Functional characterization of polymorphisms in the peptidase inhibitor 3 (Elafin) gene and validation of their contribution to risk of acute respiratory distress syndrome

American Journal of Respiratory Cell and Molecular Biology

Volumn 51, Issue 2, 2014, Pages 262-272

  Tejera, Paula ^a   O'Mahony, D Shane ^b   Owen, Caroline A ^c,d   Wei, Yongyue ^a   Wang, Zhaoxi ^a   Gupta, Kushagra ^c   Su, Li ^a   Villar, Jesus ^e,f   Wurfel, Mark ^b   Christiani, David C ^a,g  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d LOVELACE RESPIRATORY RESEARCH INSTITUTE   (United States)

^e INSTITUTO DE SALUD CARLOS III   (Spain)

^f HOSPITAL UNIVERSITARIO DE GRAN CANARIA DR NEGRÍN   (Spain)

^g MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Acute respiratory distress syndrome; Elafin; Genetic association; Replication; Singlenucleotide polymorphism

Indexed keywords

ACUTE RESPIRATORY DISTRESS SYNDROME; ELAFIN; GENETIC ASSOCIATION; REPLICATION; SINGLE-NUCLEOTIDE POLYMORPHISM;

ADULT; AGED; BINDING SITES; CASE-CONTROL STUDIES; CELL LINE, TUMOR; CYTOKINES; ELAFIN; FEMALE; FIBRONECTINS; GENE EXPRESSION REGULATION; GENE FREQUENCY; GENES, REPORTER; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; HAPLOTYPES; HUMANS; LEUKOCYTE ELASTASE; LOGISTIC MODELS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; ODDS RATIO; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; RESPIRATORY DISTRESS SYNDROME, ADULT; RISK FACTORS; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; TRANSCRIPTION, GENETIC; TRANSFECTION; TRANSGLUTAMINASES;

EID: 84905505710     PISSN: 10441549     EISSN: 15354989     Source Type: Journal    
DOI: 10.1165/rcmb.2013-0238OC     Document Type: Article

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