Synthesis of prostaglandin F ethanolamide by prostaglandin F synthase and identification of Bimatoprost as a potent inhibitor of the enzyme: New enzyme assay method using LC/ESI/MS

Archives of Biochemistry and Biophysics

Volumn 424, Issue 2, 2004, Pages 128-136

  Koda, Noriko ^a,c   Tsutsui, Yasutaka ^a   Niwa, Haruki ^b   Ito, Seiji ^c   Woodward, David F ^d   Watanabe, Kikuko ^a  

^a UNIVERSITY OF EAST ASIA   (Japan)

^b UNIVERSITY OF ELECTRO COMMUNICATIONS   (Japan)

^c KANSAI MEDICAL UNIVERSITY   (Japan)

^d ALLERGAN INC   (United States)

Author keywords

Bimatoprost; Liquid chromatographic electrospray ionization mass spectrometry; Prostaglandin ethanolamide; Prostaglandin F synthase

Indexed keywords

11 EPIPROSTAGLANDIN F2 ALPHA; 11 EPIPROSTAGLANDIN F2 ALPHA ETHANOLAMIDE; AMIDE; ANTIGLAUCOMA AGENT; BIMATOPROST; ONO 1349; ONO 1370; ONO 1373; PROSTAGLANDIN F2 ALPHA; PROSTAGLANDIN G2; PROSTAGLANDIN H2; PROSTAGLANDIN SYNTHASE; STAFIL; TOLRESTAT; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CATALYST; DRUG EFFECT; ELECTROSPRAY MASS SPECTROMETRY; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME SUBSTRATE; GEL; IC 50; ION MONITORING; LIQUID CHROMATOGRAPHY; PRIORITY JOURNAL; REDUCTION; SEPARATION TECHNIQUE;

AMIDES; CHROMATOGRAPHY, LIQUID; ENZYME INHIBITORS; ENZYME STABILITY; HUMANS; HYDROXYPROSTAGLANDIN DEHYDROGENASES; LIPIDS; PROSTAGLANDIN D2; PROSTAGLANDINS F, SYNTHETIC; RECOMBINANT PROTEINS; RESTRICTION MAPPING; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SUBSTRATE SPECIFICITY;

EID: 1642422719     PISSN: 00039861     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.abb.2004.02.009     Document Type: Article

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