Activation of neutral-sphingomyelinase, MAPKs, and p75 NTR-mediating caffeic acid phenethyl ester-induced apoptosis in C6 glioma cells

Journal of Biomedical Science

Volumn 21, Issue 1, 2014, Pages

  Tseng, Tsui Hwa ^a,b   Shen, Chien Heng ^c,d   Huang, Wen Shih ^c,d   Chen, Cheng Nan ^e   Liang, Wen Hai ^a   Lin, Tseng Hsi ^a,f   Kuo, Hsing Chun ^g  

^a CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^b CHUNG SHAN MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^c CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^d CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^e NATIONAL CHIAYI UNIVERSITY   (Taiwan)

^f TAICHUNG VETERANS GENERAL HOSPITAL   (Taiwan)

^g CHANG GUNG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

Author keywords

C6 glioma cells; Caffeic acid phenethyl ester; MAPK; Nerve growth factor; Neutral sphingomyelinase; p75 neurotrophin receptor

Indexed keywords

3,3' (1,4 PHENYLENE)BIS[N [4 (4,5 DIHYDRO 1H IMIDAZOL 2 YL)PHENYL]ACRYLAMIDE]; ACTIN; CAFFEIC ACID PHENETHYL ESTER; CASPASE 3; CERAMIDE; JANUS KINASE 2; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; NERVE GROWTH FACTOR; NEUROTROPHIN RECEPTOR P75; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; SPHINGOMYELIN PHOSPHODIESTERASE; CAFFEIC ACID DERIVATIVE; NERVE GROWTH FACTOR RECEPTOR; PHENETHYL ALCOHOL; TUMOR PROTEIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DNA FRAGMENTATION; ENZYME ACTIVATION; ENZYME ACTIVITY; GLIOMA CELL; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; RAT; UPREGULATION; WESTERN BLOTTING; ANALOGS AND DERIVATIVES; ANIMAL; DRUG EFFECTS; GENETICS; GLIOMA; METABOLISM; PATHOLOGY; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

ANIMALS; APOPTOSIS; CAFFEIC ACIDS; CELL LINE, TUMOR; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GLIOMA; MAP KINASE SIGNALING SYSTEM; NEOPLASM PROTEINS; PHENYLETHYL ALCOHOL; RATS; RECEPTOR, NERVE GROWTH FACTOR; SPHINGOMYELIN PHOSPHODIESTERASE;

EID: 84905560007     PISSN: 10217770     EISSN: 14230127     Source Type: Journal    
DOI: 10.1186/1423-0127-21-61     Document Type: Article

References (28)

1. Apoptosis and altered redox state induced by caffeic acid phenethyl ester (CAPE) in transformed rat fibroblast cells. Chiao C, Carothers AM, Grunberger D, Solomon G, Preston GA, Barrett JC, Cancer Res 1995 55 3576 3583 7543016
2. Inhibition of HIV-1 integrase by flavones, caffeic acid phenethyl ester (CAPE) and related compounds. Fesen MR, Pommier Y, Leteurtre F, Hiroguchi S, Yung J, Kohn KW, Biochem Pharmacol 1994 48 595 608 10.1016/0006-2952(94)90291-7 7520698
3. Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-kappa B. Natarajan K, Singh S, Burke TR Jr, Grunberger D, Aggarwal BB, Proc Natl Acad Sci U S A 1996 93 9090 9095 10.1073/pnas.93.17.9090 8799159
4. Inhibitory effects of caffeic acid phenethyl ester on the activity and expression of cyclooxygenase-2 in human oral epithelial cells and in a rat model of inflammation. Michaluart P, Masferrer JL, Carothers AM, Subbaramaiah K, Zweifel BS, Koboldt C, Mestre JR, Grunberger D, Sacks PG, Tanabe T, Dannenberg AJ, Cancer Res 1999 59 2347 2352 10344742
5. Caffeic acid phenethyl ester induces apoptosis by inhibition of NFkappa B and activation of Fas in human breast cancer MCF-7 cells. Watabe M, Hishikawa K, Takayanagi A, Shimizu N, Nakaki T, J Biol Chem 2004 279 6017 6026 14625298
6. Inhibitory effect of caffeic acid phenethyl ester on angiogenesis, tumor invasion, and metastasis. Liao HF, Chen YY, Liu JJ, Hsu ML, Shieh HJ, Liao HJ, Shieh CJ, Shiao MS, Chen YJ, J Agric Food Chem 2003 51 7907 7912 10.1021/jf034729d 14690372
7. Preferential cytotoxicity of caffeic acid phenethyl ester analogues on oral cancer cells. Lee YJ, Liao PH, Chen WK, Yang CY, Cancer Lett 2000 153 51 56 10.1016/S0304-3835(00)00389-X 10779629
8. Involvement of tumor suppressor protein p53 and p38 MAPK in caffeic acid phenethyl ester induced-apoptosis of C6 glioma cells. Lee YJ, Kuo HC, Chu CY, Wang CJ, Lin WC, Tseng TH, Biochem Pharmacol 2003 66 2281 2289 10.1016/j.bcp.2003.07.014 14637186
9. Inhibitory effect of caffeic acid phenethyl ester on the growth of C6 glioma cells in vitro and in vivo. Kuo HC, Kuo WH, Lee YJ, Lin WL, Chou FP, Tseng TH, Cancer Lett 2006 234 199 208 10.1016/j.canlet.2005.03.046 15885897
10. Enhancement of caffeic acid phenethyl ester on all-trans retinoic acid-induced differentiation in human leukemia HL-60 cells. Kuo HC, Kuo WH, Lee YJ, Wang CJ, Tseng TH, Toxicol Appl Pharmacol 2006 216 80 88 10.1016/j.taap.2006.04.007 16766008
11. From receptors to stress-activated MAP kinases. Ichijo H, Oncogene 1999 18 6087 6093 10.1038/sj.onc.1203129 10557099
12. Mitogen-activated protein kinase pathway mediates hyperoxia induced apoptosis in cultured macrophage cells. Petrache I, Choi ME, Otterbein LE, Chin BY, Mantell LL, Horowitz S, Choi AM, Am J Physiol 1999 277 589 L595 10484467
13. Requirement of activation of JNK and p38 for environmental stress-induced erythroid differentiation and apoptosis and of inhibition of ERK for apoptosis. Nagata Y, Todokoro K, Blood 1999 94 853 863 10419875
14. Mitogen-activated protein kinases in apoptosis regulation. Wada T, Penninger JM, Oncogene 2004 23 2838 2849 10.1038/sj.onc.1207556 15077147
15. TrkA receptors delay C6-2B glioma cell growth in rat striatum. Rabin SJ, Tornatore C, Baker-Cairns B, Spiga G, Mocchetti I, Brain Res Mol Brain Res 1998 56 273 276 10.1016/S0169-328X(98)00020-5 9602149
16. p75 and Trk: a two-receptor system. Chao MV, Hempstead BL, Trends Neurosci 1995 18 321 326 10.1016/0166-2236(95)93922-K 7571013
17. The low affinity NGF receptor, p75, can collaborate with each of the Trks to potentiate functional responses to the neurotrophins. Hantzopoulos PA, Suri C, Glass DJ, Goldfarb MP, Yancopoulos GD, Neuron 1994 13 187 201 10.1016/0896-6273(94)90469-3 8043276
18. Induction of apoptosis by the low-affinity NGF receptor. Rabizadeh S, Oh J, Zhong LT, Yang J, Bitler CM, Butcher LL, Bredesen DE, Science 1993 261 345 348 10.1126/science.8332899 8332899
19. The TNF receptor superfamily of cellular and viral proteins: activation, costimulation, and death. Smith CA, Farrah T, Goodwin RG, Cell 1994 76 959 962 10.1016/0092-8674(94)90372-7 8137429
20. Signalling sphingomyelinases: which, where, how and why? Levade T, Jaffrézou JP, Biochim Biophys Acta 1999 1438 1 17 10.1016/S1388-1981(99) 00038-4 10216276
21. Ceramide in apoptosis: an overview and current perspectives. Pettus BJ, Chalfant CE, Hannun YA, Biochim Biophys Acta 2002 1585 114 125 10.1016/S1388-1981(02)00331-1 12531544
22. Induction of nerve growth factor synthesis by sphingomyelinase and ceramide in primary astrocyte cultures. Galve-Roperh I, Haro A, Díaz-Laviada I, Brain Res Mol Brain Res 1997 52 90 97 10.1016/S0169-328X(97)00230-1 9450681
23. Differential actions of nerve growth factor receptors TrkA and p75NTR in a rat model of epileptogenesis. Li S, Saragovi HU, Nedev H, Zhao C, Racine RJ, Fahnestock M, Mol Cell Neurosci 2005 29 162 172 10.1016/j.mcn.2005.02.007 15911341
24. Differentiated rat glial cell strain in tissue culture. Benda P, Lightbody J, Sato G, Levine L, Sweet, Science 1968 161 370 371 10.1126/science.161.3839.370 4873531
25. Expression of neutral sphingomyelinase identifies a distinct pool of sphingomyelin involved in apoptosis. Zhang P, Liu B, Jenkins GM, Hannun YA, Obeid LM, J Biol Chem 1997 272 9609 9612 10.1074/jbc.272.15.9609 9092485
26. Hannun, Glutathione regulation of neutral sphingomyelinase in tumor necrosis factor-alpha-induced cell death. Liu B, Andrieu-Abadie N, Levade T, Zhang P, Obeid LM, Hannun YA, J Biol Chem 1998 273 11313 11320 10.1074/jbc.273.18.11313 9556624
27. Implication of radical oxygen species in ceramide generation, c-Jun N-terminal kinase activation and apoptosis induced by daunorubicin. Mansat-de Mas V, Bezombes C, Quillet-Mary A, Bettaïeb A, D'orgeix AD, Laurent G, Jaffrézou JP, Mol Pharmacol 1999 56 867 874 10531389
28. Neurotrophin-regulated signaling pathways. Reichardt LF, Philos Trans R Soc Lond B Biol Sci 2006 361 1545 1564 10.1098/rstb.2006.1894 16939974