Effect of the N-butanoyl glutathione (GSH) derivative and acyclovir on HSV-1 replication and Th1 cytokine expression in human macrophages

Medical Microbiology and Immunology

Volumn 203, Issue 4, 2014, Pages 283-289

  Fraternale, Alessandra ^a   Schiavano, Giuditta Fiorella ^a   Paoletti, Maria Filomena ^a   Palma, Linda ^a   Magnani, Mauro ^a   Brandi, Giorgio ^a  

^a UNIVERSITY OF URBINO   (Italy)

Author keywords

HSV 1; N butanoyl glutathione derivative; Th1 interleukins

Indexed keywords

ACICLOVIR; CYTOKINE; GLUTATHIONE DERIVATIVE; INTERLEUKIN 12; INTERLEUKIN 12P35; INTERLEUKIN 12P40; INTERLEUKIN 27; INTERLEUKIN 27EBI3; INTERLEUKIN 27P28; MESSENGER RNA; N BUTANOYL GLUTATHIONE DERIVATIVE; THIOL; UNCLASSIFIED DRUG; ANTIVIRUS AGENT; GLUTATHIONE; GLUTATHIONE-C4; IL27 PROTEIN, HUMAN; INTERLEUKIN DERIVATIVE;

ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOKINE RESPONSE; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; HERPES SIMPLEX; HERPES SIMPLEX VIRUS 1; HUMAN; HUMAN CELL; IL 12P35 GENE; IL 12P40 GENE; IL 27EBI3 GENE; IL 27P28 GENE; IMMUNOREGULATION; MACROPHAGE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TH1 CELL; VIRUS INHIBITION; VIRUS REPLICATION; ADULT; ANALOGS AND DERIVATIVES; CELL CULTURE; DRUG EFFECTS; GENE EXPRESSION PROFILING; GENETICS; IMMUNOLOGY; PHYSIOLOGY; SECRETION (PROCESS); VIROLOGY;

ACYCLOVIR; ADULT; ANTIVIRAL AGENTS; CELLS, CULTURED; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION PROFILING; GLUTATHIONE; HERPESVIRUS 1, HUMAN; HUMANS; INTERLEUKIN-12; INTERLEUKINS; MACROPHAGES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TH1 CELLS; VIRUS REPLICATION;

EID: 84905582264     PISSN: 03008584     EISSN: 14321831     Source Type: Journal    
DOI: 10.1007/s00430-014-0335-4     Document Type: Article

References (26)

1. Roizman B, Knipe D, Whitley R (2007) Herpes simplex viruses. In: Knipe DMHP (ed) Fields' virology, 5th edn. Lippincott Williams & Wilkins, Philadelphia, pp 2501-2601
2. Whitley RJ, Roizman B (2001) Herpes simplex virus infections. Lancet 357:1513-1518 (Pubitemid 32488876)
3. Kodukula P, Liu T, van Rooijen N, Jager MJ, Hendricks RL (1999) Macrophage control of Herpes simplex virus type 1 replication in the peripheral nervous system. J Immunol 162:2895-2905 (Pubitemid 29309317)
4. Milligan GN, Bernstein DI (1997) Interferon-γ enhances resolution of Herpes simplex virus type 2 infection of the murine genital tract. Virology 229:259-268 (Pubitemid 27243509)
5. Scieux C (1997) Herpes simplex virus and macrophages. Pathol Biol 45:159-164
6. Trinchieri G (2003) Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat Rev Immunol 3:133-146
7. Batten M, Ghilardi N (2007) The biology and therapeutic potential of interleukin 27. J Biol Med 85:661-672 (Pubitemid 47063520)
8. Kumaraguru U, Rouse BT (2002) The IL-12 response to herpes simplex virus is mainly a paracrine response of reactive inflammatory cells. J Leukoc Biol 72:564-570
9. Mertz GJ (1990) Herpes virus simplex. In: Galasso GJ, Whitley RJ, Merigan TC (eds) Antiviral agents and viral disease of man. Raven Press, New York, pp 265-300
10. Fraternale A, Paoletti MF, Casabianca A, Nencioni L, Garaci E, Palamara AT, Magnani M (2009) GSH and analogs in antiviral therapy. Mol Aspects Med 30:99-110
11. Murata Y, Shimamura T, Hamuro J (2002) The polarization of T(h)1 T(h)2 balance is dependent on the intracellular thiol redox status of macrophages due to the distinctive cytokine production. Int Immunol 14:201-212 (Pubitemid 34144744)
12. Koike Y, Hisada T, Utsugi M, Ishizuka T, Shimizu Y et al (2007) Glutathione redox regulates airway hyperresponsiveness and airway inflammation in mice. Am J Respir Cell Mol Biol 37:322-329 (Pubitemid 350067611)
13. Fraternale A, Paoletti MF, Dominici S et al (2010) The increase in intra-macrophage thiols induced by new pro-GSH molecules directs the Th1 skewing in ovalbumin immunized mice. Vaccine 28:7676-7682
14. Fraternale A, Paoletti MF, Dominici S et al (2011) Modulation of Th1/Th2 immune responses to HIV-1 Tat by new pro-GSH molecules. Vaccine 29:6823-6829
15. Brandi G, Schiavano GF, Balestra E, Tavazzi B, Perno C-F, Magnani M (2001) The potency of acyclovir can be markedly different in different cell types. Life Sci 69:1285-1290 (Pubitemid 32758698)
16. Dobashi K, Aihara M, Araki T et al (2001) Regulation of LPS induced IL-12 production by IFN-gamma and IL-4 through intracellular glutathione status in human alveolar macrophages. Clin Exp Immunol 124:290-296 (Pubitemid 32587614)
17. Beutler E (1984) Red cell metabolism. In: Grune Stratton (ed) A manual of biochemical methods. USA Press, New York, pp 131-133
18. Palamara AT, Brandi G, Rossi L et al (2004) New synthetic glutathione derivatives with increased antiviral activities. Antivir Chem Chemother 15:11-19
19. D'Andrea A, Rengaraju M, Valiante NM et al (1992) Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells. J Exp Med 176:1387-1398
20. Frank GM, Divito SJ, Maker DM, Xu M, Hendricks RL (2010) A novel p40-independent function of IL-12p35 is required for progression and maintenance of herpes stromal keratitis. Invest Ophthalmol Vis Sci 51:3591-3598
21. Schnurr M, Toy T, Shin A, Wagner M, Cebon J, Maraskvsky E (2005) Extracellular nucleotide signalling by P2 receptors inhibits IL-12 and enhances IL-23 expression in human dendritic cells: a novel role fro the cAMP pathway. Blood 105:1582-1589 (Pubitemid 40223678)
22. Sareneva T, Matikainen S, Kurimoto M, Julkunen I (1998) Influenza A virus-induced IFN-alpha/beta and IL-18 synergistically enhance IFN-gamma gene expression in human T cells. J Immunol 160:6032-6038 (Pubitemid 28298066)
23. Mazzeo D, Sacco S, Di Lucia P et al (2002) Thiol antioxidants inhibit the formation of the interleukin-12 heterodimer: a novel mechanism for the inhibition of IL-12 production. Cytokine 17:285-293
24. Alam K, Ghousunnissa S, Nair S, Valluri VL, Mukhopadhyay S (2010) Glutathione-redox balance regulates c-rel-driven IL-12 production in macrophages: possible implications in antituberculosis immunotherapy. J Immunol 184:2918-2929
25. Patel A, Hanson J, McLean T et al (1998) Herpes simplex type 1 induction of persistent NF-kB nuclear translocation increases the efficiency of virus replication. Virology 247:212-222 (Pubitemid 28384012)
26. Murphy TL, Cleveland MG, Kulesza P, Magram J, Murphy KM (1995) Regulation of interleukin 12 p40 expression through an NF-kB half-site. Mol Cell Biol 17:5258-5267