메뉴 건너뛰기




Volumn 5, Issue JUN, 2014, Pages

Oncogene-induced senescence as a new mechanism of disease: The paradigm of Erdheim-Chester disease

Author keywords

BRAF kinases; Erdheim Chester disease; Histiocytosis; Inflammation; Macrophages; Oncogene induced senescence

Indexed keywords


EID: 84905659020     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2014.00281     Document Type: Short Survey
Times cited : (44)

References (50)
  • 1
  • 2
    • 84883820890 scopus 로고    scopus 로고
    • The multifaceted clinical presentations and manifestations of Erdheim-Chester disease: comprehensive review of the literature and of 10 new cases
    • doi:10.1136/annrheumdis-2012-202542
    • Cavalli G, Guglielmi B, Berti A, Campochiaro C, Sabbadini MG, Dagna L. The multifaceted clinical presentations and manifestations of Erdheim-Chester disease: comprehensive review of the literature and of 10 new cases. Ann Rheum Dis (2013) 72(10):1691-5. doi:10.1136/annrheumdis-2012-202542
    • (2013) Ann Rheum Dis , vol.72 , Issue.10 , pp. 1691-1695
    • Cavalli, G.1    Guglielmi, B.2    Berti, A.3    Campochiaro, C.4    Sabbadini, M.G.5    Dagna, L.6
  • 4
    • 80054787366 scopus 로고    scopus 로고
    • Erdheim-Chester disease: imaging-guided therapeutic approach
    • doi:10.1097/RLU.0b013e318217ade7
    • Della Torre E, Dagna L, Mapelli P, Mellone R, Grazia Sabbadini M. Erdheim-Chester disease: imaging-guided therapeutic approach. Clin Nucl Med (2011) 36(8):704-6. doi:10.1097/RLU.0b013e318217ade7
    • (2011) Clin Nucl Med , vol.36 , Issue.8 , pp. 704-706
    • Della Torre, E.1    Dagna, L.2    Mapelli, P.3    Mellone, R.4    Grazia Sabbadini, M.5
  • 5
    • 84878391690 scopus 로고    scopus 로고
    • Diagnosing Erdheim-Chester disease
    • doi:10.1136/annrheumdis-2013-203685
    • Cavalli G, Berti A, Campochiaro C, Dagna L. Diagnosing Erdheim-Chester disease. Ann Rheum Dis (2013) 72(7):e19. doi:10.1136/annrheumdis-2013-203685
    • (2013) Ann Rheum Dis , vol.72 , Issue.7
    • Cavalli, G.1    Berti, A.2    Campochiaro, C.3    Dagna, L.4
  • 6
    • 84940385131 scopus 로고    scopus 로고
    • BRAF V600E-mutation is invariably present and associated to oncogene-induced senescence in Erdheim-Chester disease
    • doi:10.1136/annrheumdis-2013-204924
    • Cangi MG, Biavasco R, Cavalli G, Grassini G, Dal-cin E, Campochiaro C, et al. BRAF V600E-mutation is invariably present and associated to oncogene-induced senescence in Erdheim-Chester disease. Ann Rheum Dis (2014):1-7. doi:10.1136/annrheumdis-2013-204924
    • (2014) Ann Rheum Dis , pp. 1-7
    • Cangi, M.G.1    Biavasco, R.2    Cavalli, G.3    Grassini, G.4    Dal-cin, E.5    Campochiaro, C.6
  • 7
    • 84866596727 scopus 로고    scopus 로고
    • High prevalence of BRAF V600E mutations in Erdheim-Chester disease but not in other non-Langerhans cell histiocytoses
    • doi:10.1182/blood-2012-05-430140
    • Haroche J, Charlotte F, Arnaud L, von Deimling A, Hélias-Rodzewicz Z, Hervier B, et al. High prevalence of BRAF V600E mutations in Erdheim-Chester disease but not in other non-Langerhans cell histiocytoses. Blood (2012) 120(13):2700-3. doi:10.1182/blood-2012-05-430140
    • (2012) Blood , vol.120 , Issue.13 , pp. 2700-2703
    • Haroche, J.1    Charlotte, F.2    Arnaud, L.3    von Deimling, A.4    Hélias-Rodzewicz, Z.5    Hervier, B.6
  • 8
    • 84870252822 scopus 로고    scopus 로고
    • The Relapsing Polychondritis Disease Activity Index: development of a disease activity score for relapsing polychondritis
    • doi:10.1016/j.autrev.2012.06.005
    • Arnaud L, Devilliers H, Peng SL, Mathian A, Costedoat-Chalumeau N, Buckner J, et al. The Relapsing Polychondritis Disease Activity Index: development of a disease activity score for relapsing polychondritis. Autoimmun Rev (2012) 12(2):204-9. doi:10.1016/j.autrev.2012.06.005
    • (2012) Autoimmun Rev , vol.12 , Issue.2 , pp. 204-209
    • Arnaud, L.1    Devilliers, H.2    Peng, S.L.3    Mathian, A.4    Costedoat-Chalumeau, N.5    Buckner, J.6
  • 9
    • 84873361772 scopus 로고    scopus 로고
    • BRAF mutations in Erdheim-Chester disease
    • doi:10.1200/JCO.2012.46.9676
    • Emile J-F, Charlotte F, Amoura Z, Haroche J. BRAF mutations in Erdheim-Chester disease. J Clin Oncol (2013) 31(3):398. doi:10.1200/JCO.2012.46.9676
    • (2013) J Clin Oncol , vol.31 , Issue.3 , pp. 398
    • Emile, J.-F.1    Charlotte, F.2    Amoura, Z.3    Haroche, J.4
  • 10
    • 84869401885 scopus 로고    scopus 로고
    • Erdheim-Chester disease harboring the BRAF V600E mutation
    • doi:10.1200/JCO.2012.43.2260
    • Blombery P, Wong SQ, Lade S, Prince HM. Erdheim-Chester disease harboring the BRAF V600E mutation. J Clin Oncol (2012) 30(32):e331-2. doi:10.1200/JCO.2012.43.2260
    • (2012) J Clin Oncol , vol.30 , Issue.32
    • Blombery, P.1    Wong, S.Q.2    Lade, S.3    Prince, H.M.4
  • 11
    • 84876498502 scopus 로고    scopus 로고
    • Dramatic efficacy of vemurafenib in both multisystemic and refractory Erdheim-Chester disease and Langerhans cell histiocytosis harboring the BRAF V600E mutation
    • doi:10.1182/blood-2012-07-446286
    • Haroche J, Cohen-Aubart F, Emile J-F, Arnaud L, Maksud P, Charlotte F, et al. Dramatic efficacy of vemurafenib in both multisystemic and refractory Erdheim-Chester disease and Langerhans cell histiocytosis harboring the BRAF V600E mutation. Blood (2013) 121:1495-500. doi:10.1182/blood-2012-07-446286
    • (2013) Blood , vol.121 , pp. 1495-1500
    • Haroche, J.1    Cohen-Aubart, F.2    Emile, J.-F.3    Arnaud, L.4    Maksud, P.5    Charlotte, F.6
  • 12
    • 82955203659 scopus 로고    scopus 로고
    • Langerhans cell histiocytosis and Erdheim-Chester disease
    • doi:10.1097/BOR.0b013e32834db53e
    • Wilejto M, Abla O. Langerhans cell histiocytosis and Erdheim-Chester disease. Curr Opin Rheumatol (2012) 24(1):90-6. doi:10.1097/BOR.0b013e32834db53e
    • (2012) Curr Opin Rheumatol , vol.24 , Issue.1 , pp. 90-96
    • Wilejto, M.1    Abla, O.2
  • 15
    • 0036089164 scopus 로고    scopus 로고
    • Erdheim-Chester disease: case report, PCR-based analysis of clonality, and review of literature
    • doi:10.1038/modpathol.3880583
    • Al-Quran S, Reith J, Bradley J, Rimsza L. Erdheim-Chester disease: case report, PCR-based analysis of clonality, and review of literature. Mod Pathol (2002) 15(6):666-72. doi:10.1038/modpathol.3880583
    • (2002) Mod Pathol , vol.15 , Issue.6 , pp. 666-672
    • Al-Quran, S.1    Reith, J.2    Bradley, J.3    Rimsza, L.4
  • 17
    • 33845610535 scopus 로고    scopus 로고
    • Immunohistochemical evidence of a cytokine and chemokine network in three patients with Erdheim-Chester disease: implications for pathogenesis
    • doi:10.1002/art.22280
    • Stoppacciaro A, Ferrarini M, Salmaggi C, Colarossi C, Praderio L, Tresoldi M, et al. Immunohistochemical evidence of a cytokine and chemokine network in three patients with Erdheim-Chester disease: implications for pathogenesis. Arthritis Rheum (2006) 54:4018-22. doi:10.1002/art.22280
    • (2006) Arthritis Rheum , vol.54 , pp. 4018-4022
    • Stoppacciaro, A.1    Ferrarini, M.2    Salmaggi, C.3    Colarossi, C.4    Praderio, L.5    Tresoldi, M.6
  • 18
    • 84857883847 scopus 로고    scopus 로고
    • Macrophage plasticity and polarization: in vivo veritas
    • doi:10.1172/JCI59643
    • Sica A, Mantovani A. Macrophage plasticity and polarization: in vivo veritas. J Clin Invest (2012) 122(3):787-95. doi:10.1172/JCI59643
    • (2012) J Clin Invest , vol.122 , Issue.3 , pp. 787-795
    • Sica, A.1    Mantovani, A.2
  • 19
    • 79953111158 scopus 로고    scopus 로고
    • Systemic perturbation of cytokine and chemokine networks in Erdheim-Chester disease: a single-center series of 37 patients
    • doi:10.1182/blood-2010-10-313510
    • Arnaud L, Gorochov G, Charlotte F, Lvovschi V, Parizot C, Larsen M, et al. Systemic perturbation of cytokine and chemokine networks in Erdheim-Chester disease: a single-center series of 37 patients. Blood (2011) 117(10):2783-90. doi:10.1182/blood-2010-10-313510
    • (2011) Blood , vol.117 , Issue.10 , pp. 2783-2790
    • Arnaud, L.1    Gorochov, G.2    Charlotte, F.3    Lvovschi, V.4    Parizot, C.5    Larsen, M.6
  • 20
    • 84890930276 scopus 로고    scopus 로고
    • TNF-a in Erdheim-Chester disease pericardial effusion promotes endothelial leakage in vitro and is neutralized by infliximab
    • doi:10.1093/rheumatology/ket246
    • Ferrero E, Belloni D, Corti A, Doglioni C, Dagna L, Ferrarini M. TNF-a in Erdheim-Chester disease pericardial effusion promotes endothelial leakage in vitro and is neutralized by infliximab. Rheumatology (Oxford) (2014) 53(1):198-200. doi:10.1093/rheumatology/ket246
    • (2014) Rheumatology , vol.53 , Issue.1 , pp. 198-200
    • Ferrero, E.1    Belloni, D.2    Corti, A.3    Doglioni, C.4    Dagna, L.5    Ferrarini, M.6
  • 21
    • 77953508453 scopus 로고    scopus 로고
    • Erdheim-Chester disease: report on a case and new insights on its immunopathogenesis
    • doi:10.1093/rheumatology/kep461
    • Dagna L, Girlanda S, Langheim S, Rizzo N, Bozzolo EP, Sabbadini MG, et al. Erdheim-Chester disease: report on a case and new insights on its immunopathogenesis. Rheumatology (Oxford) (2010) 49(6):1203-6. doi:10.1093/rheumatology/kep461
    • (2010) Rheumatology , vol.49 , Issue.6 , pp. 1203-1206
    • Dagna, L.1    Girlanda, S.2    Langheim, S.3    Rizzo, N.4    Bozzolo, E.P.5    Sabbadini, M.G.6
  • 22
    • 80155130609 scopus 로고    scopus 로고
    • Partial regression of CNS lesions of Erdheim-Chester disease after treatment with 2-chlorodeoxyadenosine and their full remission following treatment with lenalidomide
    • Adam Z, Sprláková A, Rehák Z, Koukalová R, Szturz P, Krejcí M, et al. Partial regression of CNS lesions of Erdheim-Chester disease after treatment with 2-chlorodeoxyadenosine and their full remission following treatment with lenalidomide. Klin Onkol (2011) 24(5):367-81.
    • (2011) Klin Onkol , vol.24 , Issue.5 , pp. 367-381
    • Adam, Z.1    Sprláková, A.2    Rehák, Z.3    Koukalová, R.4    Szturz, P.5    Krejcí, M.6
  • 23
    • 2642553950 scopus 로고    scopus 로고
    • Treatment of Erdheim-Chester disease with cladribine: a rational approach
    • doi:10.1136/bjo.2003.035584
    • Myra C, Sloper L, Tighe PJ, McIntosh RS, Stevens SE, Gregson RHS, et al. Treatment of Erdheim-Chester disease with cladribine: a rational approach. Br J Ophthalmol (2004) 88(6):844-7. doi:10.1136/bjo.2003.035584
    • (2004) Br J Ophthalmol , vol.88 , Issue.6 , pp. 844-847
    • Myra, C.1    Sloper, L.2    Tighe, P.J.3    McIntosh, R.S.4    Stevens, S.E.5    Gregson, R.H.S.6
  • 24
    • 84861223869 scopus 로고    scopus 로고
    • Treatment of Erdheim-Chester disease with long-term high-dose interferon-a
    • doi:10.1016/j.semarthrit.2011.11.004
    • Hervier B, Arnaud L, Charlotte F, Wechsler B, Piette JC, Amoura Z, et al. Treatment of Erdheim-Chester disease with long-term high-dose interferon-a. Semin Arthritis Rheum (2012) 41(6):907-13. doi:10.1016/j.semarthrit.2011.11.004
    • (2012) Semin Arthritis Rheum , vol.41 , Issue.6 , pp. 907-913
    • Hervier, B.1    Arnaud, L.2    Charlotte, F.3    Wechsler, B.4    Piette, J.C.5    Amoura, Z.6
  • 25
    • 79953124751 scopus 로고    scopus 로고
    • CNS involvement and treatment with interferon-a are independent prognostic factors in Erdheim-Chester disease: a multicenter survival analysis of 53 patients
    • doi:10.1182/blood-2010-06-294108
    • Arnaud L, Hervier B, Néel A, Hamidou MA, Kahn J-E, Wechsler B, et al. CNS involvement and treatment with interferon-a are independent prognostic factors in Erdheim-Chester disease: a multicenter survival analysis of 53 patients. Blood (2011) 117(10):2778-82. doi:10.1182/blood-2010-06-294108
    • (2011) Blood , vol.117 , Issue.10 , pp. 2778-2782
    • Arnaud, L.1    Hervier, B.2    Néel, A.3    Hamidou, M.A.4    Kahn, J.-E.5    Wechsler, B.6
  • 26
    • 0023598336 scopus 로고
    • Treatment of Langerhans cell histiocytosis with alpha-interferon
    • doi:10.1016/S0140-6736(87)92649-3
    • Jakobson AM, Kreuger A, Hagberg H, Sundström C. Treatment of Langerhans cell histiocytosis with alpha-interferon. Lancet (1987) 2(8574):1520-1. doi:10.1016/S0140-6736(87)92649-3
    • (1987) Lancet , vol.2 , Issue.8574 , pp. 1520-1521
    • Jakobson, A.M.1    Kreuger, A.2    Hagberg, H.3    Sundström, C.4
  • 27
  • 28
    • 0036201905 scopus 로고    scopus 로고
    • IFN-alpha enhances CD40 ligand-mediated activation of immature monocyte-derived dendritic cells
    • doi:10.1093/intimm/14.4.367
    • Luft T, Luetjens P, Hochrein H, Toy T, Masterman K-A, Rizkalla M, et al. IFN-alpha enhances CD40 ligand-mediated activation of immature monocyte-derived dendritic cells. Int Immunol (2002) 14(4):367-80. doi:10.1093/intimm/14.4.367
    • (2002) Int Immunol , vol.14 , Issue.4 , pp. 367-380
    • Luft, T.1    Luetjens, P.2    Hochrein, H.3    Toy, T.4    Masterman, K.-A.5    Rizkalla, M.6
  • 29
    • 0032529213 scopus 로고    scopus 로고
    • Type I IFNs enhance the terminal differentiation of dendritic cells
    • Luft T, Pang KC, Thomas E, Hertzog P, Hart DN, Trapani J, et al. Type I IFNs enhance the terminal differentiation of dendritic cells. J Immunol (1998) 161(4):1947-53.
    • (1998) J Immunol , vol.161 , Issue.4 , pp. 1947-1953
    • Luft, T.1    Pang, K.C.2    Thomas, E.3    Hertzog, P.4    Hart, D.N.5    Trapani, J.6
  • 30
    • 78549269492 scopus 로고    scopus 로고
    • Rationale and efficacy of interleukin-1 targeting in Erdheim-Chester disease
    • doi:10.1182/blood-2010-04-279240
    • Aouba A, Georgin-Lavialle S, Pagnoux C, Martin Silva N, Renand A, Galateau-Salle F, et al. Rationale and efficacy of interleukin-1 targeting in Erdheim-Chester disease. Blood (2010) 116(20):4070-6. doi:10.1182/blood-2010-04-279240
    • (2010) Blood , vol.116 , Issue.20 , pp. 4070-4076
    • Aouba, A.1    Georgin-Lavialle, S.2    Pagnoux, C.3    Martin Silva, N.4    Ren, A.5    Galateau-Salle, F.6
  • 31
    • 84875521991 scopus 로고    scopus 로고
    • Favorable radiological outcome of skeletal Erdheim-Chester disease involvement with anakinra
    • doi:10.1016/j.jbspin.2012.07.005
    • Aubert O, Aouba A, Deshayes S, Georgin-Lavialle S, Rieu P, Hermine O. Favorable radiological outcome of skeletal Erdheim-Chester disease involvement with anakinra. Joint Bone Spine (2013) 80(2):206-7. doi:10.1016/j.jbspin.2012.07.005
    • (2013) Joint Bone Spine , vol.80 , Issue.2 , pp. 206-207
    • Aubert, O.1    Aouba, A.2    Deshayes, S.3    Georgin-Lavialle, S.4    Rieu, P.5    Hermine, O.6
  • 32
    • 84898547836 scopus 로고    scopus 로고
    • Successful treatment of Erdheim-Chester disease by interleukin-1 receptor antagonist protein
    • doi:10.1016/j.jbspin.2013.06.013
    • Courcoul A, Vignot E, Chapurlat R. Successful treatment of Erdheim-Chester disease by interleukin-1 receptor antagonist protein. Joint Bone Spine (2014) 81(2):175-7. doi:10.1016/j.jbspin.2013.06.013
    • (2014) Joint Bone Spine , vol.81 , Issue.2 , pp. 175-177
    • Courcoul, A.1    Vignot, E.2    Chapurlat, R.3
  • 33
    • 84867083505 scopus 로고    scopus 로고
    • Tumor necrosis factor a as a master regulator of inflammation in Erdheim-Chester disease: rationale for the treatment of patients with infliximab
    • doi:10.1200/JCO.2012.41.9911
    • Dagna L, Corti A, Langheim S, Guglielmi B, De Cobelli F, Doglioni C, et al. Tumor necrosis factor a as a master regulator of inflammation in Erdheim-Chester disease: rationale for the treatment of patients with infliximab. J Clin Oncol (2012) 30(28):e286-90. doi:10.1200/JCO.2012.41.9911
    • (2012) J Clin Oncol , vol.30 , Issue.28
    • Dagna, L.1    Corti, A.2    Langheim, S.3    Guglielmi, B.4    De Cobelli, F.5    Doglioni, C.6
  • 34
  • 35
    • 84886878689 scopus 로고    scopus 로고
    • Detection of an NRAS mutation in Erdheim-Chester disease
    • doi:10.1182/blood-2013-02-482984
    • Diamond EL, Abdel-Wahab O, Pentsova E, Borsu L, Chiu A, Teruya-Feldstein J, et al. Detection of an NRAS mutation in Erdheim-Chester disease. Blood (2013) 122(6):1089-91. doi:10.1182/blood-2013-02-482984
    • (2013) Blood , vol.122 , Issue.6 , pp. 1089-1091
    • Diamond, E.L.1    Abdel-Wahab, O.2    Pentsova, E.3    Borsu, L.4    Chiu, A.5    Teruya-Feldstein, J.6
  • 36
    • 79959795786 scopus 로고    scopus 로고
    • Improved survival with vemurafenib in melanoma with BRAF V600E mutation
    • doi:10.1056/NEJMoa1103782
    • Chapman PB, Hauschild A, Robert C, Haanen JB, Ascierto P, Larkin J, et al. Improved survival with vemurafenib in melanoma with BRAF V600E mutation. N Engl J Med (2011) 364(26):2507-16. doi:10.1056/NEJMoa1103782
    • (2011) N Engl J Med , vol.364 , Issue.26 , pp. 2507-2516
    • Chapman, P.B.1    Hauschild, A.2    Robert, C.3    Haanen, J.B.4    Ascierto, P.5    Larkin, J.6
  • 37
    • 42949149240 scopus 로고    scopus 로고
    • Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity
    • doi:10.1073/pnas.0711741105
    • Tsai J, Lee JT, Wang W, Zhang J, Cho H, Mamo S, et al. Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity. Proc Natl Acad Sci U S A (2008) 105(8):3041-6. doi:10.1073/pnas.0711741105
    • (2008) Proc Natl Acad Sci U S A , vol.105 , Issue.8 , pp. 3041-3046
    • Tsai, J.1    Lee, J.T.2    Wang, W.3    Zhang, J.4    Cho, H.5    Mamo, S.6
  • 38
    • 77957089182 scopus 로고    scopus 로고
    • The RAF inhibitor PLX4032 inhibits ERK signaling and tumor cell proliferation in a V600E BRAF-selective manner
    • doi:10.1073/pnas.1008990107
    • Joseph EW, Pratilas CA, Poulikakos PI, Tadi M, Wang W, Taylor BS, et al. The RAF inhibitor PLX4032 inhibits ERK signaling and tumor cell proliferation in a V600E BRAF-selective manner. Proc Natl Acad Sci U S A (2010) 107(33):14903-8. doi:10.1073/pnas.1008990107
    • (2010) Proc Natl Acad Sci U S A , vol.107 , Issue.33 , pp. 14903-14908
    • Joseph, E.W.1    Pratilas, C.A.2    Poulikakos, P.I.3    Tadi, M.4    Wang, W.5    Taylor, B.S.6
  • 39
    • 38149000163 scopus 로고    scopus 로고
    • Selective amplification of rare mutations using locked nucleic acid oligonucleotides that competitively inhibit primer binding to wild-type DNA
    • doi:10.1038/sj.jid.5700920
    • Oldenburg RP, Liu MS, Kolodney MS. Selective amplification of rare mutations using locked nucleic acid oligonucleotides that competitively inhibit primer binding to wild-type DNA. J Invest Dermatol (2008) 128(2):398-402. doi:10.1038/sj.jid.5700920
    • (2008) J Invest Dermatol , vol.128 , Issue.2 , pp. 398-402
    • Oldenburg, R.P.1    Liu, M.S.2    Kolodney, M.S.3
  • 40
    • 29144435996 scopus 로고    scopus 로고
    • Computational modelling of the receptor-tyrosine-kinase-activated MAPK pathway.
    • doi:10.1042/BJ20050908
    • Orton RJ, Sturm OE, Vyshemirsky V, Calder M, Gilbert DR, Kolch W. Computational modelling of the receptor-tyrosine-kinase-activated MAPK pathway. Biochem J (2005) 392(Pt 2):249-61. doi:10.1042/BJ20050908
    • (2005) Biochem J , vol.392 , Issue.PART 2 , pp. 249-261
    • Orton, R.J.1    Sturm, O.E.2    Vyshemirsky, V.3    Calder, M.4    Gilbert, D.R.5    Kolch, W.6
  • 41
    • 80155161402 scopus 로고    scopus 로고
    • Vemurafenib (PLX4032): an orally available inhibitor of mutated BRAF for the treatment of metastatic melanoma
    • doi:10.1345/aph.1Q363
    • Heakal Y, Kester M, Savage S. Vemurafenib (PLX4032): an orally available inhibitor of mutated BRAF for the treatment of metastatic melanoma. Ann Pharmacother (2011) 45(11):1399-405. doi:10.1345/aph.1Q363
    • (2011) Ann Pharmacother , vol.45 , Issue.11 , pp. 1399-1405
    • Heakal, Y.1    Kester, M.2    Savage, S.3
  • 42
    • 70350364867 scopus 로고    scopus 로고
    • Targeting of the BRAF gene in papillary thyroid carcinoma (review)
    • doi:10.3892/or_00000487
    • Li Y, Nakamura M, Kakudo K. Targeting of the BRAF gene in papillary thyroid carcinoma (review). Oncol Rep (2009) 22(4):671-81. doi:10.3892/or_00000487
    • (2009) Oncol Rep , vol.22 , Issue.4 , pp. 671-681
    • Li, Y.1    Nakamura, M.2    Kakudo, K.3
  • 43
    • 77954218212 scopus 로고    scopus 로고
    • BRAF as therapeutic target in melanoma
    • doi:10.1016/j.bcp.2010.03.019
    • Wellbrock C, Hurlstone A. BRAF as therapeutic target in melanoma. Biochem Pharmacol (2010) 80(5):561-7. doi:10.1016/j.bcp.2010.03.019
    • (2010) Biochem Pharmacol , vol.80 , Issue.5 , pp. 561-567
    • Wellbrock, C.1    Hurlstone, A.2
  • 45
    • 33748422079 scopus 로고    scopus 로고
    • Oncogene-induced cell senescence - halting on the road to cancer
    • doi:10.1056/NEJMra062285
    • Mooi WJ, Peeper DS. Oncogene-induced cell senescence - halting on the road to cancer. N Engl J Med (2006) 355:1037-46. doi:10.1056/NEJMra062285
    • (2006) N Engl J Med , vol.355 , pp. 1037-1046
    • Mooi, W.J.1    Peeper, D.S.2
  • 47
    • 44649101304 scopus 로고    scopus 로고
    • Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network
    • doi:10.1016/j.cell.2008.03.039
    • Kuilman T, Michaloglou C, Vredeveld LCW, Douma S, Van Doorn R, Desmet CJ, et al. Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network. Cell (2008) 133:1019-31. doi:10.1016/j.cell.2008.03.039
    • (2008) Cell , vol.133 , pp. 1019-1031
    • Kuilman, T.1    Michaloglou, C.2    Vredeveld, L.C.W.3    Douma, S.4    Van Doorn, R.5    Desmet, C.J.6
  • 48
    • 84872806275 scopus 로고    scopus 로고
    • Genetic and pharmacological targeting of CSF-1/CSF-1R inhibits tumor-associated macrophages and impairs BRAF-induced thyroid cancer progression
    • doi:10.1371/journal.pone.0054302
    • Ryder M, Gild M, Hohl TM, Pamer E, Knauf J, Ghossein R, et al. Genetic and pharmacological targeting of CSF-1/CSF-1R inhibits tumor-associated macrophages and impairs BRAF-induced thyroid cancer progression. PLoS One (2013) 8(1):e54302. doi:10.1371/journal.pone.0054302
    • (2013) PLoS One , vol.8 , Issue.1
    • Ryder, M.1    Gild, M.2    Hohl, T.M.3    Pamer, E.4    Knauf, J.5    Ghossein, R.6
  • 49
    • 84905657472 scopus 로고    scopus 로고
    • Oncogene-induced senescence distinguishes indolent from aggressive forms of pulmonary and non-pulmonary Langerhans cell histiocytosis.
    • doi:10.3109/10428194.2014.887713
    • Chilosi M, Facchetti F, Caliò A, Zamò A, Brunelli M, Martignoni G, et al. Oncogene-induced senescence distinguishes indolent from aggressive forms of pulmonary and non-pulmonary Langerhans cell histiocytosis. Leuk Lymphoma (2014). doi:10.3109/10428194.2014.887713
    • (2014) Leuk Lymphoma
    • Chilosi, M.1    Facchetti, F.2    Caliò, A.3    Zamò, A.4    Brunelli, M.5    Martignoni, G.6
  • 50
    • 84874603171 scopus 로고    scopus 로고
    • Cellular senescence and the senescent secretory phenotype: therapeutic opportunities
    • doi:10.1172/JCI64098
    • Tchkonia T, Zhu Y, van Deursen J, Campisi J, Kirkland JL. Cellular senescence and the senescent secretory phenotype: therapeutic opportunities. J Clin Invest (2013) 123(3):966-72. doi:10.1172/JCI64098
    • (2013) J Clin Invest , vol.123 , Issue.3 , pp. 966-972
    • Tchkonia, T.1    Zhu, Y.2    van Deursen, J.3    Campisi, J.4    Kirkland, J.L.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.