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Volumn 4, Issue 2, 2014, Pages 75-81

The effect of single dose of thymoquinone, the main constituents of Nigella sativa, in guinea pig model of asthma

Author keywords

Asthma; Inflammation; Responsiveness; Thymoquinone; Tracheal

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 4; METHACHOLINE; THYMOQUINONE;

EID: 84905487771     PISSN: 22285652     EISSN: 22285660     Source Type: Journal    
DOI: 10.5681/bi.2014.006     Document Type: Article
Times cited : (37)

References (30)
  • 1
    • 50849094871 scopus 로고    scopus 로고
    • The Rabbit a Model to Study Asthma and Other Lung Diseases
    • Keir S, Page C. The Rabbit a Model to Study Asthma and Other Lung Diseases. Pulm Pharmacol Ther 2008; 21: 721-30.
    • (2008) Pulm Pharmacol Ther , vol.21 , pp. 721-730
    • Keir, S.1    Page, C.2
  • 2
    • 33745007923 scopus 로고    scopus 로고
    • Downregulation of Leukotriene Biosynthesis by Thymoquinone Attenuates Airway Inflammation in a Mouse Model of Allergic Asthma
    • El Gazzar M, El Mezayen R, Nicolls MR, Marecki JC, Dreskin SC. Downregulation of Leukotriene Biosynthesis by Thymoquinone Attenuates Airway Inflammation in a Mouse Model of Allergic Asthma. Biochim Biophys Acta 2006; 1760: 1088-95.
    • (2006) Biochim Biophys Acta , vol.1760 , pp. 1088-1095
    • El Gazzar, M.1    El Mezayen, R.2    Nicolls, M.R.3    Marecki, J.C.4    Dreskin, S.C.5
  • 3
    • 33644778637 scopus 로고    scopus 로고
    • Adenosine in the Airways: Implications and Applications
    • Spicuzza L, Di Maria G, Polosa R. Adenosine in the Airways: Implications and Applications. Eur J Pharm Biopharm 2006; 533: 77-88.
    • (2006) Eur J Pharm Biopharm , vol.533 , pp. 77-88
    • Spicuzza, L.1    Di Maria, G.2    Polosa, R.3
  • 5
    • 11044232238 scopus 로고    scopus 로고
    • Inhibition of 5-Lipoxygenase and Leukotriene C4 Synthase in Human Blood Cells by Thymoquinone
    • Mansour M, Tornhamre S. Inhibition of 5-Lipoxygenase and Leukotriene C4 Synthase in Human Blood Cells by Thymoquinone. J Enzyme Inhib Med Chem 2004; 19: 431-6.
    • (2004) J Enzyme Inhib Med Chem , vol.19 , pp. 431-436
    • Mansour, M.1    Tornhamre, S.2
  • 6
    • 84855810908 scopus 로고    scopus 로고
    • Thymoquinone: Potential Cure for Inflammatory Disorders and Cancer
    • Woo CC, Kumar AP, Sethi G, Tan KH. Thymoquinone: Potential Cure for Inflammatory Disorders and Cancer. Biochem Pharmacol 2012; 83: 443-51.
    • (2012) Biochem Pharmacol , vol.83 , pp. 443-451
    • Woo, C.C.1    Kumar, A.P.2    Sethi, G.3    Tan, K.H.4
  • 7
    • 0346095660 scopus 로고    scopus 로고
    • Effect of Nigella Sativa (Black Seed) on Subjective Feeling in Patients with Allergic Diseases
    • Kalus U, Pruss A, Bystron J, Jurecka M, Smekalova A, Lichius JJ, et al. Effect of Nigella Sativa (Black Seed) on Subjective Feeling in Patients with Allergic Diseases. Phytother Res 2003; 17: 1209-14.
    • (2003) Phytother Res , vol.17 , pp. 1209-1214
    • Kalus, U.1    Pruss, A.2    Bystron, J.3    Jurecka, M.4    Smekalova, A.5    Lichius, J.J.6
  • 8
    • 81855201819 scopus 로고    scopus 로고
    • Comparative evaluation of anti-inflammatory poperties of thymoquinone and curcumin using an asthmatic murine model
    • Ammar el SM, Gameil NM, Shawky NM, Nader MA. Comparative evaluation of anti-inflammatory poperties of thymoquinone and curcumin using an asthmatic murine model. Int Immunopharmacol 2011; 11: 2232-6.
    • (2011) Int Immunopharmacol , vol.11 , pp. 2232-2236
    • Ammar el, S.M.1    Gameil, N.M.2    Shawky, N.M.3    Nader, M.A.4
  • 10
    • 77049125281 scopus 로고    scopus 로고
    • The effect of thymoquinone, the main constituent of Nigella sativa on tracheal responsiveness and white blood cell count in lung lavage of sensitized guinea pigs
    • Keyhanmanesh R, Boskabady MH, Eslamizadeh MJ, Khamneh S, Ebrahimi MA. The effect of thymoquinone, the main constituent of Nigella sativa on tracheal responsiveness and white blood cell count in lung lavage of sensitized guinea pigs. Planta Med 2009; 76: 218-22.
    • (2009) Planta Med , vol.76 , pp. 218-222
    • Keyhanmanesh, R.1    Boskabady, M.H.2    Eslamizadeh, M.J.3    Khamneh, S.4    Ebrahimi, M.A.5
  • 11
    • 79551494122 scopus 로고    scopus 로고
    • Effect of thymoquinone on the lung pathology and cytokine levels of ovalbumin-sensitized guinea pigs
    • Keyhanmanesh R, Boskabady MH, Khamneh S, Doostar Y. Effect of thymoquinone on the lung pathology and cytokine levels of ovalbumin-sensitized guinea pigs. Pharmacol Rep 2010; 62: 910-6.
    • (2010) Pharmacol Rep , vol.62 , pp. 910-916
    • Keyhanmanesh, R.1    Boskabady, M.H.2    Khamneh, S.3    Doostar, Y.4
  • 12
    • 79954563577 scopus 로고    scopus 로고
    • Potential Immunomodulation Effect of the Extract of Nigella Sativa on Ovalbumin Sensitized Guinea Pigs
    • Boskabady MH, Keyhanmanesh R, Khamneh S, Doostar Y, Khakhzad MR. Potential Immunomodulation Effect of the Extract of Nigella Sativa on Ovalbumin Sensitized Guinea Pigs. J Zhejiang Univ-Sci B 2011; 12: 201-9.
    • (2011) J Zhejiang Univ-Sci B , vol.12 , pp. 201-209
    • Boskabady, M.H.1    Keyhanmanesh, R.2    Khamneh, S.3    Doostar, Y.4    Khakhzad, M.R.5
  • 13
    • 67549093936 scopus 로고    scopus 로고
    • Relaxant Effect of Different Fractions from Nigella Sativa L, On Guinea Pig Tracheal Chains and Its Possible Mechanism(S)
    • Boskabady MH, Keyhanmanesh R, Ebrahimi Saadatlou MA. Relaxant Effect of Different Fractions from Nigella Sativa L. On Guinea Pig Tracheal Chains and Its Possible Mechanism(S). Indian J Experimental Biology 2008; 46: 805-10.
    • (2008) Indian J Experimental Biology , vol.46 , pp. 805-810
    • Boskabady, M.H.1    Keyhanmanesh, R.2    Ebrahimi Saadatlou, M.A.3
  • 14
    • 79960747963 scopus 로고    scopus 로고
    • The Effect of Nigella Sativa Extract on Tracheal Responsiveness and Lung Inflammation in Ovalbumin Sensitized Guinea Pigs
    • Boskabady MH, Keyhanmanesh R, Khamneh S, Ebrahimi Saadatlou MA. The Effect of Nigella Sativa Extract on Tracheal Responsiveness and Lung Inflammation in Ovalbumin Sensitized Guinea Pigs. Clinics (Sao Paulo) 2011; 66: 879-87.
    • (2011) Clinics (Sao Paulo) , vol.66 , pp. 879-887
    • Boskabady, M.H.1    Keyhanmanesh, R.2    Khamneh, S.3    Ebrahimi Saadatlou, M.A.4
  • 15
    • 0029040416 scopus 로고
    • Effect of Allergen Provocation on Inflammatory Cell Profile and Endothelin-Like Immunoreactivity in Guinea-Pig Airways
    • Andersson SE, Zackrisson C, Behrens K, Hemsen A, Forsberg K, Linden M, et al. Effect of Allergen Provocation on Inflammatory Cell Profile and Endothelin-Like Immunoreactivity in Guinea-Pig Airways. Allergy 1995; 50: 349-58.
    • (1995) Allergy , vol.50 , pp. 349-358
    • Andersson, S.E.1    Zackrisson, C.2    Behrens, K.3    Hemsen, A.4    Forsberg, K.5    Linden, M.6
  • 17
    • 0037003174 scopus 로고    scopus 로고
    • Inhibitory Effect of Nigella Sativa on Histamine (H1) Receptors of Isolated Guinea Pig Tracheal Chains
    • Boskabady M, Shiravi N. Inhibitory Effect of Nigella Sativa on Histamine (H1) Receptors of Isolated Guinea Pig Tracheal Chains. Pharmac Biol 2002; 40: 596-602.
    • (2002) Pharmac Biol , vol.40 , pp. 596-602
    • Boskabady, M.1    Shiravi, N.2
  • 18
    • 2342626583 scopus 로고    scopus 로고
    • Black Cumin Seed Essential Oil, as a Potent Analgesic and Anti-Inflammatory Drug
    • Hajhashemi V, Ghannadi A, Jafarabadi H. Black Cumin Seed Essential Oil, as a Potent Analgesic and Anti-Inflammatory Drug. Phytother Res 2004; 18: 195-9.
    • (2004) Phytother Res , vol.18 , pp. 195-199
    • Hajhashemi, V.1    Ghannadi, A.2    Jafarabadi, H.3
  • 19
    • 28444497796 scopus 로고    scopus 로고
    • Possible Relaxant Effects of Thymoquinone on Guinea Pig Tracheal Chain
    • Boskabady MH, Aslani MR. Possible Relaxant Effects of Thymoquinone on Guinea Pig Tracheal Chain. Iran Biomed J 2005; 9: 123-8.
    • (2005) Iran Biomed J , vol.9 , pp. 123-128
    • Boskabady, M.H.1    Aslani, M.R.2
  • 21
    • 28044473224 scopus 로고    scopus 로고
    • The Role of the Foxp3 Transcription Factor in the Immune Regulation of Allergic Asthma
    • Schmidt-Weber CB, Blaser K. The Role of the Foxp3 Transcription Factor in the Immune Regulation of Allergic Asthma. Curr Allergy Asthma Rep 2005; 5: 356-61.
    • (2005) Curr Allergy Asthma Rep , vol.5 , pp. 356-361
    • Schmidt-Weber, C.B.1    Blaser, K.2
  • 22
    • 21744433238 scopus 로고    scopus 로고
    • Cd4/Cd25 Regulatory T Lymphocytes in Allergy and Asthma
    • Shi HZ, Qin XJ. Cd4/Cd25 Regulatory T Lymphocytes in Allergy and Asthma. Allergy 2005; 60: 986-95.
    • (2005) Allergy , vol.60 , pp. 986-995
    • Shi, H.Z.1    Qin, X.J.2
  • 23
    • 0023235855 scopus 로고
    • Enhanced Alveolar Cell Luminol-Dependent Chemiluminescence in Asthma
    • Cluzel M, Damon M, Chanez P. Enhanced Alveolar Cell Luminol-Dependent Chemiluminescence in Asthma. J Allergy Clin Immunol 1987; 80: 195-201.
    • (1987) J Allergy Clin Immunol , vol.80 , pp. 195-201
    • Cluzel, M.1    Damon, M.2    Chanez, P.3
  • 24
    • 0025186606 scopus 로고
    • Oxygen Metabolites Stimulate Release of High-Molecular-Weight Glycoconjugates by Cell and Organ Cultures of Rodent Respiratory Epithelium Via an Arachidonic Acid Dependent Mechanism
    • Adler KB, Holden-Stauffer WJ, Repine JE. Oxygen Metabolites Stimulate Release of High-Molecular-Weight Glycoconjugates by Cell and Organ Cultures of Rodent Respiratory Epithelium Via an Arachidonic Acid Dependent Mechanism. J Clin Invest 1990; 85: 75-85.
    • (1990) J Clin Invest , vol.85 , pp. 75-85
    • Adler, K.B.1    Holden-Stauffer, W.J.2    Repine, J.E.3
  • 25
    • 0000926036 scopus 로고
    • Nigellimine-N-Oxide - a New Isoquinoline Alkaloid from the Seeds of Nigella Sativa
    • Rahman A, Malik S, Ahmed S, Choudhary M I, Rehman H. Nigellimine-N-Oxide - a New Isoquinoline Alkaloid from the Seeds of Nigella Sativa. Heterocycles 1985; 23: 953-955.
    • (1985) Heterocycles , vol.23 , pp. 953-955
    • Rahman, A.1    Malik, S.2    Ahmed, S.3    Choudhary, M.I.4    Rehman, H.5
  • 27
    • 0002850038 scopus 로고
    • Some Pharmacological Properties of Some Constituents of Nigella Sativa L Seeds: The Carbonyl Fraction of Essential Oil
    • EL-Dakhakhany M. Some Pharmacological Properties of Some Constituents of Nigella Sativa L Seeds: The Carbonyl Fraction of Essential Oil. Proceedings of the 2ndInternational Conference on Islamic Medicine 1982; 426-31.
    • (1982) Proceedings of the 2ndInternational Conference on Islamic Medicine , pp. 426-431
    • El-Dakhakhany, M.1
  • 28
    • 27744476617 scopus 로고    scopus 로고
    • Immunomodulatory and Therapeutic Properties of the Nigella Sativa L. Seed.
    • Labib Salem M. Immunomodulatory and Therapeutic Properties of the Nigella Sativa L. Seed. Int J Immunopharmacol 2005; 5: 1749-1770.
    • (2005) Int J Immunopharmacol , vol.5 , pp. 1749-1770
    • Labib Salem, M.1
  • 29
    • 78649673581 scopus 로고    scopus 로고
    • Effects of Nigella Sativa and Thymoquinone on Biochemical and Subcellular Changes in Pancreatic Beta-Cells of Streptozotocin-Induced Diabetic Rats
    • Abdelmeguid NE, Fakhoury R, Kamal SM, Al Wafai RJ. Effects of Nigella Sativa and Thymoquinone on Biochemical and Subcellular Changes in Pancreatic Beta-Cells of Streptozotocin-Induced Diabetic Rats. J Diabetes 2010; 2: 256-66.
    • (2010) J Diabetes , vol.2 , pp. 256-266
    • Abdelmeguid, N.E.1    Fakhoury, R.2    Kamal, S.M.3    Al Wafai, R.J.4
  • 30
    • 0028852880 scopus 로고
    • Fixed Oil of Nigella Sativa and Derived Thymoquinone Inhibit Eicosanoid Generation in Leukocytes and Membrane Lipidperoxidation
    • Houghton P, Zarka R, De las Heras B, Hoult J. Fixed Oil of Nigella Sativa and Derived Thymoquinone Inhibit Eicosanoid Generation in Leukocytes and Membrane Lipidperoxidation. Planta Med 1995; 61: 33-6
    • (1995) Planta Med , vol.61 , pp. 33-36
    • Houghton, P.1    Zarka, R.2    De las Heras, B.3    Hoult, J.4


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