Calpain 1 inhibitor BDA-410 ameliorates α-klotho-deficiency phenotypes resembling human aging-related syndromes

Scientific Reports

Volumn 4, Issue , 2014, Pages

  Nabeshima, Yoko ^a   Washida, Miwa ^a   Tamura, Masaru ^b   Maeno, Akiteru ^b   Ohnishi, Mutsuko ^c   Shiroishi, Toshihiko ^b   Imura, Akihiro ^a   Razzaque, M Shawkat ^c,d   Nabeshima, Yo Ichi ^a  

^a INSTITUTE OF BIOMEDICAL RESEARCH AND INNOVATION   (Japan)

^b NATIONAL INSTITUTE OF GENETICS   (Japan)

^c HARVARD SCHOOL OF DENTAL MEDICINE   (United States)

^d FORSYTH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GLUCURONIDASE; CALPAIN; CAPN1 PROTEIN, MOUSE; FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 23; KLOTHO PROTEIN; N-1-(HYDROXY(3-OXO-2-PHENYL-1-CYCLOPROPEN-1-YL)METHYL)-2-METHYLPROPYL-2-BENZENESULFONYLAMINO-4-METHYLPENTANAMIDE; SULFONAMIDE;

AGING; ANIMAL; ANTAGONISTS AND INHIBITORS; BLOOD; DEFICIENCY; DRUG SCREENING; FEMALE; GENETICS; HUMAN; KNOCKOUT MOUSE; MALE; METABOLISM; PHENOTYPE; RENAL INSUFFICIENCY, CHRONIC; VASCULAR CALCIFICATION;

AGING; ANIMALS; CALPAIN; DRUG EVALUATION, PRECLINICAL; FEMALE; FIBROBLAST GROWTH FACTORS; GLUCURONIDASE; HUMANS; MALE; MICE, KNOCKOUT; PHENOTYPE; RENAL INSUFFICIENCY, CHRONIC; SULFONAMIDES; VASCULAR CALCIFICATION;

EID: 84905454991     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep05847     Document Type: Article

References (50)

1. Kuro-o, M. et al. Mutation of the mouse Klotho gene leads to a syndrome resembling ageing. Nature 390, 45-51 (1997
2. Y,oshida, T., Fujimori, T. & Nabeshima, Y. Mediation of unusually high concentrations of 1,25-dihydroxyvitamin D3 in homozygous klothomutantmice by increased expression of renal 1alpha-hydroxylase gene. Endocrinology 143, 683-689 (2002 (Pubitemid 34107224)
3. Tsujikawa, H., Kurotaki, Y., Fujimori, T., Fukuda, K. & Nabeshima, Y. Klotho, a gene related to a syndrome resembling human premature aging, functions in a negative regulatory circuit of vitamin D endocrine system. Mol. Endocrinol. 17, 2393-2403 (2003 (Pubitemid 37542205)
4. Ohnishi, M., Nakatani, T., Lanske, B. & Razzaque, M. S. Reversal of mineral ion homeostasis and soft-tissue calcification of klotho knockout mice by deletion of vitamin D 1a-hydroxylase. Kidney Int. 75, 1166-1172 (2006
5. Razzaque, M. S., Sitara, D., Taguchi, T., St-Arnaud, R. & Lanske, B. Premature aging-like phenotype in fibroblast growth factor 23 null mice is a vitamin D mediated process. FASEB J. 20, 720-722 (2006 (Pubitemid 46671193)
6. Nakatani, T. et al. In vivo genetic evidence for klotho-dependent, fibroblast growth factor 23 (Fgf23)-mediated regulation of systemic phosphate homeostasis. FASEB J. 23, 433-41 (2009
7. Urakawa, I. et al. Klotho converts canonical FGF receptor into a specific receptor for FGF23. Nature 444, 770-774 (2006 (Pubitemid 44949607)
8. Bhattacharyya, N., Chong, W. H., Gafni, R. I. & Collins, M. T. Fibroblast growth factor 23: State of the field and future directions. Trends in Endocrinology & Metabolism 23, 610-618 (2012
9. Kovesdy, C. P. & Quarles, L. D. Fibroblast growth factor-23: What we know, what we don't know, and what we need to know. Nephrol. Dial. Transplant. Apr 25 (2013
10. London, G. M. & Drueke, T. B. Atherosclerosis and arteriosclerosis in chronic renal failure. Kidney Int. 51, 1678-1695 (1997 (Pubitemid 27252735)
11. Rostand, S. G. & Drueke, T. B. Parathyroid hormone, vitamin D, and cardiovascular disease in chronic renal failure. Kidney Int. 56, 383-392 (1999 (Pubitemid 29353135)
12. Milliner, D. S., Zinsmeister, A. R., Lieberman, E. & Landing, B. Soft tissue calcification in pediatric patients with end-stage renal disease. Kidney Int. 38, 931-936 (1990 (Pubitemid 20362865)
13. Urena, P. & De Vernejoul, M. C. Circulating biochemical markers of bone remodeling in uremic patients. Kidney Int. 55, 2141-2156 (1999 (Pubitemid 29256470)
14. Kuizon, B. D. & Salusky, I. B. Growth retardation in children with chronic renal failure. J. Bone Miner. Res. 14, 1680-1690 (1999 (Pubitemid 29455816)
15. Koh, N. et al. Severely reduced expression of Klotho gene in human chronic renal failure kidney. Biochem. Biophys. Res. Commun. 280, 1015-1020 (2001 (Pubitemid 32924441)
16. Mathew, S., Tustison, K. S., Sugatani, T., Chaudhary, L. R., Rifas, L. & Hruska, K. A. Themechanism of phosphorus as a cardiovascular risk factor in CKD. J. Am. Soc. Nephrol. 19, 1092-1105 (2008
17. Komaba, H. & Fukagawa, M. The role of FGF23 in CKD-with or without Klotho. Nat. Rev. Nephrol. 8, 484-90 (2012
18. Quarles, L. D. Role of FGF23 in vitamin D and phosphate metabolism: Implications in chronic kidney disease. Exp. Cell Res. 318, 1040-1048 (2012
19. Stubbs, J. R. et al. Role of hyperphosphatemia and 1,25-dihydroxyvitamin D in vascular calcification and mortality in fibroblastic growth factor 23 null mice. J Am Soc Nephrol 18, 2116-2124 (2007 (Pubitemid 47041077)
20. Wallin, R., Wajih, N., Greenwood, G. T. & Sane, D. C. Arterial calcification: A review of mechanisms, animal models, and the prospects for therapy. Med Res Rev 21, 274-301 (2001 (Pubitemid 32565495)
21. Proudfoot, D. & Shanahan, C. M. Molecular mechanisms mediating vascular calcification: Role of matrix Gla protein. Nephrology 11, 455-461 (2006 (Pubitemid 44470096)
22. Moe, S. M. et al. Role of calcification inhibitors in the pathogenesis of vascular calcification in chronic kidney disease (CKD). Kidney Int. 67, 2295-2304 (2005 (Pubitemid 41623389)
23. Mellgren, R. L. & Huang, X. Fetuin A stabilizes m-calpain and facilitates plasma membrane repair. J Biol Chem 282, 35868-35877 (2007 (Pubitemid 350277142)
24. Razzaque, M. S. & Lanske, B. Hypervitaminosis D and premature aging: Lessons learned from Fgf23 and Klotho mutant mice. Trends Mol Med. 12, 298-305 (2006 (Pubitemid 44110001)
25. Razzaque, M. S. Phosphate toxicity: New insights into an old problem. Clin Sci (Lond). 120, 91-7 (2011
26. Ohnishi, M.&Razzaque,M. S.Dietary and genetic evidence for phosphate toxicity accelerating mammalian aging. FASEB J. 24, 3562-3571 (2010
27. Narvaez, C. J., Zinser, G. &Welsh, J. Functions of 1a, 25-dihydroxyvitamin D3 in mammary gland: From normal development to breast cancer. Steroids 66, 301-308 (2001 (Pubitemid 32140908)
28. Johnson, C. S., Hershberger, P. A. & Trump, D. L. Vitamin D-related therapies in prostate cancer. Cancer Metastasis Rev. 21, 147-158 (2002 (Pubitemid 35351835)
29. Johnson, C. S., Muindi, J. R., Hershberger, P. A. & Trump, D. L. The antitumor efficacy of calcitriol: Preclinical studies. Anticancer Res. 26, 2543-2549 (2006 (Pubitemid 44155533)
30. Demay, M. B. Mechanism of vitamin D receptor action. Ann. N. Y. Acad. Sci. 1068, 204-213 (2006 (Pubitemid 43824151)
31. Medici, D. et al. FGF-23-Klotho signaling stimulates proliferation and prevents vitamin D-induced apoptosis. J. Cell Biol. 182, 459-465 (2008
32. Manya, H., Fujimori, T.,Nabeshima, Y.&Endo, T. Klotho protein deficiency leads to overactivation of (Mu)-calpain. J. Biol. Chem. 277, 35503-35508 (2002
33. Goll, D. E., Thompson, V. F., Li, H., Wei, W. & Cong, J. The calpain system. Physiol. Rev. 83, 731-801 (2003 (Pubitemid 36828925)
34. Campbell, R. L. & Davies, P. L. Structure-function relationships in calpains. Biochem. J. 447, 335-351 (2012
35. Wang, K. K. & Yuen, P. W. Calpain inhibition: An overview of its therapeutic potential. Trends Pharmacol. Sci. 15, 412-419 (1994 (Pubitemid 24360511)
36. Lee, M. S. et al. Neurotoxicity induces cleavage of p35 to p25 by calpain. Nature 405, 360-364 (2000
37. Sato, A. et al. Morphological mechanism of the development of pulmonary emphysema in klotho mice. Proc. Natl. Acad. Sci. USA 104, 2361-2365 (2007 (Pubitemid 46391402)
38. Calleja-Agius, J., Muscat-Baron, Y. & Brincat, M. P. Skin ageing. Menopause Int. 13, 60-64 (2007
39. Alonso, L. & Fuchs, E. The hair cycle. J. Cell Sci. 119, 391-393 (2006
40. Sage, A. P., Tintut, Y. & Demer, L. L. Regulatory mechanisms in atherosclerotic calcification. Nat. Rev. Cardiol. 7, 528-536 (2010
41. Shao, J. S., Cheng, S. L., Sadhu, J.&Towler, D. A. Inflammation and the osteogenic regulation of vascular calcification: A review and perspective. Hypertension 55, 579-592 (2010
42. Sergeev, I. N. 1,25-Dihydroxyvitamin D3 induces Ca21-mediated apoptosis in adipocytes via activation of calpain and caspase-12. Biochem. Biophys. Res. Commun. 384, 18-21 (2009
43. Sergeev, I. N. Calcium signaling in cancer and vitamin D. J. Steroid Biochem.Mol. Biol. 97, 145-151 (2005 (Pubitemid 41546224)
44. Trinchese, F. et al. Inhibition of calpains improves memory and synaptic transmission in a mouse model of Alzheimer disease. J. Clin. Invest. 118, 2796-2807 (2008
45. Isakova, T. et al. Chronic Renal Insufficiency Cohort Study Group: Fibroblast growth factor 23 is elevated before parathyroid hormone and phosphate in chronic kidney disease. Kidney Int. 79, 1370-1378 (2011
46. Kendrick, J. & Chonchol, M. The role of phosphorus in the development and progression of vascular calcification. Am. J. Kidney Dis. 58, 826-834 (2011
47. Dardenne, O., Prud'homme, J., Arabian, A., Glorieux, F. H. & St-Arnaud, R. Targeted inactivation of the 25-hydroxyvitamin D(3)-1(alpha)-hydroxylase gene (CYP27B1) creates an animal model of pseudovitamin D-deficiency rickets. Endocrinology 142, 3135-3141 (2001 (Pubitemid 32575552)
48. Li, X., Chen, H., Jeong, J.-J., Athar, H.&Chishti, A. H. BDA-410: Anovel synthetic calpain inhibitor active against blood stage malaria. Mol. Biochem. Parasitol. 155, 26-32 (2007 (Pubitemid 47042214)
49. De Franceschi, L. et al. Pharmacological inhibition of calpain-1 prevents red cell dehydration and reduces Gardos channel activity in a mouse model of sickle cell disease. FASEB J. 27, 750-759 (2013
50. Subramanian, V. et al. Calpain inhibition attenuates angiotensin II-induced abdominal aortic aneurysms and atherosclerosis in low-density lipoprotein receptor-deficient mice. J. Cardiovasc. Pharmacol. 59, 66-76 (2012).