Comparative gene and protein expression analyses of a panel of cytokines in acute and chronic drug-induced liver injury in rats

Toxicology

Volumn 324, Issue , 2014, Pages 43-54

  Hanafusa, Hiroyuki ^a   Morikawa, Yuji ^a,b   Uehara, Takeki ^a,b   Kaneto, Masako ^a   Ono, Atsushi ^b,c   Yamada, Hiroshi ^b   Ohno, Yasuo ^c   Urushidani, Tetsuro ^b,d  

^a SHIONOGI AND CO LTD   (Japan)

^b NATIONAL INSTITUTE OF BIOMEDICAL INNOVATION   (Japan)

^c NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^d DOSHISHA WOMEN'S COLLEGE OF LIBERAL ARTS   (Japan)

Author keywords

Biomarkers; Cytokines; Hepatotoxicity; MRNA; Protein; Toxicogenomics

Indexed keywords

1 NAPHTHYL ISOTHIOCYANATE; CISPLATIN; CYCLOSPORIN A; DANTROLENE; DICLOFENAC; DIETHYLNITROSAMINE; ETHAMBUTOL; ETHINYLESTRADIOL; ETHIONAMIDE; FLUTAMIDE; GEMFIBROZIL; GENTAMICIN; INDOMETACIN; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; MESSENGER RNA; METHAPYRILENE; MONOCROTALINE; MONOCYTE CHEMOTACTIC PROTEIN 1; N (2 FLUORENYL)ACETAMIDE; PHENOBARBITAL; RANTES; RETINOL; RIFAMPICIN; THIOACETAMIDE; VASCULAR CELL ADHESION MOLECULE 1; VASCULOTROPIN A; CYTOKINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COMPARATIVE STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DATA BASE; GENE EXPRESSION; HISTOPATHOLOGY; LIVER TOXICITY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RECEIVER OPERATING CHARACTERISTIC; TOXIC HEPATITIS; UPREGULATION; CONTROLLED STUDY; GENE EXPRESSION PROFILING; MICROARRAY ANALYSIS;

RATTUS;

BIOMARKERS; CYTOKINES; HEPATOTOXICITY; MRNA; PROTEIN; TOXICOGENOMICS;

ACUTE DISEASE; ANIMALS; AREA UNDER CURVE; CLUSTER ANALYSIS; CYTOKINES; DATABASES, GENETIC; DISEASE MODELS, ANIMAL; DRUG-INDUCED LIVER INJURY; DRUG-INDUCED LIVER INJURY, CHRONIC; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; IMMUNOASSAY; MALE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; ROC CURVE; TOXICOGENETICS;

EID: 84905241047     PISSN: 0300483X     EISSN: 18793185     Source Type: Journal    
DOI: 10.1016/j.tox.2014.07.005     Document Type: Article

References (33)

1. Afshari C.A.I., Hamadeh H.K., Bushel P.R. The evolution of bioinformatics in toxicology: advancing toxicogenomics. Toxicol. Sci. 2011, 120:225S-237S.
2. Amanzada A., Moriconi F., Mansuroglu T., Cameron S., Ramadori G., Malik A. Induction of chemokines and cytokines before neutrophils and macrophage recruitment in different regions of rat liver after TAA administration. Lab. Invest. 2014, 94:235-247.
3. Ansede J.H., Smith W.R., Perry C.H., St Claire R.L., Brouwer K.R. An in vitro assay to assess transporter-based cholestatic hepatotoxicity using sandwich-cultured rat hepatocytes. Drug Metab. Dispos. 2010, 38:276-280.
4. Blazka M.E., Wilmer J.L., Holladay S.D., Wilson R.E., Luster M.I. Role of proinflammatory cytokines in acetaminophen hepatotoxicity. Toxicol. Appl. Pharmacol. 1995, 133:43-52.
5. Borg B.B., Seetharam A., Subramanian V., Basha H.I., Lisker-Melman M., Korenblat K., Anderson C.D., Shenoy S., Chapman W.C., Crippin J.S., Mohanakumar T. Immune response to extracellular matrix collagen in chronic hepatitis C-induced liver fibrosis. Liver Transpl. 2011, 17:814-823.
6. Cui Y., Paules R.S. Use of transcriptomics in understanding mechanisms of drug-induced toxicity. Pharmacogenomics 2010, 11:573-585.
7. Deshmane S.L., Kremlev S., Amini S., Sawaya B.E. Monocyte chemo-attractant protein-1 (MCP-1): an overview. J. Interferon Cytokine Res. 2009, 29:313-326.
8. Guengerich F.P. Mechanisms of drug toxicity and relevance to pharmaceutical development. Drug Metab. Pharmacokinet. 2011, 26:3-14.
9. Ihaka R., Gentleman R. R: a language for data analysis and graphics. J. Comput. Graph. Stat. 1996, 5:299-314.
10. Kishida T., Onozato T., Kanazawa T., Tanaka S., Kuroda J. Increase in covalent binding of 5-hydroxydiclofenac to hepatic tissues in rats co-treated with lipopolysaccharide and diclofenac: involvement in the onset of diclofenac-induced idiosyncratic hepatotoxicity. J. Toxicol. Sci. 2012, 37:1143-1156.
11. Kulp G.A., Tilton R.G., Herndon D.N., Jeschke M.G. Hyperglycemia exacerbates burn-induced liver inflammation via noncanonical nuclear factor-B pathway activation. Mol. Med. 2012, 18:948-956.
12. Lasser K.E., Allen P.D., Woolhandler S.J., Himmelstein D.U., Wolfe S.M., Bor D.H. Timing of new black box warnings and withdrawals for prescription medications. JAMA 2002, 287:2215-2220.
13. Lee K.S., Oh S.J., Kim H.M., Lee K.H., Kim S.K. Assessment of reactive metabolites in drug-induced liver injury. Arch. Pharm. Res. 2011, 34:1879-1886.
14. Li X., Qin J. Modulation of Toll-interleukin 1 receptor mediated signaling. J. Mol. Med. (Berl.) 2005, 83:258-266.
15. Liu A., Krausz K.W., Fang Z.Z., Brocker C., Qu A., Gonzalez F.J. Gemfibrozil disrupts lysophosphatidylcholine and bile acid homeostasis via PPARα and its relevance to hepatotoxicity. Arch. Toxicol. 2014, 24385052. PMID.
16. Low Y., Uehara T., Minowa Y., Yamada H., Ohno Y., Urushidani T., Sedykh A., Muratov E., Kuz'min V., Fourches D., Zhu H., Rusyn I., Tropsha A. Predicting drug-induced hepatotoxicity using QSAR and toxicogenomics approaches. Chem. Res. Toxicol. 2011, 24:1251-1262.
17. Mandrekar P., Szabo G. Signalling pathways in alcohol-induced liver inflammation. J. Hepatol. 2009, 50:1258-1266.
18. Paquet J., Goebel J.C., Delaunay C., Pinzano A., Grossin L., Cournil-Henrionnet C., Gillet P., Netter P., Jouzeau J.Y., Moulin D. Cytokines profiling by multiplex analysis in experimental arthritis: which pathophysiological relevance for articular versus systemic mediators?. Arthrits Res. Ther. 2012, 14:R60.
19. Rioja I., Bush K.A., Buckton J.B., Dickson M.C., Life P.F. Joint cytokine quantification in two rodent arthritis models: kinetics of expression correlation of mRNA and protein levels and response to prednisolone treatment. Clin. Exp. Immunol. 2004, 137:65-73.
20. Saiman Y., Friedman S.L. The role of chemokines in acute liver injury. Front Physiol. 2012, 3:213.
21. Schwanhäusser B., Busse D., Li N., Dittmar G., Schuchhardt J., Wolf J., Chen W., Selbach M. Global quantification of mammalian gene expression control. Nature 2011, 473:337-342.
22. Seki E., De Minicis S., Gwak G.Y., Kluwe J., Inokuchi S., Bursill C.A., Llovet J.M., Brenner D.A., Schwabe R.F. CCR1 and CCR5 promote hepatic fibrosis in mice. J. Clin. Invest. 2009, 119:1858-1870.
23. Shebl F.M., Pinto L.A., García-Piñeres A., Lempicki R., Williams M., Harro C., Hildesheim A. Comparison of mRNA and protein measures of cytokines following vaccination with human papillomavirus-16 L1 virus-like particles. Cancer Epidemiol. Biomarkers Prev. 2010, 19:978-981.
24. Sims J.E., Smith D.E. The IL-1 family: regulators of immunity. Nat. Rev. Immunol. 2010, 10:89-102.
25. Singh R.A., Sodhi A. Antigen presentation by cisplatin-activated macrophages: role of soluble factor(s) and second messengers. Immunol. Cell Biol. 1998, 76:513-519.
26. Stevens J.L., Baker T.K. The future of drug safety testing: expanding the view and narrowing the focus. Drug Discov. Today 2009, 14:162-167.
27. Uehara T., Ono A., Maruyama T., Kato I., Yamada H., Ohno Y., Urushidani T. The Japanese toxicogenomics project: application of toxicogenomics. Mol. Nutr. Food Res. 2010, 54:218-227.
28. Wang L., Wang X., Wang L., Chiu J.D., van de Ven G., Gaarde W.A., Deleve L.D. Hepatic vascular endothelial growth factor regulates recruitment of rat liver sinusoidal endothelial cell progenitor cells. Gastroenterology 2012, 143:1555-1563.
29. Xu J.J., Henstock P.V., Dunn M.C., Smith A.R., Chabot J.R., de Graaf D. Cellular imaging predictions of clinical drug-induced liver injury. Toxicol. Sci. 2008, 105:97-105.
30. Yasumiba S., Tazuma S., Ochi H., Chayama K., Kajiyama G. Cyclosporin A reduces canalicular membrane fluidity and regulates transporter function in rats. Biochem. J. 2001, 354:591-596.
31. Yanagida C., Ito K., Komiya I., Horie T. Protective effect of fosfomycin on gentamicin-induced lipid peroxidation of rat renal tissue. Chem. Biol. Interact. 2004, 148:139-147.
32. Zangar R.C., Davydov D.R., Verma S. Mechanisms that regulate production of reactive oxygen species by cytochrome P450. Toxicol. Appl. Pharmacol. 2004, 199:316-331.
33. Zimmermann H.W., Trautwein C., Tacke F. Functional role of monocytes and macrophages for the inflammatory response in acute liver injury. Front. Physiol. 2012, 3:56.