Single-Chain antibody conjugated to a cage amine chelator and labeled with positron-emitting copper-64 for diagnostic imaging of activated platelets

Molecular Pharmaceutics

Volumn 11, Issue 8, 2014, Pages 2855-2863

  Alt, Karen ^a,b   Paterson, Brett M ^c   Ardipradja, Katie ^a,b,d,e   Schieber, Christine ^c   Buncic, Gojko ^c   Lim, Bock ^a,b   Poniger, Stan S ^d   Jakoby, Bjoern ^f,g   Wang, Xiaowei ^b   Okeefe, Graeme J ^d,e   Tochon Danguy, Henri J ^d   Scott, Andrew M ^d,e,h   Ackermann, Uwe ^d,e,h   Peter, Karlheinz ^b,i   Donnelly, Paul S ^c   Hagemeyer, Christoph E ^a,j  

^a BAKER IDI HEART AND DIABETES INSTITUTE   (Australia)

^b Atherothrombosis and Vascular Biology Laboratory   (Australia)

^c UNIVERSITY OF MELBOURNE   (Australia)

^d AUSTIN HEALTH   (Australia)

^e UNIVERSITY OF MELBOURNE   (Australia)

^f SIEMENS AG   (Germany)

^g UNIVERSITY OF SURREY   (United Kingdom)

^h OLIVIA NEWTON JOHN CANCER RESEARCH INSTITUTE   (Australia)

ⁱ MONASH UNIVERSITY   (Australia)

^j RMIT UNIVERSITY   (Australia)

more..

Author keywords

integrin GPIIb IIIa; platelets; positron emission tomography; single chain antibody

Indexed keywords

CHELATING AGENT; COPPER 64; DIAGNOSTIC AGENT; FIBRINOGEN RECEPTOR INTEGRIN SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY CAGE AMINE SARCOPHAGINE CHELATOR CU 64; FIBRINOGEN RECEPTOR INTEGRIN SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY TETRAXETAN; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; TETRAXETAN; UNCLASSIFIED DRUG; 1,4,7,10-TETRAAZACYCLODODECANE- 1,4,7,10-TETRAACETIC ACID; COPPER; LIGAND; RADIOPHARMACEUTICAL AGENT; SINGLE HETEROCYCLIC RINGS;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN BINDING; ARTICLE; CAROTID ARTERY THROMBOSIS; CONTROLLED STUDY; DIAGNOSTIC IMAGING; DIAGNOSTIC TEST ACCURACY STUDY; DIAGNOSTIC VALUE; DRUG CONJUGATION; DRUG DISTRIBUTION; EARLY DIAGNOSIS; FLOW CYTOMETRY; IMMUNOHISTOLOGY; IMMUNOREACTIVITY; IN VITRO STUDY; IN VIVO STUDY; ISOTOPE LABELING; MOUSE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; THIN LAYER CHROMATOGRAPHY; THROMBOCYTE ACTIVATION; ANIMAL; BAGG ALBINO MOUSE; CAROTID ARTERY; CHEMISTRY; DIAGNOSTIC USE; DISEASE MODEL; DRUG EFFECTS; INFLAMMATION; METABOLISM; MICRO-COMPUTED TOMOGRAPHY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PATHOPHYSIOLOGY; THROMBOCYTE; THROMBOSIS;

ANIMALS; BLOOD PLATELETS; CAROTID ARTERIES; CHELATING AGENTS; COPPER; COPPER RADIOISOTOPES; DIAGNOSTIC IMAGING; DISEASE MODELS, ANIMAL; FLOW CYTOMETRY; HETEROCYCLIC COMPOUNDS, 1-RING; INFLAMMATION; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MICE; MICE, INBRED BALB C; PLATELET ACTIVATION; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS; SINGLE-CHAIN ANTIBODIES; THROMBOSIS; X-RAY MICROTOMOGRAPHY;

EID: 84905454386     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp500209a     Document Type: Article

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