Levels of 4-1BB transcripts and soluble 4-1BB protein are elevated in the adipose tissue of human obese subjects and are associated with inflammatory and metabolic parameters

International Journal of Obesity

Volumn 38, Issue 8, 2014, Pages 1075-1082

  Tu, T H ^a   Kim, C S ^a   Kang, J H ^a   Nam Goong, I S ^b   Nam, C W ^b   Kim, E S ^b   Kim, Y I ^b   Choi, J I ^c   Kawada, T ^d   Goto, T ^d   Park, T ^e   Yoon Park, J H ^f   Choi, M S ^g   Yu, R ^a  

^a University of Ulsan   (South Korea)

^b University of Ulsan College of Medicine   (South Korea)

^c University of Ulsan College of Medicine   (South Korea)

^d KYOTO UNIVERSITY   (Japan)

^e Yonsei University   (South Korea)

^f Hallym University   (South Korea)

^g Kyungpook National University   (South Korea)

Author keywords

adipose tissue; inflammation; metabolic syndrome

Indexed keywords

CD137 ANTIGEN; CD137 LIGAND; TNFRSF9 PROTEIN, HUMAN;

ADIPOCYTE; ADIPOSE TISSUE; BODY MASS; CELL CULTURE; COMPARATIVE STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; IMMUNOLOGY; INFLAMMATION; MALE; METABOLISM; OBESITY; PATHOPHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION; SOLUBILITY;

4-1BB LIGAND; ADIPOCYTES; ADIPOSE TISSUE; ANTIGENS, CD137; BODY MASS INDEX; CELLS, CULTURED; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; INFLAMMATION; MALE; OBESITY; REAL-TIME POLYMERASE CHAIN REACTION; SOLUBILITY;

EID: 84905640163     PISSN: 03070565     EISSN: 14765497     Source Type: Journal    
DOI: 10.1038/ijo.2013.222     Document Type: Article

References (54)

1. Hotamisligil GS, Arner P, Caro JF, Atkinson RL, Spiegelman BM. Increased adipose tissue expression of tumor necrosis factor-Alpha in human obesity and insulin resistance. J Clin Invest 1995; 95: 2409.
2. Rasouli N, Kern PA. Adipocytokines and the metabolic complications of obesity. J Clin Endocrinol Metab 2008; 93: S64-s73.
3. Grundy SM. Obesity, metabolic syndrome, and cardiovascular disease. J Clin Endocrinol Metab 2004; 89: 2595-2600. (Pubitemid 38766337)
4. Wisse BE. The inflammatory syndrome: The role of adipose tissue cytokines in metabolic disorders linked to obesity. J Am Soc Nephrol 2004; 15: 2792-2800. (Pubitemid 41103388)
5. Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, Ferrante Jr. AW. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 2003; 112: 1796-1808. (Pubitemid 38063703)
6. Shoelson SE, Lee J, Goldfine AB. Inflammation and insulin resistance. J Clin Invest 2006; 116: 1793-1801. (Pubitemid 44033299)
7. Suganami T, Nishida J, Ogawa YA. Paracrine loop between adipocytes and macrophages aggravates inflammatory changes: Role of free fatty acids and tumor necrosis factor a. Arterioscler Thromb Vac Biol 2005; 25: 2062-2068. (Pubitemid 41416301)
8. Poggi M, Jager J, Paulmyer-Lacroix O, Peiretti F, Gremeaux T, Verdier M et al. The inflammatory receptor CD40 is expressed on human adipocytes: Contribution to crosstalk between lymphocytes and adipocytes. Diabetologia 2009; 52: 1152-1163.
9. Tu TH, Kim C-S, Goto T, Kawada T, Kim B-S, Yu R. 4-1BB/4-1BBL interaction promotes obesity-induced adipose inflammation by triggering bidirectional inflammatory signaling in adipocytes/macrophages. Mediators Inflamm 2012; 2012: 972629.
10. Brake DK, Smith EB, Mersmann H, Smith CW, Robker RL. ICAM-1 expression in adipose tissue: Effects of diet-induced obesity in mice. Am J Physiol Cell Physiol 2006; 291: C1232-C1239. (Pubitemid 44878594)
11. Lumeng CN, Maillard I, Saltiel AR. T-ing up inflammation in fat. Nat Med 2009; 15: 846-847.
12. Kim HM, Jeong CS, Choi HS, Kawada T, Yu R. LIGHT/TNFSF14 enhances adipose tissue inflammatory responses through its interaction with HVEM. FEBS Lett 2011; 33: 144-152.
13. Bassols J, Moreno JM, Ortega F, Ricart W, Fernandez-Real JM. Characterization of herpes virus entry mediator as a factor linked to obesity. Obesity 2010; 18: Q239-246.
14. Metkar SS, Naresh K, Manna PP, Srinivas V, Advani S, Nadkarni J. Circulating levels of TNFa and TNF receptor superfamily members in lymphoid neoplasia. Am J Hematol 2000; 65: 105-110.
15. Seijkens T, Kusters P, Engel D, Lutgens E. CD40-CD40L: Linking pancreatic, adipose tissue and vascular inflammation in type 2 diabetes and its complications. Diab Vasc Dis Res 2013; 10: 115-122.
16. Desideri G, Ferri C. Effects of obesity and weight loss on soluble CD40L levels. JAMA 2003; 289: 1781-1782. (Pubitemid 37430244)
17. Missiou A, Wolf D, Platzer I, Ernst S, Walter C, Rudolf P et al. CD40L induces inflammation and adipogenesis in adipose cells-A potential link between metabolic and cardiovascular disease. Thromb Haemost 2010; 103: 788.
18. Vinay DS, Choi BK, Bae JS, Kim WY, Gebhardt BM, Kwon BS. CD137-deficient mice have reduced NK/NKT cell numbers and function, are resistant to lipopolysaccharide-induced shock syndromes, and have lower IL-4 responses. J Immunol 2004; 173: 4218-4229. (Pubitemid 39280788)
19. Kim D-H, Chang W-S, Lee Y-S, Lee K-A, Kim Y-K, Kwon BS et al. 4-1BB engagement costimulates NKT cell activation and exacerbates NKT cell ligand-induced airway hyperresponsiveness and inflammation. J Immunol 2008; 180: 2062-2068.
20. Kim C-S, Kim JG, Lee B-J, Choi M-S, Choi H-S, Kawada T et al. Deficiency for costimulatory receptor 4-1BB protects against obesity-induced inflammation and metabolic disorders. Diabetes 2011; 60: 3159-3168.
21. Shao Z, Schwarz H. CD137 ligand, a member of the tumor necrosis factor family, regulates immune responses via reverse signal transduction. J Leukoc Biol 2011; 89: 21-29.
22. Lippert U, Zachmann K, Ferrari DM, Schwarz H, Brunner E, Latif A et al. CD137 ligand reverse signaling has multiple functions in human dendritic cells during an adaptive immune response. Eur J Immunol 2008; 38: 1024-1032.
23. Jeon HJ, Choi J-H, Jung I-H, Park J-G, Lee M-R, Lee M-N et al. CD137 (4-1BB) deficiency reduces atherosclerosis in hyperlipidemic mice. Circulation 2010; 121: 1124-1133.
24. Seo SK, Park HY, Choi JH, Kim WY, Kim YH, Jung HW et al. Blocking 4-1BB/4-1BB ligand interactions prevents herpetic stromal keratitis. J Immunol 2003; 171: 576-583. (Pubitemid 36871364)
25. Kwon B. CD137-CD137 ligand interactions in inflammation. Immune Netw 2009; 9: 84-89.
26. Shao Z, Schäffler A, Hamer O, Dickopf J, Goetz A, Landfried K et al. Admission levels of soluble CD137 are increased in patients with acute pancreatitis and are associated with subsequent complications. Exp Mol Pathol 2012; 92: 1-6.
27. Dongming L, Zuxun L, Liangjie X, Biao W, Ping Y. Enhanced levels of soluble and membrane-bound CD137 levels in patients with acute coronary syndromes. Clin Chim Acta 2010; 411: 406-410.
28. Jung HW, Choi SW, Choi JI, Kwon BS. Serum concentrations of soluble 4-1BB and 4-1BB ligand correlated with the disease severity in rheumatoid arthritis. Exp Mol Med 2004; 36: 13-22. (Pubitemid 38379632)
29. Michel J, Langstein J, Hofstädter F, Schwarz H. A soluble form of CD137 (ILA/4-1BB), a member of the TNF receptor family, is released by activated lymphocytes and is detectable in sera of patients with rheumatoid arthritis. Eur J Immunol 1998; 28: 290-295. (Pubitemid 28048299)
30. Sharief M. Heightened intrathecal release of soluble CD137 in patients with multiple sclerosis. Eur J Neurol 2002; 9: 49-54.
31. Yan J, Gong J, Liu P, Wang C, Chen G. Positive correlation between CD137 expression and complex stenosis morphology in patients with acute coronary syndromes. Clin Chim Acta 2011; 412: 993-998.
32. Yan J, Wang C, Chen R, Yang H. Clinical implications of elevated serum soluble CD137 levels in patients with acute coronary syndrome. Clinics 2013; 68: 193.
33. Organization WH. The Asia-Pacific Perspective: Redefining Obesity and its Treatment. World Health Organization: Geneva, Switzerland, 2000.
34. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972; 18: 499-502.
35. Matthews D, Hosker J, Rudenski A, Naylor B, Treacher D, Turner R. Homeostasis model assessment: Insulin resistance and b-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985; 28: 412-419. (Pubitemid 15018832)
36. Alberti KGMM Eckel RH, Grundy SM, Zimmet PZ, Cleeman JI, Donato KA et al. Harmonizing the metabolic syndrome: A joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation 2009; 120: 1640-1645.
37. Alberti K, Zimmet P, Shaw J. Metabolic syndrome-A new world-wide definition. A Consensus Statement from the International Diabetes Federation. Diabet Med 2006; 23: 469-480.
38. Shao Z, Schäffler A, Hamer O, Dickopf J, Goetz A, Landfried K et al. Admission levels of soluble CD137 are increased in patients with acute pancreatitis and are associated with subsequent complications. Exp Mol Pathol 2011; 92: 1-6.
39. Olsson I, Gatanaga T, Gullberg U, Lantz M, Granger G. Tumour necrosis factor (TNF) binding proteins (soluble TNF receptor forms) with possible roles in inflammation and malignancy. Eur Cytokine Netw 1993; 4: 169.
40. Jones SA, Horiuchi S, Topley N, Yamamoto N, Fuller GM. The soluble interleukin 6 receptor: Mechanisms of production and implications in disease. FASEB J 2001; 15: 43-58. (Pubitemid 32061655)
41. Heaney ML, Golde DW. Soluble receptors in human disease. J Leukoc Biol 1998; 64: 135-146. (Pubitemid 28354974)
42. Kim W, Kim J, Jung D, Kim H, Choi H-J, Cho HR et al. Induction of lethal graft-versus-host disease by anti-CD137 monoclonal antibody in mice prone to chronic graft-versus-host disease. Biol Blood Marrow Transplant 2009; 15: 306-314.
43. Cartier A, CôtéM, Bergeron J, Alméras N, Tremblay A, Lemieux I et al. Plasma soluble tumour necrosis factor-A receptor 2 is elevated in obesity: Specific contribution of visceral adiposity. Clin Endocrinol (Oxf) 2010; 72: 349-357.
44. Choi JW, Kim SK. Relationships of soluble APO-1 (Fas/CD95) concentrations, obesity, and serum lipid parameters in healthy adults. Ann Clin Lab Sci 2005; 35: 290-296. (Pubitemid 41176789)
45. Anderson DR, Poterucha JT, Mikuls TR, Duryee MJ, Garvin RP, Klassen LW et al. IL-6 and its receptors in coronary artery disease and acute myocardial infarction. Cytokine 2013; 62: 395-400.
46. Michel J, Schwarz H. Expression of soluble CD137 correlates with activationinduced cell death of lymphocytes. Cytokine 2000; 12: 742-746. (Pubitemid 30453509)
47. Nishimura S, Manabe I, Nagasaki M, Eto K, Yamashita H, Ohsugi M et al. CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity. Nat Med 2009; 15: 914-920.
48. Salih HR, Schmetzer HM, Burke C, Starling GC, Dunn R, Pelka-Fleischer R et al. Soluble CD137 (4-1BB) ligand is released following leukocyte activation and is found in sera of patients with hematological malignancies. J Immunol 2001; 167: 4059-4066. (Pubitemid 32910853)
49. Van Zee KJ, Kohno T, Fischer E, Rock CS, Moldawer LL, Lowry SF. Tumor necrosis factor soluble receptors circulate during experimental and clinical inflammation and can protect against excessive tumor necrosis factor alpha in vitro and in vivo. Proc Natl Acad Sci USA 1992; 89: 4845-4849.
50. Hirano T. Interleukin 6 and its receptor: Ten years later. Int Rev Immunol 1998; 16: 249-284. (Pubitemid 28102256)
51. Furtner M, Straub R, Krüger S, Schwarz H. Levels of soluble CD137 are enhanced in sera of leukemia and lymphoma patients and are strongly associated with chronic lymphocytic leukemia. Leukemia 2005; 19: 883-885. (Pubitemid 40663117)
52. Olofsson PS, Soderström LA, Wagsater D, Sheikine Y, Ocaya P, Lang F et al. CD137 is expressed in human atherosclerosis and promotes development of plaque inflammation in hypercholesterolemic mice. Circulation 2008; 117: 1292-1301. (Pubitemid 351365671)
53. He M, Li ETS, Harris S, Huff MW, Yau CY, Anderson GH. Canadian global village reality: Anthropometric surrogate cutoffs and metabolic abnormalities among Canadians of East Asian, South Asian, and European descent. Can Fam Physician 2010; 56: E174-e182.
54. Rakugi H, Ogihara T. The metabolic syndrome in the Asian population. Curr Sci Inc 2005; 7: 103-109. . (Pubitemid 40796728)