SA. Mammalian mastermind like 2 11q21 gene rearrangement in bronchopulmonary mucoepidermoid carcinoma. Hum Pathol. 2009;40: 854-60.
33. Lennerz JK, Perry A, Mills JC, Huettner PC, Pfeifer JD. Mucoepidermoid carcinoma of the cervix: another tumor with the t(11;19)-associated CRTC1-MAML2 gene fusion. Am J Surg Pathol. 2009;33(6): 835-43.
34. Roden AC, Erickson-Johnson MR, Yi ES, Garcia JJ. Analysis of MAML2 rearrangement in mucoepidermoid carcinoma of the thymus. Hum Pathol. 2013;44: 2799-805.
35. Bell D, El-Naggar AK. Molecular heterogeneity in mucoepidermoid carcinoma: conceptual and practical implications. Head Neck Pathol. 2013;7: 23-7.