Structure of Aurora B-INCENP in complex with barasertib reveals a potential transinhibitory mechanism

Acta Crystallographica Section F:Structural Biology Communications

Volumn 70, Issue 3, 2014, Pages 294-298

  Sessa, Fabio ^b   Villa, Fabrizio ^a  

^a EUROPEAN INSTITUTE OF ONCOLOGY   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

Author keywords

Aurora kinases; barasertib; cancer; PKA; small molecule inhibitors

Indexed keywords

2 ((3 ((4 ((5 (2 ((3 FLUOROPHENYL)AMINO) 2 OXOETHYL) 1H PYRAZOL 3 YL)AMINO)QUINAZOLIN 7 YL)OXY)PROPYL)(ETHYL)AMINO)ETHYL DIHYDROGEN PHOSPHATE; 2-((3-((4-((5-(2-((3-FLUOROPHENYL)AMINO)-2-OXOETHYL)-1H-PYRAZOL-3-YL)AMINO)QUINAZOLIN-7-YL)OXY)PROPYL)(ETHYL)AMINO)ETHYL DIHYDROGEN PHOSPHATE; ADENYLYLIMIDODIPHOSPHATE; ANTINEOPLASTIC AGENT; AURORA B KINASE; AURORA KINASE; BARASERTIB; INCENP PROTEIN, XENOPUS; NONHISTONE PROTEIN; ORGANOPHOSPHATE; QUINAZOLINE DERIVATIVE; XENOPUS PROTEIN;

AMINO ACID SEQUENCE; ANIMAL; ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME ACTIVE SITE; HUMAN; HYDROGEN BOND; MOLECULAR GENETICS; NEOPLASM; PKA; PROTEIN BINDING; PROTEIN QUATERNARY STRUCTURE; PROTEIN SECONDARY STRUCTURE; SMALL-MOLECULE INHIBITORS; STRUCTURAL HOMOLOGY; X RAY CRYSTALLOGRAPHY; XENOPUS LAEVIS;

AURORA KINASES; BARASERTIB; CANCER; PKA; SMALL-MOLECULE INHIBITORS;

ADENYLYL IMIDODIPHOSPHATE; AMINO ACID SEQUENCE; ANIMALS; ANTINEOPLASTIC AGENTS; AURORA KINASE B; CATALYTIC DOMAIN; CHROMOSOMAL PROTEINS, NON-HISTONE; CRYSTALLOGRAPHY, X-RAY; HUMANS; HYDROGEN BONDING; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; ORGANOPHOSPHATES; PROTEIN BINDING; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, SECONDARY; QUINAZOLINES; STRUCTURAL HOMOLOGY, PROTEIN; XENOPUS LAEVIS; XENOPUS PROTEINS;

EID: 84905499629     PISSN: None     EISSN: 2053230X     Source Type: Journal    
DOI: 10.1107/S2053230X14002118     Document Type: Article

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