Detection of an NRAS mutation in Erdheim-Chester disease

Blood

Volumn 122, Issue 6, 2013, Pages 1089-1091

  Diamond, Eli L ^a   Abdel Wahab, Omar ^a   Pentsova, Elena ^a   Borsu, Laetitia ^a   Chiu, April ^a   Teruya Feldstein, Julie ^a   Hyman, David M ^a   Rosenblum, Marc ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B RAF KINASE; CD68 ANTIGEN; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; GADOLINIUM; T6 ANTIGEN; RAS PROTEIN;

ABDOMINAL RADIOGRAPHY; AGED; AKT1 GENE; BONE SCINTISCANNING; CASE REPORT; COGNITIVE DEFECT; COMPUTER ASSISTED TOMOGRAPHY; CONTRAST ENHANCEMENT; DETERIORATION; ERDHEIM CHESTER DISEASE; FATIGUE; GAIT; GENE; GENE MUTATION; HISTIOCYTE; HUMAN; KIDNEY TUMOR; LETTER; MALE; MAP2K1 GENE; NUCLEAR MAGNETIC RESONANCE IMAGING; ONCOGENE K RAS; ONCOGENE N RAS; PELVIS RADIOGRAPHY; PIK3CA GENE; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; THORAX RADIOGRAPHY; URINE INCONTINENCE; BRAIN; GENETICS; MUTATION; NUCLEOTIDE SEQUENCE; ONCOGENE RAS; PATHOLOGY;

AGED; BRAIN; COGNITION DISORDERS; DNA MUTATIONAL ANALYSIS; ERDHEIM-CHESTER DISEASE; GENES, RAS; HUMANS; MALE; MUTATION; RAS PROTEINS;

EID: 84886878689     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2013-02-482984     Document Type: Letter

References (5)

1. Haroche J, Cohen-Aubart F, Emile JF, et al. Dramatic efficacy of vemurafenib in both multisystemic and refractory Erdheim-Chester disease and Langerhans cell histiocytosis harboring the BRAF V600E mutation. Blood. 2013;121(9): 1495-1500.
2. Haroche J, Charlotte F, Arnaud L, et al. High prevalence of BRAF V600E mutations in Erdheim-Chester disease but not in other non-Langerhans cell histiocytoses. Blood. 2012;120(13):2700-2703.
3. Emile JF, Charlotte F, Amoura Z, Haroche J. BRAF mutations in Erdheim-Chester disease. J Clin Oncol. 2013;31(3):398.
4. Colombino M, Capone M, Lissia A, et al. BRAF/NRAS mutation frequencies among primary tumors and metastases in patients with melanoma. J Clin Oncol. 2012;30(20):2522-2529.
5. Wang Y, Velho S, Vakiani E, et al. Mutant N-RAS protects colorectal cancer cells from stress-induced apoptosis and contributes to cancer development and progression. Cancer Discov. 2013;3(3):294-307.