Genome-wide mapping of estrogen receptor-β-binding regions reveals extensive cross-talk with transcription factor activator protein-1

Cancer Research

Volumn 70, Issue 12, 2010, Pages 5174-5183

  Zhao, Chunyan ^a   Gao, Hui ^a   Liu, Yawen ^b   Papoutsi, Zoi ^a   Jaffrey, Sadaf ^a   Gustafsson, Jan Åke ^a,c   Dahlman Wright, Karin ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b JILIN UNIVERSITY   (China)

^c University of Houston   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIESTROGEN; DNA; ESTRADIOL; ESTROGEN RECEPTOR BETA; PROTEIN C FOS; PROTEIN C JUN; SMALL INTERFERING RNA; TAMOXIFEN; TRANSCRIPTION FACTOR AP 1;

ARTICLE; BINDING SITE; BREAST CANCER; CANCER CELL CULTURE; CELL STRAIN MCF 7; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DNA BINDING; GENE MAPPING; GENE OVEREXPRESSION; GENETIC ASSOCIATION; GENOME ANALYSIS; HUMAN; HUMAN CELL; MOLECULAR INTERACTION; ONCOGENE C FOS; ONCOGENE C JUN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

BLOTTING, WESTERN; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; CHROMATIN; CHROMATIN IMMUNOPRECIPITATION; ESTROGEN RECEPTOR BETA; ESTROGENS; FEMALE; GENOME, HUMAN; HUMANS; LUCIFERASES; PROMOTER REGIONS, GENETIC; RESPONSE ELEMENTS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRANSCRIPTION FACTOR AP-1;

EID: 77953740831     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-09-4407     Document Type: Article

References (44)

1. Hall JM, Couse JF, Korach KS. The multifaceted mechanisms of estradiol and estrogen receptor signaling. J Biol Chem 2001;276: 36869-72.
2. Nilsson S, Gustafsson JA. Estrogen receptor action. Crit Rev Eukaryot Gene Expr 2002;12:237-57.
3. Klinge CM. Estrogen receptor interaction with estrogen response elements. Nucleic Acids Res 2001;29:2905-19.
4. Kushner PJ, Agard DA, Greene GL, et al. Estrogen receptor pathways to AP-1. J Steroid Biochem Mol Biol 2000;74:311-7.
5. Saville B, Wormke M, Wang F, et al. Ligand-, cell-, and estrogen receptor subtype (α/aβ)-dependent activation at GC-rich (Sp1) promoter elements. J Biol Chem 2000;275:5379-87.
6. Cheung E, Acevedo ML, Cole PA, Kraus WL. Altered pharmacology and distinct coactivator usage for estrogen receptor-dependent transcription through activating protein-1. Proc Natl Acad Sci U S A 2005;102:559-64.
7. Paech K, Webb P, Kuiper GG, et al. Differential ligand activation of estrogen receptors ERα and ERaβ at AP1 sites. Science 1997;277: 1508-10.
8. Webb P, Nguyen P, Valentine C, et al. The estrogen receptor enhances AP-1 activity by two distinct mechanisms with different requirements for receptor transactivation functions. Mol Endocrinol 1999;13:1672-85.
9. Umayahara Y, Kawamori R, Watada H, et al. Estrogen regulation of the insulin-like growth factor I gene transcription involves an AP-1 enhancer. J Biol Chem 1994;269:16433-42.
10. Schmitt M, Bausero P, Simoni P, et al. Positive and negative effects of nuclear receptors on transcription activation by AP-1 of the human choline acetyltransferase proximal promoter. J Neurosci Res 1995; 40:152-64.
11. Angel P, Baumann I, Stein B, Delius H, Rahmsdorf HJ, Herrlich P. 12-O-tetradecanoyl-phorbol-13-acetate induction of the human collagenase gene is mediated by an inducible enhancer element located in the 5′-flanking region. Mol Cell Biol 1987;7:2256-66.
12. Shaulian E, Karin M. AP-1 as a regulator of cell life and death. Nat Cell Biol 2002;4:E131-6.
13. van Dam H, Castellazzi M. Distinct roles of Jun: Fos and Jun: ATF dimers in oncogenesis. Oncogene 2001;20:2453-64.
14. Carroll JS, Meyer CA, Song J, et al. Genome-wide analysis of estrogen receptor binding sites. Nat Genet 2006;38:1289-97.
15. Lin CY, Vega VB, Thomsen JS, et al. Whole-genome cartography of estrogen receptor α binding sites. PLoS Genet 2007;3:e87.
16. Welboren WJ, van Driel MA, Janssen-Megens EM, et al. ChIP-Seq of ERα and RNA polymerase II defines genes differentially responding to ligands. EMBO J 2009;28:1418-28.
17. Papoutsi Z, Zhao C, Putnik M, Gustafsson JA, Dahlman-Wright K. Binding of estrogen receptor α/β heterodimers to chromatin in MCF-7 cells. J Mol Endocrinol 2009;43:65-72.
18. Zhao C, Matthews J, Tujague M, et al. Estrogen receptor β2 negatively regulates the transactivation of estrogen receptor α in human breast cancer cells. Cancer Res 2007;67:3955-62.
19. Liu Y, Gao H, Marstrand TT, et al. The genome landscape of ERα- and ERβ-binding DNA regions. Proc Natl Acad Sci U S A 2008;105:2604-9.
20. Johnson WE, Li W, Meyer CA, et al. Model-based analysis of tiling-arrays for ChIP-chip. Proc Natl Acad Sci U S A 2006;103:12457-62.
21. Frith MC, Fu Y, Yu L, Chen JF, Hansen U, Weng Z. Detection of functional DNA motifs via statistical over-representation. Nucleic Acids Res 2004;32:1372-81.
22. Gao H, Falt S, Sandelin A, Gustafsson JA, Dahlman-Wright K. Genome-wide identification of estrogen receptor α-binding sites in mouse liver. Mol Endocrinol 2008;22:10-22.
23. Mahony S, Benos PV. STAMP: a web tool for exploring DNA-binding motif similarities. Nucleic Acids Res 2007;35:253-8.
24. Carroll JS, Liu XS, Brodsky AS, et al. Chromosome-wide mapping of estrogen receptor binding reveals long-range regulation requiring the forkhead protein FoxA1. Cell 2005;122:33-43.
25. Laganiere J, Deblois G, Lefebvre C, Bataille AR, Robert F, Giguere V. From the cover: location analysis of estrogen receptor α target promoters reveals that FOXA1 defines a domain of the estrogen response. Proc Natl Acad Sci U S A 2005;102:11651-6.
26. Charn TH, Liu ET, Chang EC, Lee YK, Katzenellenbogen JA, Katzenellenbogen BS. Genome-wide dynamics of chromatin binding of estrogen receptors α and β: mutual restriction and competitive site selection. Mol Endocrinol 2010;24:47-59.
27. Chang EC, Frasor J, Komm B, Katzenellenbogen BS. Impact of estrogen receptor β on gene networks regulated by estrogen receptor α in breast cancer cells. Endocrinology 2006;147:4831-42.
28. Williams C, Edvardsson K, Lewandowski SA, Strom A, Gustafsson JA. A genome-wide study of the repressive effects of estrogen receptor β on estrogen receptor α signaling in breast cancer cells. Oncogene 2008;27:1019-32.
29. Chang EC, Charn TH, Park SH, et al. Estrogen receptors α and β as determinants of gene expression: influence of ligand, dose, and chromatin binding. Mol Endocrinol 2008;22:1032-43.
30. Lu C, Shen Q, DuPre E, Kim H, Hilsenbeck S, Brown PH. cFos is critical for MCF-7 breast cancer cell growth. Oncogene 2005; 24:6516-24.
31. Pike JW, Meyer MB, Watanuki M, et al. Perspectives on mechanisms of gene regulation by 1,25-dihydroxyvitamin D3 and its receptor. J Steroid Biochem Mol Biol 2007;103:389-95.
32. So AY, Chaivorapol C, Bolton EC, Li H, Yamamoto KR. Determinants of cell- and gene-specific transcriptional regulation by the glucocorticoid receptor. PLoS Genet 2007;3:e94.
33. Wang Q, Li W, Liu XS, et al. A hierarchical network of transcription factors governs androgen receptor-dependent prostate cancer growth. Mol Cell 2007;27:380-92.
34. Kininis M, Kraus WL. A global view of transcriptional regulation by nuclear receptors: gene expression, factor localization, and DNA sequence analysis. Nucl Recept Signal 2008;6:e005.
35. Cheng AS, Jin VX, Fan M, et al. Combinatorial analysis of transcription factor partners reveals recruitment of c-MYC to estrogen receptor-α responsive promoters. Mol Cell 2006;21:393-404. (Pubitemid 43163534)
36. Jones C, Payne J, Wells D, Delhanty JD, Lakhani SR, Kortenkamp A. Comparative genomic hybridization reveals extensive variation among different MCF-7 cell stocks. Cancer Genet Cytogenet 2000; 117:153-8.
37. Nugoli M, Chuchana P, Vendrell J, et al. Genetic variability in MCF-7 sublines: evidence of rapid genomic and RNA expression profile modifications. BMC Cancer 2003;3:13. (Pubitemid 38851336)
38. Lin CY, Strom A, Li Kong S, et al. Inhibitory effects of estrogen receptor β on specific hormone-responsive gene expression and association with disease outcome in primary breast cancer. Breast Cancer Res 2007;9:R25. (Pubitemid 350215162)
39. Secreto FJ, Monroe DG, Dutta S, Ingle JN, Spelsberg TC. Estrogen receptor α/β isoforms, but not betacx, modulate unique patterns of gene expression and cell proliferation in Hs578T cells. J Cell Biochem 2007;101:1125-47.
40. Metivier R, Gallais R, Tiffoche C, et al. Cyclical DNA methylation of a transcriptionally active promoter. Nature 2008;452:45-50. (Pubitemid 351355084)
41. Pan YF, Wansa KD, Liu MH, et al. Regulation of estrogen receptor-mediated long range transcription via evolutionarily conserved distal response elements. J Biol Chem 2008;283:32977-88.
42. Reid G, Hubner MR, Metivier R, et al. Cyclic, proteasome-mediated turnover of unliganded and liganded ERα on responsive promoters is an integral feature of estrogen signaling. Mol Cell 2003;11: 695-707. (Pubitemid 36385123)
43. Curtis SW, Washburn T, Sewall C, et al. Physiological coupling of growth factor and steroid receptor signaling pathways: estrogen receptor knockout mice lack estrogen-like response to epidermal growth factor. Proc Natl Acad Sci U S A 1996;93:12626-30.
44. Available from: http://research.dfci.harvard.edu/brownlab/datasets/.