메뉴 건너뛰기




Volumn 7, Issue , 2014, Pages 1367-1373

Lapatinib for the treatment of breast cancer in the people's Republic of China

Author keywords

Breast cancer; HER2 positive; Lapatinib; Molecular targeting therapy

Indexed keywords

CAPECITABINE; EPIDERMAL GROWTH FACTOR RECEPTOR 2; LAPATINIB; PLACEBO; TRASTUZUMAB;

EID: 84905592700     PISSN: None     EISSN: 11786930     Source Type: Journal    
DOI: 10.2147/OTT.S60586     Document Type: Review
Times cited : (15)

References (59)
  • 2
    • 33846568336 scopus 로고    scopus 로고
    • American Society of Clinical Oncology/College of American Pathologists guideline recommendations for human epidermal growth factor receptor 2 testing in breast cancer
    • Wolff AC, Hammond ME, Schwartz JN, et al. American Society of Clinical Oncology/College of American Pathologists guideline recommendations for human epidermal growth factor receptor 2 testing in breast cancer. Arch Pathol Lab Med. 2007; 131(1): 18-43.
    • (2007) Arch Pathol Lab Med. , vol.131 , Issue.1 , pp. 18-43
    • Wolff, A.C.1    Hammond, M.E.2    Schwartz, J.N.3
  • 3
    • 66249091930 scopus 로고    scopus 로고
    • The HER-2 receptor and breast cancer: Ten years of targeted anti-HER-2 therapy and personalized medicine
    • Ross JS, Slodkowska EA, Symmans WF, et al. The HER-2 receptor and breast cancer: ten years of targeted anti-HER-2 therapy and personalized medicine. Oncologist. 2009; 14(4): 320-368.
    • (2009) Oncologist. , vol.14 , Issue.4 , pp. 320-368
    • Ross, J.S.1    Slodkowska, E.A.2    Symmans, W.F.3
  • 4
    • 37549056583 scopus 로고    scopus 로고
    • Adjuvant letrozole versus tamoxifen according to centrally-assessed ERBB2 status for postmenopausal women with endocrine-responsive early breast cancer: Supplementary results from the BIG 1-98 randomised trial
    • Rasmussen BB, Regan MM, Lykkesfeldt AE, et al. Adjuvant letrozole versus tamoxifen according to centrally-assessed ERBB2 status for postmenopausal women with endocrine-responsive early breast cancer: supplementary results from the BIG 1-98 randomised trial. Lancet Oncol. 2008; 9(1): 23-28.
    • (2008) Lancet Oncol. , vol.9 , Issue.1 , pp. 23-28
    • Rasmussen, B.B.1    Regan, M.M.2    Lykkesfeldt, A.E.3
  • 5
    • 1842614245 scopus 로고    scopus 로고
    • Safety of treatment of metastatic breast cancer with trastuzumab beyond disease progression
    • Tripathy D, Slamon DJ, Cobleigh M, et al. Safety of treatment of metastatic breast cancer with trastuzumab beyond disease progression. J Clin Oncol. 2004; 22(6): 1063-1070.
    • (2004) J Clin Oncol. , vol.22 , Issue.6 , pp. 1063-1070
    • Tripathy, D.1    Slamon, D.J.2    Cobleigh, M.3
  • 6
    • 33645792831 scopus 로고    scopus 로고
    • Outcome of patients with HER2-positive advanced breast cancer progressing during trastuzumab-based therapy
    • Montemurro F, Donadio M, Clavarezza M, et al. Outcome of patients with HER2-positive advanced breast cancer progressing during trastuzumab-based therapy. Oncologist. 2006; 11(4): 318-324.
    • (2006) Oncologist. , vol.11 , Issue.4 , pp. 318-324
    • Montemurro, F.1    Donadio, M.2    Clavarezza, M.3
  • 7
    • 34447293294 scopus 로고    scopus 로고
    • Lapatinib plus capecitabine in patients with HER2-positive advanced breast cancer
    • Cameron D. Lapatinib plus capecitabine in patients with HER2-positive advanced breast cancer. Clin Adv Hematol Oncol. 2007; 5(6): 456-458.
    • (2007) Clin Adv Hematol Oncol. , vol.5 , Issue.6 , pp. 456-458
    • Cameron, D.1
  • 8
    • 20244388653 scopus 로고    scopus 로고
    • Study of the biologic effects of lapatinib, a reversible inhibitor of ErbB1 and ErbB2 tyrosine kinases, on tumor growth and survival pathways in patients with advanced malignancies
    • Spector NL, Xia W, Burris H 3rd, et al. Study of the biologic effects of lapatinib, a reversible inhibitor of ErbB1 and ErbB2 tyrosine kinases, on tumor growth and survival pathways in patients with advanced malignancies. J Clin Oncol. 2005; 23(11): 2502-2512.
    • (2005) J Clin Oncol. , vol.23 , Issue.11 , pp. 2502-2512
    • Spector, N.L.1    Xia, W.2    Burris III, H.3
  • 9
    • 0037068741 scopus 로고    scopus 로고
    • Anti-tumor activity of GW572016: A dual tyrosine kinase inhibitor blocks EGF activation of EGFR/erbB2 and downstream Erk1/2 and AKT pathways
    • Xia W, Mullin RJ, Keith BR, et al. Anti-tumor activity of GW572016: a dual tyrosine kinase inhibitor blocks EGF activation of EGFR/erbB2 and downstream Erk1/2 and AKT pathways. Oncogene. 2002; 21(41): 6255-6263.
    • (2002) Oncogene. , vol.21 , Issue.41 , pp. 6255-6263
    • Xia, W.1    Mullin, R.J.2    Keith, B.R.3
  • 10
    • 32944461545 scopus 로고    scopus 로고
    • Activity of the dual kinase inhibitor lapatinib (GW572016) against HER-2-overexpressing and trastuzumab-treated breast cancer cells
    • Konecny GE, Pegram MD, Venkatesan N, et al. Activity of the dual kinase inhibitor lapatinib (GW572016) against HER-2-overexpressing and trastuzumab-treated breast cancer cells. Cancer Res. 2006; 66(3): 1630-1639.
    • (2006) Cancer Res. , vol.66 , Issue.3 , pp. 1630-1639
    • Konecny, G.E.1    Pegram, M.D.2    Venkatesan, N.3
  • 11
    • 84879098944 scopus 로고    scopus 로고
    • ATP-competitive inhibitors block protein kinase recruitment to the Hsp90-Cdc37 system
    • Polier S, Samant RS, Clarke PA, et al. ATP-competitive inhibitors block protein kinase recruitment to the Hsp90-Cdc37 system. Nat Chem Biol. 2013; 9(5): 307-312.
    • (2013) Nat Chem Biol. , vol.9 , Issue.5 , pp. 307-312
    • Polier, S.1    Samant, R.S.2    Clarke, P.A.3
  • 12
    • 85027940454 scopus 로고    scopus 로고
    • Phosphoproteomic mass spectrometry profiling links Src family kinases to escape from HER2 tyrosine kinase inhibition
    • Rexer BN, Ham AJ, Rinehart C, et al. Phosphoproteomic mass spectrometry profiling links Src family kinases to escape from HER2 tyrosine kinase inhibition. Oncogene. 2011; 30(40): 4163-4174.
    • (2011) Oncogene. , vol.30 , Issue.40 , pp. 4163-4174
    • Rexer, B.N.1    Ham, A.J.2    Rinehart, C.3
  • 13
    • 84892173065 scopus 로고    scopus 로고
    • Phosphoproteomic analysis identifies activated MET-axis PI3K/AKT and MAPK/ERK in lapatinib-resistant cancer cell line
    • Lee YY, Kim HP, Kang MJ, et al. Phosphoproteomic analysis identifies activated MET-axis PI3K/AKT and MAPK/ERK in lapatinib-resistant cancer cell line. Exp Mol Med. 2013; 45: e64.
    • (2013) Exp Mol Med. , vol.45
    • Lee, Y.Y.1    Kim, H.P.2    Kang, M.J.3
  • 14
    • 0035553174 scopus 로고    scopus 로고
    • The effects of the novel, reversible epidermal growth factor receptor/ErbB-2 tyrosine kinase inhibitor, GW2016, on the growth of human normal and tumor-derived cell lines in vitro and in vivo
    • Rusnak DW, Lackey K, Affleck K, et al. The effects of the novel, reversible epidermal growth factor receptor/ErbB-2 tyrosine kinase inhibitor, GW2016, on the growth of human normal and tumor-derived cell lines in vitro and in vivo. Mol Cancer Ther. 2001; 1(2): 85-94.
    • (2001) Mol Cancer Ther. , vol.1 , Issue.2 , pp. 85-94
    • Rusnak, D.W.1    Lackey, K.2    Affleck, K.3
  • 15
    • 33144481305 scopus 로고    scopus 로고
    • Lapatinib: A novel dual tyrosine kinase inhibitor with activity in solid tumors
    • Nelson MH, Dolder CR. Lapatinib: a novel dual tyrosine kinase inhibitor with activity in solid tumors. Ann Pharmacother. 2006; 40(2): 261-269.
    • (2006) Ann Pharmacother. , vol.40 , Issue.2 , pp. 261-269
    • Nelson, M.H.1    Dolder, C.R.2
  • 16
    • 84905566147 scopus 로고    scopus 로고
    • Lapatinib Plus Paclitaxel Versus Paclitaxel Alone in the Second-Line Treatment of HER2-Amplified Advanced Gastric Cancer in Asian Populations: TyTAN-A Randomized, Phase III Study
    • Satoh T, Xu RH, Chung HC, et al. Lapatinib Plus Paclitaxel Versus Paclitaxel Alone in the Second-Line Treatment of HER2-Amplified Advanced Gastric Cancer in Asian Populations: TyTAN-A Randomized, Phase III Study. J Clin Oncol. 2014; 32(19): 2039-2049.
    • (2014) J Clin Oncol. , vol.32 , Issue.19 , pp. 2039-2049
    • Satoh, T.1    Xu, R.H.2    Chung, H.C.3
  • 17
    • 84894226146 scopus 로고    scopus 로고
    • Targeted treatment of head and neck squamous-cell carcinoma: Potential of lapatinib
    • Gandhi MD, Agulnik M. Targeted treatment of head and neck squamous-cell carcinoma: potential of lapatinib. Onco Targets Ther. 2014; 7: 245-251.
    • (2014) Onco Targets Ther. , vol.7 , pp. 245-251
    • Gandhi, M.D.1    Agulnik, M.2
  • 18
    • 41549138328 scopus 로고    scopus 로고
    • The role of efflux and uptake transporters in [N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine (GW572016, lapatinib) disposition and drug interactions
    • Polli JW, Humphreys JE, Harmon KA, et al. The role of efflux and uptake transporters in [N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine (GW572016, lapatinib) disposition and drug interactions. Drug Metab Dispos. 2008; 36(4): 695-701.
    • (2008) Drug Metab Dispos. , vol.36 , Issue.4 , pp. 695-701
    • Polli, J.W.1    Humphreys, J.E.2    Harmon, K.A.3
  • 19
    • 59649115878 scopus 로고    scopus 로고
    • An unexpected synergist role of P-glycoprotein and breast cancer resistance protein on the central nervous system penetration of the tyrosine kinase inhibitor lapatinib (N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine; GW572016)
    • Polli JW, Olson KL, Chism JP, et al. An unexpected synergist role of P-glycoprotein and breast cancer resistance protein on the central nervous system penetration of the tyrosine kinase inhibitor lapatinib (N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine; GW572016). Drug Metab Dispos. 2009; 37(2): 439-442.
    • (2009) Drug Metab Dispos. , vol.37 , Issue.2 , pp. 439-442
    • Polli, J.W.1    Olson, K.L.2    Chism, J.P.3
  • 20
    • 34250221510 scopus 로고    scopus 로고
    • Increased permeability of the blood-brain barrier to chemotherapy in metastatic brain tumors: Establishing a treatment paradigm
    • Gerstner ER, Fine RL. Increased permeability of the blood-brain barrier to chemotherapy in metastatic brain tumors: establishing a treatment paradigm. J Clin Oncol. 2007; 25(16): 2306-2312.
    • (2007) J Clin Oncol. , vol.25 , Issue.16 , pp. 2306-2312
    • Gerstner, E.R.1    Fine, R.L.2
  • 21
    • 79955475531 scopus 로고    scopus 로고
    • Brain metastases as preventive and therapeutic targets
    • Steeg PS, Camphausen KA, Smith QR. Brain metastases as preventive and therapeutic targets. Nat Rev Cancer. 2011; 11(5): 352-363.
    • (2011) Nat Rev Cancer. , vol.11 , Issue.5 , pp. 352-363
    • Steeg, P.S.1    Camphausen, K.A.2    Smith, Q.R.3
  • 22
    • 84860003304 scopus 로고    scopus 로고
    • Lapatinib distribution in HER2 overexpressing experimental brain metastases of breast cancer
    • Taskar KS, Rudraraju V, Mittapalli RK, et al. Lapatinib distribution in HER2 overexpressing experimental brain metastases of breast cancer. Pharm Res. 2012; 29(3): 770-781.
    • (2012) Pharm Res. , vol.29 , Issue.3 , pp. 770-781
    • Taskar, K.S.1    Rudraraju, V.2    Mittapalli, R.K.3
  • 23
    • 49449112267 scopus 로고    scopus 로고
    • Effect of lapatinib on the outgrowth of metastatic breast cancer cells to the brain
    • Gril B, Palmieri D, Bronder JL, et al. Effect of lapatinib on the outgrowth of metastatic breast cancer cells to the brain. J Natl Cancer Inst. 2008; 100(15): 1092-1103.
    • (2008) J Natl Cancer Inst. , vol.100 , Issue.15 , pp. 1092-1103
    • Gril, B.1    Palmieri, D.2    Bronder, J.L.3
  • 24
    • 84905587305 scopus 로고    scopus 로고
    • Brain metastases in HER2-positive metastatic breast cancer patients who received chemotherapy with or without trastuzumab
    • Epub January 3
    • Kaplan MA, Ertugrul H, Firat U, et al. Brain metastases in HER2-positive metastatic breast cancer patients who received chemotherapy with or without trastuzumab. Breast Cancer. Epub January 3, 2014.
    • (2014) Breast Cancer.
    • Kaplan, M.A.1    Ertugrul, H.2    Firat, U.3
  • 25
    • 84890439476 scopus 로고    scopus 로고
    • A phase I study of lapatinib with whole brain radiotherapy in patients with Human Epidermal Growth Factor Receptor 2 (HER2)-positive breast cancer brain metastases
    • Lin NU, Freedman RA, Ramakrishna N, et al. A phase I study of lapatinib with whole brain radiotherapy in patients with Human Epidermal Growth Factor Receptor 2 (HER2)-positive breast cancer brain metastases. Breast Cancer Res Treat. 2013; 142(2): 405-414.
    • (2013) Breast Cancer Res Treat. , vol.142 , Issue.2 , pp. 405-414
    • Lin, N.U.1    Freedman, R.A.2    Ramakrishna, N.3
  • 26
    • 4644289313 scopus 로고    scopus 로고
    • A unique structure for epidermal growth factor receptor bound to GW572016 (Lapatinib): Relationships among protein conformation, inhibitor off-rate, and receptor activity in tumor cells
    • Wood ER, Truesdale AT, McDonald OB, et al. A unique structure for epidermal growth factor receptor bound to GW572016 (Lapatinib): relationships among protein conformation, inhibitor off-rate, and receptor activity in tumor cells. Cancer Res. 2004; 64(18): 6652-6659.
    • (2004) Cancer Res. , vol.64 , Issue.18 , pp. 6652-6659
    • Wood, E.R.1    Truesdale, A.T.2    McDonald, O.B.3
  • 27
    • 0035476866 scopus 로고    scopus 로고
    • The characterization of novel, dual ErbB-2/EGFR, tyrosine kinase inhibitors: Potential therapy for cancer
    • Rusnak DW, Affleck K, Cockerill SG, et al. The characterization of novel, dual ErbB-2/EGFR, tyrosine kinase inhibitors: potential therapy for cancer. Cancer Res. 2001; 61(19): 7196-7203.
    • (2001) Cancer Res. , vol.61 , Issue.19 , pp. 7196-7203
    • Rusnak, D.W.1    Affleck, K.2    Cockerill, S.G.3
  • 28
    • 79551610758 scopus 로고    scopus 로고
    • Cardiotoxicity of kinase inhibitors: The prediction and translation of preclinical models to clinical outcomes
    • Force T, Kolaja KL. Cardiotoxicity of kinase inhibitors: the prediction and translation of preclinical models to clinical outcomes. Nat Rev Drug Discov. 2011; 10(2): 111-126.
    • (2011) Nat Rev Drug Discov. , vol.10 , Issue.2 , pp. 111-126
    • Force, T.1    Kolaja, K.L.2
  • 29
    • 84863726300 scopus 로고    scopus 로고
    • Comparison of preclinical cardiotoxic effects of different ErbB2 inhibitors
    • Fedele C, Riccio G, Coppola C, et al. Comparison of preclinical cardiotoxic effects of different ErbB2 inhibitors. Breast Cancer Res Treat. 2012; 133(2): 511-521.
    • (2012) Breast Cancer Res Treat. , vol.133 , Issue.2 , pp. 511-521
    • Fedele, C.1    Riccio, G.2    Coppola, C.3
  • 30
    • 85067712076 scopus 로고    scopus 로고
    • FDA [webpage on the Internet]: Available from. Accessed on July 16, 2014
    • FDA. Tykerb (Lapatinib) FDA NDA Pharmacology Review [webpage on the Internet]. 2008: Available from: http:// www. accessdata. fda. gov/drugsatfda_docs/nda/2007/022059s000TOC. cfm. Accessed on July 16, 2014.
    • (2008) Tykerb (Lapatinib) FDA NDA Pharmacology Review
  • 31
    • 84880286988 scopus 로고    scopus 로고
    • Evaluation of cardiac safety of lapatinib therapy for ErbB2-positive metastatic breast cancer: A single center experience
    • Dogan E, Yorgun H, Petekkaya I, et al. Evaluation of cardiac safety of lapatinib therapy for ErbB2-positive metastatic breast cancer: a single center experience. Med Oncol. 2012; 29(5): 3232-3239.
    • (2012) Med Oncol. , vol.29 , Issue.5 , pp. 3232-3239
    • Dogan, E.1    Yorgun, H.2    Petekkaya, I.3
  • 32
    • 34547537264 scopus 로고    scopus 로고
    • Activation of AMP-activated protein kinase by human EGF receptor 2/EGF receptor tyrosine kinase inhibitor protects cardiac cells
    • Spector NL, Yarden Y, Smith B, et al. Activation of AMP-activated protein kinase by human EGF receptor 2/EGF receptor tyrosine kinase inhibitor protects cardiac cells. Proc Natl Acad Sci U S A. 2007; 104(25): 10607-10612.
    • (2007) Proc Natl Acad Sci U S A. , vol.104 , Issue.25 , pp. 10607-10612
    • Spector, N.L.1    Yarden, Y.2    Smith, B.3
  • 33
    • 53949100887 scopus 로고    scopus 로고
    • Research Triangle Park, NC: GlaxoSmithKline
    • Tykerb® [package insert]. Research Triangle Park, NC: GlaxoSmithKline; 2007.
    • (2007) Tykerb® [package insert]
  • 34
    • 11244257032 scopus 로고    scopus 로고
    • The dual ErbB1/ErbB2 inhibitor, lapatinib (GW572016), cooperates with tamoxifen to inhibit both cell proliferation-and estrogen-dependent gene expression in antiestrogen-resistant breast cancer
    • Chu I, Blackwell K, Chen S, Slingerland J. The dual ErbB1/ErbB2 inhibitor, lapatinib (GW572016), cooperates with tamoxifen to inhibit both cell proliferation-and estrogen-dependent gene expression in antiestrogen-resistant breast cancer. Cancer Res. 2005; 65(1): 18-25.
    • (2005) Cancer Res. , vol.65 , Issue.1 , pp. 18-25
    • Chu, I.1    Blackwell, K.2    Chen, S.3    Slingerland, J.4
  • 35
    • 60149109196 scopus 로고    scopus 로고
    • Lapatinib, a HER2 tyrosine kinase inhibitor, induces stabilization and accumulation of HER2 and potentiates trastuzumab-dependent cell cytotoxicity
    • Scaltriti M, Verma C, Guzman M, et al. Lapatinib, a HER2 tyrosine kinase inhibitor, induces stabilization and accumulation of HER2 and potentiates trastuzumab-dependent cell cytotoxicity. Oncogene. 2009; 28(6): 803-814.
    • (2009) Oncogene. , vol.28 , Issue.6 , pp. 803-814
    • Scaltriti, M.1    Verma, C.2    Guzman, M.3
  • 36
    • 84922686529 scopus 로고    scopus 로고
    • Compensatory activation of estrogen receptor alpha signaling in acquired resistance to lapatinib of HER-2 overexpressing/ER alpha-positive breast cancer cells
    • Chinese
    • Li Z, Chang T, Shi l. [Compensatory activation of estrogen receptor alpha signaling in acquired resistance to lapatinib of HER-2 overexpressing/ER alpha-positive breast cancer cells]. Academic Journal of Second Military Medical University. 2013; 34: 616-622. Chinese.
    • (2013) Academic Journal of Second Military Medical University. , vol.34 , pp. 616-622
    • Li, Z.1    Chang, T.2    Shi, L.3
  • 37
    • 85067722349 scopus 로고    scopus 로고
    • Wnt/β-catenin[Effect of Wnt/β-catenin pathway on lapatinib resistance in breast cancer]
    • Chinese
    • Zhao L. Wnt/β-catenin[Effect of Wnt/β-catenin pathway on lapatinib resistance in breast cancer]. Jiangsu Medical Journal. 2013; 39: 2242-2249. Chinese.
    • (2013) Jiangsu Medical Journal. , vol.39 , pp. 2242-2249
    • Zhao, L.1
  • 38
    • 85067722837 scopus 로고    scopus 로고
    • Mechanism of Her-2 overexpressed breast cancer cell apoptosis induced by lapatinib
    • Chinese
    • Zhang H, Mao X, Lin Z, et al. [Mechanism of Her-2 overexpressed breast cancer cell apoptosis induced by lapatinib]. Shandong Medicine Journal. 2011; 51: 1-3. Chinese.
    • (2011) Shandong Medicine Journal. , vol.51 , pp. 1-3
    • Zhang, H.1    Mao, X.2    Lin, Z.3
  • 39
    • 77955479419 scopus 로고    scopus 로고
    • Combined detection of Her2/neu gene amplification and protein overexpression in effusions from patients with breast and ovarian cancer
    • Schluter B, Gerhards R, Strumberg D, Voigtmann R. Combined detection of Her2/neu gene amplification and protein overexpression in effusions from patients with breast and ovarian cancer. J Cancer Res Clin Oncol. 2010; 136(9): 1389-1400.
    • (2010) J Cancer Res Clin Oncol. , vol.136 , Issue.9 , pp. 1389-1400
    • Schluter, B.1    Gerhards, R.2    Strumberg, D.3    Voigtmann, R.4
  • 40
    • 33845886440 scopus 로고    scopus 로고
    • Lapatinib plus capecitabine for HER2-positive advanced breast cancer
    • Geyer CE, Forster J, Lindquist D, et al. Lapatinib plus capecitabine for HER2-positive advanced breast cancer. N Engl J Med. 2006; 355(26): 2733-2743.
    • (2006) N Engl J Med. , vol.355 , Issue.26 , pp. 2733-2743
    • Geyer, C.E.1    Forster, J.2    Lindquist, D.3
  • 41
    • 84871712684 scopus 로고    scopus 로고
    • Adjuvant lapatinib for women with early-stage HER2-positive breast cancer: A randomised, controlled, phase 3 trial
    • Goss PE, Smith IE, O'Shaughnessy J, et al. Adjuvant lapatinib for women with early-stage HER2-positive breast cancer: a randomised, controlled, phase 3 trial. Lancet Oncol. 2013; 14(1): 88-96.
    • (2013) Lancet Oncol. , vol.14 , Issue.1 , pp. 88-96
    • Goss, P.E.1    Smith, I.E.2    O'Shaughnessy, J.3
  • 42
    • 78650712593 scopus 로고    scopus 로고
    • Treatment options for locally advanced breast cancer-experience in an Asian tertiary hospital
    • Chong HY, Taib NA, Rampal S, et al. Treatment options for locally advanced breast cancer-experience in an Asian tertiary hospital. Asian Pac J Cancer Prev. 2010; 11(4): 913-917.
    • (2010) Asian Pac J Cancer Prev. , vol.11 , Issue.4 , pp. 913-917
    • Chong, H.Y.1    Taib, N.A.2    Rampal, S.3
  • 43
    • 34250644339 scopus 로고    scopus 로고
    • Novel SLC22A16 polymorphisms and influence on doxorubicin pharmacokinetics in Asian breast cancer patients
    • Lal S, Wong ZW, Jada SR, et al. Novel SLC22A16 polymorphisms and influence on doxorubicin pharmacokinetics in Asian breast cancer patients. Pharmacogenomics. 2007; 8(6): 567-575.
    • (2007) Pharmacogenomics. , vol.8 , Issue.6 , pp. 567-575
    • Lal, S.1    Wong, Z.W.2    Jada, S.R.3
  • 44
    • 85067724192 scopus 로고    scopus 로고
    • Therapeutic effect of lapatinib on HER-2 positive advanced breast cancer
    • Chinese
    • Han C, You J, Jing F, et al. [Therapeutic effect of lapatinib on HER-2 positive advanced breast cancer]. J Chinese PLA Postgrad Med Sch. 2013; 4: 325-326. Chinese.
    • (2013) J Chinese PLA Postgrad Med Sch. , vol.4 , pp. 325-326
    • Han, C.1    You, J.2    Jing, F.3
  • 45
    • 79958157530 scopus 로고    scopus 로고
    • Lapatinib plus capecitabine in treating HER2-positive advanced breast cancer: Efficacy, safety, and biomarker results from Chinese patients
    • Xu BH, Jiang ZF, Chua D, et al. Lapatinib plus capecitabine in treating HER2-positive advanced breast cancer: efficacy, safety, and biomarker results from Chinese patients. Chin J Cancer. 2011; 30(5): 327-335.
    • (2011) Chin J Cancer. , vol.30 , Issue.5 , pp. 327-335
    • Xu, B.H.1    Jiang, Z.F.2    Chua, D.3
  • 46
    • 56549113680 scopus 로고    scopus 로고
    • A phase III randomized comparison of lapatinib plus capecitabine versus capecitabine alone in women with advanced breast cancer that has progressed on trastuzumab: Updated efficacy and biomarker analyses
    • Cameron D, Casey M, Press M, et al. A phase III randomized comparison of lapatinib plus capecitabine versus capecitabine alone in women with advanced breast cancer that has progressed on trastuzumab: updated efficacy and biomarker analyses. Breast Cancer Res Treat. 2008; 112(3): 533-543.
    • (2008) Breast Cancer Res Treat. , vol.112 , Issue.3 , pp. 533-543
    • Cameron, D.1    Casey, M.2    Press, M.3
  • 47
    • 22044445517 scopus 로고    scopus 로고
    • Erlotinib in previously treated non-small-cell lung cancer
    • Shepherd FA, Rodrigues Pereira J, Ciuleanu T, et al. Erlotinib in previously treated non-small-cell lung cancer. N Engl J Med. 2005; 353(2): 123-132.
    • (2005) N Engl J Med. , vol.353 , Issue.2 , pp. 123-132
    • Shepherd, F.A.1    Rodrigues Pereira, J.2    Ciuleanu, T.3
  • 48
    • 69949162760 scopus 로고    scopus 로고
    • Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma
    • Mok TS, Wu YL, Thongprasert S, et al. Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma. N Engl J Med. 2009; 361(10): 947-957.
    • (2009) N Engl J Med. , vol.361 , Issue.10 , pp. 947-957
    • Mok, T.S.1    Wu, Y.L.2    Thongprasert, S.3
  • 49
    • 85067737953 scopus 로고    scopus 로고
    • Therapeutic criteria and strategy in advanced breast cancer
    • Chinese
    • Xu B. [Therapeutic criteria and strategy in advanced breast cancer]. China Medical Herald. 2010; 7: 6-8. Chinese.
    • (2010) China Medical Herald. , vol.7 , pp. 6-8
    • Xu, B.1
  • 50
    • 79955060337 scopus 로고    scopus 로고
    • National guidline for management of human epidermal growth factor receptor 2 positive breast cancer
    • Chinese
    • Jiang Z, Shao Z, Xu B. [National guidline for management of human epidermal growth factor receptor 2 positive breast cancer]. Chin J Oncol. 2010; 32: 158-160. Chinese.
    • (2010) Chin J Oncol. , vol.32 , pp. 158-160
    • Jiang, Z.1    Shao, Z.2    Xu, B.3
  • 51
    • 70349912269 scopus 로고    scopus 로고
    • Lapatinib plus capecitabine versus capecitabine alone for HER2+ (ErbB2+) metastatic breast cancer: Quality-of-life assessment
    • Zhou X, Cella D, Cameron D, et al. Lapatinib plus capecitabine versus capecitabine alone for HER2+ (ErbB2+) metastatic breast cancer: quality-of-life assessment. Breast Cancer Res Treat. 2009; 117(3): 577-589.
    • (2009) Breast Cancer Res Treat. , vol.117 , Issue.3 , pp. 577-589
    • Zhou, X.1    Cella, D.2    Cameron, D.3
  • 52
    • 73349089659 scopus 로고    scopus 로고
    • Presenting features of breast cancer differ by molecular subtype
    • Wiechmann L, Sampson M, Stempel M, et al. Presenting features of breast cancer differ by molecular subtype. Ann Surg Oncol. 2009; 16(10): 2705-2710.
    • (2009) Ann Surg Oncol. , vol.16 , Issue.10 , pp. 2705-2710
    • Wiechmann, L.1    Sampson, M.2    Stempel, M.3
  • 53
    • 1242273590 scopus 로고    scopus 로고
    • Truncated ErbB2 receptor (p95ErbB2) is regulated by heregulin through heterodimer formation with ErbB3 yet remains sensitive to the dual EGFR/ErbB2 kinase inhibitor GW572016
    • Xia W, Liu LH, Ho P, Spector NL. Truncated ErbB2 receptor (p95ErbB2) is regulated by heregulin through heterodimer formation with ErbB3 yet remains sensitive to the dual EGFR/ErbB2 kinase inhibitor GW572016. Oncogene. 2004; 23(3): 646-653.
    • (2004) Oncogene. , vol.23 , Issue.3 , pp. 646-653
    • Xia, W.1    Liu, L.H.2    Ho, P.3    Spector, N.L.4
  • 54
    • 33847369020 scopus 로고    scopus 로고
    • Lapatinib induces apoptosis in trastuzumab-resistant breast cancer cells: Effects on insulin-like growth factor I signaling
    • Nahta R, Yuan LX, Du Y, Esteva FJ. Lapatinib induces apoptosis in trastuzumab-resistant breast cancer cells: effects on insulin-like growth factor I signaling. Mol Cancer Ther. 2007; 6(2): 667-674.
    • (2007) Mol Cancer Ther. , vol.6 , Issue.2 , pp. 667-674
    • Nahta, R.1    Yuan, L.X.2    Du, Y.3    Esteva, F.J.4
  • 55
    • 33847013396 scopus 로고    scopus 로고
    • Lapatinib antitumor activity is not dependent upon phosphatase and tensin homologue deleted on chromosome 10 in ErbB2-overexpressing breast cancers
    • Xia W, Husain I, Liu L, et al. Lapatinib antitumor activity is not dependent upon phosphatase and tensin homologue deleted on chromosome 10 in ErbB2-overexpressing breast cancers. Cancer Res. 2007; 67(3): 1170-1175.
    • (2007) Cancer Res. , vol.67 , Issue.3 , pp. 1170-1175
    • Xia, W.1    Husain, I.2    Liu, L.3
  • 56
    • 33646712747 scopus 로고    scopus 로고
    • Mechanisms of disease: Understanding resistance to HER2-targeted therapy in human breast cancer
    • Nahta R, Yu D, Hung MC, Hortobagyi GN, Esteva FJ. Mechanisms of disease: understanding resistance to HER2-targeted therapy in human breast cancer. Nat Clin Pract Oncol. 2006; 3(5): 269-280.
    • (2006) Nat Clin Pract Oncol. , vol.3 , Issue.5 , pp. 269-280
    • Nahta, R.1    Yu, D.2    Hung, M.C.3    Hortobagyi, G.N.4    Esteva, F.J.5
  • 57
    • 85067729674 scopus 로고    scopus 로고
    • Clinical evaluation of trastuzumab in the treatment of lapatinib-resistant breast cancer
    • Chinese
    • Ma F, Li Q, Li H, et al. [Clinical evaluation of trastuzumab in the treatment of lapatinib-resistant breast cancer] Zhong Hua Yi Xue Zhong Liu Xue Hui Lun Wen Hui Bian. 2011; 7: 6-8. Chinese.
    • (2011) Zhong Hua Yi Xue Zhong Liu Xue Hui Lun Wen Hui Bian. , vol.7 , pp. 6-8
    • Ma, F.1    Li, Q.2    Li, H.3
  • 58
    • 33751205030 scopus 로고    scopus 로고
    • Lapatinib: Current status and future directions in breast cancer
    • Moy B, Goss PE. Lapatinib: current status and future directions in breast cancer. Oncologist. 2006; 11(10): 1047-1057.
    • (2006) Oncologist. , vol.11 , Issue.10 , pp. 1047-1057
    • Moy, B.1    Goss, P.E.2
  • 59
    • 63149110733 scopus 로고    scopus 로고
    • Multicenter phase II study of lapatinib in patients with brain metastases from HER2-positive breast cancer
    • Lin NU, Dieras V, Paul D, et al. Multicenter phase II study of lapatinib in patients with brain metastases from HER2-positive breast cancer. Clin Cancer Res. 2009; 15(4): 1452-1459.
    • (2009) Clin Cancer Res. , vol.15 , Issue.4 , pp. 1452-1459
    • Lin, N.U.1    Dieras, V.2    Paul, D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.