메뉴 건너뛰기




Volumn 28, Issue 9, 2013, Pages 2228-2236

Fibroblast growth factor-23: What we know, what we don't know, and what we need to know

Author keywords

Chronic kidney disease; FGF23; Outcomes; Physiology

Indexed keywords

FIBROBLAST GROWTH FACTOR 23; FIBROBLAST GROWTH FACTOR RECEPTOR;

EID: 84884522131     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gft065     Document Type: Review
Times cited : (90)

References (102)
  • 2
    • 1642413198 scopus 로고    scopus 로고
    • Longitudinal followup and outcomes among a population with chronic kidney disease in a large managed care organization
    • Keith DS, Nichols GA, Gullion CM et al. Longitudinal followup and outcomes among a population with chronic kidney disease in a large managed care organization. Arch Intern Med 2004; 164: 659-663
    • (2004) Arch Intern Med , vol.164 , pp. 659-663
    • Keith, D.S.1    Nichols, G.A.2    Gullion, C.M.3
  • 3
    • 20144387681 scopus 로고    scopus 로고
    • Cardiovascular mortality risk in chronic kidney disease: Comparison of traditional and novel risk factors
    • Shlipak MG, Fried LF, Cushman M et al. Cardiovascular mortality risk in chronic kidney disease: comparison of traditional and novel risk factors. JAMA 2005; 293: 1737-1745
    • (2005) JAMA , vol.293 , pp. 1737-1745
    • Shlipak, M.G.1    Fried, L.F.2    Cushman, M.3
  • 4
    • 0035901585 scopus 로고    scopus 로고
    • Renal insufficiency as a predictor of cardiovascular outcomes and the impact of ramipril: The HOPE randomized trial
    • Mann JF, Gerstein HC, Pogue J et al. Renal insufficiency as a predictor of cardiovascular outcomes and the impact of ramipril: the HOPE randomized trial. Ann Intern Med 2001; 134: 629-636
    • (2001) Ann Intern Med , vol.134 , pp. 629-636
    • Mann, J.F.1    Gerstein, H.C.2    Pogue, J.3
  • 5
    • 0037337398 scopus 로고    scopus 로고
    • Reverse epidemiology of cardiovascular risk factors in maintenance dialysis patients
    • Kalantar-Zadeh K, Block G, Humphreys MH et al. Reverse epidemiology of cardiovascular risk factors in maintenance dialysis patients. Kidney Int 2003; 63: 793-808
    • (2003) Kidney Int , vol.63 , pp. 793-808
    • Kalantar-Zadeh, K.1    Block, G.2    Humphreys, M.H.3
  • 6
    • 33846029870 scopus 로고    scopus 로고
    • Inverse association between lipid levels and mortality in men with chronic kidney disease who are not yet on dialysis: Effects of case mix and the malnutrition-inflammation-cachexia syndrome
    • Kovesdy CP, Anderson JE, Kalantar-Zadeh K. Inverse association between lipid levels and mortality in men with chronic kidney disease who are not yet on dialysis: effects of case mix and the malnutrition-inflammation-cachexia syndrome. J Am Soc Nephrol 2007; 18: 304-311
    • (2007) J Am Soc Nephrol , vol.18 , pp. 304-311
    • Kovesdy, C.P.1    Anderson, J.E.2    Kalantar-Zadeh, K.3
  • 7
    • 33646165340 scopus 로고    scopus 로고
    • Association of low blood pressure with increased mortality in patients with moderate to severe chronic kidney disease
    • Kovesdy CP, Trivedi BK, Kalantar-Zadeh K et al. Association of low blood pressure with increased mortality in patients with moderate to severe chronic kidney disease. Nephrol Dial Transplant 2006; 21: 1257-1262
    • (2006) Nephrol Dial Transplant , vol.21 , pp. 1257-1262
    • Kovesdy, C.P.1    Trivedi, B.K.2    Kalantar-Zadeh, K.3
  • 8
    • 34247476791 scopus 로고    scopus 로고
    • Paradoxical association between body mass index and mortality in men with CKD not yet on dialysis
    • Kovesdy CP, Anderson JE, Kalantar-Zadeh K. Paradoxical association between body mass index and mortality in men with CKD not yet on dialysis. Am J Kidney Dis 2007; 49: 581-591
    • (2007) Am J Kidney Dis , vol.49 , pp. 581-591
    • Kovesdy, C.P.1    Anderson, J.E.2    Kalantar-Zadeh, K.3
  • 9
    • 63849163945 scopus 로고    scopus 로고
    • Rosuvastatin and cardiovascular events in patients undergoing hemodialysis
    • Fellstrom BC, Jardine AG, Schmieder RE et al. Rosuvastatin and cardiovascular events in patients undergoing hemodialysis. N Engl J Med 2009; 360: 1395-1407
    • (2009) N Engl J Med , vol.360 , pp. 1395-1407
    • Fellstrom, B.C.1    Jardine, A.G.2    Schmieder, R.E.3
  • 10
    • 22344458137 scopus 로고    scopus 로고
    • Atorvastatin in patients with type 2 diabetes mellitus undergoing hemodialysis
    • Wanner C, Krane V, Marz Wet al. Atorvastatin in patients with type 2 diabetes mellitus undergoing hemodialysis. N Engl J Med 2005; 353: 238-248
    • (2005) N Engl J Med , vol.353 , pp. 238-248
    • Wanner, C.1    Krane, V.2    Marz, W.3
  • 11
    • 77950801451 scopus 로고    scopus 로고
    • Outcomes associated with serum phosphorus level in males with non-dialysis dependent chronic kidney disease
    • Kovesdy CP, Anderson JE, Kalantar-Zadeh K. Outcomes associated with serum phosphorus level in males with non-dialysis dependent chronic kidney disease. Clin Nephrol 2010; 73: 268-275
    • (2010) Clin Nephrol , vol.73 , pp. 268-275
    • Kovesdy, C.P.1    Anderson, J.E.2    Kalantar-Zadeh, K.3
  • 12
    • 33947320099 scopus 로고    scopus 로고
    • Association of disorders in mineral metabolism with progression of chronic kidney disease
    • Schwarz S, Trivedi BK, Kalantar-Zadeh K et al. Association of disorders in mineral metabolism with progression of chronic kidney disease. Clin J Am Soc Nephrol 2006; 1: 825-831
    • (2006) Clin J Am Soc Nephrol , vol.1 , pp. 825-831
    • Schwarz, S.1    Trivedi, B.K.2    Kalantar-Zadeh, K.3
  • 13
    • 77749251788 scopus 로고    scopus 로고
    • Outcomes associated with serum calcium level in men with non-dialysis-dependent chronic kidney disease
    • Kovesdy CP, Kuchmak O, Lu JL et al. Outcomes associated with serum calcium level in men with non-dialysis-dependent chronic kidney disease. Clin J Am Soc Nephrol 2010; 5: 468-476
    • (2010) Clin J Am Soc Nephrol , vol.5 , pp. 468-476
    • Kovesdy, C.P.1    Kuchmak, O.2    Lu, J.L.3
  • 14
    • 43749124436 scopus 로고    scopus 로고
    • Secondary hyperparathyroidism is associated with higher mortality in men with moderate to severe chronic kidney disease
    • Kovesdy CP, Ahmadzadeh S, Anderson JE et al. Secondary hyperparathyroidism is associated with higher mortality in men with moderate to severe chronic kidney disease. Kidney Int 2008; 73: 1296-1302
    • (2008) Kidney Int , vol.73 , pp. 1296-1302
    • Kovesdy, C.P.1    Ahmadzadeh, S.2    Anderson, J.E.3
  • 15
    • 77956236574 scopus 로고    scopus 로고
    • Outcome predictability of serum alkaline phosphatase in men with pre-dialysis CKD
    • Kovesdy CP, Ureche V, Lu JL et al. Outcome predictability of serum alkaline phosphatase in men with pre-dialysis CKD. Nephrol Dial Transplant 2010; 25: 3003-3011
    • (2010) Nephrol Dial Transplant , vol.25 , pp. 3003-3011
    • Kovesdy, C.P.1    Ureche, V.2    Lu, J.L.3
  • 16
    • 33845745462 scopus 로고    scopus 로고
    • Chronic kidney diseasemineral-bone disorder: A new paradigm
    • Moe SM, Drueke T, Lameire N et al. Chronic kidney diseasemineral-bone disorder: a new paradigm. Adv Chronic Kidney Dis 2007; 14: 3-12
    • (2007) Adv Chronic Kidney Dis , vol.14 , pp. 3-12
    • Moe, S.M.1    Drueke, T.2    Lameire, N.3
  • 17
    • 0015514781 scopus 로고
    • On the pathogenesis of the uremic state. An exposition of the "trade-off hypothesis"
    • Bricker NS. On the pathogenesis of the uremic state. An exposition of the "trade-off hypothesis". N Engl J Med 1972; 286: 1093-1099
    • (1972) N Engl J Med , vol.286 , pp. 1093-1099
    • Bricker, N.S.1
  • 18
    • 84856720641 scopus 로고    scopus 로고
    • Regulation and function of the FGF23/klotho endocrine pathways
    • Martin A, David V, Quarles LD. Regulation and function of the FGF23/klotho endocrine pathways. Physiol Rev 2012; 92: 131-155
    • (2012) Physiol Rev , vol.92 , pp. 131-155
    • Martin, A.1    David, V.2    Quarles, L.D.3
  • 19
    • 84859852194 scopus 로고    scopus 로고
    • Role of FGF23 in vitamin D and phosphate metabolism: Implications in chronic kidney disease
    • Quarles LD. Role of FGF23 in vitamin D and phosphate metabolism: implications in chronic kidney disease. Exp Cell Res 2012; 318: 1040-1048
    • (2012) Exp Cell Res , vol.318 , pp. 1040-1048
    • Quarles, L.D.1
  • 20
    • 57449105957 scopus 로고    scopus 로고
    • Endocrine functions of bone in mineral metabolism regulation
    • Quarles LD. Endocrine functions of bone in mineral metabolism regulation. J Clin Invest 2008; 118: 3820-3828
    • (2008) J Clin Invest , vol.118 , pp. 3820-3828
    • Quarles, L.D.1
  • 21
    • 79957870135 scopus 로고    scopus 로고
    • Fibroblast growth factor 23 is elevated before parathyroid hormone and phosphate in chronic kidney disease
    • Isakova T, Wahl P, Vargas GS et al. Fibroblast growth factor 23 is elevated before parathyroid hormone and phosphate in chronic kidney disease. Kidney Int 2011; 79: 1370-1378
    • (2011) Kidney Int , vol.79 , pp. 1370-1378
    • Isakova, T.1    Wahl, P.2    Vargas, G.S.3
  • 22
    • 34548497123 scopus 로고    scopus 로고
    • Fibroblast growth factor 23 (FGF23) predicts progression of chronic kidney disease: The Mild to Moderate Kidney Disease (MMKD) Study
    • Fliser D, Kollerits B, Neyer U et al. Fibroblast growth factor 23 (FGF23) predicts progression of chronic kidney disease: the Mild to Moderate Kidney Disease (MMKD) Study. J Am Soc Nephrol 2007; 18: 2600-2608
    • (2007) J Am Soc Nephrol , vol.18 , pp. 2600-2608
    • Fliser, D.1    Kollerits, B.2    Neyer, U.3
  • 23
    • 49249104701 scopus 로고    scopus 로고
    • Fibroblast growth factor 23 and mortality among patients undergoing hemodialysis
    • Gutierrez OM, Mannstadt M, Isakova T et al. Fibroblast growth factor 23 and mortality among patients undergoing hemodialysis. N Engl J Med 2008; 359: 584-592
    • (2008) N Engl J Med , vol.359 , pp. 584-592
    • Gutierrez, O.M.1    Mannstadt, M.2    Isakova, T.3
  • 24
    • 79958724181 scopus 로고    scopus 로고
    • Fibroblast growth factor 23 and risks of mortality and end-stage renal disease in patients with chronic kidney disease
    • Isakova T, Xie H, Yang W et al. Fibroblast growth factor 23 and risks of mortality and end-stage renal disease in patients with chronic kidney disease. JAMA 2011; 305: 2432-2439
    • (2011) JAMA , vol.305 , pp. 2432-2439
    • Isakova, T.1    Xie, H.2    Yang, W.3
  • 25
    • 80053517709 scopus 로고    scopus 로고
    • FGF-23 associates with death, cardiovascular events, and initiation of chronic dialysis
    • Kendrick J, Cheung AK, Kaufman JS et al. FGF-23 Associates with Death, Cardiovascular Events, and Initiation of Chronic Dialysis. J Am Soc Nephrol 2011; 22: 1913-1922
    • (2011) J Am Soc Nephrol , vol.22 , pp. 1913-1922
    • Kendrick, J.1    Cheung, A.K.2    Kaufman, J.S.3
  • 26
    • 69249106380 scopus 로고    scopus 로고
    • High levels of serum fibroblast growth factor (FGF)-23 are associated with increased mortality in long haemodialysis patients
    • Jean G, Terrat JC, Vanel T et al. High levels of serum fibroblast growth factor (FGF)-23 are associated with increased mortality in long haemodialysis patients. Nephrol Dial Transplant 2009; 24: 2792-2796
    • (2009) Nephrol Dial Transplant , vol.24 , pp. 2792-2796
    • Jean, G.1    Terrat, J.C.2    Vanel, T.3
  • 27
    • 4744372082 scopus 로고    scopus 로고
    • Evolution of the Fgf and Fgfr gene families
    • Itoh N, Ornitz DM. Evolution of the Fgf and Fgfr gene families. Trends Genet 2004; 20: 563-569
    • (2004) Trends Genet , vol.20 , pp. 563-569
    • Itoh, N.1    Ornitz, D.M.2
  • 28
  • 30
    • 1642494893 scopus 로고    scopus 로고
    • The crystal structure of fibroblast growth factor (FGF) 19 reveals novel features of the FGF family and offers a structural basis for its unusual receptor affinity
    • Harmer NJ, Pellegrini L, Chirgadze D et al. The crystal structure of fibroblast growth factor (FGF) 19 reveals novel features of the FGF family and offers a structural basis for its unusual receptor affinity. Biochemistry 2004; 43: 629-640
    • (2004) Biochemistry , vol.43 , pp. 629-640
    • Harmer, N.J.1    Pellegrini, L.2    Chirgadze, D.3
  • 31
    • 84865258676 scopus 로고    scopus 로고
    • Conversion of a paracrine fibroblast growth factor into an endocrine fibroblast growth factor
    • Goetz R, Ohnishi M, Kir S et al. Conversion of a paracrine fibroblast growth factor into an endocrine fibroblast growth factor. J Biol Chem 2012; 287: 29134-29146
    • (2012) J Biol Chem , vol.287 , pp. 29134-29146
    • Goetz, R.1    Ohnishi, M.2    Kir, S.3
  • 32
    • 33744937606 scopus 로고    scopus 로고
    • Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family
    • Zhang X, Ibrahimi OA, Olsen SK et al. Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family. J Biol Chem 2006; 281: 15694-15700
    • (2006) J Biol Chem , vol.281 , pp. 15694-15700
    • Zhang, X.1    Ibrahimi, O.A.2    Olsen, S.K.3
  • 33
    • 0030724491 scopus 로고    scopus 로고
    • Mutation of the mouse klotho gene leads to a syndrome resembling ageing
    • Kuro OM, Matsumura Y, Aizawa H et al. Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature 1997; 390: 45-51
    • (1997) Nature , vol.390 , pp. 45-51
    • Kuro, O.M.1    Matsumura, Y.2    Aizawa, H.3
  • 34
    • 36849017126 scopus 로고    scopus 로고
    • The parathyroid is a target organ for FGF23 in rats
    • Ben-Dov IZ, Galitzer H, Lavi-Moshayoff V et al. The parathyroid is a target organ for FGF23 in rats. J Clin Invest 2007; 117: 4003-4008
    • (2007) J Clin Invest , vol.117 , pp. 4003-4008
    • Ben-Dov, I.Z.1    Galitzer, H.2    Lavi-Moshayoff, V.3
  • 35
    • 34249883939 scopus 로고    scopus 로고
    • How fibroblast growth factor 23 works
    • Liu S, Quarles LD. How fibroblast growth factor 23 works. J Am Soc Nephrol 2007; 18: 1637-1647
    • (2007) J Am Soc Nephrol , vol.18 , pp. 1637-1647
    • Liu, S.1    Quarles, L.D.2
  • 36
    • 33646367420 scopus 로고    scopus 로고
    • Fibroblast growth factor 23 is a counter-regulatory phosphaturic hormone for vitamin D
    • Liu S, Tang W, Zhou J et al. Fibroblast growth factor 23 is a counter-regulatory phosphaturic hormone for vitamin D. J Am Soc Nephrol 2006; 17: 1305-1315
    • (2006) J Am Soc Nephrol , vol.17 , pp. 1305-1315
    • Liu, S.1    Tang, W.2    Zhou, J.3
  • 37
    • 34948866160 scopus 로고    scopus 로고
    • Parathyroid hormone regulates fibroblast growth factor-23 in a mouse model of primary hyperparathyroidism
    • Kawata T, Imanishi Y, Kobayashi K et al. Parathyroid hormone regulates fibroblast growth factor-23 in a mouse model of primary hyperparathyroidism. J Am Soc Nephrol 2007; 18: 2683-2688
    • (2007) J Am Soc Nephrol , vol.18 , pp. 2683-2688
    • Kawata, T.1    Imanishi, Y.2    Kobayashi, K.3
  • 38
    • 77957993384 scopus 로고    scopus 로고
    • PTH increases FGF23 gene expression and mediates the high-FGF23 levels of experimental kidney failure: A bone parathyroid feedback loop
    • Lavi-Moshayoff V, Wasserman G, Meir T et al. PTH increases FGF23 gene expression and mediates the high-FGF23 levels of experimental kidney failure: a bone parathyroid feedback loop. Am J Physiol Renal Physiol 2010; 299: F882-F889
    • (2010) Am J Physiol Renal Physiol , vol.299
    • Lavi-Moshayoff, V.1    Wasserman, G.2    Meir, T.3
  • 39
    • 80052303008 scopus 로고    scopus 로고
    • Parathyroid hormone receptor signaling in osteocytes increases the expression of fibroblast growth factor-23 in vitro and in vivo
    • Rhee Y, Bivi N, Farrow E et al. Parathyroid hormone receptor signaling in osteocytes increases the expression of fibroblast growth factor-23 in vitro and in vivo. Bone 2011; 49: 636-643
    • (2011) Bone , vol.49 , pp. 636-643
    • Rhee, Y.1    Bivi, N.2    Farrow, E.3
  • 40
    • 4444308167 scopus 로고    scopus 로고
    • Total parathyroidectomy reduces elevated circulating fibroblast growth factor 23 in advanced secondary hyperparathyroidism
    • Sato T, Tominaga Y, Ueki T et al. Total parathyroidectomy reduces elevated circulating fibroblast growth factor 23 in advanced secondary hyperparathyroidism. Am J Kidney Dis 2004; 44: 481-487
    • (2004) Am J Kidney Dis , vol.44 , pp. 481-487
    • Sato, T.1    Tominaga, Y.2    Ueki, T.3
  • 41
    • 78349288025 scopus 로고    scopus 로고
    • Fibroblast growth factor 23 production in bone is directly regulated by 1{alpha},25-dihydroxyvitamin D, but not PTH
    • Saji F, Shigematsu T, Sakaguchi T et al. Fibroblast growth factor 23 production in bone is directly regulated by 1{alpha},25-dihydroxyvitamin D, but not PTH. Am J Physiol Renal Physiol 2010; 299: F1212-F1217
    • (2010) Am J Physiol Renal Physiol , vol.299
    • Saji, F.1    Shigematsu, T.2    Sakaguchi, T.3
  • 42
    • 77955766757 scopus 로고    scopus 로고
    • Leptin stimulates fibroblast growth factor 23 expression in bone and suppresses renal 1alpha,25-dihydroxyvitamin D3 synthesis in leptin-deficient mice
    • Tsuji K, Maeda T, Kawane T et al. Leptin stimulates fibroblast growth factor 23 expression in bone and suppresses renal 1alpha,25-dihydroxyvitamin D3 synthesis in leptin-deficient mice. J Bone Miner Res 2010; 25: 1711-1723
    • (2010) J Bone Miner Res , vol.25 , pp. 1711-1723
    • Tsuji, K.1    Maeda, T.2    Kawane, T.3
  • 43
    • 0344945402 scopus 로고    scopus 로고
    • Circulating concentration of FGF-23 increases as renal function declines in patients with chronic kidney disease, but does not change in response to variation in phosphate intake in healthy volunteers
    • Larsson T, Nisbeth U, Ljunggren O et al. Circulating concentration of FGF-23 increases as renal function declines in patients with chronic kidney disease, but does not change in response to variation in phosphate intake in healthy volunteers. Kidney Int 2003; 64: 2272-2279
    • (2003) Kidney Int , vol.64 , pp. 2272-2279
    • Larsson, T.1    Nisbeth, U.2    Ljunggren, O.3
  • 44
    • 33845322655 scopus 로고    scopus 로고
    • Acute effect of oral phosphate loading on serum fibroblast growth factor 23 levels in healthy men
    • Nishida Y, Taketani Y, Yamanaka-Okumura H et al. Acute effect of oral phosphate loading on serum fibroblast growth factor 23 levels in healthy men. Kidney Int 2006; 70: 2141-2147
    • (2006) Kidney Int , vol.70 , pp. 2141-2147
    • Nishida, Y.1    Taketani, Y.2    Yamanaka-Okumura, H.3
  • 45
    • 79551500014 scopus 로고    scopus 로고
    • Pilot study of dietary phosphorus restriction and phosphorus binders to target fibroblast growth factor 23 in patients with chronic kidney disease
    • Isakova T, Gutierrez OM, Smith K et al. Pilot study of dietary phosphorus restriction and phosphorus binders to target fibroblast growth factor 23 in patients with chronic kidney disease. Nephrol Dial Transplant 2011; 26: 584-591
    • (2011) Nephrol Dial Transplant , vol.26 , pp. 584-591
    • Isakova, T.1    Gutierrez, O.M.2    Smith, K.3
  • 46
    • 33747719260 scopus 로고    scopus 로고
    • Dietary phosphorus regulates serum fibroblast growth factor-23 concentrations in healthy men
    • Antoniucci DM, Yamashita T, Portale AA. Dietary phosphorus regulates serum fibroblast growth factor-23 concentrations in healthy men. J Clin Endocrinol Metab 2006; 91: 3144-3149
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 3144-3149
    • Antoniucci, D.M.1    Yamashita, T.2    Portale, A.A.3
  • 47
    • 33746406756 scopus 로고    scopus 로고
    • Regulation of C-terminal and intact FGF-23 by dietary phosphate in men and women
    • Burnett SM, Gunawardene SC, Bringhurst FR et al. Regulation of C-terminal and intact FGF-23 by dietary phosphate in men and women. J Bone Miner Res 2006; 21: 1187-1196
    • (2006) J Bone Miner Res , vol.21 , pp. 1187-1196
    • Burnett, S.M.1    Gunawardene, S.C.2    Bringhurst, F.R.3
  • 48
    • 15944376583 scopus 로고    scopus 로고
    • Fibroblast growth factor-23 relationship to dietary phosphate and renal phosphate handling in healthy young men
    • Ferrari SL, Bonjour JP, Rizzoli R. Fibroblast growth factor-23 relationship to dietary phosphate and renal phosphate handling in healthy young men. J Clin Endocrinol Metab 2005; 90: 1519-1524
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 1519-1524
    • Ferrari, S.L.1    Bonjour, J.P.2    Rizzoli, R.3
  • 49
    • 27844501565 scopus 로고    scopus 로고
    • Dietary and serum phosphorus regulate fibroblast growth factor 23 expression and 1,25-dihydroxyvitamin D metabolism in mice
    • Perwad F, Azam N, Zhang MY et al. Dietary and serum phosphorus regulate fibroblast growth factor 23 expression and 1,25-dihydroxyvitamin D metabolism in mice. Endocrinology 2005; 146: 5358-5364
    • (2005) Endocrinology , vol.146 , pp. 5358-5364
    • Perwad, F.1    Azam, N.2    Zhang, M.Y.3
  • 50
    • 79951926433 scopus 로고    scopus 로고
    • Effects of dietary phosphate and calcium intake on fibroblast growth factor-23
    • Vervloet MG, van Ittersum FJ, Buttler RM et al. Effects of dietary phosphate and calcium intake on fibroblast growth factor-23. Clin J Am Soc Nephrol 2011; 6: 383-389
    • (2011) Clin J Am Soc Nephrol , vol.6 , pp. 383-389
    • Vervloet, M.G.1    Van Ittersum, F.J.2    Buttler, R.M.3
  • 51
    • 79951895648 scopus 로고    scopus 로고
    • Vegetarian compared with meat dietary protein source and phosphorus homeostasis in chronic kidney disease
    • Moe SM, Zidehsarai MP, Chambers MA et al. Vegetarian compared with meat dietary protein source and phosphorus homeostasis in chronic kidney disease. Clin J Am Soc Nephrol 2011; 6: 257-264
    • (2011) Clin J Am Soc Nephrol , vol.6 , pp. 257-264
    • Moe, S.M.1    Zidehsarai, M.P.2    Chambers, M.A.3
  • 52
    • 0141844575 scopus 로고    scopus 로고
    • Regulation of fibroblastic growth factor 23 expression but not degradation by PHEX
    • Liu S, Guo R, Simpson LG et al. Regulation of fibroblastic growth factor 23 expression but not degradation by PHEX. J Biol Chem 2003; 278: 37419-37426
    • (2003) J Biol Chem , vol.278 , pp. 37419-37426
    • Liu, S.1    Guo, R.2    Simpson, L.G.3
  • 53
    • 76249084836 scopus 로고    scopus 로고
    • Isolated C-terminal tail of FGF23 alleviates hypophosphatemia by inhibiting FGF23-FGFR-Klotho complex formation
    • Goetz R, Nakada Y, Hu MC et al. Isolated C-terminal tail of FGF23 alleviates hypophosphatemia by inhibiting FGF23-FGFR-Klotho complex formation. Proc Natl Acad Sci U S A 2010; 107: 407-412
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 407-412
    • Goetz, R.1    Nakada, Y.2    Hu, M.C.3
  • 54
    • 79955031820 scopus 로고    scopus 로고
    • Instability of fibroblast growth factor-23 (FGF-23): Implications for clinical studies
    • Smith ER, Ford ML, Tomlinson LA et al. Instability of fibroblast growth factor-23 (FGF-23): implications for clinical studies. Clin Chim Acta 2011; 412: 1008-1011
    • (2011) Clin Chim Acta , vol.412 , pp. 1008-1011
    • Smith, E.R.1    Ford, M.L.2    Tomlinson, L.A.3
  • 55
    • 15044340886 scopus 로고    scopus 로고
    • The role of fibroblast growth factor 23 in renal disease
    • Jonsson KB. The role of fibroblast growth factor 23 in renal disease. Nephrol Dial Transplant 2005; 20: 479-482
    • (2005) Nephrol Dial Transplant , vol.20 , pp. 479-482
    • Jonsson, K.B.1
  • 56
    • 84862149482 scopus 로고    scopus 로고
    • Klotho in health and disease
    • Kuro O.M. Klotho in health and disease. Curr Opin Nephrol Hypertens 2012; 21: 362-368
    • (2012) Curr Opin Nephrol Hypertens , vol.21 , pp. 362-368
    • Kuro, O.M.1
  • 57
    • 20844459989 scopus 로고    scopus 로고
    • Serum fibroblast growth factor-23 levels predict the future refractory hyperparathyroidism in dialysis patients
    • Nakanishi S, Kazama JJ, Nii-Kono T et al. Serum fibroblast growth factor-23 levels predict the future refractory hyperparathyroidism in dialysis patients. Kidney Int 2005; 67: 1171-1178
    • (2005) Kidney Int , vol.67 , pp. 1171-1178
    • Nakanishi, S.1    Kazama, J.J.2    Nii-Kono, T.3
  • 58
    • 74449094013 scopus 로고    scopus 로고
    • Parathyroid cell resistance to fibroblast growth factor 23 in secondary hyperparathyroidism of chronic kidney disease
    • Galitzer H, Ben-Dov IZ, Silver J et al. Parathyroid cell resistance to fibroblast growth factor 23 in secondary hyperparathyroidism of chronic kidney disease. Kidney Int 2010; 77: 211-218
    • (2010) Kidney Int , vol.77 , pp. 211-218
    • Galitzer, H.1    Ben-Dov, I.Z.2    Silver, J.3
  • 59
    • 84866127175 scopus 로고    scopus 로고
    • A Comparative Transcriptome Analysis Identifying FGF23 Regulated Genes in the Kidney of a Mouse CKD Model
    • Dai B, David V, Martin A et al. A Comparative Transcriptome Analysis Identifying FGF23 Regulated Genes in the Kidney of a Mouse CKD Model. PLoS One 2012; 7: e44161
    • (2012) PLoS One , vol.7
    • Dai, B.1    David, V.2    Martin, A.3
  • 60
    • 27744545673 scopus 로고    scopus 로고
    • Fibroblast growth factor-23 mitigates hyperphosphatemia but accentuates calcitriol deficiency in chronic kidney disease
    • Gutierrez O, Isakova T, Rhee E et al. Fibroblast growth factor-23 mitigates hyperphosphatemia but accentuates calcitriol deficiency in chronic kidney disease. J Am Soc Nephrol 2005; 16: 2205-2215
    • (2005) J Am Soc Nephrol , vol.16 , pp. 2205-2215
    • Gutierrez, O.1    Isakova, T.2    Rhee, E.3
  • 61
    • 0141525564 scopus 로고    scopus 로고
    • Serum FGF23 levels in normal and disordered phosphorus homeostasis
    • Weber TJ, Liu S, Indridason OS et al. Serum FGF23 levels in normal and disordered phosphorus homeostasis. J Bone Miner Res 2003; 18: 1227-1234
    • (2003) J Bone Miner Res , vol.18 , pp. 1227-1234
    • Weber, T.J.1    Liu, S.2    Indridason, O.S.3
  • 62
    • 76149101238 scopus 로고    scopus 로고
    • Circulating fibroblast growth factor 23 in patients with end-stage renal disease treated by peritoneal dialysis is intact and biologically active
    • Shimada T, Urakawa I, Isakova T et al. Circulating fibroblast growth factor 23 in patients with end-stage renal disease treated by peritoneal dialysis is intact and biologically active. J Clin Endocrinol Metab 2010; 95: 578-585
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. 578-585
    • Shimada, T.1    Urakawa, I.2    Isakova, T.3
  • 63
    • 70350223807 scopus 로고    scopus 로고
    • Patterns of FGF-23, DMP1, and MEPE expression in patients with chronic kidney disease
    • Pereira RC, Juppner H, Azucena-Serrano CE et al. Patterns of FGF-23, DMP1, and MEPE expression in patients with chronic kidney disease. Bone 2009; 45: 1161-1168
    • (2009) Bone , vol.45 , pp. 1161-1168
    • Pereira, R.C.1    Juppner, H.2    Azucena-Serrano, C.E.3
  • 64
    • 79955603792 scopus 로고    scopus 로고
    • Elevated fibroblast growth factor 23 is a risk factor for kidney transplant loss and mortality
    • Wolf M, Molnar MZ, Amaral AP et al. Elevated fibroblast growth factor 23 is a risk factor for kidney transplant loss and mortality. J Am Soc Nephrol 2011; 22: 956-966
    • (2011) J Am Soc Nephrol , vol.22 , pp. 956-966
    • Wolf, M.1    Molnar, M.Z.2    Amaral, A.P.3
  • 65
    • 77952996999 scopus 로고    scopus 로고
    • The associations of fibroblast growth factor 23 and uncarboxylated matrix Gla protein with mortality in coronary artery disease: The Heart and Soul Study
    • Parker BD, Schurgers LJ, Brandenburg VM et al. The associations of fibroblast growth factor 23 and uncarboxylated matrix Gla protein with mortality in coronary artery disease: the Heart and Soul Study. Ann Intern Med 2010; 152: 640-648
    • (2010) Ann Intern Med , vol.152 , pp. 640-648
    • Parker, B.D.1    Schurgers, L.J.2    Brandenburg, V.M.3
  • 66
    • 84871768555 scopus 로고    scopus 로고
    • Higher fibroblast growth factor-23 increases the risk of all-cause and cardiovascular mortality in the community
    • Arnlov J, Carlsson AC, Sundstrom J et al. Higher fibroblast growth factor-23 increases the risk of all-cause and cardiovascular mortality in the community. Kidney Int 2013; 83: 160-166
    • (2013) Kidney Int , vol.83 , pp. 160-166
    • Arnlov, J.1    Carlsson, A.C.2    Sundstrom, J.3
  • 67
    • 84877599062 scopus 로고    scopus 로고
    • FGF-23 and the progression of coronary arterial calcification in patients new to dialysis
    • Khan AM, Chirinos JA, Litt H et al. FGF-23 and the Progression of Coronary Arterial Calcification in Patients New to Dialysis. Clin J Am Soc Nephrol 2012; 7: 2017-2022
    • (2012) Clin J Am Soc Nephrol , vol.7 , pp. 2017-2022
    • Khan, A.M.1    Chirinos, J.A.2    Litt, H.3
  • 68
    • 66349097180 scopus 로고    scopus 로고
    • Fibroblast growth factor 23 and left ventricular hypertrophy in chronic kidney disease
    • Gutierrez OM, Januzzi JL, Isakova T et al. Fibroblast growth factor 23 and left ventricular hypertrophy in chronic kidney disease. Circulation 2009; 119: 2545-2552
    • (2009) Circulation , vol.119 , pp. 2545-2552
    • Gutierrez, O.M.1    Januzzi, J.L.2    Isakova, T.3
  • 69
    • 70450230670 scopus 로고    scopus 로고
    • Serum intact FGF23 associate with left ventricular mass, hypertrophy and geometry in an elderly population
    • Mirza MA, Larsson A, Melhus H et al. Serum intact FGF23 associate with left ventricular mass, hypertrophy and geometry in an elderly population. Atherosclerosis 2009; 207: 546-551
    • (2009) Atherosclerosis , vol.207 , pp. 546-551
    • Mirza, M.A.1    Larsson, A.2    Melhus, H.3
  • 70
    • 80555148939 scopus 로고    scopus 로고
    • FGF23 induces left ventricular hypertrophy
    • Faul C, Amaral AP, Oskouei B et al. FGF23 induces left ventricular hypertrophy. J Clin Invest 2011; 121: 4393-4408
    • (2011) J Clin Invest , vol.121 , pp. 4393-4408
    • Faul, C.1    Amaral, A.P.2    Oskouei, B.3
  • 71
    • 61849155234 scopus 로고    scopus 로고
    • Fibroblast growth factor 23: A possible cause of left ventricular hypertrophy in hemodialysis patients
    • Hsu HJ, Wu MS. Fibroblast growth factor 23: a possible cause of left ventricular hypertrophy in hemodialysis patients. Am J Med Sci 2009; 337: 116-122
    • (2009) Am J Med Sci , vol.337 , pp. 116-122
    • Hsu, H.J.1    Wu, M.S.2
  • 72
    • 80755172594 scopus 로고    scopus 로고
    • The phosphatonin fibroblast growth factor 23 links calcium-phosphate metabolism with left-ventricular dysfunction and atrial fibrillation
    • Seiler S, Cremers B, Rebling NM et al. The phosphatonin fibroblast growth factor 23 links calcium-phosphate metabolism with left-ventricular dysfunction and atrial fibrillation. Eur Heart J 2011; 32: 2688-2696
    • (2011) Eur Heart J , vol.32 , pp. 2688-2696
    • Seiler, S.1    Cremers, B.2    Rebling, N.M.3
  • 73
    • 79953880208 scopus 로고    scopus 로고
    • Serum fibroblast growth factor-23 (FGF-23) levels are independently associated with left ventricular mass and myocardial performance index in maintenance haemodialysis patients
    • Kirkpantur A, Balci M, Gurbuz OA et al. Serum fibroblast growth factor-23 (FGF-23) levels are independently associated with left ventricular mass and myocardial performance index in maintenance haemodialysis patients. Nephrol Dial Transplant 2011; 26: 1346-1354
    • (2011) Nephrol Dial Transplant , vol.26 , pp. 1346-1354
    • Kirkpantur, A.1    Balci, M.2    Gurbuz, O.A.3
  • 74
    • 78649698386 scopus 로고    scopus 로고
    • Fibroblast growth factor 23 in chronic kidney disease: Bridging the gap between bone mineral metabolism and left ventricular hypertrophy
    • Canziani ME, Tomiyama C, Higa A et al. Fibroblast growth factor 23 in chronic kidney disease: bridging the gap between bone mineral metabolism and left ventricular hypertrophy. Blood Purif 2011; 31: 26-32
    • (2011) Blood Purif , vol.31 , pp. 26-32
    • Canziani, M.E.1    Tomiyama, C.2    Higa, A.3
  • 75
    • 84862119120 scopus 로고    scopus 로고
    • Fibroblast growth factor 23 predicts left ventricular mass and induces cell adhesion molecule formation
    • Stevens KK, McQuarrie EP, Sands W et al. Fibroblast growth factor 23 predicts left ventricular mass and induces cell adhesion molecule formation. Int J Nephrol 2011; 2011: 297070
    • (2011) Int J Nephrol , vol.2011 , pp. 297070
    • Stevens, K.K.1    McQuarrie, E.P.2    Sands, W.3
  • 76
    • 67650892239 scopus 로고    scopus 로고
    • Circulating fibroblast growth factor-23 is associated with vascular dysfunction in the community
    • Mirza MA, Larsson A, Lind L et al. Circulating fibroblast growth factor-23 is associated with vascular dysfunction in the community. Atherosclerosis 2009; 205: 385-390
    • (2009) Atherosclerosis , vol.205 , pp. 385-390
    • Mirza, M.A.1    Larsson, A.2    Lind, L.3
  • 77
  • 78
    • 49449104636 scopus 로고    scopus 로고
    • 25-hydroxyvitamin D levels and the risk of mortality in the general population
    • Melamed ML, Michos ED, Post W et al. 25-hydroxyvitamin D levels and the risk of mortality in the general population. Arch Intern Med 2008; 168: 1629-1637
    • (2008) Arch Intern Med , vol.168 , pp. 1629-1637
    • Melamed, M.L.1    Michos, E.D.2    Post, W.3
  • 79
    • 70350077680 scopus 로고    scopus 로고
    • Chronic kidney disease, hypovitaminosis D, and mortality in the United States
    • Mehrotra R, Kermah DA, Salusky IB et al. Chronic kidney disease, hypovitaminosis D, and mortality in the United States. Kidney Int 2009; 76: 977-983
    • (2009) Kidney Int , vol.76 , pp. 977-983
    • Mehrotra, R.1    Kermah, D.A.2    Salusky, I.B.3
  • 80
    • 34948869354 scopus 로고    scopus 로고
    • Vitamin D levels and early mortality among incident hemodialysis patients
    • Wolf M, Shah A, Gutierrez O et al. Vitamin D levels and early mortality among incident hemodialysis patients. Kidney Int 2007; 72: 1004-1013
    • (2007) Kidney Int , vol.72 , pp. 1004-1013
    • Wolf, M.1    Shah, A.2    Gutierrez, O.3
  • 81
    • 40449107836 scopus 로고    scopus 로고
    • Association of activated vitamin D treatment and mortality in chronic kidney disease
    • Kovesdy CP, Ahmadzadeh S, Anderson JE et al. Association of activated vitamin D treatment and mortality in chronic kidney disease. Arch Intern Med 2008; 168: 397-403
    • (2008) Arch Intern Med , vol.168 , pp. 397-403
    • Kovesdy, C.P.1    Ahmadzadeh, S.2    Anderson, J.E.3
  • 82
    • 80052318645 scopus 로고    scopus 로고
    • Cross talk between the renin-angiotensin-aldosterone system and vitamin D-FGF-23-klotho in chronic kidney disease
    • de Borst MH, Vervloet MG, ter Wee PM et al. Cross talk between the renin-angiotensin-aldosterone system and vitamin D-FGF-23-klotho in chronic kidney disease. J Am Soc Nephrol 2011; 22: 1603-1609
    • (2011) J Am Soc Nephrol , vol.22 , pp. 1603-1609
    • De Borst, M.H.1    Vervloet, M.G.2    Ter Wee, P.M.3
  • 83
    • 44449113816 scopus 로고    scopus 로고
    • Vitamin D receptor activation and survival in chronic kidney disease
    • Kovesdy CP, Kalantar-Zadeh K. Vitamin D receptor activation and survival in chronic kidney disease. Kidney Int 2008; 73: 1355-1363
    • (2008) Kidney Int , vol.73 , pp. 1355-1363
    • Kovesdy, C.P.1    Kalantar-Zadeh, K.2
  • 84
    • 0037368234 scopus 로고    scopus 로고
    • Renin-angiotensin-aldosterone system: Fundamental aspects and clinical implications in renal and cardiovascular disorders
    • Perazella MA, Setaro JF. Renin-angiotensin-aldosterone system: fundamental aspects and clinical implications in renal and cardiovascular disorders. J Nucl Cardiol 2003; 10: 184-196
    • (2003) J Nucl Cardiol , vol.10 , pp. 184-196
    • Perazella, M.A.1    Setaro, J.F.2
  • 85
    • 0025770664 scopus 로고
    • Pathological hypertrophy and cardiac interstitium. Fibrosis and renin-angiotensin-aldosterone system
    • Weber KT, Brilla CG. Pathological hypertrophy and cardiac interstitium. Fibrosis and renin-angiotensin-aldosterone system. Circulation 1991; 83: 1849-1865
    • (1991) Circulation , vol.83 , pp. 1849-1865
    • Weber, K.T.1    Brilla, C.G.2
  • 86
    • 80053502175 scopus 로고    scopus 로고
    • Phosphate may promote ckd progression and attenuate renoprotective effect of ace inhibition
    • Zoccali C, Ruggenenti P, Perna A et al. Phosphate may promote ckd progression and attenuate renoprotective effect of ace inhibition. J Am Soc Nephrol 2011; 22: 1923-1930
    • (2011) J Am Soc Nephrol , vol.22 , pp. 1923-1930
    • Zoccali, C.1    Ruggenenti, P.2    Perna, A.3
  • 87
    • 1642552162 scopus 로고    scopus 로고
    • Comparing outcome predictability of markers of malnutrition-inflammation complex syndrome in haemodialysis patients
    • Kalantar-Zadeh K, Kopple JD, Humphreys MH et al. Comparing outcome predictability of markers of malnutrition-inflammation complex syndrome in haemodialysis patients. Nephrol Dial Transplant 2004; 19: 1507-1519
    • (2004) Nephrol Dial Transplant , vol.19 , pp. 1507-1519
    • Kalantar-Zadeh, K.1    Kopple, J.D.2    Humphreys, M.H.3
  • 88
    • 0033815254 scopus 로고    scopus 로고
    • Elevated serum levels of soluble adhesion molecules predict death in pre-dialysis patients: Association with malnutrition, inflammation, and cardiovascular disease
    • Stenvinkel P, Lindholm B, Heimburger M et al. Elevated serum levels of soluble adhesion molecules predict death in pre-dialysis patients: association with malnutrition, inflammation, and cardiovascular disease. Nephrol Dial Transplant 2000; 15: 1624-1630
    • (2000) Nephrol Dial Transplant , vol.15 , pp. 1624-1630
    • Stenvinkel, P.1    Lindholm, B.2    Heimburger, M.3
  • 89
    • 77953164325 scopus 로고    scopus 로고
    • Organic and inorganic dietary phosphorus and its management in chronic kidney disease
    • Noori N, Sims JJ, Kopple JD et al. Organic and inorganic dietary phosphorus and its management in chronic kidney disease. Iran J Kidney Dis 2010; 4: 89-100
    • (2010) Iran J Kidney Dis , vol.4 , pp. 89-100
    • Noori, N.1    Sims, J.J.2    Kopple, J.D.3
  • 90
    • 29144475911 scopus 로고    scopus 로고
    • Sevelamer hydrochloride and calcium bicarbonate reduce serum fibroblast growth factor 23 levels in dialysis patients
    • Koiwa F, Kazama JJ, Tokumoto A et al. Sevelamer hydrochloride and calcium bicarbonate reduce serum fibroblast growth factor 23 levels in dialysis patients. Ther Apher Dial 2005; 9: 336-339
    • (2005) Ther Apher Dial , vol.9 , pp. 336-339
    • Koiwa, F.1    Kazama, J.J.2    Tokumoto, A.3
  • 91
    • 77749334660 scopus 로고    scopus 로고
    • Early control of PTH and FGF23 in normophosphatemic CKD patients: A new target in CKD-MBD therapy?
    • Oliveira RB, Cancela AL, Graciolli FG et al. Early control of PTH and FGF23 in normophosphatemic CKD patients: a new target in CKD-MBD therapy? Clin J Am Soc Nephrol 2010; 5: 286-291
    • (2010) Clin J Am Soc Nephrol , vol.5 , pp. 286-291
    • Oliveira, R.B.1    Cancela, A.L.2    Graciolli, F.G.3
  • 92
    • 84855827125 scopus 로고    scopus 로고
    • Comparison of calcium acetate and sevelamer on vascular function and fibroblast growth factor 23 in CKD patients: A randomized clinical trial
    • Yilmaz MI, Sonmez A, Saglam M et al. Comparison of calcium acetate and sevelamer on vascular function and fibroblast growth factor 23 in CKD patients: a randomized clinical trial. Am J Kidney Dis 2012; 59: 177-185
    • (2012) Am J Kidney Dis , vol.59 , pp. 177-185
    • Yilmaz, M.I.1    Sonmez, A.2    Saglam, M.3
  • 93
    • 79961052017 scopus 로고    scopus 로고
    • Lanthanum carbonate reduces FGF23 in chronic kidney disease Stage 3 patients
    • Gonzalez-Parra E, Gonzalez-Casaus ML, Galan A et al. Lanthanum carbonate reduces FGF23 in chronic kidney disease Stage 3 patients. Nephrol Dial Transplant 2011; 26: 2567-2571
    • (2011) Nephrol Dial Transplant , vol.26 , pp. 2567-2571
    • Gonzalez-Parra, E.1    Gonzalez-Casaus, M.L.2    Galan, A.3
  • 94
    • 77952718903 scopus 로고    scopus 로고
    • Effect of paricalcitol and cinacalcet on serum phosphate, FGF-23, and bone in rats with chronic kidney disease
    • Finch JL, Tokumoto M, Nakamura H et al. Effect of paricalcitol and cinacalcet on serum phosphate, FGF-23, and bone in rats with chronic kidney disease. Am J Physiol Renal Physiol 2010; 298: F1315-F1322
    • (2010) Am J Physiol Renal Physiol , vol.298
    • Finch, J.L.1    Tokumoto, M.2    Nakamura, H.3
  • 95
    • 77957294474 scopus 로고    scopus 로고
    • Survival benefits with vitamin D receptor activation: New insights since 2003
    • Kovesdy CP. Survival benefits with vitamin D receptor activation: new insights since 2003. Clin J Am Soc Nephrol 2010; 5: 1704-1709
    • (2010) Clin J Am Soc Nephrol , vol.5 , pp. 1704-1709
    • Kovesdy, C.P.1
  • 96
    • 75749131627 scopus 로고    scopus 로고
    • Effects of cinacalcet and concurrent low-dose vitamin D on FGF23 levels in ESRD
    • Wetmore JB, Liu S, Krebill R et al. Effects of cinacalcet and concurrent low-dose vitamin D on FGF23 levels in ESRD. Clin J Am Soc Nephrol 2010; 5: 110-116
    • (2010) Clin J Am Soc Nephrol , vol.5 , pp. 110-116
    • Wetmore, J.B.1    Liu, S.2    Krebill, R.3
  • 97
    • 81255194004 scopus 로고    scopus 로고
    • Cinacalcet treatment and serum FGF23 levels in haemodialysis patients with secondary hyperparathyroidism
    • Koizumi M, Komaba H, Nakanishi S et al. Cinacalcet treatment and serum FGF23 levels in haemodialysis patients with secondary hyperparathyroidism. Nephrol Dial Transplant 2012; 27: 784-790
    • (2012) Nephrol Dial Transplant , vol.27 , pp. 784-790
    • Koizumi, M.1    Komaba, H.2    Nakanishi, S.3
  • 98
    • 84871675923 scopus 로고    scopus 로고
    • Effect of cinacalcet on cardiovascular disease in patients undergoing dialysis
    • Chertow GM, Block GA, Correa-Rotter R et al. Effect of cinacalcet on cardiovascular disease in patients undergoing dialysis. N Engl J Med 2012; 367: 2482-2494
    • (2012) N Engl J Med , vol.367 , pp. 2482-2494
    • Chertow, G.M.1    Block, G.A.2    Correa-Rotter, R.3
  • 99
    • 42149115639 scopus 로고    scopus 로고
    • Novel targets and new potential: Developments in the treatment of inflammation in chronic kidney disease
    • Kovesdy CP, Kalantar-Zadeh K. Novel targets and new potential: developments in the treatment of inflammation in chronic kidney disease. Expert Opin Investig Drugs 2008; 17: 451-467
    • (2008) Expert Opin Investig Drugs , vol.17 , pp. 451-467
    • Kovesdy, C.P.1    Kalantar-Zadeh, K.2
  • 100
    • 84875302265 scopus 로고    scopus 로고
    • Pharmacological inhibition of FGFR signaling ameliorates FGF23-mediated hypophosphatemic rickets
    • doi: 10.1002/jbmr.1810. [Epub ahead of print]
    • Wohrle S, Henninger C, Bonny O et al. Pharmacological inhibition of FGFR signaling ameliorates FGF23-mediated hypophosphatemic rickets. J Bone Miner Res 2012. doi: 10.1002/jbmr.1810. [Epub ahead of print]
    • (2012) J Bone Miner Res
    • Wohrle, S.1    Henninger, C.2    Bonny, O.3
  • 101
    • 73949119246 scopus 로고    scopus 로고
    • Therapeutic effects of anti-FGF23 antibodies in hypophosphatemic rickets/osteomalacia
    • Aono Y, Yamazaki Y, Yasutake J et al. Therapeutic effects of anti-FGF23 antibodies in hypophosphatemic rickets/osteomalacia. J Bone Miner Res 2009; 24: 1879-1888
    • (2009) J Bone Miner Res , vol.24 , pp. 1879-1888
    • Aono, Y.1    Yamazaki, Y.2    Yasutake, J.3
  • 102
    • 84863550146 scopus 로고    scopus 로고
    • FGF23 neutralization improves chronic kidney disease-associated hyperparathyroidism yet increases mortality
    • Shalhoub V, Shatzen EM, Ward SC et al. FGF23 neutralization improves chronic kidney disease-associated hyperparathyroidism yet increases mortality. J Clin Invest 2012; 122: 2543-2553
    • (2012) J Clin Invest , vol.122 , pp. 2543-2553
    • Shalhoub, V.1    Shatzen, E.M.2    Ward, S.C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.