Synergistic effects of prostaglandin E1 and lithium in a rat model of cerebral ischemia

Acta Pharmacologica Sinica

Volumn 29, Issue 10, 2008, Pages 1141-1149

  Han, Rong ^a   Gao, Bo ^a   Sheng, Rui ^a   Zhang, Li Sha ^a   Zhang, Hui Lin ^a   Gu, Zhen Lun ^a   Qin, Zheng Hong ^a  

^a MEDICAL COLLEGE OF SOOCHOW UNIVERSITY   (China)

Author keywords

Cerebral ischemia; Heat shock proteins; Lithium; Neuroprotection; Prostaglandin El

Indexed keywords

4',6 DIAMIDINO 2 PHENYLINDOLE; HEAT SHOCK PROTEIN; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 70 ANTIBODY; HEME OXYGENASE 1; LITHIUM; PROSTAGLANDIN E1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY TEMPERATURE; BRAIN BLOOD FLOW; BRAIN EDEMA; BRAIN INFARCTION; BRAIN ISCHEMIA; CELL PROTECTION; CELL SURVIVAL; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DIAGNOSTIC VALUE; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENTIATION; IMMUNOBLOTTING; LOCOMOTION; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROPROTECTION; NONHUMAN; RAT; SINGLE DRUG DOSE; STROKE;

ALPROSTADIL; ANIMALS; BODY TEMPERATURE; BRAIN ISCHEMIA; CEREBROVASCULAR CIRCULATION; DRUG SYNERGISM; HEAT-SHOCK PROTEINS; HEME OXYGENASE-1; INFARCTION, MIDDLE CEREBRAL ARTERY; LITHIUM CHLORIDE; MALE; MIDDLE CEREBRAL ARTERY; RATS; RATS, SPRAGUE-DAWLEY; VASODILATOR AGENTS;

EID: 53749096213     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1111/j.1745-7254.2008.00873.x     Document Type: Article

References (29)

1. Onteniente B, Rasika S, Benchoua A, Guegan C. Molecular pathways in cerebral ischemia: cues to novel therapeutic strategies. Mol Neurobiol 2003 27 : 33 72.
2. Ohtsukal K, Suzuki T. Roles of molecular chaperones in the nervous system. Brain Res Bull 2000 53 : 141 6.
3. Tsuchiya D, Hong S, Matsumori Y, Shiina H, Kayama T, Swanson RA, et al. Overerexpression of rat heat shock protein 70 is associated with reduction of early mitochondrial cytochrome C release and subsequent DNA fragmentation after permanent focal ischemia. J Cereb Blood Metab 2003 23 : 718 27.
4. Majda BT, Meloni BP, Rixon N, Knuckey NW. Suppression subtraction hybridization and northern analysis reveal upregulation of heat shock, trkB, and sodium calcium exchanger genes following global cerebral ischemia in the rat. Mol Brain Res 2001 93 : 173 9.
5. Geddes JW, Pettigrew LC, Holtz ML, Craddock SD, Maines MD. Permanent focal and transient global cerebral ischemia increase glial and neuronal expression of heme oxygenase-1, but not heme oxy-genase-2, protein in rat brain. Neurosci Let 1996 210 : 205 8.
6. Schror K, Hohlfeld T. Mechanisms of anti-ischemic action of prostaglandin El in peripheral arterial occlusive disease. Vasa 2004 33 : 119 24.
7. Matsuo K, Togo S, Sekido H, Morita T, Kamiyama M, Morioka D, et al. Pharmacologic preconditioning effects: prostaglandin El induces heat-shock proteins immediately after ischemia/reperfusion of the mouse liver. J Gastrointest Surg 2005 9 : 758 68.
8. Bauer M, Alda M, Priller J, Young LT. International Group For The Study Of lithium Treated Patients (IGSLI). Implications of the neuro-protective effects of lithium for the treatment of bipolar and neurode-gerative disorders. Pharmacopsychiatry 2003 36 : S250 4.
9. Chuang DM, Chen RW, Chalecka-Franaszek E, Ren M, Hashimoto R, Senatorov V, et al. Neuroprotective effects of lithium in cultured cells and animal models of diseases. Bipolar Disord 2002 4 : 129 36.
10. Ren M, Senatotov VV, Chen RW, Chuang DM. Postinsult treatment with lithium reduces brain damage and facilitates neurological recovery in a rat ischemia/reperfusion model. Proc Natl Acad Sci USA 2003 100 : 6210 5.
11. Xu XH, Zhang HL, Han R, Gu ZL, Qin ZH. Enhancement of neuro-protection and heat shock protein induction by combined prostaglandin Al and lithium in rodent models of focal ischemia. Brain Res 2006 1102 : 154 62.
12. Xu XH, Hua YN, Zhang HL, Wu JC, Miao YZ, Han R, et al. Greater stress protein expression enhanced by combined prostaglandin Al and lithium in a rat model of focal ischemia. Acta Pharmacol Sin 2007 28 : 1097 104.
13. Longa EZ, Weinstein PR, Carlson S, Cummins R. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 1989 20 : 84 91.
14. Li F, Omae T, Fisher M. Spontaneous hyperthermia and its mechanism in the intraluminal suture middle cerebral artery occlusion model of rats. Stroke 1999 30 : 2464 71.
15. Zhang Y, Wang L, Li J, Wang XL. 2-(1-Hydroxypentyl)-benzoate increases cerebral blood flow and reduces infarct volume in rats model of transient focal cerebral ischemia. J Pharmacol Exp Ther 2006 317 : 973 9.
16. Tamura A, Graham DI, McCulloch J, Teasdale GM. Focal cerebral ischemia in the rat. Description of technique and early neuropatho-logical consequences following middle cerebral artery occlusion. J Cereb Blood Flow Metabol 1981 1 : 53 60.
17. Rosenberg GA, Scremin O, Estrada E, Kyner WT. Arginine vas-opressin VI-antagonist and atrial natriuretic peptide reduce hemor-rhagic brain edema in rats. Stroke 1992 23 : 1767 73.
18. Qin ZH, Chen RW, Wang Y, Nakai M, Chuang DM, Chase TN. Nuclear factor kappar B nuclear translocation upregulates c-Myc and p53 expression during NMDA receptor-mediated apoptosis in rat stratium. J Neurosci 1999 19 : 4023 33.
19. Abe H, Sugino N, Matsuda T, Ueda Y, Mori H, Aono M. Effects of prostaglandin El on transient forebrain ischemia, especially in hip-pocampal CA 1 regions of the gerbil. Masui 1996 45 : 1216 22.
20. Wagstaff MJD, Collaco-Moraes Y, Aspey BS, Coffin RS, Harrison MJG, Latchman DS, et al. Focal cerebral ischaemia increases the levels of several classes of heat shock proteins and their corresponding mRNAs. Mol Brain Res 1996 42 : 236 44.
21. Ravagnan L, Gurbuxani S, Susin SA, Maisse C, Daugas E, Zamzami N, et al. Heat-shock protein 70 antagonizes apoptosis-inducing factor. Nat Cell Biol 2001 3 : 839 43.
22. Kim H, Huh PW, Kim C, Kim YJ, Park EM, Par YM. Cerebral activation and distribution of inducible hsp110 and hsp70 mRNAs following focal ischemia in rat. Toxicology 2001 167 : 135 44.
23. Li CY, Lee JS, Ko YG, Kim JI, Seo JS. Heat shock protein 70 inhibits apoptosis downstream of cytochrome c release and up stream of caspase-3 activation. J Biol Chem 2000 275 : 25 665 71.
24. Feinstein DL, Galea E, Aquino DA, Li GC, Xu H, Reis DJ. Heat shock protein 70 suppresses astroglial-inducible nitric-oxide synthase expression by decreasing NF kappa B activation. J Biol Chem 1996 271 : 17 724 32.
25. Lee SH, Kwon HM, Kim YJ, Lee KM, Kim M, Yoon BW. Effects of HSP70.1 gene knockout on the mitochondrial apoptotic pathway after focal cerebral ischemia. Stroke 2004 35 : 2195 9.
26. Panahian N, Yoshiura M, Maines MD. Overexpression of heme oxygenase-1 is neuroprotective in a model of permanent middle cerebral artery occlusion in transgenic mice. J Neurochem 1999 72 : 1187 203.
27. Ma J, Zhang GY. Lithium reduced N-methyl-D-aspartate receptor subunit 2A tyrosine phosphorylation and its interactions with Src and Fyn mediated by PSD-95 in rat hippocampus following cerebral ischemia. Neurosci Lett 2003 348 : 185 9.
28. Chen G, Zeng WZ, Yuang PX, Huang LD, Jiang YM, Zhao ZH. The mood-stabilizing agents lithium and valproate robustly increase the levels of the neuroprotective protein bcl-2 in the CNS. J Neurochem 1999 72 : 879 82.
29. Fukumoto T, Morinobu S, Okamoto Y, Kagaya A, Yamawaki S. Chronic lithium treatment increases the expression of brain-derived neurotrophic factor in the brain. Psychopharmacology 2001 158 : 100 6.