ERβ- and prostaglandin E2-regulated pathways integrate cell proliferation via Ras-like and estrogen-regulated growth inhibitor in endometriosis

Molecular Endocrinology

Volumn 28, Issue 8, 2014, Pages 1304-1315

  Monsivais, D ^a   Dyson, M T ^a   Yin, P ^a   Coon, J S ^a   Navarro, A ^a   Feng, G ^a   Malpani, S S ^a   Ono, M ^a   Ercan, C M ^a   Wei, J J ^a   Pavone, M E ^a   Su, E ^a   Bulun, S E ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; ESTRADIOL; ESTROGEN RECEPTOR BETA; GROWTH INHIBITOR; MESSENGER RNA; PROSTAGLANDIN E2; RAS LIKE ESTROGEN REGULATED GROWTH INHIBITOR; UNCLASSIFIED DRUG; GUANOSINE TRIPHOSPHATASE; RERG PROTEIN, HUMAN;

ADULT; APOPTOSIS; ARTICLE; BINDING SITE; BREAST CELL; CELL PROLIFERATION; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; ENDOMETRIOSIS; ENZYME PHOSPHORYLATION; EXPRESSED SEQUENCE TAG; FEMALE; GENE CONTROL; GENE EXPRESSION PROFILING; GENE ONTOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MICROARRAY ANALYSIS; NUCLEAR LOCALIZATION SIGNAL; PATHOGENESIS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; RECEPTOR BINDING; SIGNAL TRANSDUCTION; STROMA CELL; TRANSCRIPTION REGULATION; CELL NUCLEUS; GENE EXPRESSION REGULATION; HEK293 CELL LINE; METABOLISM; PATHOLOGY; PHYSIOLOGY; PROTEIN TRANSPORT;

ADULT; CELL NUCLEUS; CELL PROLIFERATION; DINOPROSTONE; ENDOMETRIOSIS; ESTRADIOL; ESTROGEN RECEPTOR BETA; FEMALE; GENE EXPRESSION REGULATION; GTP PHOSPHOHYDROLASES; HEK293 CELLS; HUMANS; PROTEIN TRANSPORT;

EID: 84905215487     PISSN: 08888809     EISSN: 19449917     Source Type: Journal    
DOI: 10.1210/me.2013-1421     Document Type: Article

References (51)

1. Bulun SE. Endometriosis. N Engl J Med. 2009;360:268-279
2. Giudice LC, Kao LC. Endometriosis. Lancet. 2004;364:1789-1799
3. Simoens S, Hummelshoj L, D'Hooghe T. Endometriosis: cost estimates and methodological perspective. Hum Reprod Update. 2007; 13:395-404
4. Berlanda N, Vercellini P, Fedele L. The outcomes of repeat surgery for recurrent symptomatic endometriosis. Curr Opin Obstet Gynecol. 2010;22:320-325
5. Wheeler JM, Malinak LR. Recurrent endometriosis: incidence, management, and prognosis. AmJ Obstet Gynecol. 1983;146:247-253
6. Johnson NP, Hummelshoj L. Consensus on current management of endometriosis. Hum Reprod. 2013;28:1552-1568
7. Ozkan S, Murk W, Arici A. Endometriosis and infertility: epidemiology and evidence-based treatments. Ann NY Acad Sci. 2008; 1127:92-100
8. Heldring N, Pike A, Andersson S, et al. Estrogen receptors: how do they signal and what are their targets. Physiol Rev. 2007;87:905-931
9. Stoica GE, Franke TF, Wellstein A, et al. Estradiol rapidly activates Akt via the ErbB2 signaling pathway. Mol Endocrinol. 2003;17: 818-830
10. Wang Y, Zhou D, Phung S, Masri S, Smith D, Chen S. SGK3 is an estrogen-inducible kinase promoting estrogen-mediated survival of breast cancer cells. Mol Endocrinol. 2011;25:72-82
11. Reis FM, Petraglia F, Taylor RN. Endometriosis: hormone regulation and clinical consequences of chemotaxis and apoptosis. Hum Reprod Update. 2013;19:406-418
12. Noble LS, Takayama K, Zeitoun KM, et al. Prostaglandin E2 stimulates aromatase expression in endometriosis-derived stromal cells. J Clin Endocrinol Metab. 1997;82:600-606
13. Tsai SJ, Wu MH, Lin CC, Sun HS, Chen HM. Regulation of steroidogenic acute regulatory protein expression and progesterone production in endometriotic stromal cells. J Clin Endocrinol Metab. 2001;86:5765-5773
14. Urata Y, Osuga Y, Akiyama I, et al. Interleukin-4 and prostaglandin E2 synergistically up-regulate 3β-hydroxysteroid dehydroge- nase type 2 in endometrioma stromal cells. J Clin Endocrinol Metab. 2013;98:1583-1590
15. Banu SK, Lee J, Speights VO Jr, Starzinski-Powitz A, Arosh JA. Selective inhibition of prostaglandin E2 receptors EP2 and EP4 induces apoptosis of human endometriotic cells through suppression of ERK1/2, AKT, NFκB, and β-catenin pathways and activation of intrinsic apoptotic mechanisms. Mol Endocrinol. 2009;23: 1291-1305
16. Xue Q, Lin Z, Cheng YH, et al. Promoter methylation regulates estrogen receptor 2 in human endometrium and endometriosis. Biol Reprod. 2007;77:681-687
17. Juhasz-Boss I, Fischer C, Lattrich C, et al. Endometrial expression of estrogen receptor β and its splice variants in patients with and without endometriosis. Arch Gynecol Obstet. 2011;284:885-891
18. Han SJ, Hawkins SM, Begum K, et al. A new isoform of steroid receptor coactivator-1 is crucial for pathogenic progression of endometriosis. Nat Med. 2012;18:1102-1111
19. Trukhacheva E, Lin Z, Reierstad S, Cheng YH, Milad M, Bulun SE. Estrogen receptor (ER) β regulates ERα expression in stromal cells derived from ovarian endometriosis. J Clin Endocrinol Metab. 2009;94:615-622
20. Grober OM, Mutarelli M, Giurato G, et al. Global analysis of estrogen receptor β binding to breast cancer cell genome reveals an extensive interplay with estrogen receptor α for target gene regulation. BMC Genomics. 2011;12:36
21. Liu Y, Gao H, Marstrand TT, et al. The genome landscape of ERα- and ERβ-binding DNA regions. Proc Natl Acad Sci USA. 2008; 105:2604-2609
22. Zhao C, Gao H, Liu Y, et al. Genome-wide mapping of estrogen receptor-β-binding regions reveals extensive cross-talk with transcription factor activator protein-1. Cancer Res. 2010;70:5174-5183
23. Du P, Kibbe WA, Lin SM. nuID: a universal naming scheme of oligonucleotides for Illumina, Affymetrix, and other microarrays. Biol Direct. 2007;2:16
24. Du P, Kibbe WA, Lin SM. lumi: a pipeline for processing Illumina microarray. Bioinformatics. 2008;24:1547-1548
25. Lin SM, Du P, Huber W, Kibbe WA. Model-based variance-stabilizing transformation for Illumina microarray data. Nucleic Acids Res. 2008;36:e11
26. Wettenhall JM, Smyth GK. limmaGUI: a graphical user interface for linear modeling of microarray data. Bioinformatics. 2004;20: 3705-3706
27. Lawrence M, Gentleman R, Carey V. rtracklayer: an R package for interfacing with genome browsers. Bioinformatics. 2009;25:1841-1842
28. Feng G, Du P, Krett NL, et al. A collection of bioconductor methods to visualize gene-list annotations. BMC Res Notes. 2010;3:10
29. Campeau E, Ruhl VE, Rodier F, et al. A versatile viral system for expression and depletion of proteins in mammalian cells. PLoS One. 2009;4:e6529
30. Lee TI, Johnstone SE, Young RA. Chromatin immunoprecipitation and microarray-based analysis of protein location. Nat Protoc. 2006;1:729-748
31. Charn TH, Liu ET, Chang EC, Lee YK, Katzenellenbogen JA, Katzenellenbogen BS. Genome-wide dynamics of chromatin binding of estrogen receptors α and β: mutual restriction and competitive site selection. Mol Endocrinol. 2010;24:47-59
32. Benvenuti S, Luciani P, Vannelli GB, et al. Estrogen and selective estrogen receptor modulators exert neuroprotective effects and stimulate the expression of selective Alzheimer's disease indicator- 1, a recently discovered antiapoptotic gene, in human neuroblast long-term cell cultures. J Clin Endocrinol Metab. 2005;90: 1775-1782
33. Bofinger DP, Feng L, Chi LH, et al. Effect of TCDD exposure on CYP1A1 and CYP1B1 expression in explant cultures of human endometrium. Toxicol Sci. 2001;62:299-314
34. Olayioye MA, Hoffmann P, Pomorski T, et al. The phosphoprotein StarD10 is overexpressed in breast cancer and cooperates with ErbB receptors in cellular transformation. Cancer Res. 2004;64:3538-3544
35. Rubel CA, Franco HL, Jeong JW, Lydon JP, DeMayo FJ. GATA2 is expressed at critical times in the mouse uterus during pregnancy. Gene Expression Patterns. 2012;12:196-203
36. Deroo BJ, Hewitt SC, Peddada SD, Korach KS. Estradiol regulates the thioredoxin antioxidant system in the mouse uterus. Endocrinology. 2004;145:5485-5492
37. Douglas NC, Papaioannou VE. The T-box transcription factors TBX2 and TBX3 in mammary gland development and breast cancer. J Mamm Gland Biol Neoplasia. 2013;18:143-147
38. Bulun SE, Cheng YH, Pavone ME, et al. Estrogen receptor-β, estrogen receptor-α, and progesterone resistance in endometriosis. Semin Reprod Med. 2010;28:36-43
39. Bukulmez O, Hardy DB, Carr BR, Word RA, Mendelson CR. Inflammatory status influences aromatase and steroid receptor expression in endometriosis. Endocrinology. 2008;149:1190-1204
40. Fujimoto J, Hirose R, Sakaguchi H, Tamaya T. Expression of oestrogen receptor-α and -β in ovarian endometriomata. Mol Hum Reprod. 1999;5:742-747
41. Cherfils J, Zeghouf M. Regulation of small GTPases by GEFs, GAPs, and GDIs. Physiol Rev. 2013;93:269-309
42. Igarashi T, Osuga U, Tsutsumi O, et al. Expression of Ah receptor and dioxin-related genes in human uterine endometrium in women with or without endometriosis. Endocr J. 1999;46:765-772
43. Salker MS, Christian M, Steel JH, et al. Deregulation of the serumand glucocorticoid-inducible kinase SGK1 in the endometrium causes reproductive failure. Nat Med. 2011;17:1509-1513
44. Lange A, Mills RE, Lange CJ, Stewart M, Devine SE, Corbett AH. Classical nuclear localization signals: definition, function, and interaction with importin α. J Biol Chem. 2007;282:5101-5105
45. Kosugi S, Hasebe M, Tomita M, Yanagawa H. Systematic identification of cell cycle-dependent yeast nucleocytoplasmic shuttling proteins by prediction of composite motifs. Proc Natl Acad Sci USA. 2009;106:10171-10176
46. Jans DA, Xiao CY, Lam MH. Nuclear targeting signal recognition: a key control point in nuclear transport? Bioessays. 2000;22:532-544
47. Finlin BS, Gau CL, Murphy GA, et al. RERG is a novel ras-related, estrogen-regulated and growth-inhibitory gene in breast cancer. J Biol Chem. 2001;276:42259-42267
48. Zhao C, Putnik M, Gustafsson JA, Dahlman-Wright K. Microarray analysis of altered gene expression in ERβ-overexpressing HEK293 cells. Endocrine. 2009;36:224-232
49. Akoum A, Lemay A, Maheux R. Estradiol and interleukin-1βexert a synergistic stimulatory effect on the expression of the chemokine regulated upon activation, normal T cell expressed, and secreted in endometriotic cells. J Clin Endocrinol Metab. 2002;87:5785-5792
50. Luk J, Seval Y, Ulukus M, Ulukus EC, Arici A, Kayisli UA. Regulation of monocyte chemotactic protein-1 expression in human endometrial endothelial cells by sex steroids: a potential mechanism for leukocyte recruitment in endometriosis. Reprod Sci. 2010;17: 278-287
51. Attar E, Tokunaga H, Imir G, et al. Prostaglandin E2 via steroidogenic factor-1 coordinately regulates transcription of steroidogenic genes necessary for estrogen synthesis in endometriosis. J Clin Endocrinol Metab. 2009;94:623-631.