Carvedilol analog modulates both basal and stimulated sinoatrial node automaticity

Heart and Vessels

Volumn 29, Issue 3, 2014, Pages 396-403

  Shinohara, Tetsuji ^a,b   Kim, Daehyeok ^a   Joung, Boyoung ^a   Maruyama, Mitsunori ^a   Vembaiyan, Kannan ^c   Back, Thomas G ^c   Wayne Chen, S R ^c   Chen, Peng Sheng ^a   Lin, Shien Fong ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b OITA UNIVERSITY   (Japan)

^c UNIVERSITY OF CALGARY   (Canada)

Author keywords

Calcium; Sarcoplasmic reticulum; Sinoatrial node; Store overload induced Ca release; Sympathetic nervous system

Indexed keywords

BETA ADRENERGIC RECEPTOR; CAFFEINE; CALCIUM; CARVEDILOL; DRUG ANALOG; ISOPRENALINE; RYANODINE; UNCLASSIFIED DRUG; VK II 36; ANTIARRHYTHMIC AGENT; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CARBAZOLE DERIVATIVE; MORPHOLINE DERIVATIVE; PROPANOLAMINE DERIVATIVE; VK-II-36 COMPOUND;

ACTION POTENTIAL; ADRENERGIC SYSTEM; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BETA ADRENERGIC STIMULATION; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CONCENTRATION RESPONSE; DOG; DOWN REGULATION; DRUG EFFECT; HEART AUTOMATICITY; HEART RIGHT ATRIUM; INHIBITION KINETICS; MEMBRANE POTENTIAL; MODULATION; NONHUMAN; PACEMAKER; PRIORITY JOURNAL; SARCOPLASMIC RETICULUM; SINOATRIAL CONDUCTION; SINOATRIAL NODE AUTOMATICITY; SINUS NODE; SINUS RHYTHM; ANIMAL; BIOLOGICAL RHYTHM; CALCIUM SIGNALING; DOSE RESPONSE; DRUG EFFECTS; HEART RATE; METABOLISM; TIME; VOLTAGE SENSITIVE DYE IMAGING;

ACTION POTENTIALS; ADRENERGIC BETA-AGONISTS; ANIMALS; ANTI-ARRHYTHMIA AGENTS; BIOLOGICAL CLOCKS; CALCIUM SIGNALING; CARBAZOLES; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; HEART RATE; MORPHOLINES; PROPANOLAMINES; SARCOPLASMIC RETICULUM; SINOATRIAL NODE; TIME FACTORS; VOLTAGE-SENSITIVE DYE IMAGING;

EID: 84905187153     PISSN: 09108327     EISSN: 16152573     Source Type: Journal    
DOI: 10.1007/s00380-013-0378-2     Document Type: Article

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