Apelin-13 decreases lipid storage in hypertrophic adipocytes in vitro through the upregulation of AQP7 expression by the PI3K signaling pathway

Medical Science Monitor

Volumn 20, Issue , 2014, Pages 1345-1352

  Guo, Mei ^a   Chen, Fu ^a   Lin, Tanfa ^a   Peng, Yanqiang ^a   Li, Weiping ^a   Zhu, Xuxin ^a   Lin, Ling ^a   Chen, Yongsong ^a  

^a SHANTOU UNIVERSITY MEDICAL COLLEGE   (China)

Author keywords

3T3 L1 cells; Adipocytes; Apelin 13; Aquaporins; Phosphatidylinositol 3 kinases

Indexed keywords

APELIN 13; AQUAPORIN 7; BETA ACTIN; FAT DROPLET; PALMITIC ACID; PHOSPHATIDYLINOSITOL 3 KINASE; ROSIGLITAZONE; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; APLN PROTEIN, MOUSE; AQP7 PROTEIN, MOUSE; AQUAPORIN; AZO COMPOUND; OIL RED O; PALMITIC ACID DERIVATIVE; SIGNAL PEPTIDE;

ADIPOCYTE; ANIMAL CELL; ARTICLE; CELL ADHESION; CELL DIFFERENTIATION; CONTROLLED STUDY; IMMUNOREACTIVITY; LIPID STORAGE; NONHUMAN; PROTEIN DETERMINATION; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION; WESTERN BLOTTING; 3T3 CELL LINE; ANALYSIS OF VARIANCE; ANIMAL; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; GENE EXPRESSION REGULATION; LIPID METABOLISM; METABOLISM; MOUSE;

3T3-L1 CELLS; ADIPOCYTES; ANALYSIS OF VARIANCE; ANIMALS; AQUAPORINS; AZO COMPOUNDS; GENE EXPRESSION REGULATION; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LIPID METABOLISM; MICE; PALMITATES; PHOSPHATIDYLINOSITOL 3-KINASES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 84905575709     PISSN: 12341010     EISSN: 16433750     Source Type: Journal    
DOI: 10.12659/MSM.890124     Document Type: Article

References (44)

1. Rosen ED, Spiegelman BM: Adipocytes as regulators of energy balance and glucose homeostasis. Nature, 2006; 444: 847-53
2. Moon HS, Lee HG, Choi YJ et al: Proposed mechanisms of (-)-epigallocatechin-3-gallate for anti-obesity. Chem Biol Interact, 2007; 167: 85-98
3. Spalding KL, Arner E, Westermark PO et al: Dynamics of fat cell turnover in humans. Nature, 2008; 453: 783-87
4. Kondo H, Shimomura I, Kishida K et al: Human aquaporin adipose (AQPap) gene. Genomic structure, promoter analysis and functional mutation. Eur J Biochem, 2002; 269: 1814-26
5. Skowronski MT, Lebeck J, Rojek A et al: AQP7 is localized in capillaries of adipose tissue, cardiac and striated muscle: implications in glycerol metabolism. Am J Physiol Renal Physiol, 2007; 292: F956-65
6. Ishibashi K, Kuwahara M, Gu Y et al: Cloning and functional expression of a new water channel abundantly expressed in the testis permeable to water, glycerol, and urea. J Biol Chem, 1997; 272: 20782-86
7. Nejsum LN, Elkjaer M, Hager H et al: Localization of aquaporin-7 in rat and mouse kidney using RT-PCR, immunoblotting, and immunocytochemistry. Biochem Biophys Res Commun, 2000; 277: 164-70
8. Fruhbeck G, Catalan V, Gomez-Ambrosi J, Rodriguez A: Aquaporin-7 and glycerol permeability as novel obesity drug-target pathways. Trends Pharmacol Sci, 2006; 27: 345-47
9. Maeda N, Funahashi T, Hibuse T et al: Adaptation to fasting by glycerol transport through aquaporin 7 in adipose tissue. Proc Natl Acad Sci USA, 2004; 101: 17801-6
10. Kishida K, Shimomura I, Kondo H et al: Genomic structure and insulin-mediated repression of the aquaporin adipose (AQPap), adipose-specific glycerol channel. J Biol Chem, 2001; 276: 36251-60
11. O'Dowd BF, Heiber M, Chan A et al: A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11. Gene, 1993; 136: 355-60
12. Tatemoto K, Hosoya M, Habata Y et al: Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor. Biochem Biophys Res Commun, 1998; 251: 471-76
13. Dray C, Debard C, Jager J et al: Apelin and APJ regulation in adipose tissue and skeletal muscle of type 2 diabetic mice and humans. Am J Physiol Endocrinol Metab, 2010; 298: E1161-69
14. Boucher J, Masri B, Daviaud D et al: Apelin, a newly identified adipokine up-regulated by insulin and obesity. Endocrinology, 2005; 146: 1764-71
15. Heinonen MV, Purhonen AK, Miettinen P et al: Apelin, orexin-A and leptin plasma levels in morbid obesity and effect of gastric banding. Regul Pept, 2005; 130: 7-13
16. Erdem G, Dogru T, Tasci I et al: Low plasma apelin levels in newly diagnosed type 2 diabetes mellitus. Exp Clin Endocrinol Diabetes, 2008; 116: 289-92
17. Higuchi K, Masaki T, Gotoh K et al: Apelin, an APJ receptor ligand, regulates body adiposity and favors the messenger ribonucleic acid expression of uncoupling proteins in mice. Endocrinology, 2007; 148: 2690-97
18. Carpene C, Dray C, Attane C et al: Expanding role for the apelin/APJ system in physiopathology. J Physiol Biochem, 2007; 63: 359-73
19. Liu C, Su T, Li F et al: PI3K/Akt signaling transduction pathway is involved in rat vascular smooth muscle cell proliferation induced by apelin-13. Acta Biochim Biophys Sin (Shanghai), 2010; 42: 396-402
20. Arai T, Kawakami Y, Matsushima T et al: Intracellular fatty acid downregulates ob gene expression in 3T3-L1 adipocytes. Biochem Biophys Res Commun, 2002; 297: 1291-96
21. Shintani M, Nishimura H, Yonemitsu S et al: Downregulation of leptin by free fatty acids in rat adipocytes: effects of triacsin C, palmitate, and 2-bromopalmitate. Metabolism, 2000; 49: 326-30
22. Zhu S, Sun F, Li W et al: Apelin stimulates glucose uptake through the PI3K/ Akt pathway and improves insulin resistance in 3T3-L1 adipocytes. Mol Cell Biochem, 2011; 353: 305-13
23. Pittenger MF, Mackay AM, Beck SC et al: Multilineage potential of adult human mesenchymal stem cells. Science, 1999; 284: 143-47
24. Curran-Everett D: Explorations in statistics: standard deviations and standard errors. Adv Physiol Educ, 2008; 32: 203-8
25. Perrini S, Natalicchio A, Laviola L et al: Dehydroepiandrosterone stimulates glucose uptake in human and murine adipocytes by inducing GLUT1 and GLUT4 translocation to the plasma membrane. Diabetes, 2004; 53: 41-52
26. Listenberger LL, Ory DS, Schaffer JE: Palmitate-induced apoptosis can occur through a ceramide-independent pathway. J Biol Chem, 2001; 276: 14890-95
27. Fruhbeck G: Obesity: aquaporin enters the picture. Nature, 2005; 438: 436-37
28. MacDougald OA, Burant CF: Obesity and metabolic perturbations after loss of aquaporin 7, the adipose glycerol transporter. Proc Natl Acad Sci USA, 2005; 102: 10759-60
29. Rodriguez A, Catalan V, Gomez-Ambrosi J, Fruhbeck G: Role of aquaporin-7 in the pathophysiological control of fat accumulation in mice. FEBS Lett, 2006; 580: 4771-76
30. Hibuse T, Maeda N, Funahashi T et al: Aquaporin 7 deficiency is associated with development of obesity through activation of adipose glycerol kinase. Proc Natl Acad Sci USA, 2005; 102: 10993-98
31. Marrades MP, Milagro FI, Martinez JA, Moreno-Aliaga MJ: Differential expression of aquaporin 7 in adipose tissue of lean and obese high fat consumers. Biochem Biophys Res Commun, 2006; 339: 785-89
32. Miranda M, Escote X, Ceperuelo-Mallafre V et al: Paired subcutaneous and visceral adipose tissue aquaporin-7 expression in human obesity and type 2 diabetes: differences and similarities between depots. J Clin Endocrinol Metab, 2010; 95: 3470-79
33. Guan HP, Li Y, Jensen MV et al: A futile metabolic cycle activated in adipocytes by antidiabetic agents. Nat Med, 2002; 8: 1122-28
34. Prudente S, Flex E, Morini E et al: A functional variant of the adipocyte glycerol channel aquaporin 7 gene is associated with obesity and related metabolic abnormalities. Diabetes, 2007; 56: 1468-74
35. Miranda M, Ceperuelo-Mallafre V, Lecube A et al: Gene expression of paired abdominal adipose AQP7 and liver AQP9 in patients with morbid obesity: relationship with glucose abnormalities. Metabolism, 2009; 58: 1762-68
36. Catalan V, Gomez-Ambrosi J, Pastor C et al: Influence of morbid obesity and insulin resistance on gene expression levels of AQP7 in visceral adipose tissue and AQP9 in liver. Obes Surg, 2008; 18: 695-701
37. Attane C, Foussal C, Le Gonidec S et al: Apelin treatment increases complete Fatty Acid oxidation, mitochondrial oxidative capacity, and biogenesis in muscle of insulin-resistant mice. Diabetes, 2012; 61: 310-20
38. Lee DH, Park DB, Lee YK et al: The effects of thiazolidinedione treatment on the regulations of aquaglyceroporins and glycerol kinase in OLETF rats. Metabolism, 2005; 54: 1282-89
39. Rodriguez A, Catalan V, Gomez-Ambrosi J et al: Insulin-and leptin-mediated control of aquaglyceroporins in human adipocytes and hepatocytes is mediated via the PI3K/Akt/mTOR signaling cascade. J Clin Endocrinol Metab, 2011; 96: E586-97
40. Cao C, Sun Y, Healey S et al: EGFR-mediated expression of aquaporin-3 is involved in human skin fibroblast migration. Biochem J, 2006; 400: 225-34
41. Bell CE, Lariviere NM, Watson PH, Watson AJ: Mitogen-activated protein kinase (MAPK) pathways mediate embryonic responses to culture medium osmolarity by regulating Aquaporin 3 and 9 expression and localization, as well as embryonic apoptosis. Hum Reprod, 2009; 24: 1373-86
42. Yang H, Li F, Kong X et al: Molecular cloning, tissue distribution and ontogenetic expression of Xiang pig chemerin and its involvement in regulating energy metabolism through Akt and ERK1/2 signaling pathways. Mol Biol Rep, 2012; 39: 1887-94
43. Suzuki Y, Song SH, Sato K et al: Chemerin analog regulates energy metabolism in sheep. Anim Sci J, 2012; 83: 263-67
44. Karmazyn M, Purdham DM, Rajapurohitam V, Zeidan A: Signalling mechanisms underlying the metabolic and other effects of adipokines on the heart. Cardiovasc Res, 2008; 79: 279-86