Combined inhibition of FAAH and COX produces enhanced anti-allodynic effects in mouse neuropathic and inflammatory pain models

Pharmacology Biochemistry and Behavior

Volumn 124, Issue , 2014, Pages 405-411

  Grim, Travis W ^a   Ghosh, Sudeshna ^a   Hsu, Ku Lung ^b   Cravatt, Benjamin F ^b   Kinsey, Steven G ^c   Lichtman, Aron H ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c WEST VIRGINIA UNIVERSITY   (United States)

Author keywords

Cyclooxygenase (COX); Endogenous cannabinoid (endocannabinoid); Fatty acid amide hydrolase; Inflammatory pain; Neuropathic pain; Prostaglandins

Indexed keywords

2 ARACHIDONOYLGLYCEROL; 5 (4 CHLORO 3 METHYLPHENYL) 1 (4 METHYLBENZYL) N (1,3,3 TRIMETHYLBICYCLO[2.2.1]HEPTAN 2 YL) 3 PYRAZOLECARBOXAMIDE; ANTINOCICEPTIVE AGENT; ARACHIDONIC ACID; CARRAGEENAN; DICLOFENAC; ENZYME INHIBITOR; FATTY ACID AMIDASE INHIBITOR; PF 3845; PROSTAGLANDIN E2; RIMONABANT; UNCLASSIFIED DRUG; AMIDASE; FATTY-ACID AMIDE HYDROLASE; PROSTAGLANDIN SYNTHASE;

ALLODYNIA; ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME INHIBITION; EXPERIMENTAL PAIN; INFLAMMATORY PAIN; MALE; MOUSE; NEUROPATHIC PAIN; NONHUMAN; PRIORITY JOURNAL; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; DISEASE MODEL; DRUG EFFECTS; HYPERALGESIA; INFLAMMATION; NEURALGIA;

AMIDOHYDROLASES; ANIMALS; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; HYPERALGESIA; INFLAMMATION; MALE; MICE; MICE, INBRED C57BL; NEURALGIA; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES;

EID: 84905366926     PISSN: 00913057     EISSN: 18735177     Source Type: Journal    
DOI: 10.1016/j.pbb.2014.07.008     Document Type: Article

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