Toxicological outcomes in rats exposed to inhaled ethanol during gestation

Neurotoxicology and Teratology

Volumn 45, Issue , 2014, Pages 59-69

  Beasley, Tracey E ^a   Evansky, Paul A ^a   Martin, Sheppard A ^a   McDaniel, Katherine L ^a   Moser, Virginia C ^a   Luebke, Robert W ^a   Norwood, Joel ^a   Rogers, John M ^a   B Copeland, Carey ^a   Bushnell, Philip J ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

Biofuels; Development; Ethanol; Inhalation; Neurotoxicity

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; ALCOHOL; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CALCIUM; CHLORIDE; CHOLESTEROL; CREATININE; GAMMA GLUTAMYLTRANSFERASE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; IMMUNOGLOBULIN M; LIPOPROTEIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MAGNESIUM; NITROGEN; TRIACYLGLYCEROL; UREA;

AIR QUALITY; ALCOHOL BLOOD LEVEL; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY TITER; ARTICLE; BODY WEIGHT; CELLULAR IMMUNITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; FEMALE; FUNCTIONAL ASSESSMENT; GESTATION PERIOD; HUMORAL IMMUNITY; INHALATION; KIDNEY FUNCTION; LIPOPROTEIN BLOOD LEVEL; LITTER SIZE; LIVER FUNCTION; MALE; MOTOR ACTIVITY; NEUROMUSCULAR FUNCTION; NEUROTOXICITY; NEWBORN; NONHUMAN; PERINATAL PERIOD; PREGNANCY; PRENATAL EXPOSURE; PRIORITY JOURNAL; PROGENY; RAT; SENSORIMOTOR FUNCTION; SYSTOLIC BLOOD PRESSURE; VAPOR; ANIMAL; DRUG EFFECTS; EATING; ENVIRONMENTAL EXPOSURE; HAND STRENGTH; IMMUNOLOGY; INHALATIONAL DRUG ADMINISTRATION; LONG EVANS RAT; PATHOPHYSIOLOGY;

ADMINISTRATION, INHALATION; ANIMALS; BODY WEIGHT; EATING; ETHANOL; FEMALE; HAND STRENGTH; MALE; MATERNAL EXPOSURE; MOTOR ACTIVITY; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; RATS; RATS, LONG-EVANS;

EID: 84905368165     PISSN: 08920362     EISSN: 18729738     Source Type: Journal    
DOI: 10.1016/j.ntt.2014.07.002     Document Type: Article

References (70)

1. Abel E.L. Prenatal effects of alcohol on adult learning in rats. Pharmacol Biochem Behav 1979, 10:239-243.
2. Abel E.L. Fetal alcohol syndrome: a cautionary note. Curr Pharm Des 2006, 12:1521-1529.
3. Abel E.L., Dintcheff B.A. Effects of prenatal alcohol exposure on growth and development in rats. J Pharmacol Exp Ther 1978, 207:916-921.
4. Agnish N.D., Keller K.A. The rationale for culling of rodent litters. Fundam Appl Toxicol 1997, 38:2-6.
5. Augustyniak R.A., Singh K., Zeldes D., Singh M., Rossi N.F. Maternal protein restriction leads to hyperresponsiveness to stress and salt-sensitive hypertension in male offspring. Am J Physiol Regul Integr Comp Physiol 2010, 298:R1375-R1382.
6. Becker H.C. Effects of ethanol on the central nervous system: fetal damage - neurobehavioral effects. Pharmacological effects of ethanol on the nervous system 1996, 409-442. CRC Press, Boca Raton, FL. R.A. Deitrich, V.G. Erwin (Eds.).
7. Benevenga N.J., Kaiser M., Clagett-Dame M. Development of the rat loft. Tech Talk 2005, 10:3.
8. Bond N.W., Di Giusto E.L. Effects of prenatal alcohol consumption on open-field behaviour and alcohol preference in rats. Psychopharmacologia 1976, 46:163-165.
9. Bond N.W., Di Giusto E.L. Prenatal alcohol consumption and open-field behaviour in rats: effects of age at time of testing. Psychopharmacology 1977, 52:311-312.
10. Boyes W.K., Degn L., Martin S.A., Lyke D.F., Hamm C.W., Herr D.W. Neurophysiological assessment of auditory, peripheral nerve, somatosensory, and visual system function after developmental exposure to ethanol vapors. Neurotoxicol Teratol 2014, 43:1-10.
11. Branchey L., Friedhoff A.J. Biochemical and behavioral changes in rats exposed to ethanol in utero. Ann N Y Acad Sci 1976, 273:328-330.
12. Chen L., Nyomba B.L.G. Effects of prenatal alcohol exposure on glucose tolerance in the rat offspring. Metabolism 2003, 52:454-462.
13. Chen L., Nyomba B.L.G. Glucose intolerance and resistin expression in rat offspring exposed to ethanol in utero: modulation by postnatal high-fat diet. Endocrinology 2003, 144:500-508.
14. Church M.W., Kaltenbach J.A. Hearing, speech, language, and vestibular disorders in the fetal alcohol syndrome: a literature review. Alcohol Clin Exp Res 1997, 21:495-512.
15. Church M.W., Abel E.L., Dintcheff B.A., Matyjasik C. Maternal age and blood alcohol concentration in the pregnant Long-Evans rat. J Pharmacol Exp Ther 1990, 253:192-199.
16. Connors G.J., Maisto S.A. Effects of alcohol, instructions, and consumption rate on affect and physiological sensations. Psychopharmacology 1979, 62:261-266.
17. Conrod P.J., Peterson J.B., Pihl R.O., Mankowski S. Biphasic effects of alcohol on heart rate are influenced by alcoholic family history and rate of alcohol ingestion. Alcohol Clin Exp Res 1997, 21:140-149.
18. Correa M., Salamone J.D., Segovia K.N., Pardo M., Longoni R., Spina L., et al. Piecing together the puzzle of acetaldehyde as a neuroactive agent. Neurosci Biobehav Rev 2012, 36:404-430.
19. da Silva V.A., Ribeiro M.J., Masur J. Developmental, behavioral, and pharmacological characteristics of rat offspring from mothers receiving ethanol during gestation or lactation. Dev Psychobiol 1980, 13:653-660.
20. DeWitt J.C., Copeland C.B., Luebke R.W. Developmental exposure to 1.0 or 2.5mg/kg of dibutyltin dichloride does not impair immune function in Sprague-Dawley rats. J Immunotoxicol 2006, 3:245-252.
21. Dopico A.M., Lovinger D.M. Acute alcohol action and desensitization of ligand-gated ion channels. Pharmacol Rev 2009, 61:98-114.
22. Driscoll C.D., Streissguth A.P., Riley E.P. Prenatal alcohol exposure: comparability of effects in humans and animal models. Neurotoxicol Teratol 1990, 12:231-237.
23. Dursun I., Jakubowska-Dogru E., Uzbay T. Effects of prenatal exposure to alcohol on activity, anxiety, motor coordination, and memory in young adult Wistar rats. Pharmacol Biochem Behav 2006, 85:345-355.
24. Eckardt M.J., File S.E., Gessa G.L., Grant K.A., Guerri C., Hoffman P.L., et al. Effects of moderate alcohol consumption on the central nervous system. Alcohol Clin Exp Res 1998, 22:998-1040.
25. Fernandez K., Caul W.F., Osborne G.L., Henderson G.I. Effects of chronic alcohol exposure on offspring activity in rats. Neurobehav Toxicol Teratol 1983, 5:135-137.
26. Guerri C., Sanchis R. Acetaldehyde and alcohol levels in pregnant rats and their fetuses. Alcohol 1985, 2:267-270.
27. Guerri C., Sanchis R. Alcohol and acetaldehyde in rat's milk following ethanol administration. Life Sci 1986, 38:1543-1556.
28. Hannigan J.H., Riley E.P. Prenatal ethanol alters gait in rats. Alcohol 1988, 5:451-454.
29. Hannigan J.H., Berman R.F., Zajac C.S. Environmental enrichment and the behavioral effects of prenatal exposure to alcohol in rats. Neurotoxicol Teratol 1993, 15:261-266.
30. Holson R.R., Freshwater L., Maurissen J.P., Moser V.C., Phang W. Statistical issues and techniques appropriate for developmental neurotoxicity testing: a report from the ILSI Research Foundation/Risk Science Institute expert working group on neurodevelopmental endpoints. Neurotoxicol Teratol 2008, 30:326-348.
31. Purina Inc. Formulab Diet 5008*, Formulab Diet, Irradiated 5008C33* 2009.
32. Jerrells T.R., Weinberg J. Influence of ethanol consumption on immune competence of adult animals exposed to ethanol in utero. Alcohol Clin Exp Res 1998, 22:391-400.
33. Jones B.M., Vega A. Cognitive performance measured on the ascending and descending limb of the blood alcohol curve. Psychopharmacologia 1972, 23:99-114.
34. Kalev-Zylinska M.L., During M.J. Paradoxical facilitatory effect of low-dose alcohol consumption on memory mediated by NMDA receptors. J Neurosci 2007, 27:10456-10467.
35. Kane C.J., Phelan K.D., Drew P.D. Neuroimmune mechanisms in fetal alcohol spectrum disorder. Dev Neurobiol 2012, 72:1302-1316.
36. Lim R.T., Gentry R.T., Ito D., Yokoyama H., Baraona E., Lieber C.S. First-pass metabolism of ethanol is predominantly gastric. Alcohol Clin Exp Res 1993, 17:1337-1344.
37. Loose L.D., Di Luzio N.R. The influence of acute and chronic ethanol or bourbon administration on phagocytic and immune responses in rats. Exp Mol Pathol 1975, 23:459-472.
38. Lopez-Tejero D., Llobera M., Herrera E. Permanent abnormal response to a glucose load after prenatal ethanol exposure in rats. Alcohol 1989, 6:469-473.
39. Lovinger D.M. Alcohols and neurotransmitter gated ion channels: past, present and future. Naunyn Schmiedebergs Arch Pharmacol 1997, 356:267-282.
40. Martin S.A., McLanahan E.D., El-Masri H., LeFew W.R., Bushnell P.J., Boyes W.K., et al. Development of multi-route physiologically-based pharmacokinetic models for ethanol in the adult, pregnant, and neonatal rat. Inhal Toxicol 2012, 24:698-722.
41. Martin S.A., Oshiro W.M., Evansky P.A., Degn L.L., Ledbetter A.D., Ford J., et al. Use of novel inhalation kinetic studies to refine physiologically-based pharmacokinetic models for ethanol in non-pregnant and pegnant rats. Inhal Toxicol 2014, (in press).
42. Mcdaniel K.L., Moser V.C. Utility of a neurobehavioral screening battery for differentiating the effects of two pyrethroids, permethrin and cypermethrin. Neurotoxicol Teratol 1993, 15:71-83.
43. McGill J., Meyerholz D.K., Edsen-Moore M., Young B., Coleman R.A., Schlueter A.J., et al. Fetal exposure to ethanol has long-term effects on the severity of influenza virus infections. J Immunol 2009, 182:7803-7808.
44. Miller R.B., Letts R.L., Potts W.J., McKenna M.J. Improved methodology for generating controlled test atmospheres. Am Ind Hyg Assoc J 1980, 41:844-846.
45. Mizisin A.P., Kalichman M.W., Garrett R.S., Dines K.C. Tactile hyperesthesia, altered epidermal innervation and plantar nerve injury in the hindfeet of rats housed on wire grates. Brain Res 1998, 788:13-19.
46. Moser V.C., Cheek B.M., MacPhail R.C. A multidisciplinary approach to toxicological screening: III. Neurobehavioral toxicity. J Toxicol Environ Health 1995, 45:173-210.
47. Moser V.C., Tilson H.A., MacPhail R.C., Becking G.C., Cuomo V., Frantik E., et al. The IPCS Collaborative Study on Neurobehavioral Screening Methods: II. Protocol design and testing procedures. Neurotoxicology 1997, 18:929-938.
48. Moskowitz H., Burns M. Effects of rate of drinking on human performance. J Stud Alcohol 1976, 37:598-605.
49. Mukherjee R.A.S., Hollins S., Abou-Saleh M.T., Turk J. Low level alcohol consumption and the fetus. BMJ 2005, 330:375-376.
50. Nelson B.K., Brightwell W.S., Burg J.R. Comparison of behavioral teratogenic effects of ethanol and n-propanol administered by inhalation to rats. Neurobehav Toxicol Teratol 1985, 7:779-783.
51. Nelson B.K., Brightwell W.S., Mackenzie D.R., Khan A., Burg J.R., Weigel W.W., et al. Teratological assessment of methanol and ethanol at high inhalation levels in rats. Fundam Appl Toxicol 1985, 5:727-736.
52. Nelson B.K., Brightwell W.S., MacKenzie-Taylor D.R., Burg J.R., Massari V.J. Neurochemical, but not behavioral, deviations in the offspring of rats following prenatal or paternal inhalation exposure to ethanol. Neurotoxicol Teratol 1988, 10:15-22.
53. Osborne G.L., Caul W.F., Fernandez K. Behavioral effects of prenatal ethanol exposure and differential early experience in rats. Pharmacol Biochem Behav 1980, 12:393-401.
54. Oshiro W.M., Beasley T.E., Mcdaniel K.L., Taylor M.M., Evansky P.A., Moser V.C., et al. Selective cognitive deficits in adult rats after prenatal exposure to inhaled ethanol. Neurotoxicol Teratol 2014, 45:44-58.
55. Pennington J.S., Shuvaeva T.I., Pennington S.N. Maternal dietary ethanol consumption is associated with hypertriglyceridemia in adult rat offspring. Alcohol Clin Exp Res 2002, 26:848-855.
56. Reiter L.W. Chemical exposures and animal activity: utility of the figure-eight maze. Dev Toxicol Environ Sci 1983, 11:73-84.
57. Ren J., Wold L.E., Natavio M., Ren B.H., Hannigan J.H., Brown R.A. Iinfluence of prenatal alcohol exposure on myocardial contractile function in adult rat hearts: role of intracellular calcium and apoptosis. Alcohol Alcohol 2002, 37:30-37.
58. Riley E.P. The long-term behavioral effects of prenatal alcohol exposure in rats. Alcohol Clin Exp Res 1990, 14:670-673.
59. Riley E.P., McGee C.L. Fetal alcohol spectrum disorders: an overview with emphasis on changes in brain and behavior. Exp Biol Med (Maywood) 2005, 230:357-365.
60. Roine R.P., Gentry R.T., Lim R.T., Baraona E., Lieber C.S. Effect of concentration of ingested ethanol on blood alcohol levels. Alcohol Clin Exp Res 1991, 15:734-738.
61. Ruppert P.H., Dean K.F., Reiter L.W. Development of locomotor activity of rat pups in figure-eight mazes. Dev Psychobiol 1985, 18:247-260.
62. Schneider M.L., Moore C.F., Adkins M.M. The effects of prenatal alcohol exposure on behavior: rodent and primate studies. Neuropsychol Rev 2011, 21:186-203.
63. Shankar K., Ronis M.J.J., Badger T.M. Effects of pregnancy and nutritional status on alcohol metabolism. Alcohol Res Health 2007, 30:55.
64. Steven W.M., Stewart G.L., Seelig L.L. The effects of maternal ethanol consumption on lactational transfer of immunity to Trichinella spiralis in rats. Alcohol Clin Exp Res 1992, 16:884-890.
65. Tran T.D., Cronise K., Marino M.D., Jenkins W.J., Kelly S.J. Critical periods for the effects of alcohol exposure on brain weight, body weight, activity and investigation. Behav Brain Res 2000, 116:99-110.
66. U.S.EPA Gasoline TBA vapor condensate: a 13-week whole-body inhalation toxicity study in rats with neurotoxicity assessments and 4-week in vivo genotoxicity and immunotoxicity assessments. Final report, volume IV of IV, Washington DC 2008.
67. U.S.EPA Biofuels and the environment: the first triennial report to Congress. 2011 Final report 2011, [Washington DC].
68. Yao X.-H., Grégoire Nyomba B.L. Abnormal glucose homeostasis in adult female rat offspring after intrauterine ethanol exposure. Am J Physiol Regul Integr Comp Physiol 2007, 292:R1926-R1933.
69. Zajac C.S., Abel E.L. Animal models of prenatal alcohol exposure. Int J Epidemiol 1992, 21(Suppl. 1):S24-S32.
70. Zhang X., Sliwowska J.H., Weinberg J. Prenatal alcohol exposure and fetal programming: effects on neuroendocrine and immune function. Exp Biol Med (Maywood) 2005, 230:376-388.