Gene expression of paired abdominal adipose AQP7 and liver AQP9 in patients with morbid obesity. Relationship with glucose abnormalities

Metabolism: Clinical and Experimental

Volumn 58, Issue 12, 2009, Pages 1762-1768

  Miranda, Merce ^a,b   Ceperuelo Mallafré, Victòria ^a,b   Lecube, Albert ^b,c   Hernandez, Cristina ^b,c   Chacon, Matilde R ^a,b   Fort, Jose M ^d   Gallart, Lluís ^a,b   Baena Fustegueras, Juan A ^d   Simó, Rafael ^b,c   Vendrell, Joan ^a,b,e  

^a HOSPITAL UNIVERSITARI JOAN XXIII   (Spain)

^b INSTITUTO DE SALUD CARLOS III   (Spain)

^c HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

^d HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

^e UNIVERSITAT ROVIRA I VIRGILI   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

AQUAPORIN 7; AQUAPORIN 9; MESSENGER RNA;

ABDOMINAL FAT; ADULT; ARTICLE; BARIATRIC SURGERY; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; INSULIN RESISTANCE; INTRAABDOMINAL FAT; LIVER; LIVER BIOPSY; MALE; MORBID OBESITY; NON INSULIN DEPENDENT DIABETES MELLITUS; ORAL GLUCOSE TOLERANCE TEST; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SUBCUTANEOUS FAT; TISSUE DISTRIBUTION;

ADIPOSE TISSUE; ADULT; ANTHROPOMETRY; AQUAPORINS; BODY MASS INDEX; DIABETES MELLITUS, TYPE 2; FEMALE; GENE EXPRESSION; GLUCOSE; GLUCOSE INTOLERANCE; HUMANS; LIVER; MALE; MIDDLE AGED; OBESITY, MORBID; RNA, MESSENGER;

EID: 72149114629     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.metabol.2009.06.004     Document Type: Article

References (25)

1. Kuriyama H., Shimomura I., Kishida K., Kondo H., Furuyama N., Nishizawa H., et al. Coordinated regulation of fat-specific and liver-specific glycerol channels, aquaporin adipose and aquaporin 9. Diabetes 51 (2002) 2915-2921
2. Baba H., Zhang X.J., and Wolfe R.R. Glycerol gluconeogenesis in fasting humans. Nutrition 11 (1995) 149-153
3. Wintour E.M., and Henry B.A. Glycerol transport: an additional target for obesity therapy?. Trends Endocrinol Metab 17 (2006) 77-78
4. Kishida K., Kuriyama H., Funahashi T., Shimomura I., Kihara S., Ouchi N., et al. Aquaporin adipose, a putative glycerol channel in adipocytes. J Biol Chem 275 (2000) 20896-20902
5. Hibuse T., Maeda N., Funahashi T., Yamamoto K., Nagasawa A., Mizunoya W., et al. Aquaporin 7 deficiency is associated with development of obesity through activation of adipose glycerol kinase. Proc Natl Acad Sci U S A 102 (2005) 10993-10998
6. Ceperuelo-Mallafré V., Miranda M., Chacón M.R., Vilarrasa N., Megia A., Gutiérrez C., et al. Adipose tissue expression of the glycerol channel aquaporin-7 gene is altered in severe obesity but not in type 2 diabetes. J Clin Endocrinol Metab 92 (2007) 3640-3645
7. Marrades M.P., Milagro F.I., Martínez J.A., and Moreno-Aliaga M.J. Differential expression of aquaporin 7 in adipose tissue of lean and obese high fat consumers. Biochem Biophys Res Commun 339 (2006) 785-789
8. Prudente S., Flex E., Morini E., Turchi F., Capponi D., De Cosmo S., et al. A functional variant of the adipocyte glycerol channel aquaporin 7 gene is associated with obesity and related metabolic abnormalities. Diabetes 56 (2007) 1468-1474
9. Catalán V., Gómez-Ambrosi J., Pastor C., Rotellar F., Silva C., Rodríguez A., et al. Influence of morbid obesity and insulin resistance on gene expression levels of AQP7 in visceral adipose tissue and AQP9 in liver. Obes Surg 18 (2008) 695-701
10. Gastrointestinal surgery for severe obesity: National Institutes of Health Consensus Development Conference Statement. Am J Clin Nutr 55 (1992) 615S-619S
11. American Diabetes Association. Standards of medical care in diabetes. Diabetes Care 30 (2007) S4-S41
12. Brunt E.M. Nonalcoholic steatohepatitis definition and pathology. Semin Liver Dis 21 (2001) 3-16
13. Matthews D.R., Hosker J.P., Rudenski A.S., Naylor B.A., Treacher D.F., and Turner R.C. Homeostasis model assessment; insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28 (1985) 412-419
14. Mattsson C., and Olsson T. Estrogens and glucocorticoid hormones in adipose tissue metabolism. Curr Med Chem 14 (2007) 2918-2924
15. Sjöholm K., Palming J., Olofsson L.E., Gummesson A., Svensson P.A., Lystig T.C., et al. A microarray search for genes predominantly expressed in human omental adipocytes: adipose tissue as a major production site of serum amyloid A. J Clin Endocrinol Metab 90 (2005) 2233-2239
16. Berndt J., Kralisch S., Klöting N., Ruschke K., Kern M., Fasshauer M., et al. Adipose triglyceride lipase gene expression in human visceral obesity. Exp Clin Endocrinol Diabetes 116 (2008) 203-210
17. Wajchenberg B.L. Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome. Endocr Rev 21 (2000) 697-738
18. Kondo H., Shimomura I., Kishida K., Kuriyama H., Makino Y., Nishizawa H., et al. Human aquaporin adipose (AQPap) gene. Genomic structure, promoter analysis and functional mutation. Eur J Biochem 269 (2002) 1814-1826
19. Large V., Peroni O., Letexier D., Ray H., and Beylot M. Metabolism of lipids in human white adipocyte. Diabetes Metab 30 (2004) 294-309
20. Maeda N., Funahashi T., Hibuse T., Nagasawa A., Kishida K., Kuriyama H., et al. Adaptation to fasting by glycerol transport through aquaporin 7 in adipose tissue. Proc Natl Acad Sci U S A 101 (2004) 17801-17806
21. Patsouris D., Mandard S., Voshol P.J., Escher P., Tan N.S., Havekes L.M., et al. PPARalpha governs glycerol metabolism. J Clin Invest 114 (2004) 94-103
22. Li X., Lei T., Xia T., Chen X., Feng S., Chen H., et al. Molecular characterization, chromosomal and expression patterns of three aquaglyceroporins (AQP3, 7, 9) from pig. Comp Biochem Physiol B Biochem Mol Biol 149 (2008) 468-476
23. Coppack S.W., Chinkes D.L., Miles J.M., Patterson B.W., and Klein S. A multicompartmental model of in vivo adipose tissue glycerol kinetics and capillary permeability in lean and obese humans. Diabetes 54 (2005) 1934-1941
24. Rojek A.M., Skowronski M.T., Füchtbauer E.M., Füchtbauer A.C., Fenton R.A., Agre P., et al. Defective glycerol metabolism in aquaporin 9 (AQP9) knockout mice. Proc Natl Acad Sci U S A 104 (2007) 3609-3614
25. Reshef L., Olswang Y., Cassuto H., Blum B., Croniger C.M., Kalhan S.C., et al. Glyceroneogenesis and the triglyceride/fatty acid cycle. J Biol Chem 278 (2003) 30413-30416