Lithium treatment reduces brain injury induced by focal ischemia with partial reperfusion and the protective mechanisms dispute the importance of Akt activity

Aging and Disease

Volumn 3, Issue 3, 2012, Pages 226-233

  Takahashi, Tetsuya ^a   Steinberg, Gary K ^a   Zhao, Heng ^a  

^a STANFORD UNIVERSITY   (United States)

Author keywords

Akt; Cerebral focal ischemia; GSK3 ; Lithium; catenin

Indexed keywords

RATTUS;

EID: 84905590324     PISSN: None     EISSN: 21525250     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Schou M, Juel-Nielsen N, Stromgren E and Voldby H (1954). The treatment of manic psychoses by the administration of lithium salts. J Neurol Neurosurg Psychiatry, 17: 250-260
2. Altamura AC, Lietti L, Dobrea C, Benatti B, Arici C and Dell'Osso B (2011). Mood stabilizers for patients with bipolar disorder: the state of the art. Expert Rev Neurother, 11: 85-99
3. Manji HK, Moore GJ and Chen G (2000). Lithium up-regulates the cytoprotective protein Bcl-2 in the CNS in vivo: a role for neurotrophic and neuroprotective effects in manic depressive illness. J Clin Psychiatry, 61 Suppl 9: 82-96
4. Wada A, Yokoo H, Yanagita T and Kobayashi H (2005). Lithium: potential therapeutics against acute brain injuries and chronic neurodegenerative diseases. J Pharmacol Sci, 99: 307-321
5. Bian Q, Shi T, Chuang DM and Qian Y (2007). Lithium reduces ischemia-induced hippocampal CA1 damage and behavioral deficits in gerbils. Brain Res, 1184: 270-276
6. Li H, Li Q, Du X, Sun Y, Wang X, Kroemer G, Blomgren K and Zhu C (2011). Lithium-mediated long-term neuroprotection in neonatal rat hypoxia-ischemia is associated with antiinflammatory effects and enhanced proliferation and survival of neural stem/progenitor cells. J Cereb Blood Flow Metab
7. Nonaka S and Chuang DM (1998). Neuroprotective effects of chronic lithium on focal cerebral ischemia in rats. Neuroreport, 9: 2081-2084
8. Sasaki T, Han F, Shioda N, Moriguchi S, Kasahara J, Ishiguro K and Fukunaga K (2006). Lithium-induced activation of Akt and CaM kinase II contributes to its neuroprotective action in a rat microsphere embolism model. Brain Res, 1108: 98-106
9. Xu J, Culman J, Blume A, Brecht S and Gohlke P (2003). Chronic treatment with a low dose of lithium protects the brain against ischemic injury by reducing apoptotic death. Stroke, 34: 1287-1292
10. Yan XB, Wang SS, Hou HL, Ji R and Zhou JN (2007). Lithium improves the behavioral disorder in rats subjected to transient global cerebral ischemia. Behav Brain Res, 177: 282-289
11. Ren M, Senatorov VV, Chen RW and Chuang DM (2003). Postinsult treatment with lithium reduces brain damage and facilitates neurological recovery in a rat ischemia/reperfusion model. Proc Natl Acad Sci U S A, 100: 6210-6215
12. Neumann-Haefelin T, du Mesnil de Rochemont R, Fiebach JB, Gass A, Nolte C, Kucinski T, Rother J, Siebler M, Singer OC, Szabo K, Villringer A and Schellinger PD (2004). Effect of incomplete (spontaneous and postthrombolytic) recanalization after middle cerebral artery occlusion: a magnetic resonance imaging study. Stroke, 35: 109-114
13. Alexandrov AV, Burgin WS, Demchuk AM, El-Mitwalli A and Grotta JC (2001). Speed of intracranial clot lysis with intravenous tissue plasminogen activator therapy: sonographic classification and short-term improvement. Circulation, 103: 2897-2902
14. Zhao H, Sapolsky RM and Steinberg GK (2006). Phosphoinositide-3-kinase/akt survival signal pathways are implicated in neuronal survival after stroke. Mol Neurobiol, 34: 249-270
15. Jope RS (2003). Lithium and GSK-3: one inhibitor, two inhibitory actions, multiple outcomes. Trends Pharmacol Sci, 24: 441-443
16. Gao X, Zhang H, Takahashi T, Hsieh J, Liao J, Steinberg GK and Zhao H (2008). The Akt signaling pathway contributes to postconditioning's protection against stroke; the protection is associated with the MAPK and PKC pathways. J Neurochem, 105: 943-955
17. Zhao H, Shimohata T, Wang JQ, Sun G, Schaal DW, Sapolsky RM and Steinberg GK (2005). Akt contributes to neuroprotection by hypothermia against cerebral ischemia in rats. J Neurosci, 25: 9794-9806
18. Gao X, Zhang H, Steinberg G and Zhao H (2010). The Akt pathway is involved in rapid ischemic tolerance in focal ischemia in Rats. Transl Stroke Res, 1: 202-209
19. Miyawaki T, Ofengeim D, Noh KM, Latuszek-Barrantes A, Hemmings BA, Follenzi A and Zukin RS (2009). The endogenous inhibitor of Akt, CTMP, is critical to ischemia-induced neuronal death. Nat Neurosci, 12: 618-626
20. Gao X, Ren C and Zhao H (2008). Protective effects of ischemic postconditioning compared with gradual reperfusion or preconditioning. J Neurosci Res, 86: 2505-2511
21. Ren C, Gao X, Niu G, Yan Z, Chen X and Zhao H (2008). Delayed postconditioning protects against focal ischemic brain injury in rats. PLoS One, 3: e3851
22. Zhao H, Sapolsky RM and Steinberg GK (2006). Interrupting reperfusion as a stroke therapy: ischemic postconditioning reduces infarct size after focal ischemia in rats. J Cereb Blood Flow Metab, 26: 1114-1121
23. Shimohata T, Zhao H, Sung JH, Sun G, Mochly-Rosen D and Steinberg GK (2007). Suppression of deltaPKC activation after focal cerebral ischemia contributes to the protective effect of hypothermia. J Cereb Blood Flow Metab, 27: 1463-1475
24. Zhao H, Yenari MA, Cheng D, Barreto-Chang OL, Sapolsky RM and Steinberg GK (2004). Bcl-2 transfection via herpes simplex virus blocks apoptosis-inducing factor translocation after focal ischemia in the rat. J Cereb Blood Flow Metab, 24: 681-692
25. Gao X, Zhang H, Steinberg G and Zhao H (2010). The Akt Pathway Is Involved in Rapid Ischemic Tolerance in Focal Ischemia in Rats. Translational Stroke Research, 1: 202-209
26. Gould TD, Chen G and Manji HK (2004). In vivo evidence in the brain for lithium inhibition of glycogen synthase kinase-3. Neuropsychopharmacology, 29: 32-38
27. Xu XH, Hua YN, Zhang HL, Wu JC, Miao YZ, Han R, Gu ZL and Qin ZH (2007). Greater stress protein expression enhanced by combined prostaglandin A1 and lithium in a rat model of focal ischemia. Acta Pharmacol Sin, 28: 1097-1104
28. Han R, Gao B, Sheng R, Zhang LS, Zhang HL, Gu ZL and Qin ZH (2008). Synergistic effects of prostaglandin E1 and lithium in a rat model of cerebral ischemia. Acta Pharmacol Sin, 29: 1141-1149