Computational docking to sweet taste receptor models

ACS Symposium Series

Volumn 979, Issue , 2008, Pages 162-167

  Walters, D Eric ^a  

^a ROSALIND FRANKLIN UNIVERSITY OF MEDICINE AND SCIENCE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; PROTEINS;

BINDING MODES; COMPUTATIONAL DOCKINGS; COMPUTER MODELING TOOLS; DOCKING CALCULATIONS; LIGAND BINDING DOMAIN; N-TERMINALS; RECEPTOR INTERACTION; SWEET PROTEIN;

FOOD ADDITIVES;

EID: 84905579066     PISSN: 00976156     EISSN: 19475918     Source Type: Book Series    
DOI: 10.1021/bk-2008-0979.ch011     Document Type: Conference Paper

References (24)

1. Nelson, G.; Hoon, M.A.; Chandrashekar, J.; Zhang, Y.; Ryba, N.J.; Zuker, C.S. Mammalian sweet taste receptors. Cell 2001, 106, 381-390.
2. Li, X.; Staszewski, L.; Xu, H.; Durick, K.; Zoller, M.; Adler, E. Human receptors for sweet and umami taste. Proc. Natl. Acad. Sci. USA 2002, 99, 4692-4696.
3. Zhao, G.Q.; Zhang, Y.; Hoon, M.A.; Chandrashekar, J.; Erlenbach, I.; Ryba, N.J.P.; Zuker, C.S. The receptors for mammalian sweet and umami taste. Cell 2003, 115, 256-266.
4. Jiang, P.; Ji, Q.; Liu, Z.; Snyder, L.A.; Benard, L.M.J.; Margolskee, R.F.; Max, M. The cysteine-rich region of T1R3 determines responses to intensely sweet proteins. J. Biol. Chem. 2004, 279, 45068-45075.
5. Xu, H.; Staszewski, L.; Tang, H.; Adler, E.; Zoller, M.; Li, X. Different functional roles of T1R subunits in the heteromeric taste receptors. Proc. Natl. Acad. Sci. USA 2004, 101, 14258-14263.
6. Jiang, P.; Cui, M.; Zhao, B.; Snyder, L.A.; Benard, L.M.J.; Osman, R.; Max, M.; Margolskee, R.F. Identification of the cyclamate interaction site within the transmembrane domain of the human sweet taste receptor subunit T1R3. J. Biol. Chem. 2005, 280, 34296-34305.
7. Kunishima, N.; Shimada, Y.; Tsuji, Y.; Sato, T.; Yamamoto, M.; Kumasaka, T.; Nakanishi, S.; Jingami, H.; Morikawa, K. Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor. Nature 2000, 407, 971-977.
8. Max, M.; Shanker, Y.G.; Huang, L.; Rong, M.; Liu, Z.; Campagne, F.; Weinstein, H.; Damak, S.; Margolskee, R.F. Tas1r3, encoding a new candidate taste receptor, is allelic to the sweet responsiveness locus Sac. Nature Genet. 2001, 28, 58-63.
9. Temussi, P.A. Why are sweet proteins sweet? Interaction of brazzein, monellin and thaumatin with the T1R2-T1R3 receptor. FEBS Lett. 2002, 526, 1-4.
10. Walters, D.E. Homology-based model of the extracellular domain of the taste receptor T1R3. Pure & Appl. Chem. 2002, 74, 1117-1123.
11. Walters, D.E.; Hellekant, G. Interactions of the sweet protein brazzein with the sweet taste receptor. J. Agric. Food Chem. 2006, 54, in press.
12. Ming, D.; Hellekant, G. Brazzein, a new high-potency thermostable sweet protein from Pentadiplandra brazzeana B. FEBS Lett. 1994, 355, 106-108.
13. Caldwell, J.E.; Abildgaard, F.; Dzakula, Z.; Ming, D.; Hellekant, G.; Markley, J.L. Solution structure of the thermostable sweet-tasting protein brazzein. Nat. Struct. Biol. 1998, 5, 427-431.
14. Vakser, I.A. Low-resolution docking: Prediction of complexes for underdetermined structures. Biopolymers, 1996, 39, 455-464.
15. Vakser, I.A.; Matar, O.G.; Lam, C.F. A systematic study of low-resolution recognition in protein-protein complexes. Proc. Natl. Acad. Sci. USA 1999, 96, 8477-8482.
16. Assadi-Porter, F.M.; Aceti, D.J.; Markley, J.L. Sweetness determinant sites of brazzein, a small, heat-stable, sweet-tasting protein. Arch. Biochem. Biophys. 2000, 376, 259-265.
17. Jin, Z.; Danilova, V.; Assadi-Porter, F.M.; Aceti, D.J.; Markley, J.L.; Hellekant, G. Critical regions for the sweetness of brazzein. FEBS Lett. 2003, 544, 33-37.
18. Kurihara, K.; Beidler, L.M. Taste-modifying protein from miracle fruit. Science 1968, 161, 1241-1243.
19. Theerasilp, S.; Hitotsuya, H.; Nakajo, S.; Nakaya, K.; Nakamura, Y.; Kurihara, Y. Complete amino acid sequence and structure characterization of the taste-modifying protein, miraculin. J. Biol. Chem. 1989, 264, 6655- 6659.
20. Takahashi, N.; Hitotsuya, H.; Hanzawa, H.; Arata, Y.; Kurihara, Y. Structural study of asparagine-linked oligosaccharide moiety of tastemodifying protein, miraculin. J. Biol. Chem. 1990, 265, 7793-7798.
21. Igeta, h.; Tamura, Y.; Nakaya, K.; Nakamura, Y.; Kurihara, Y. Determination of disulfide array and subunit structure of taste-modifying protein, miraculin. Biochim. Biophys. Acta 1991, 1079, 303-307.
22. Finn, R.D.; Mistry, J.; Schuster-Böckler, B.; Griffiths-Jones, S.; Hollich, V.; Lassmann, T.; Moxon, S.; Marshall, M.; Khanna, A.; Durbin, R.; Eddy, S.R.; Sonnhammer, E.L.L.; Bateman, A. Pfam: clans, web tools and services. Nucl. Acids Res. 2006, 34, D247-D25L.
23. Berman, H.M.; Westbrook, J.; Feng, Z.; Gilliland, G.; Bhat, T.N.; Weissig, H.; Shindyalov, I.N.; Bourne, P.E. The Protein Data Bank. Nucl. Acids Res. 2000, 28, 235-242.
24. Vallee, F.; Kadziola, A.; Bourne, Y.; Juy, M.; Rodenburg, K.W.; Svensson, B.; Haser, R. Barley alpha-amylase bound to its endogenous protein inhibitor BASI: crystal structure of the complex at 1.9 A resolution. Structure 1998, 6, 649-659.