Preformulation studies of EFdA, a novel nucleoside reverse transcriptase inhibitor for HIV prevention

Drug Development and Industrial Pharmacy

Volumn 40, Issue 8, 2014, Pages 1101-1111

  Zhang, Wei ^a,b   Parniak, Michael A ^c   Mitsuya, Hiroaki ^d,e   Sarafianos, Stefan G ^f   Graebing, Phillip W ^a   Rohan, Lisa C ^a,b  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^d KUMAMOTO UNIVERSITY   (Japan)

^e NATIONAL INSTITUTES OF HEALTH   (United States)

^f University of Missouri   (United States)

Author keywords

Caco 2 cells; EFdA; Permeability; Preformulation; Solubility; Transport

Indexed keywords

4' ETHYNYL 2 FLUORO 2 DEOXYADENOSINE; OCTANOL; RNA DIRECTED DNA POLYMERASE INHIBITOR; UNCLASSIFIED DRUG; WATER; 4'-ETHYNYL-2-FLUORO-2'-DEOXYADENOSINE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; DEOXYADENOSINE DERIVATIVE;

ARTICLE; CACO 2 CELL LINE; CONTROLLED STUDY; CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG SAFETY; DRUG SOLUBILITY; EPITHELIUM CELL; FIELD EMISSION SCANNING ELECTRON MICROSCOPY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IN VITRO STUDY; IN VIVO STUDY; MELTING POINT; PARTITION COEFFICIENT; PH; PREFORMULATION; ULTRAVIOLET RADIATION; CHEMISTRY; DRUG EFFECTS; HUMAN IMMUNODEFICIENCY VIRUS 1; MEDICINAL CHEMISTRY; PERMEABILITY; PROCEDURES; SOLUBILITY; TRANSITION TEMPERATURE; TUMOR CELL LINE;

ANTI-HIV AGENTS; CACO-2 CELLS; CELL LINE, TUMOR; CHEMISTRY, PHARMACEUTICAL; DEOXYADENOSINES; DRUG DELIVERY SYSTEMS; EPITHELIAL CELLS; HIV-1; HUMANS; HYDROGEN-ION CONCENTRATION; PERMEABILITY; REVERSE TRANSCRIPTASE INHIBITORS; SOLUBILITY; TRANSITION TEMPERATURE;

EID: 84905450163     PISSN: 03639045     EISSN: 15205762     Source Type: Journal    
DOI: 10.3109/03639045.2013.809535     Document Type: Article

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