Downregulation of expression of xenobiotic efflux genes is associated with pelvic pouch inflammation in ulcerative colitis

Inflammatory Bowel Diseases

Volumn 20, Issue 7, 2014, Pages 1157-1164

  Kabakchiev, Boyko ^a   Tyler, Andrea ^a   Stempak, Joanne M ^a,b   Milgrom, Raquel ^b   Silverberg, Mark S ^a,c  

^a MOUNT SINAI HOSPITAL   (Canada)

^b MOUNT SINAI HOSPITAL   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

Gene expression; IBD; Network analysis

Indexed keywords

TRANSCRIPTOME; XENOBIOTIC AGENT; ABCB1 PROTEIN, HUMAN; CASPASE RECRUITMENT DOMAIN PROTEIN 15; DNA BINDING PROTEIN; MECOM PROTEIN, HUMAN; MULTIDRUG RESISTANCE PROTEIN; NOD2 PROTEIN, HUMAN; ORGANIC CATION TRANSPORTER; SLC22A4 PROTEIN, HUMAN; SLC22A5 PROTEIN, HUMAN; TRANSCRIPTION FACTOR;

ABCB1 GENE; ARTICLE; CLASSIFICATION ALGORITHM; COLON RESECTION; CONTROLLED STUDY; CROHN DISEASE; DISEASE ACTIVITY; DOWN REGULATION; EXTRACELLULAR MATRIX; FAMILIAL COLON POLYPOSIS; FEMALE; GENE EXPRESSION REGULATION; GENE ONTOLOGY; HUMAN; HUMAN TISSUE; ILEITIS; ILEOANAL ANASTOMOSIS; ILEOSTOMY; ILEUM POUCH; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; PHENOTYPE; POSTOPERATIVE INFLAMMATION; PRIORITY JOURNAL; PROSPECTIVE STUDY; RECURRENT DISEASE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCORING SYSTEM; ULCERATIVE COLITIS; ADOLESCENT; ADULT; CASE CONTROL STUDY; COLITIS, ULCERATIVE; COLOSTOMY BAG; GENETICS; PROTO ONCOGENE; REAL TIME POLYMERASE CHAIN REACTION; SENSITIVITY AND SPECIFICITY; YOUNG ADULT;

ADOLESCENT; ADULT; CASE-CONTROL STUDIES; COLITIS, ULCERATIVE; COLONIC POUCHES; DNA-BINDING PROTEINS; DOWN-REGULATION; FEMALE; GENE EXPRESSION REGULATION; HUMANS; MALE; NOD2 SIGNALING ADAPTOR PROTEIN; ORGANIC CATION TRANSPORT PROTEINS; P-GLYCOPROTEINS; POUCHITIS; PROSPECTIVE STUDIES; PROTO-ONCOGENES; REAL-TIME POLYMERASE CHAIN REACTION; SENSITIVITY AND SPECIFICITY; TRANSCRIPTION FACTORS; YOUNG ADULT;

EID: 84905507191     PISSN: 10780998     EISSN: 15364844     Source Type: Journal    
DOI: 10.1097/MIB.0000000000000078     Document Type: Article

References (42)

1. Sandborn WJ, Pardi DS. Clinical management of pouchitis. Gastroenterology. 2004;127:1809-1814.
2. Strong SA. Surgical treatment of inflammatory bowel disease. Curr Opin Gastroenterol. 2002;18:441-446.
3. Parks AG, Nicholls RJ. Proctocolectomy without ileostomy for ulcerative colitis. Br Med J. 1978;2:85-88.
4. Meagher AP, Farouk R, Dozois RR, et al. J ileal pouch-anal anastomosis for chronic ulcerative colitis: complications and long-term outcome in 1310 patients. Br J Surg. 1998;85:800-803.
5. Stahlberg D, Gullberg K, Liljeqvist L, et al. Pouchitis following pelvic pouch operation for ulcerative colitis. Incidence, cumulative risk, and risk factors. Dis Colon Rectum. 1996;39:1012-1018.
6. Shen B. Crohn's disease of the ileal pouch: reality, diagnosis, and management. Inflamm Bowel Dis. 2009;15:284-294.
7. Kmiot WA, Williams MR, Keighley MR. Pouchitis following colectomy and ileal reservoir construction for familial adenomatous polyposis. Br J Surg. 1990;77:1283.
8. Miyoshi Y, Ando H, Nagase H, et al. Germ-line mutations of the APC gene in 53 familial adenomatous polyposis patients. Proc Natl Acad Sci U S A. 1992;89:4452-4456.
9. Campbell WJ, Spence RA, Parks TG. Familial adenomatous polyposis. Br J Surg. 1994;81:1722-1733.
10. Stallmach A, Chan CC, Ecker KW, et al. Comparable expression of matrix metalloproteinases 1 and 2 in pouchitis and ulcerative colitis. Gut. 2000;47:415-422.
11. Heuschen G, Leowardi C, Hinz U, et al. Differential expression of toll-like receptor 3 and 5 in ileal pouch mucosa of ulcerative colitis patients. Int J Colorectal Dis. 2007;22:293-301.
12. Patel RT, Bain I, Youngs D, et al. Cytokine production in pouchitis is similar to that in ulcerative colitis. Dis Colon Rectum. 1995;38:831-837.
13. Moskowitz RL, Shepherd NA, Nicholls RJ. An assessment of inflammation in the reservoir after restorative proctocolectomy with ileoanal ileal reservoir. Int J Colorectal Dis. 1986;1:167-174.
14. Sandborn WJ, Tremaine WJ, Batts KP, et al. Pouchitis after ileal pouchanal anastomosis: a Pouchitis Disease Activity Index. Mayo Clin Proc. 1994;69:409-415.
15. Tyler AD, Knox N, Kabakchiev B, et al. Characterization of the gutassociated microbiome in inflammatory pouch complications following ileal pouch-anal anastomosis. PLoS One. 2013;8:e66934.
16. Schroeder A, Mueller O, Stocker S, et al. The RIN: an RNA integrity number for assigning integrity values to RNA measurements. BMC Mol Biol. 2006;7:3.
17. Irizarry RA, Hobbs B, Collin F, et al. Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics. 2003;4:249-264.
18. Johnson WE, Li C, Rabinovic A. Adjusting batch effects in microarray expression data using empirical Bayes methods. Biostatistics. 2007;8:118-127.
19. Benjamini Y, Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Stat Soc Series B Methodol. 1995;57:289-300.
20. Huang da W, Sherman BT, Lempicki RA. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc. 2009;4:44-57.
21. Huang da W, Sherman BT, Lempicki RA. Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists. Nucleic Acids Res. 2009;37:1-13.
22. Subramanian A, Tamayo P, Mootha VK, et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A. 2005;102:15545-15550.
23. Mootha VK, Lindgren CM, Eriksson KF, et al. PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat Genet. 2003;34:267-273.
24. Nacu S, Critchley-Thorne R, Lee P, et al. Gene expression network analysis and applications to immunology. Bioinformatics. 2007;23:850-858.
25. Hirano T, Onda K, Toma T, et al. MDR1 mRNA expressions in peripheral blood mononuclear cells of patients with ulcerative colitis in relation to glucocorticoid administration. J Clin Pharmacol. 2004;44:481-486.
26. Ho GT, Nimmo ER, Tenesa A, et al. Allelic variations of the multidrug resistance gene determine susceptibility and disease behavior in ulcerative colitis. Gastroenterology. 2005;128:288-296.
27. Lal S, Stempak JM, Law C, et al. Association between the C3435T polymorphism of the MDR1 gene and Crohn's disease. Inflamm Bowel Dis. 2006;12:1006-1007.
28. Kawaguchi AL, Dunn JC, Saing MS, et al. Functional and morphologic changes of the ileal mucosa after ileoanal pouch procedure. J Am Coll Surg. 2000;190:310-314.
29. de Silva HJ, Millard PR, Kettlewell M, et al. Mucosal characteristics of pelvic ileal pouches. Gut. 1991;32:61-65.
30. Yamamoto T, Umegae S, Kitagawa T, et al. The impact of the fecal stream and stasis on immunologic reactions in ileal pouch after restorative proctocolectomy for ulcerative colitis: a prospective, pilot study. Am J Gastroenterol. 2005;100:2248-2253.
31. Garcia-Armengol J, Hinojosa J, Lledo S, et al. Prospective study of morphologic and functional changes with time in the mucosa of the ileoanal pouch: functional appraisal using transmucosal potential differences. Dis Colon Rectum. 1998;41:846-853.
32. Ostvik AE, Granlund AV, Bugge M, et al. Enhanced expression of CXCL10 in inflammatory bowel disease: potential role of mucosal Tolllike receptor 3 stimulation. Inflamm Bowel Dis. 2013;19:265-274.
33. Christophi GP, Rong R, Holtzapple PG, et al. Immune markers and differential signaling networks in ulcerative colitis and Crohn's disease. Inflamm Bowel Dis. 2012;18:2342-2356.
34. Subramanian S, Rhodes JM, Hart CA, et al. Characterization of epithelial IL-8 response to inflammatory bowel disease mucosal E. coli and its inhibition by mesalamine. Inflamm Bowel Dis. 2008;14:162-175.
35. Rieder F, Fiocchi C. Intestinal fibrosis in inflammatory bowel disease: progress in basic and clinical science. Curr Opin Gastroenterol. 2008;24:462-468.
36. Englund G, Jacobson A, Rorsman F, et al. Efflux transporters in ulcerative colitis: decreased expression of BCRP (ABCG2) and Pgp (ABCB1). Inflamm Bowel Dis. 2007;13:291-297.
37. Blokzijl H, Vander Borght S, Bok LI, et al. Decreased P-glycoprotein (P-gp/MDR1) expression in inflamed human intestinal epithelium is independent of PXR protein levels. Inflamm Bowel Dis. 2007;13:710-720.
38. Ufer M, Hasler R, Jacobs G, et al. Decreased sigmoidal ABCB1 (P-glycoprotein) expression in ulcerative colitis is associated with disease activity. Pharmacogenomics. 2009;10:1941-1953.
39. Palmieri O, Latiano A, Scimeca D, et al. IL23R, ATG16L1, IRGM, OCTN1, and OCTN2 mRNA expression in inflamed and noninflamed mucosa of IBD patients. Inflamm Bowel Dis. 2011;17:1832-1833.
40. Sartor RB. Mechanisms of disease: pathogenesis of Crohn's disease and ulcerative colitis. Nat Clin Pract Gastroenterol Hepatol. 2006;3:390-407.
41. Zhang T, DeSimone RA, Jiao X, et al. Host genes related to paneth cells and xenobiotic metabolism are associated with shifts in human ileumassociated microbial composition. PLoS One. 2012;7:e30044.
42. Repnik K, Potocnik U. Haplotype in the IBD5 region is associated with refractory Crohn's disease in Slovenian patients and modulates expression of the SLC22A5 gene. J Gastroenterol. 2011;46:1081-1091.