TMEM129 is a Derlin-1 associated ERAD E3 ligase essential for virus-induced degradation of MHC-I

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 31, 2014, Pages 11425-11430

  Van Den Boomen, Dick J H ^a   Timms, Richard T ^a   Grice, Guinevere L ^a   Stagg, Helen R ^a   Skdøt, Karsten ^b   Dougan, Gordon ^c   Nathan, James A ^a   Lehner, Paul J ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^c WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

HLA A2 ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MEMBRANE PROTEIN; PROTEIN TMEM 129; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

ARTICLE; CELL SURFACE; CHROMOSOME 4; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; DISEASE MARKER; DOWN REGULATION; ENDOPLASMIC RETICULUM ASSOCIATED DEGRADATION; ENZYME ACTIVITY; FEMALE; FIBROBLAST; GENETIC SCREENING; HALF LIFE TIME; HELA CELL LINE; HUMAN; HUMAN CELL; HUMAN CYTOMEGALOVIRUS; IMMUNOPRECIPITATION; INTERNAL RIBOSOME ENTRY SITE; MAJOR HISTOCOMPATIBILITY COMPLEX; MUTAGENESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN TRANSPORT; PYROSEQUENCING; RING FINGER MOTIF; UBIQUITINATION; WILD TYPE;

AMINO ACID SEQUENCE; BIOCATALYSIS; CYTOSOL; DOWN-REGULATION; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM-ASSOCIATED DEGRADATION; GENES, VIRAL; GENETIC TESTING; HAPLOIDY; HERPESVIRUS 1, HUMAN; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN STABILITY; PROTEINS; PROTEOLYSIS; RNA-BINDING PROTEINS; UBIQUITIN-CONJUGATING ENZYMES; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION; VIRAL PROTEINS;

EID: 84905656790     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1409099111     Document Type: Article

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