Vitamin A and feeding statuses modulate the insulin-regulated gene expression in Zucker lean and fatty primary rat hepatocytes

PLoS ONE

Volumn 9, Issue 8, 2014, Pages

  Chen, Wei ^a   Howell, Meredith L ^a   Li, Yang ^a   Li, Rui ^a   Chen, Guoxun ^a  

^a UNIVERSITY OF TENNESSEE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOKINASE; INSULIN; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); RETINOIC ACID; RETINOL; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; PHOSPHOENOLPYRUVATE CARBOXYKINASE (ATP);

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY MASS; CALORIC INTAKE; CONTROLLED STUDY; DIETARY INTAKE; GENE EXPRESSION; GENE EXPRESSION REGULATION; GLUCOKINASE GENE; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIVER CELL; MALE; MOLECULAR PATHOLOGY; NONHUMAN; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP) GENE; RAT; RETINOL DEFICIENCY; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C GENE; ANALYSIS OF VARIANCE; ANIMAL; COMPARATIVE STUDY; DIET SUPPLEMENTATION; DRUG EFFECTS; METABOLISM; PHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION; ZUCKER RAT;

ANALYSIS OF VARIANCE; ANIMALS; DIETARY SUPPLEMENTS; GENE EXPRESSION REGULATION; HEPATOCYTES; INSULIN; INSULIN RESISTANCE; MALE; PHOSPHOENOLPYRUVATE CARBOXYKINASE (ATP); RATS; RATS, ZUCKER; REAL-TIME POLYMERASE CHAIN REACTION; TRETINOIN;

EID: 84905660312     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0100868     Document Type: Article

References (31)

1. Chen G (2013) Roles of Vitamin A Metabolism in the Development of Hepatic Insulin Resistance. ISRN Hepatology 2013: 1-21. doi:10.1016/j.cmet.2011.12.017.
2. Brown MS, Goldstein JL (2008) Selective versus total insulin resistance: a pathogenic paradox. Cell Metab 7: 95-96. doi:10.1016/j.cmet.2007.12.009. (Pubitemid 351168559)
3. Angulo P (2002) Nonalcoholic fatty liver disease. N Engl J Med 346: 1221-1231. doi:10.1056/NEJMra011775.
4. Johnson AMF, Olefsky JM (2013) The Origins and Drivers of Insulin Resistance. Cell 152: 673-684. doi:10.1016/j.cell.2013.01.041.
5. O'Brien RM, Granner DK (1996) Regulation of gene expression by insulin. Physiol Rev 76: 1109-1161. (Pubitemid 26346818)
6. Iynedjian PB (2009) Molecular physiology of mammalian glucokinase. Cell Mol Life Sci 66: 27-42. doi:10.1007/s00018-008-8322-9.
7. Brown MS, Goldstein JL (1997) The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. Cell 89: 331-340. (Pubitemid 27220877)
8. Lefebvre P, Martin PJ, Flajollet S, Dedieu S, Billaut X, et al. (2005) Transcriptional activities of retinoic acid receptors. Vitam Horm 70: 199-264. doi:10.1016/S0083-6729(05)70007-8. (Pubitemid 43589019)
9. Zhang Y, Chen W, Li R, Li Y, Ge Y, et al. (2011) Insulin-regulated Srebp-1c and Pck1 mRNA expression in primary hepatocytes from zucker fatty but not lean rats is affected by feeding conditions. PLoS ONE 6: e21342. doi:10.1371/journal.pone.0021342.
10. Chen G, Zhang Y, Lu D, Li N-Q, Ross AC (2009) Retinoids synergize with insulin to induce hepatic Gck expression. Biochem J 419: 645-653. doi:10.1042/BJ20082368.
11. Li R, Chen W, Li Y, Zhang Y, Chen G (2011) Retinoids synergized with insulin to induce Srebp-1c expression and activated its promoter via the two liver X receptor binding sites that mediate insulin action. Biochem Biophys Res Commun 406: 268-272. doi:10.1016/j.bbrc.2011.02.031.
12. Zhang Y, Li R, Chen W, Li Y, Chen G (2011) Retinoids induced Pck1 expression and attenuated insulin-mediated suppression of its expression via activation of retinoic acid receptor in primary rat hepatocytes. Mol Cell Biochem 355: 1-8. doi:10.1007/s11010-011-0831-4.
13. Zhang Y, Li R, Li Y, Chen W, Zhao S, et al. (2012) Vitamin A status affects obesity development and hepatic expression of key genes for fuel metabolism in Zucker fatty rats. Biochem Cell Biol 90: 548-557. doi:10.1139/o2012-012.
14. Mayer J, Krehl WA (1948) Influence of vitamin A deficiency on the gross efficiency of growth of rats. Yale J Biol Med 20: 403-405.
15. Anzano MA, Lamb AJ, Olson JA (1979) Growth, appetite, sequence of pathological signs and survival following the induction of rapid, synchronous vitamin A deficiency in the rat. J Nutr 109: 1419-1431. (Pubitemid 9241699)
16. Li Y, Zhang Y, Li R, Chen W, Howell M, et al. (2012) The hepatic Raldh1 expression is elevated in Zucker fatty rats and its over-expression introduced the retinal-induced Srebp-1c expression in INS-1 cells. PLoS ONE 7: e45210. doi:10.1371/journal.pone.0045210.
17. Alapatt P, Guo F, Komanetsky SM, Wang S, Cai J, et al. (2013) Liver retinol transporter and receptor for serum retinol-binding protein (RBP4). Journal of Biological Chemistry 288: 1250-1265. doi:10.1074/jbc.M112.369132.
18. Napoli JL (2012) Physiological insights into all-trans-retinoic acid biosynthesis. Biochim Biophys Acta 1821: 152-167. doi:10.1016/j.bbalip.2011.05. 004.
19. Wang Y, Zolfaghari R, Ross AC (2002) Cloning of rat cytochrome P450RAI (CYP26) cDNA and regulation of its gene expression by all-trans-retinoic acid in vivo. Arch Biochem Biophys 401: 235-243. doi:10.1016/S0003-9861(02)00043-7. (Pubitemid 34848626)
20. Phillips MS, Liu Q, Hammond HA, Dugan V, Hey PJ, et al. (1996) Leptin receptor missense mutation in the fatty Zucker rat. Nature Genetics 13: 18-19. doi:doi:10.1038/ng0596-18.
21. Zucker LM, Antoniades HN (1972) Insulin and obesity in the Zucker genetically obese rat "fatty". Endocrinology 90: 1320-1330.
22. Clark JB, Keen S, Clark CM (1982) Studies on the regulation of insulin binding by liver plasma membranes from Zucker fatty rats. Diabetes 31: 867-873. (Pubitemid 12013790)
23. Li S, Brown MS, Goldstein JL (2010) Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis. Proceedings of the National Academy of Sciences 107: 3441-3446. doi:10.1073/pnas.0914798107.
24. Moon Y-A, Liang G, Xie X, Frank-Kamenetsky M, Fitzgerald K, et al. (2012) The Scap/SREBP pathway is essential for developing diabetic fatty liver and carbohydrate-induced hypertriglyceridemia in animals. Cell Metab 15: 240-246. doi:10.1016/j.cmet.2011.12.017.
25. Cahill F, Amini P, Wadden D, Khalili S, Randell E, et al. (2013) Short-term overfeeding increases circulating adiponectin independent of obesity status. PLoS ONE 8: e74215. doi:10.1371/journal.pone.0074215.
26. Wadden D, Cahill F, Amini P, Randell E, Vasdev S, et al. (2013) Circulating glucagon-like peptide-1 increases in response to short-term overfeeding in men. Nutr Metab (Lond) 10: 33. doi:10.1186/1743-7075-10-33.
27. Heilbronn LK, Coster ACF, Campbell LV, Greenfield JR, Lange K, et al. (2013) The effect of short-term overfeeding on serum lipids in healthy humans. Obesity (Silver Spring). doi:10.1002/oby.20508.
28. Magkos F, Smith GI, Reeds DN, Okunade A, Patterson BW, et al. (2013) One day of overfeeding impairs nocturnal glucose but not fatty acid homeostasis in overweight men. Obesity (Silver Spring). doi:10.1002/oby.20562.
29. Lecoultre V, Egli L, Carrel G, Theytaz F, Kreis R, et al. (2013) Effects of fructose and glucose overfeeding on hepatic insulin sensitivity and intrahepatic lipids in healthy humans. Obesity (Silver Spring) 21: 782-785. doi:10.1002/oby.20377.
30. Elizondo G, Corchero J, Sterneck E, Gonzalez FJ (2000) Feedback inhibition of the retinaldehyde dehydrogenase gene ALDH1 by retinoic acid through retinoic acid receptor alpha and CCAAT/enhancer-binding protein beta. J Biol Chem 275: 39747-39753. doi:10.1074/jbc.M004987200. (Pubitemid 32059004)
31. Elizondo G, Medina-Díaz IM, Cruz R, Gonzalez FJ, Vega L (2009) Retinoic acid modulates retinaldehyde dehydrogenase 1 gene expression through the induction of GADD153-C/EBPbeta interaction. Biochem Pharmacol 77: 248-257. doi:10.1016/j.bcp.2008.10.011.