MiR-17-5p modulates osteoblastic differentiation and cell proliferation by targeting SMAD7 in non-traumatic osteonecrosis

Experimental and Molecular Medicine

Volumn 46, Issue 7, 2014, Pages

  Jia, Jie ^a   Feng, Xiaobo ^a   Xu, Weihua ^a   Yang, Shuhua ^a   Zhang, Qing ^a   Liu, Xianzhe ^a   Dai, Yong Feng Zhipeng ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; CORTICOSTEROID; MICRORNA; MICRORNA 17; SMAD7 PROTEIN; UNCLASSIFIED DRUG; BMP2 PROTEIN, HUMAN; BONE MORPHOGENETIC PROTEIN 2; MIRN17 MICRORNA, HUMAN; SMAD7 PROTEIN, HUMAN;

3' UNTRANSLATED REGION; ADULT; ARTICLE; BONE NECROSIS; CANCER CELL; CELL DIFFERENTIATION; CELL INVASION; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FEMUR HEAD; GENE EXPRESSION; HIP OSTEOARTHRITIS; HUMAN; HUMAN CELL; MALE; MESENCHYMAL STEM CELL; NUCLEAR MAGNETIC RESONANCE IMAGING; OSTEOARTHRITIS; OSTEOBLAST; PATHOGENESIS; PROTEIN EXPRESSION; PROTEIN TARGETING; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; BONE DEVELOPMENT; CELL LINE; CYTOLOGY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MIDDLE AGED; NUCLEOTIDE SEQUENCE; PATHOLOGY; SIGNAL TRANSDUCTION;

ADULT; BASE SEQUENCE; BETA CATENIN; BONE MORPHOGENETIC PROTEIN 2; CELL DIFFERENTIATION; CELL LINE; CELL PROLIFERATION; FEMALE; GENE EXPRESSION REGULATION; HUMANS; MALE; MICRORNAS; MIDDLE AGED; OSTEOARTHRITIS; OSTEOBLASTS; OSTEOGENESIS; OSTEONECROSIS; SIGNAL TRANSDUCTION; SMAD7 PROTEIN;

EID: 84905240498     PISSN: 12263613     EISSN: 20926413     Source Type: Journal    
DOI: 10.1038/emm.2014.43     Document Type: Article

References (26)

1. Ficat RP. Idiopathic bone necrosis of the femoral head. Early diagnosis and treatment. J Bone Joint Surg Br 1985; 67: 3-9.
2. Mont MA, Marulanda GA, Jones L.C., Saleh KJ, Gordon N, Hungerford DS et al. Systematic analysis of classification systems for osteonecrosis of the femoral head. J Bone Joint Surg Am 2006; 88(Suppl 3), 16-26.
3. Lee JS, Roh HL, Kim C.H., Jung JS, Suh KT. Alterations in the differentiation ability of mesenchymal stem cells in patients with nontraumatic osteonecrosis of the femoral head: comparative analysis according to the risk factor. J Orthop Res 2006; 24: 604-609.
4. Yan Z, Hang D, Guo C., Chen Z. Fate of mesenchymal stem cells transplanted to osteonecrosis of femoral head. J Orthop Res 2009; 27: 442-446.
5. Ahmed FE, Ahmed NC, Vos P.W., Bonnerup C., Atkins JN, Casey M et al. Diagnostic microRNA markers to screen for sporadic human colon cancer in stool: I. Proof of principle. Cancer Genomics Proteomics 2013; 10: 93-113.
6. van Wijnen A.J., van de Peppel J, van Leeuwen JP, Lian JB, Stein GS, Westendorf JJ et al. MicroRNA functions in osteogenesis and dysfunctions in osteoporosis. Curr Osteoporos. Rep 2013; 11: 72-82.
7. Yamasaki K, Nakasa T, Miyaki S., Yamasaki T, Yasunaga Y, Ochi M. Angiogenic microRNA-210 is present in cells surrounding osteonecrosis. J Orthop Res 2012; 30: 1263-1270.
8. Ukai T, Sato M, Akutsu H., Umezawa A, Mochida J. MicroRNA-199a-3p, microRNA-193b, and microRNA-320c are correlated to aging and regulate human cartilage metabolism. J Orthop Res 2012; 30: 1915-1922.
9. Lagos-Quintana M., Rauhut R, Lendeckel W., Tuschl T. Identification of novel genes coding for small expressed RNAs. Science 2001; 294: 853-858.
10. Lau NC, Lim LP, Weinstein E.G., Bartel DP. An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans. Science 2001; 294: 858-862.
11. Lee RC, Ambros V. An extensive class of small RNAs in Caenorhabditis elegans. Science 2001; 294: 862-864.
12. Duan Z, Choy E, Nielsen G.P., Rosenberg A., Iafrate J, Yang C et al. Differential expression of microRNA (miRNA) in chordoma reveals a role for miRNA-1 in Met expression. J Orthop Res 2010; 28: 746-752.
13. Matsubara H, Takeuchi T, Nishikawa E., Yanagisawa K, Hayashita Y, Ebi H et al. Apoptosis induction by antisense oligonucleotides against miR-17-5p and miR-20a in lung cancers overexpressing miR-17-92. Oncogene 2007; 26: 6099-6105.
14. Hossain A, Kuo MT, Saunders GF Mir-17-5p regulates breast cancer cell proliferation by inhibiting translation of AIB1 mRNA. Mol Cell Biol 2006; 26: 8191-8201.
15. Volinia S, Calin GA, Liu C.G., Ambs S., Cimmino A, Petrocca F et al. A microRNA expression signature of human solid tumors defines cancer gene targets. Proc Natl Acad Sci USA 2006; 103: 2257-2261.
16. Nishimori S, Tanaka Y, Chiba T., Fujii M, Imamura T, Miyazono K et al. Smad-mediated transcription is required for transforming growth factor-beta 1-induced p57(Kip2) proteolysis in osteoblastic cells. J Biol Chem 2001; 276: 10700-10705.
17. Jiang S, Zu Y, Fu Y., Zhang Y, Efferth T. Activation of the mitochondria-driven pathway of apoptosis in human PC-3 prostate cancer cells by a novel hydrophilic paclitaxel derivative, 7-xylosyl-10-deacetylpaclitaxel. Int J Oncol 2008; 33: 103-111.
18. Mukai T, Otsuka F, Otani H., Yamashita M, Takasugi K, Inagaki K et al. TNF-alpha inhibits BMP-induced osteoblast differentiation through activating SAPK/JNK signaling. Biochem Biophys Res Commun 2007; 356: 1004-1010.
19. Yano M, Inoue Y, Tobimatsu T., Hendy G, Canaff L, Sugimoto Tet al. Smad7 inhibits differentiation and mineralization of mouse osteoblastic cells. Endocr J 2012; 59: 653-662.
20. Zhang M, Yan Y, Lim Y.B., Tang D., Xie R, Chen A et al. BMP-2 modulates beta-catenin signaling through stimulation of Lrp5 expression and inhibition of beta-TrCP expression in osteoblasts. J Cell Biochem 2009; 108: 896-905.
21. Zhang N, Wei P, Gong A., Chiu WT, Lee HT, Colman H et al. FoxM1 promotes beta-catenin nuclear localization and controls Wnt target-gene expression and glioma tumorigenesis. Cancer Cell 2011; 20: 427-442.
22. Lee JH, Kim BG, Ahn J.M., Park HJ, Park SK, Yoo JS et al. Role of PI3K on the regulation of BMP2-induced beta-Catenin activation in human bone marrow stem cells. Bone 2010; 46: 1522-1532.
23. Fontana L, Fiori ME, Albini S, Cifaldi L., Giovinazzi S, Forloni M et al. Antagomir-17-5p abolishes the growth of therapy-resistant neuroblastoma through p21 and BIM. PLoS ONE 2008; 3: e2236.
24. O'Donnell K.A., Wentzel EA, Zeller K.I., Dang CV, Mendell JT. c-Myc-regulated microRNAs modulate E2F1 expression. Nature 2005; 435: 839-843.
25. Attisano L, Wrana JL Signal transduction by the TGF-beta superfamily. Science 2002; 296: 1646-1647.
26. Day TF, Guo X, Garrett-Beal L, Yang Y. Wnt/beta-catenin signaling in mesenchymal progenitors controls osteoblast and chondrocyte differentiation during vertebrate skeletogenesis. Dev. Cell 2005; 8: 739-750.