Endothelin-1 driven proliferation of pulmonary arterial smooth muscle cells is c-fos dependent

International Journal of Biochemistry and Cell Biology

Volumn 54, Issue , 2014, Pages 137-148

  Biasin, Valentina ^a   Chwalek, Karolina ^b   Wilhelm, Jochen ^b   Best, Johannes ^b   Marsh, Leigh M ^a   Ghanim, Bahil ^a,c   Klepetko, Walter ^c   Fink, Ludger ^b,d   Schermuly, Ralph T ^b   Weissmann, Norbert ^b   Olschewski, Andrea ^a,e   Kwapiszewska, Grazyna ^a,e  

^a LUDWIG BOLTZMANN INSTITUTE FOR LUNG VASCULAR RESEARCH   (Austria)

^b JUSTUS LIEBIG UNIVERSITY GIESSEN   (Germany)

^c MEDICAL UNIVERSITY OF VIENNA   (Austria)

^d Institute of Pathology and Cytology   (Germany)

^e MEDICAL UNIVERSITY OF GRAZ   (Austria)

Author keywords

c Fos; Endothelin 1; Proliferation; Pulmonary hypertension; Transcription factor

Indexed keywords

CONNECTIVE TISSUE GROWTH FACTOR; CYCLIN D1; ENDOTHELIN 1; KI 67 ANTIGEN; MITOGEN ACTIVATED PROTEIN KINASE; MONOCROTALINE; PLATELET DERIVED GROWTH FACTOR; PROTEIN C JUN; SMALL INTERFERING RNA; BIOLOGICAL MARKER; MESSENGER RNA; PROTEIN C FOS;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL CYCLE PROGRESSION; CELL PROLIFERATION; CELL STIMULATION; CLINICAL ARTICLE; CONTROLLED STUDY; DNA SYNTHESIS; GENE SILENCING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOXIA; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; LUNG BLOOD VESSEL; LUNG HOMOGENATE; MALE; NONHUMAN; ONCOGENE C FOS; PROTEIN ISOLATION; PROTEIN PHOSPHORYLATION; PULMONARY ARTERY; PULMONARY ARTERY SMOOTH MUSCLE CELL; PULMONARY HYPERTENSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; RNA ISOLATION; SMOOTH MUSCLE FIBER; UPREGULATION; WESTERN BLOTTING; ANIMAL; ANOXIA; APOPTOSIS; BAGG ALBINO MOUSE; C57BL MOUSE; CASE CONTROL STUDY; CELL CULTURE; COMPARATIVE STUDY; CYTOLOGY; DNA MICROARRAY; DRUG EFFECTS; ENZYME IMMUNOASSAY; FAMILIAL PRIMARY PULMONARY HYPERTENSION; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION PROFILING; GENETICS; LUNG; METABOLISM; MOUSE; PATHOLOGY; PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT; VASCULAR SMOOTH MUSCLE; ARTERY MUSCLE; MICROARRAY ANALYSIS; PROTEIN EXPRESSION; VASCULAR REMODELING;

ANIMALS; ANOXIA; APOPTOSIS; BIOLOGICAL MARKERS; BLOTTING, WESTERN; CASE-CONTROL STUDIES; CELL PROLIFERATION; CELLS, CULTURED; ENDOTHELIN-1; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FAMILIAL PRIMARY PULMONARY HYPERTENSION; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION PROFILING; HUMANS; IMMUNOENZYME TECHNIQUES; LUNG; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MITOGEN-ACTIVATED PROTEIN KINASES; MUSCLE, SMOOTH, VASCULAR; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-FOS; PULMONARY ARTERY; RATS; RATS, SPRAGUE-DAWLEY; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION;

MUS; RATTUS;

EID: 84905164466     PISSN: 13572725     EISSN: 18785875     Source Type: Journal    
DOI: 10.1016/j.biocel.2014.06.020     Document Type: Article

References (52)

1. N.R. Bauer, and T.M. Moore et al. Rodent models of PAH: are we there yet? Am J Physiol Lung Cell Mol Physiol 293 3 2007 L580 L582
2. V. Biasin, and L.M. Marsh et al. Meprin beta, a novel mediator of vascular remodeling underlying pulmonary hypertension J Pathol 233 1 2014 7 17
3. C.B. Dean, and J.D. Nielsen Generalized linear mixed models: a review and some extensions Lifetime Data Anal 13 4 2007 497 512
4. J.T. Erler, and K.L. Bennewith et al. Lysyl oxidase is essential for hypoxia-induced metastasis Nature 440 7088 2006 1222 1226
5. 2+ entry in human pulmonary artery endothelial cells Am J Physiol Lung Cell Mol Physiol 285 6 2003 L1233 L1245
6. S.Y. Fuchs, and L. Dolan et al. Phosphorylation-dependent targeting of c-Jun ubiquitination by Jun N-kinase Oncogene 13 7 1996 1531 1535 (Pubitemid 26354201)
7. M. Gonzalez-Ramos, and I. Mora et al. Intracellular redox equilibrium is essential for the constitutive expression of AP-1 dependent genes in resting cells: studies on TGF-beta1 regulation Int J Biochem Cell Biol 44 6 2012 963 971
8. S.M. Hall, and N. Davie et al. Endothelin receptor expression in idiopathic pulmonary arterial hypertension: effect of bosentan and epoprostenol treatment Eur Respir J 38 4 2011 851 860
9. S. Healy, and P. Khan et al. Immediate early response genes and cell transformation Pharmacol Ther 137 1 2013 64 77
10. D.F. Higgins, and M.P. Biju et al. Hypoxic induction of Ctgf is directly mediated by Hif-1 Am J Physiol Renal Physiol 287 6 2004 F1223 F1232
11. J. Hu, and D.J. Discher et al. Hypoxia regulates expression of the endothelin-1 gene through a proximal hypoxia-inducible factor-1 binding site on the antisense strand Biochem Biophys Res Commun 245 3 1998 894 899 (Pubitemid 28414014)
12. 2+]i signaling but potentiates endothelin's effect on c-fos and c-jun induction in vascular smooth muscle and glomerular mesangial cells Am Heart J 125 2 Pt 2 1993 589 597 (Pubitemid 23054254)
13. J. Kelley, and J.P. Fabisiak et al. Cytokine signaling in lung: transforming growth factor-beta secretion by lung fibroblasts Am J Physiol 260 2 Pt 1 1991 L123 L128
14. S. Kourembanas, and P.A. Marsden et al. Hypoxia induces endothelin gene expression and secretion in cultured human endothelium J Clin Invest 88 3 1991 1054 1057
15. N. Kunichika, and J.W. Landsberg et al. Bosentan inhibits transient receptor potential channel expression in pulmonary vascular myocytes Am J Respir Crit Care Med 170 10 2004 1101 1107 (Pubitemid 39488623)
16. G. Kwapiszewska, and K. Chwalek et al. BDNF/TrkB signaling augments smooth muscle cell proliferation in pulmonary hypertension Am J Pathol 181 6 2012 2018 2029
17. G. Kwapiszewska, and P. Markart et al. PAR-2 inhibition reverses experimental pulmonary hypertension Circ Res 110 9 2012 1179 1191
18. C. Lambers, and M. Roth et al. The interaction of endothelin-1 and TGF-beta1 mediates vascular cell remodeling PLoS One 8 8 2013 e73399
19. J.W. Lee, and S.H. Bae et al. Hypoxia-inducible factor (HIF-1)alpha: its protein stability and biological functions Exp Mol Med 36 1 2004 1 12
20. H.Y. Lin, and C.H. Tang et al. Peptidoglycan induces interleukin-6 expression through the TLR2 receptor, JNK, c-Jun, and AP-1 pathways in microglia J Cell Physiol 226 6 2011 1573 1582
21. I. Martin, and M. Humbert et al. Plasminogen activation by blood monocytes and alveolar macrophages in primary pulmonary hypertension Blood Coagul Fibrinolysis 13 5 2002 417 422 (Pubitemid 35001858)
22. S.L. Merklinger, and R.A. Wagner et al. Increased fibulin-5 and elastin in S100A4/Mts1 mice with pulmonary hypertension Circ Res 97 6 2005 596 604 (Pubitemid 41361751)
23. N.H. Moritani, and S. Kubota et al. Interaction of AP-1 and the ctgf gene: a possible driver of chondrocyte hypertrophy in growth cartilage J Bone Miner Metab 21 4 2003 205 210 (Pubitemid 41184285)
24. N.W. Morrell, and S. Adnot et al. Cellular and molecular basis of pulmonary arterial hypertension J Am Coll Cardiol 54 1 Suppl 2009 S20 S31
25. T. Nishimura, and P.K. Vogt The avian cellular homolog of the oncogene jun Oncogene 3 6 1988 659 663 (Pubitemid 19030376)
26. M. Nootens, and E. Kaufmann et al. Neurohormonal activation in patients with right ventricular failure from pulmonary hypertension: relation to hemodynamic variables and endothelin levels J Am Coll Cardiol 26 7 1995 1581 1585
27. K. Okazaki, and N. Sagata The Mos/MAP kinase pathway stabilizes c-Fos by phosphorylation and augments its transforming activity in NIH 3T3 cells EMBO J 14 20 1995 5048 5059
28. H. Olschewski, and F. Rose et al. Cellular pathophysiology and therapy of pulmonary hypertension J Lab Clin Med 138 6 2001 367 377 (Pubitemid 34010020)
29. G. Pearson, and F. Robinson et al. Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions Endocr Rev 22 2 2001 153 183 (Pubitemid 32458157)
30. F. Perros, and D. Montani et al. Platelet-derived growth factor expression and function in idiopathic pulmonary arterial hypertension Am J Respir Crit Care Med 178 1 2008 81 88 (Pubitemid 351919196)
31. L.J. Rubin, and D.B. Badesch et al. Bosentan therapy for pulmonary arterial hypertension N Engl J Med 346 12 2002 896 903 (Pubitemid 34984638)
32. T. Sasaki, and H. Kojima et al. Spatiotemporal regulation of c-Fos by ERK5 and the E3 ubiquitin ligase UBR1, and its biological role Mol Cell 24 1 2006 63 75 (Pubitemid 44466681)
33. R.T. Schermuly, and E. Dony et al. Reversal of experimental pulmonary hypertension by PDGF inhibition J Clin Invest 115 10 2005 2811 2821 (Pubitemid 41434408)
34. R.T. Schermuly, and H.A. Ghofrani et al. Mechanisms of disease: pulmonary arterial hypertension Nat Rev Cardiol 8 8 2011 443 455
35. E. Shaulian, and M. Karin AP-1 in cell proliferation and survival Oncogene 20 19 2001 2390 2400 (Pubitemid 32531297)
36. M. Silbermann, and J. Schmidt et al. In vitro induction of osteosarcomalike lesion by transformation of differentiating skeletal precursor cells with FBR murine osteosarcoma virus Calcif Tissue Int 41 4 1987 208 217
37. G.K. Smyth, and T. Speed Normalization of cDNA microarray data Methods 31 4 2003 265 273 (Pubitemid 37338763)
38. K.R. Stenmark, and K.A. Fagan et al. Hypoxia-induced pulmonary vascular remodeling: cellular and molecular mechanisms Circ Res 99 7 2006 675 691 (Pubitemid 44498302)
39. K.R. Stenmark, and B. Meyrick et al. Animal models of pulmonary arterial hypertension: the hope for etiological discovery and pharmacological cure Am J Physiol Lung Cell Mol Physiol 297 6 2009 L1013 L1032
40. T. Tanos, and M.J. Marinissen et al. Phosphorylation of c-Fos by members of the p38 MAPK family. Role in the AP-1 response to UV light J Biol Chem 280 19 2005 18842 18852 (Pubitemid 41379586)
41. H. ten Freyhaus, and M. Dagnell et al. Hypoxia enhances platelet-derived growth factor signaling in the pulmonary vasculature by down-regulation of protein tyrosine phosphatases Am J Respir Crit Care Med 183 8 2011 1092 1102
42. M. Toshner, and T. Tajsic et al. Pulmonary hypertension: advances in pathogenesis and treatment Br Med Bull 94 2010 21 32
43. J.R. Vane, and R.M. Botting Secretory functions of the vascular endothelium J Physiol Pharmacol 43 3 1992 195 207
44. C. Veith, and S. Schmitt et al. Cofilin, a hypoxia-regulated protein in murine lungs identified by 2DE: role of the cytoskeletal protein cofilin in pulmonary hypertension Proteomics 13 1 2013 75 88
45. O.F. Wagner, and G. Christ et al. Polar secretion of endothelin-1 by cultured endothelial cells J Biol Chem 267 23 1992 16066 16068
46. Z. Wang, and N. Jin et al. Rho-kinase activation is involved in hypoxia-induced pulmonary vasoconstriction Am J Respir Cell Mol Biol 25 5 2001 628 635 (Pubitemid 33087114)
47. F.C. Weisel, and C. Kloepping et al. Impact of S-adenosylmethionine decarboxylase 1 on pulmonary vascular remodeling Circulation 129 14 2014 1510 1523
48. K. White, and L. Loughlin et al. Serotonin transporter, sex, and hypoxia: microarray analysis in the pulmonary arteries of mice identifies genes with relevance to human PAH Physiol Genomics 43 8 2011 417 437
49. K. Yamashita, and D.J. Discher et al. Molecular regulation of the endothelin-1 gene by hypoxia. Contributions of hypoxia-inducible factor-1, activator protein-1, GATA-2, AND p300/CBP J Biol Chem 276 16 2001 12645 12653
50. +)channel activity in pulmonary artery smooth muscle cells Circulation 104 13 2001 1557 1563 (Pubitemid 32917351)
51. J.X. Yuan, and L.J. Rubin Pathogenesis of pulmonary arterial hypertension: the need for multiple hits Circulation 111 5 2005 534 538 (Pubitemid 40216478)
52. R. Zhang, and L. Shi et al. Transgelin as a therapeutic target to prevent hypoxic pulmonary hypertension Am J Physiol Lung Cell Mol Physiol 306 6 2014 L574 L583