메뉴 건너뛰기




Volumn 42, Issue 8, 2014, Pages 651-660

Expression profiling of leukemia patients: Key lessons and future directions

Author keywords

[No Author keywords available]

Indexed keywords

MICRORNA; MICRORNA 10A; MICRORNA 10B; MICRORNA 126; MICRORNA 127; MICRORNA 128; MICRORNA 130A; MICRORNA 17; MICRORNA 181B; MICRORNA 204; MICRORNA 299; MICRORNA 323; MICRORNA 368; MICRORNA 382; MICRORNA 451; UNCLASSIFIED DRUG;

EID: 84905163247     PISSN: 0301472X     EISSN: 18732399     Source Type: Journal    
DOI: 10.1016/j.exphem.2014.04.006     Document Type: Review
Times cited : (35)

References (96)
  • 1
    • 0033569406 scopus 로고    scopus 로고
    • Molecular classification of cancer: class discovery and class prediction by gene expression monitoring
    • Golub T.R., Slonim D.K., Tamayo P., et al. Molecular classification of cancer: class discovery and class prediction by gene expression monitoring. Science 1999, 286:531-537.
    • (1999) Science , vol.286 , pp. 531-537
    • Golub, T.R.1    Slonim, D.K.2    Tamayo, P.3
  • 2
    • 72949114887 scopus 로고    scopus 로고
    • Leukaemogenesis: more than mutant genes
    • Chen J., Odenike O., Rowley J.D. Leukaemogenesis: more than mutant genes. Nat Rev Cancer 2010, 10:23-36.
    • (2010) Nat Rev Cancer , vol.10 , pp. 23-36
    • Chen, J.1    Odenike, O.2    Rowley, J.D.3
  • 3
    • 33751267902 scopus 로고    scopus 로고
    • Acute myeloid leukaemia
    • Estey E., Dohner H. Acute myeloid leukaemia. Lancet 2006, 368:1894-1907.
    • (2006) Lancet , vol.368 , pp. 1894-1907
    • Estey, E.1    Dohner, H.2
  • 4
    • 27244437619 scopus 로고    scopus 로고
    • Gene expression profiling in acute myeloid leukemia
    • Bullinger L., Valk P.J.M. Gene expression profiling in acute myeloid leukemia. J Clin Oncol 2005, 23:6296-6305.
    • (2005) J Clin Oncol , vol.23 , pp. 6296-6305
    • Bullinger, L.1    Valk, P.J.M.2
  • 5
    • 79958097977 scopus 로고    scopus 로고
    • Gene expression profiling in MDS and AML: potential and future avenues
    • Theilgaard-Monch K., Boultwood J., Ferrari S., et al. Gene expression profiling in MDS and AML: potential and future avenues. Leukemia 2011, 25:909-920.
    • (2011) Leukemia , vol.25 , pp. 909-920
    • Theilgaard-Monch, K.1    Boultwood, J.2    Ferrari, S.3
  • 6
    • 58849167390 scopus 로고    scopus 로고
    • A decade of genome-wide gene expression profiling in acute myeloid leukemia: flashback and prospects
    • Wouters B.J., Lowenberg B., Delwel R. A decade of genome-wide gene expression profiling in acute myeloid leukemia: flashback and prospects. Blood 2009, 113:291-298.
    • (2009) Blood , vol.113 , pp. 291-298
    • Wouters, B.J.1    Lowenberg, B.2    Delwel, R.3
  • 8
    • 16544369516 scopus 로고    scopus 로고
    • Use of gene-expression profiling to identify prognostic subclasses in adult acute myeloid leukemia
    • Bullinger L., Dohner K., Bair E., et al. Use of gene-expression profiling to identify prognostic subclasses in adult acute myeloid leukemia. N Engl J Med 2004, 350:1605-1616.
    • (2004) N Engl J Med , vol.350 , pp. 1605-1616
    • Bullinger, L.1    Dohner, K.2    Bair, E.3
  • 9
    • 34548018092 scopus 로고    scopus 로고
    • Gene-expression profiling identifies distinct subclasses of core binding factor acute myeloid leukemia
    • Bullinger L., Rucker F.G., Kurz S., et al. Gene-expression profiling identifies distinct subclasses of core binding factor acute myeloid leukemia. Blood 2007, 110:1291-1300.
    • (2007) Blood , vol.110 , pp. 1291-1300
    • Bullinger, L.1    Rucker, F.G.2    Kurz, S.3
  • 10
    • 77649223936 scopus 로고    scopus 로고
    • KIT mutations confer a distinct gene expression signature in core binding factor leukaemia
    • Luck S.C., Russ A.C., Du J., et al. KIT mutations confer a distinct gene expression signature in core binding factor leukaemia. Br J Haematol 2010, 148:925-937.
    • (2010) Br J Haematol , vol.148 , pp. 925-937
    • Luck, S.C.1    Russ, A.C.2    Du, J.3
  • 11
    • 11144358111 scopus 로고    scopus 로고
    • Prognostically useful gene-expression profiles in acute myeloid leukemia
    • Valk P.J., Verhaak R.G., Beijen M.A., et al. Prognostically useful gene-expression profiles in acute myeloid leukemia. N Engl J Med 2004, 350:1617-1628.
    • (2004) N Engl J Med , vol.350 , pp. 1617-1628
    • Valk, P.J.1    Verhaak, R.G.2    Beijen, M.A.3
  • 12
    • 33745957993 scopus 로고    scopus 로고
    • Gene expression profiling of adult acute myeloid leukemia identifies novel biologic clusters for risk classification and outcome prediction
    • Wilson C.S., Davidson G.S., Martin S.B., et al. Gene expression profiling of adult acute myeloid leukemia identifies novel biologic clusters for risk classification and outcome prediction. Blood 2006, 108:685-696.
    • (2006) Blood , vol.108 , pp. 685-696
    • Wilson, C.S.1    Davidson, G.S.2    Martin, S.B.3
  • 13
    • 63849241865 scopus 로고    scopus 로고
    • Double CEBPA mutations, but not single CEBPA mutations, define a subgroup of acute myeloid leukemia with a distinctive gene expression profile that is uniquely associated with a favorable outcome
    • Wouters B.J., Löwenberg B., Erpelinck-Verschueren C.A.J., Van Putten W.L.J., Valk P.J.M., Delwel R. Double CEBPA mutations, but not single CEBPA mutations, define a subgroup of acute myeloid leukemia with a distinctive gene expression profile that is uniquely associated with a favorable outcome. Blood 2009, 113:3088-3091.
    • (2009) Blood , vol.113 , pp. 3088-3091
    • Wouters, B.J.1    Löwenberg, B.2    Erpelinck-Verschueren, C.A.J.3    Van Putten, W.L.J.4    Valk, P.J.M.5    Delwel, R.6
  • 14
    • 77955134007 scopus 로고    scopus 로고
    • Clinical utility of microarray-based gene expression profiling in the diagnosis and subclassification of leukemia: report from the International Microarray Innovations in Leukemia Study Group
    • Haferlach T., Kohlmann A., Wieczorek L., et al. Clinical utility of microarray-based gene expression profiling in the diagnosis and subclassification of leukemia: report from the International Microarray Innovations in Leukemia Study Group. J Clin Oncol 2010, 28:2529-2537.
    • (2010) J Clin Oncol , vol.28 , pp. 2529-2537
    • Haferlach, T.1    Kohlmann, A.2    Wieczorek, L.3
  • 15
    • 84863269138 scopus 로고    scopus 로고
    • Up-regulation of a HOXA-PBX3 homeobox-gene signature following down-regulation of miR-181 is associated with adverse prognosis in patients with cytogenetically abnormal AML
    • Li Z., Huang H., Li Y., et al. Up-regulation of a HOXA-PBX3 homeobox-gene signature following down-regulation of miR-181 is associated with adverse prognosis in patients with cytogenetically abnormal AML. Blood 2012, 119:2314-2324.
    • (2012) Blood , vol.119 , pp. 2314-2324
    • Li, Z.1    Huang, H.2    Li, Y.3
  • 16
    • 16544369516 scopus 로고    scopus 로고
    • Use of gene-expression profiling to identify prognostic subclasses in adult acute myeloid leukemia
    • Bullinger L., Döhner K., Bair E., et al. Use of gene-expression profiling to identify prognostic subclasses in adult acute myeloid leukemia. N Engl J Med 2004, 350:1605-1616.
    • (2004) N Engl J Med , vol.350 , pp. 1605-1616
    • Bullinger, L.1    Döhner, K.2    Bair, E.3
  • 17
    • 41649119008 scopus 로고    scopus 로고
    • Distinctive microRNA signature of acute myeloid leukemia bearing cytoplasmic mutated nucleophosmin
    • Garzon R., Garofalo M., Martelli M.P., et al. Distinctive microRNA signature of acute myeloid leukemia bearing cytoplasmic mutated nucleophosmin. Proc Natl Acad Sci U S A 2008, 105:3945-3950.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 3945-3950
    • Garzon, R.1    Garofalo, M.2    Martelli, M.P.3
  • 18
    • 28444446313 scopus 로고    scopus 로고
    • Mutations in nucleophosmin (NPM1) in acute myeloid leukemia (AML): association with other gene abnormalities and previously established gene expression signatures and their favorable prognostic significance
    • Verhaak R.G.W., Goudswaard C.S., Van Putten W., et al. Mutations in nucleophosmin (NPM1) in acute myeloid leukemia (AML): association with other gene abnormalities and previously established gene expression signatures and their favorable prognostic significance. Blood 2005, 106:3747-3754.
    • (2005) Blood , vol.106 , pp. 3747-3754
    • Verhaak, R.G.W.1    Goudswaard, C.S.2    Van Putten, W.3
  • 19
    • 35348896184 scopus 로고    scopus 로고
    • Distinct gene expression profiles of acute myeloid/T-lymphoid leukemia with silenced CEBPA and mutations in NOTCH1
    • Wouters B.J., Jordà M.A., Keeshan K., et al. Distinct gene expression profiles of acute myeloid/T-lymphoid leukemia with silenced CEBPA and mutations in NOTCH1. Blood 2007, 110:3706-3714.
    • (2007) Blood , vol.110 , pp. 3706-3714
    • Wouters, B.J.1    Jordà, M.A.2    Keeshan, K.3
  • 20
    • 47149115310 scopus 로고    scopus 로고
    • An FLT3 gene-expression signature predicts clinical outcome in normal karyotype AML
    • Bullinger L., Döhner K., Kranz R., et al. An FLT3 gene-expression signature predicts clinical outcome in normal karyotype AML. Blood 2008, 111:4490-4495.
    • (2008) Blood , vol.111 , pp. 4490-4495
    • Bullinger, L.1    Döhner, K.2    Kranz, R.3
  • 21
    • 77952536841 scopus 로고    scopus 로고
    • IDH1 and IDH2 gene mutations identify novel molecular subsets within de novo cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study
    • Marcucci G., Maharry K., Wu Y.Z., et al. IDH1 and IDH2 gene mutations identify novel molecular subsets within de novo cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study. J Clin Oncol 2010 May 10, 28:2348-2355.
    • (2010) J Clin Oncol , vol.28 , pp. 2348-2355
    • Marcucci, G.1    Maharry, K.2    Wu, Y.Z.3
  • 22
    • 79954428737 scopus 로고    scopus 로고
    • TET2 mutations improve the new European LeukemiaNet risk classification of acute myeloid leukemia: a Cancer and Leukemia Group B study
    • Metzeler K.H., Maharry K., Radmacher M.D., et al. TET2 mutations improve the new European LeukemiaNet risk classification of acute myeloid leukemia: a Cancer and Leukemia Group B study. J Clin Oncol 2011, 29:1373-1381.
    • (2011) J Clin Oncol , vol.29 , pp. 1373-1381
    • Metzeler, K.H.1    Maharry, K.2    Radmacher, M.D.3
  • 23
    • 84862266735 scopus 로고    scopus 로고
    • TET2 mutations in acute myeloid leukemia (AML): results from a comprehensive genetic and clinical analysis of the AML study group
    • Gaidzik V.I., Paschka P., Spath D., et al. TET2 mutations in acute myeloid leukemia (AML): results from a comprehensive genetic and clinical analysis of the AML study group. J Clin Oncol 2012, 30:1350-1357.
    • (2012) J Clin Oncol , vol.30 , pp. 1350-1357
    • Gaidzik, V.I.1    Paschka, P.2    Spath, D.3
  • 24
    • 84255176496 scopus 로고    scopus 로고
    • ASXL1 mutations identify a high-risk subgroup of older patients with primary cytogenetically normal AML within the ELN Favorable genetic category
    • Metzeler K.H., Becker H., Maharry K., et al. ASXL1 mutations identify a high-risk subgroup of older patients with primary cytogenetically normal AML within the ELN Favorable genetic category. Blood 2011, 118:6920-6929.
    • (2011) Blood , vol.118 , pp. 6920-6929
    • Metzeler, K.H.1    Becker, H.2    Maharry, K.3
  • 25
    • 79954448043 scopus 로고    scopus 로고
    • RUNX1 mutations in acute myeloid leukemia: results from a comprehensive genetic and clinical analysis from the AML study group
    • Gaidzik V.I., Bullinger L., Schlenk R.F., et al. RUNX1 mutations in acute myeloid leukemia: results from a comprehensive genetic and clinical analysis from the AML study group. J Clin Oncol 2011, 29:1364-1372.
    • (2011) J Clin Oncol , vol.29 , pp. 1364-1372
    • Gaidzik, V.I.1    Bullinger, L.2    Schlenk, R.F.3
  • 26
    • 77954569665 scopus 로고    scopus 로고
    • Gene expression profiling in AML with normal karyotype can predict mutations for molecular markers and allows novel insights into perturbed biological pathways
    • Kohlmann A., Bullinger L., Thiede C., et al. Gene expression profiling in AML with normal karyotype can predict mutations for molecular markers and allows novel insights into perturbed biological pathways. Leukemia 2010, 24:1216-1220.
    • (2010) Leukemia , vol.24 , pp. 1216-1220
    • Kohlmann, A.1    Bullinger, L.2    Thiede, C.3
  • 27
    • 33747420007 scopus 로고    scopus 로고
    • Independent confirmation of a prognostic gene-expression signature in adult acute myeloid leukemia with a normal karyotype: a Cancer and Leukemia Group B study
    • Radmacher M.D., Marcucci G., Ruppert A.S., et al. Independent confirmation of a prognostic gene-expression signature in adult acute myeloid leukemia with a normal karyotype: a Cancer and Leukemia Group B study. Blood 2006, 108:1677-1683.
    • (2006) Blood , vol.108 , pp. 1677-1683
    • Radmacher, M.D.1    Marcucci, G.2    Ruppert, A.S.3
  • 28
    • 57449103508 scopus 로고    scopus 로고
    • An 86-probe-set gene-expression signature predicts survival in cytogenetically normal acute myeloid leukemia
    • Metzeler K.H., Hummel M., Bloomfield C.D., et al. An 86-probe-set gene-expression signature predicts survival in cytogenetically normal acute myeloid leukemia. Blood 2008, 112:4193-4201.
    • (2008) Blood , vol.112 , pp. 4193-4201
    • Metzeler, K.H.1    Hummel, M.2    Bloomfield, C.D.3
  • 29
    • 84875999131 scopus 로고    scopus 로고
    • Identification of a 24-gene prognostic signature that improves the European LeukemiaNet risk classification of acute myeloid leukemia: an international collaborative study
    • Li Z., Herold T., He C., et al. Identification of a 24-gene prognostic signature that improves the European LeukemiaNet risk classification of acute myeloid leukemia: an international collaborative study. J Clin Oncol 2013, 31:1172-1181.
    • (2013) J Clin Oncol , vol.31 , pp. 1172-1181
    • Li, Z.1    Herold, T.2    He, C.3
  • 30
    • 7244236503 scopus 로고    scopus 로고
    • Gene expression profiles at diagnosis in de novo childhood AML patients identify FLT3 mutations with good clinical outcomes
    • Lacayo N.J., Meshinchi S., Kinnunen P., et al. Gene expression profiles at diagnosis in de novo childhood AML patients identify FLT3 mutations with good clinical outcomes. Blood 2004, 104:2646-2654.
    • (2004) Blood , vol.104 , pp. 2646-2654
    • Lacayo, N.J.1    Meshinchi, S.2    Kinnunen, P.3
  • 31
    • 77951644021 scopus 로고    scopus 로고
    • Gene expression-based classification as an independent predictor of clinical outcome in juvenile myelomonocytic leukemia
    • Bresolin S., Zecca M., Flotho C., et al. Gene expression-based classification as an independent predictor of clinical outcome in juvenile myelomonocytic leukemia. J Clin Oncol 2010, 28:1919-1927.
    • (2010) J Clin Oncol , vol.28 , pp. 1919-1927
    • Bresolin, S.1    Zecca, M.2    Flotho, C.3
  • 32
    • 80052468964 scopus 로고    scopus 로고
    • Stem cell gene expression programs influence clinical outcome in human leukemia
    • Eppert K., Takenaka K., Lechman E.R., et al. Stem cell gene expression programs influence clinical outcome in human leukemia. Nat Med 2011, 17:1086-1093.
    • (2011) Nat Med , vol.17 , pp. 1086-1093
    • Eppert, K.1    Takenaka, K.2    Lechman, E.R.3
  • 33
    • 84885662838 scopus 로고    scopus 로고
    • A stem cell-like gene expression signature associates with inferior outcomes and a distinct microRNA expression profile in adults with primary cytogenetically normal acute myeloid leukemia
    • Metzeler K.H., Maharry K., Kohlschmidt J., et al. A stem cell-like gene expression signature associates with inferior outcomes and a distinct microRNA expression profile in adults with primary cytogenetically normal acute myeloid leukemia. Leukemia 2013, 27:2023-2031.
    • (2013) Leukemia , vol.27 , pp. 2023-2031
    • Metzeler, K.H.1    Maharry, K.2    Kohlschmidt, J.3
  • 34
    • 77949715448 scopus 로고    scopus 로고
    • Integrative meta-analysis of differential gene expression in acute myeloid leukemia
    • Miller B.G., Stamatoyannopoulos J.A. Integrative meta-analysis of differential gene expression in acute myeloid leukemia. PLoS One 2010, 5:e9466.
    • (2010) PLoS One , vol.5
    • Miller, B.G.1    Stamatoyannopoulos, J.A.2
  • 35
    • 80054010617 scopus 로고    scopus 로고
    • Somatic SF3B1 mutation in myelodysplasia with ring sideroblasts
    • Papaemmanuil E., Cazzola M., Boultwood J., et al. Somatic SF3B1 mutation in myelodysplasia with ring sideroblasts. N Engl J Med 2011, 365:1384-1395.
    • (2011) N Engl J Med , vol.365 , pp. 1384-1395
    • Papaemmanuil, E.1    Cazzola, M.2    Boultwood, J.3
  • 36
    • 80053900941 scopus 로고    scopus 로고
    • Frequent pathway mutations of splicing machinery in myelodysplasia
    • Yoshida K., Sanada M., Shiraishi Y., et al. Frequent pathway mutations of splicing machinery in myelodysplasia. Nature 2011, 478:64-69.
    • (2011) Nature , vol.478 , pp. 64-69
    • Yoshida, K.1    Sanada, M.2    Shiraishi, Y.3
  • 37
    • 84859597590 scopus 로고    scopus 로고
    • Mutations in the spliceosome machinery, a novel and ubiquitous pathway in leukemogenesis
    • Makishima H., Visconte V., Sakaguchi H., et al. Mutations in the spliceosome machinery, a novel and ubiquitous pathway in leukemogenesis. Blood 2012, 119:3203-3210.
    • (2012) Blood , vol.119 , pp. 3203-3210
    • Makishima, H.1    Visconte, V.2    Sakaguchi, H.3
  • 38
    • 84868554484 scopus 로고    scopus 로고
    • Commonly altered genomic regions in acute myeloid leukemia are enriched for somatic mutations involved in chromatin remodeling and splicing
    • Dolnik A., Engelmann J.C., Scharfenberger-Schmeer M., et al. Commonly altered genomic regions in acute myeloid leukemia are enriched for somatic mutations involved in chromatin remodeling and splicing. Blood 2012, 120:e83-e92.
    • (2012) Blood , vol.120
    • Dolnik, A.1    Engelmann, J.C.2    Scharfenberger-Schmeer, M.3
  • 39
    • 36249026230 scopus 로고    scopus 로고
    • Alternately spliced WT1 antisense transcripts interact with WT1 sense RNA and show epigenetic and splicing defects in cancer
    • Dallosso A.R., Hancock A.L., Malik S., et al. Alternately spliced WT1 antisense transcripts interact with WT1 sense RNA and show epigenetic and splicing defects in cancer. RNA 2007, 13:2287-2299.
    • (2007) RNA , vol.13 , pp. 2287-2299
    • Dallosso, A.R.1    Hancock, A.L.2    Malik, S.3
  • 40
    • 84895817817 scopus 로고    scopus 로고
    • A genome-wide aberrant RNA splicing in patients with acute myeloid leukemia identifies novel potential disease markers and therapeutic targets
    • Adamia S., Haibe-Kains B., Pilarski P.M., et al. A genome-wide aberrant RNA splicing in patients with acute myeloid leukemia identifies novel potential disease markers and therapeutic targets. Clin Cancer Res 2014, 20:1135.
    • (2014) Clin Cancer Res , vol.20 , pp. 1135
    • Adamia, S.1    Haibe-Kains, B.2    Pilarski, P.M.3
  • 41
    • 50949105626 scopus 로고    scopus 로고
    • A general definition and nomenclature for alternative splicing events
    • Sammeth M., Foissac S., Guigo R. A general definition and nomenclature for alternative splicing events. PLoS Comput Biol 2008, 4:e1000147.
    • (2008) PLoS Comput Biol , vol.4
    • Sammeth, M.1    Foissac, S.2    Guigo, R.3
  • 42
    • 84902575253 scopus 로고    scopus 로고
    • NOTCH2 and FLT3 gene mis-splicing are common events in patients with acute myeloid leukemia (AML): new potential targets in AML
    • Adamia S., Bar-Natan M., Haibe-Kains B., et al. NOTCH2 and FLT3 gene mis-splicing are common events in patients with acute myeloid leukemia (AML): new potential targets in AML. Blood 2014, 123:2816-2825.
    • (2014) Blood , vol.123 , pp. 2816-2825
    • Adamia, S.1    Bar-Natan, M.2    Haibe-Kains, B.3
  • 43
    • 84899748605 scopus 로고    scopus 로고
    • A pan-cancer analysis of transcriptome changes associated with somatic mutations in U2AF1 reveals commonly altered splicing events
    • Brooks A.N., Choi P.S., de Waal L., et al. A pan-cancer analysis of transcriptome changes associated with somatic mutations in U2AF1 reveals commonly altered splicing events. PLoS One 2014, 9:e87361.
    • (2014) PLoS One , vol.9
    • Brooks, A.N.1    Choi, P.S.2    de Waal, L.3
  • 44
    • 84886905271 scopus 로고    scopus 로고
    • Patterns of missplicing due to somatic U2AF1 mutations in myeloid neoplasms
    • Przychodzen B., Jerez A., Guinta K., et al. Patterns of missplicing due to somatic U2AF1 mutations in myeloid neoplasms. Blood 2013, 122:999-1006.
    • (2013) Blood , vol.122 , pp. 999-1006
    • Przychodzen, B.1    Jerez, A.2    Guinta, K.3
  • 46
    • 0347444723 scopus 로고    scopus 로고
    • MicroRNAs: genomics, biogenesis, mechanism, and function
    • Bartel D.P. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 2004, 116:281-297.
    • (2004) Cell , vol.116 , pp. 281-297
    • Bartel, D.P.1
  • 47
    • 58249088751 scopus 로고    scopus 로고
    • MicroRNAs: Target recognition and regulatory functions
    • Bartel D.P. MicroRNAs: Target recognition and regulatory functions. Cell 2009, 136:215-233.
    • (2009) Cell , vol.136 , pp. 215-233
    • Bartel, D.P.1
  • 48
    • 84890053144 scopus 로고    scopus 로고
    • Integrated analysis of miRNA and mRNA during differentiation of human CD34+ cells delineates the regulatory roles of microRNA in hematopoiesis
    • 14-27.e1-2
    • Raghavachari N., Liu P., Barb J.J., et al. Integrated analysis of miRNA and mRNA during differentiation of human CD34+ cells delineates the regulatory roles of microRNA in hematopoiesis. Exp Hematol 2014, 42:14-27.e1-2.
    • (2014) Exp Hematol , vol.42
    • Raghavachari, N.1    Liu, P.2    Barb, J.J.3
  • 49
    • 70249085864 scopus 로고    scopus 로고
    • MicroRNAs: New players in acute myeloid leukaemia
    • Havelange V., Garzon R., Croce C.M. MicroRNAs: New players in acute myeloid leukaemia. Br J Cancer 2009, 101:743-748.
    • (2009) Br J Cancer , vol.101 , pp. 743-748
    • Havelange, V.1    Garzon, R.2    Croce, C.M.3
  • 50
    • 76649121200 scopus 로고    scopus 로고
    • MicroRNAs in acute myeloid leukemia: expression patterns, correlations with genetic and clinical parameters, and prognostic significance
    • Wieser R., Scheideler M., Hackl H., et al. MicroRNAs in acute myeloid leukemia: expression patterns, correlations with genetic and clinical parameters, and prognostic significance. Genes Chromosomes Cancer 2010, 49:193-203.
    • (2010) Genes Chromosomes Cancer , vol.49 , pp. 193-203
    • Wieser, R.1    Scheideler, M.2    Hackl, H.3
  • 51
    • 79251585937 scopus 로고    scopus 로고
    • The prognostic and functional role of microRNAs in acute myeloid leukemia
    • Marcucci G., Mrozek K., Radmacher M.D., Garzon R., Bloomfield C.D. The prognostic and functional role of microRNAs in acute myeloid leukemia. Blood 2011, 117:1121-1129.
    • (2011) Blood , vol.117 , pp. 1121-1129
    • Marcucci, G.1    Mrozek, K.2    Radmacher, M.D.3    Garzon, R.4    Bloomfield, C.D.5
  • 52
    • 20444460289 scopus 로고    scopus 로고
    • MicroRNA expression profiles classify human cancers
    • Lu J., Getz G., Miska E.A., et al. MicroRNA expression profiles classify human cancers. Nature 2005, 435:834-838.
    • (2005) Nature , vol.435 , pp. 834-838
    • Lu, J.1    Getz, G.2    Miska, E.A.3
  • 53
    • 55749099505 scopus 로고    scopus 로고
    • Distinct microRNA expression profiles in acute myeloid leukemia with common translocations
    • Li Z., Lu J., Sun M., et al. Distinct microRNA expression profiles in acute myeloid leukemia with common translocations. Proc Natl Acad Sci U S A 2008, 105:15535-15540.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 15535-15540
    • Li, Z.1    Lu, J.2    Sun, M.3
  • 54
    • 46749108531 scopus 로고    scopus 로고
    • MicroRNA expression profiling in relation to the genetic heterogeneity of acute myeloid leukemia
    • Jongen-Lavrencic M., Sun S.M., Dijkstra M.K., Valk P.J., Lowenberg B. MicroRNA expression profiling in relation to the genetic heterogeneity of acute myeloid leukemia. Blood 2008, 111:5078-5085.
    • (2008) Blood , vol.111 , pp. 5078-5085
    • Jongen-Lavrencic, M.1    Sun, S.M.2    Dijkstra, M.K.3    Valk, P.J.4    Lowenberg, B.5
  • 55
    • 47749117212 scopus 로고    scopus 로고
    • Distinctive patterns of microRNA expression associated with karyotype in acute myeloid leukaemia
    • Dixon-McIver A., East P., Mein C.A., et al. Distinctive patterns of microRNA expression associated with karyotype in acute myeloid leukaemia. PLoS One 2008, 3:e2141.
    • (2008) PLoS One , vol.3
    • Dixon-McIver, A.1    East, P.2    Mein, C.A.3
  • 56
    • 42949083345 scopus 로고    scopus 로고
    • MicroRNA expression in cytogenetically normal acute myeloid leukemia
    • Marcucci G., Radmacher M.D., Maharry K., et al. MicroRNA expression in cytogenetically normal acute myeloid leukemia. N Engl J Med 2008, 358:1919-1928.
    • (2008) N Engl J Med , vol.358 , pp. 1919-1928
    • Marcucci, G.1    Radmacher, M.D.2    Maharry, K.3
  • 57
    • 82855177846 scopus 로고    scopus 로고
    • Integrative nucleophosmin mutation-associated microRNA and gene expression pattern analysis identifies novel microRNA-target gene interactions in acute myeloid leukemia
    • Russ A.C., Sander S., Luck S.C., et al. Integrative nucleophosmin mutation-associated microRNA and gene expression pattern analysis identifies novel microRNA-target gene interactions in acute myeloid leukemia. Haematologica 2011, 96:1783-1791.
    • (2011) Haematologica , vol.96 , pp. 1783-1791
    • Russ, A.C.1    Sander, S.2    Luck, S.C.3
  • 58
    • 42449141513 scopus 로고    scopus 로고
    • MicroRNA signatures associated with cytogenetics and prognosis in acute myeloid leukemia
    • Garzon R., Volinia S., Liu C.G., et al. MicroRNA signatures associated with cytogenetics and prognosis in acute myeloid leukemia. Blood 2008, 111:3183-3189.
    • (2008) Blood , vol.111 , pp. 3183-3189
    • Garzon, R.1    Volinia, S.2    Liu, C.G.3
  • 59
    • 55549103713 scopus 로고    scopus 로고
    • Prognostic significance of, and gene and microRNA expression signatures associated with, CEBPA mutations in cytogenetically normal acute myeloid leukemia with high-risk molecular features: a Cancer and Leukemia Group B Study
    • Marcucci G., Maharry K., Radmacher M.D., et al. Prognostic significance of, and gene and microRNA expression signatures associated with, CEBPA mutations in cytogenetically normal acute myeloid leukemia with high-risk molecular features: a Cancer and Leukemia Group B Study. J Clin Oncol 2008, 26:5078-5087.
    • (2008) J Clin Oncol , vol.26 , pp. 5078-5087
    • Marcucci, G.1    Maharry, K.2    Radmacher, M.D.3
  • 60
    • 78650459322 scopus 로고    scopus 로고
    • C/EBPalpha regulated microRNA-34a targets E2F3 during granulopoiesis and is down-regulated in AML with CEBPA mutations
    • Pulikkan J.A., Peramangalam P.S., Dengler V., et al. C/EBPalpha regulated microRNA-34a targets E2F3 during granulopoiesis and is down-regulated in AML with CEBPA mutations. Blood 2010, 116:5638-5649.
    • (2010) Blood , vol.116 , pp. 5638-5649
    • Pulikkan, J.A.1    Peramangalam, P.S.2    Dengler, V.3
  • 61
    • 84865720625 scopus 로고    scopus 로고
    • RUNX1 mutations are associated with poor outcome in younger and older patients with cytogenetically normal acute myeloid leukemia and with distinct gene and MicroRNA expression signatures
    • Mendler J.H., Maharry K., Radmacher M.D., et al. RUNX1 mutations are associated with poor outcome in younger and older patients with cytogenetically normal acute myeloid leukemia and with distinct gene and MicroRNA expression signatures. J Clin Oncol 2012, 30:3109-3118.
    • (2012) J Clin Oncol , vol.30 , pp. 3109-3118
    • Mendler, J.H.1    Maharry, K.2    Radmacher, M.D.3
  • 62
    • 84863116398 scopus 로고    scopus 로고
    • Age-related prognostic impact of different types of DNMT3A mutations in adults with primary cytogenetically normal acute myeloid leukemia
    • Marcucci G., Metzeler K.H., Schwind S., et al. Age-related prognostic impact of different types of DNMT3A mutations in adults with primary cytogenetically normal acute myeloid leukemia. J Clin Oncol 2012, 30:742-750.
    • (2012) J Clin Oncol , vol.30 , pp. 742-750
    • Marcucci, G.1    Metzeler, K.H.2    Schwind, S.3
  • 63
    • 67650312343 scopus 로고    scopus 로고
    • Prognostic importance of MN1 transcript levels, and biologic insights from MN1-associated gene and microRNA expression signatures in cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study
    • Langer C., Marcucci G., Holland K.B., et al. Prognostic importance of MN1 transcript levels, and biologic insights from MN1-associated gene and microRNA expression signatures in cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study. J Clin Oncol 2009, 27:3198-3204.
    • (2009) J Clin Oncol , vol.27 , pp. 3198-3204
    • Langer, C.1    Marcucci, G.2    Holland, K.B.3
  • 64
    • 79251585678 scopus 로고    scopus 로고
    • Prognostic significance of expression of a single microRNA, miR-181a, in cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study
    • Schwind S., Maharry K., Radmacher M.D., et al. Prognostic significance of expression of a single microRNA, miR-181a, in cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study. J Clin Oncol 2010, 28:5257-5264.
    • (2010) J Clin Oncol , vol.28 , pp. 5257-5264
    • Schwind, S.1    Maharry, K.2    Radmacher, M.D.3
  • 65
    • 70649110008 scopus 로고    scopus 로고
    • MicroRNA patterns associated with clinical prognostic parameters and CNS relapse prediction in pediatric acute leukemia
    • Zhang H., Luo X.Q., Zhang P., et al. MicroRNA patterns associated with clinical prognostic parameters and CNS relapse prediction in pediatric acute leukemia. PLoS One 2009, 4:e7826.
    • (2009) PLoS One , vol.4
    • Zhang, H.1    Luo, X.Q.2    Zhang, P.3
  • 66
    • 84885424565 scopus 로고    scopus 로고
    • Clinical role of microRNAs in cytogenetically normal acute myeloid leukemia: miR-155 upregulation independently identifies high-risk patients
    • Marcucci G., Maharry K.S., Metzeler K.H., et al. Clinical role of microRNAs in cytogenetically normal acute myeloid leukemia: miR-155 upregulation independently identifies high-risk patients. J Clin Oncol 2013, 31:2086-2093.
    • (2013) J Clin Oncol , vol.31 , pp. 2086-2093
    • Marcucci, G.1    Maharry, K.S.2    Metzeler, K.H.3
  • 67
    • 84898446853 scopus 로고    scopus 로고
    • MicroRNA expression at diagnosis adds relevant prognostic information to molecular categorization in patients with intermediate-risk cytogenetic acute myeloid leukemia
    • Diaz-Beya M., Brunet S., Nomdedeu J., et al. MicroRNA expression at diagnosis adds relevant prognostic information to molecular categorization in patients with intermediate-risk cytogenetic acute myeloid leukemia. Leukemia 2014, 28:804-812.
    • (2014) Leukemia , vol.28 , pp. 804-812
    • Diaz-Beya, M.1    Brunet, S.2    Nomdedeu, J.3
  • 68
    • 84882349051 scopus 로고    scopus 로고
    • Circulating microRNAs in hematological diseases: principles, challenges, and perspectives
    • Grasedieck S., Sorrentino A., Langer C., et al. Circulating microRNAs in hematological diseases: principles, challenges, and perspectives. Blood 2013, 121:4977-4984.
    • (2013) Blood , vol.121 , pp. 4977-4984
    • Grasedieck, S.1    Sorrentino, A.2    Langer, C.3
  • 69
    • 84869097194 scopus 로고    scopus 로고
    • Impact of serum storage conditions on microRNA stability
    • Grasedieck S., Scholer N., Bommer M., et al. Impact of serum storage conditions on microRNA stability. Leukemia 2012, 26:2414-2416.
    • (2012) Leukemia , vol.26 , pp. 2414-2416
    • Grasedieck, S.1    Scholer, N.2    Bommer, M.3
  • 70
    • 84874191746 scopus 로고    scopus 로고
    • Circulating miR-150 and miR-342 in plasma are novel potential biomarkers for acute myeloid leukemia
    • Fayyad-Kazan H., Bitar N., Najar M., et al. Circulating miR-150 and miR-342 in plasma are novel potential biomarkers for acute myeloid leukemia. J Transl Med 2013, 11:31.
    • (2013) J Transl Med , vol.11 , pp. 31
    • Fayyad-Kazan, H.1    Bitar, N.2    Najar, M.3
  • 71
    • 65849322883 scopus 로고    scopus 로고
    • Down-regulation of miR-92 in human plasma is a novel marker for acute leukemia patients
    • Tanaka M., Oikawa K., Takanashi M., et al. Down-regulation of miR-92 in human plasma is a novel marker for acute leukemia patients. PLoS One 2009, 4:e5532.
    • (2009) PLoS One , vol.4
    • Tanaka, M.1    Oikawa, K.2    Takanashi, M.3
  • 72
    • 84874268409 scopus 로고    scopus 로고
    • Identification of circulating microRNAs as potential biomarkers for detecting acute myeloid leukemia
    • Zhi F., Cao X., Xie X., et al. Identification of circulating microRNAs as potential biomarkers for detecting acute myeloid leukemia. PLoS One 2013, 8:e56718.
    • (2013) PLoS One , vol.8
    • Zhi, F.1    Cao, X.2    Xie, X.3
  • 73
    • 80053176421 scopus 로고    scopus 로고
    • Comprehensive analysis of mammalian miRNA* species and their role in myeloid cells
    • Kuchenbauer F., Mah S.M., Heuser M., et al. Comprehensive analysis of mammalian miRNA* species and their role in myeloid cells. Blood 2011, 118:3350-3358.
    • (2011) Blood , vol.118 , pp. 3350-3358
    • Kuchenbauer, F.1    Mah, S.M.2    Heuser, M.3
  • 75
    • 84875369248 scopus 로고    scopus 로고
    • Circular RNAs are a large class of animal RNAs with regulatory potency
    • Memczak S., Jens M., Elefsinioti A., et al. Circular RNAs are a large class of animal RNAs with regulatory potency. Nature 2013, 495:333-338.
    • (2013) Nature , vol.495 , pp. 333-338
    • Memczak, S.1    Jens, M.2    Elefsinioti, A.3
  • 76
    • 84870325420 scopus 로고    scopus 로고
    • Concise review: The Piwi-piRNA axis: Pivotal beyond transposon silencing
    • Bamezai S., Rawat V.P., Buske C. Concise review: The Piwi-piRNA axis: Pivotal beyond transposon silencing. Stem Cells 2012, 30:2603-2611.
    • (2012) Stem Cells , vol.30 , pp. 2603-2611
    • Bamezai, S.1    Rawat, V.P.2    Buske, C.3
  • 77
    • 84892573723 scopus 로고    scopus 로고
    • The multilayered complexity of ceRNA crosstalk and competition
    • Tay Y., Rinn J., Pandolfi P.P. The multilayered complexity of ceRNA crosstalk and competition. Nature 2014, 505:344-352.
    • (2014) Nature , vol.505 , pp. 344-352
    • Tay, Y.1    Rinn, J.2    Pandolfi, P.P.3
  • 78
    • 70149093912 scopus 로고    scopus 로고
    • Recurring mutations found by sequencing an acute myeloid leukemia genome
    • Mardis E.R., Ding L., Dooling D.J., et al. Recurring mutations found by sequencing an acute myeloid leukemia genome. N Engl J Med 2009, 361:1058-1066.
    • (2009) N Engl J Med , vol.361 , pp. 1058-1066
    • Mardis, E.R.1    Ding, L.2    Dooling, D.J.3
  • 79
    • 57749195712 scopus 로고    scopus 로고
    • RNA-Seq: a revolutionary tool for transcriptomics
    • Wang Z., Gerstein M., Snyder M. RNA-Seq: a revolutionary tool for transcriptomics. Nat Rev Genet 2009, 10:57-63.
    • (2009) Nat Rev Genet , vol.10 , pp. 57-63
    • Wang, Z.1    Gerstein, M.2    Snyder, M.3
  • 80
    • 78751570979 scopus 로고    scopus 로고
    • RNA sequencing: advances, challenges and opportunities
    • Ozsolak F., Milos P.M. RNA sequencing: advances, challenges and opportunities. Nat Rev Genet 2011, 12:87-98.
    • (2011) Nat Rev Genet , vol.12 , pp. 87-98
    • Ozsolak, F.1    Milos, P.M.2
  • 81
    • 79551634069 scopus 로고    scopus 로고
    • Mayday SeaSight: combined analysis of deep sequencing and microarray data
    • Battke F., Nieselt K. Mayday SeaSight: combined analysis of deep sequencing and microarray data. PLoS One 2011, 6:e16345.
    • (2011) PLoS One , vol.6
    • Battke, F.1    Nieselt, K.2
  • 82
    • 84885586438 scopus 로고    scopus 로고
    • Genomic landscapes and clonality of de novo AML
    • Miller C.A., Wilson R.K., Ley T.J. Genomic landscapes and clonality of de novo AML. N Engl J Med 2013, 369:1473.
    • (2013) N Engl J Med , vol.369 , pp. 1473
    • Miller, C.A.1    Wilson, R.K.2    Ley, T.J.3
  • 83
    • 73649110641 scopus 로고    scopus 로고
    • DNA methylation signatures identify biologically distinct subtypes in acute myeloid leukemia
    • Figueroa M.E., Lugthart S., Li Y., et al. DNA methylation signatures identify biologically distinct subtypes in acute myeloid leukemia. Cancer Cell 2010, 17:13-27.
    • (2010) Cancer Cell , vol.17 , pp. 13-27
    • Figueroa, M.E.1    Lugthart, S.2    Li, Y.3
  • 84
    • 77449157068 scopus 로고    scopus 로고
    • Quantitative DNA methylation predicts survival in adult acute myeloid leukemia
    • Bullinger L., Ehrich M., Dohner K., et al. Quantitative DNA methylation predicts survival in adult acute myeloid leukemia. Blood 2010, 115:636-642.
    • (2010) Blood , vol.115 , pp. 636-642
    • Bullinger, L.1    Ehrich, M.2    Dohner, K.3
  • 85
    • 84898679051 scopus 로고    scopus 로고
    • Epigenetics meets genetics in acute myeloid leukemia: clinical impact of a novel seven-gene score
    • Marcucci G., Yan P., Maharry K., et al. Epigenetics meets genetics in acute myeloid leukemia: clinical impact of a novel seven-gene score. J Clin Oncol 2014, 32:548-556.
    • (2014) J Clin Oncol , vol.32 , pp. 548-556
    • Marcucci, G.1    Yan, P.2    Maharry, K.3
  • 86
    • 84879895082 scopus 로고    scopus 로고
    • Detection of significantly differentially methylated regions in targeted bisulfite sequencing data
    • Hebestreit K., Dugas M., Klein H.U. Detection of significantly differentially methylated regions in targeted bisulfite sequencing data. Bioinformatics 2013, 29:1647-1653.
    • (2013) Bioinformatics , vol.29 , pp. 1647-1653
    • Hebestreit, K.1    Dugas, M.2    Klein, H.U.3
  • 87
    • 84876045450 scopus 로고    scopus 로고
    • Gene set control analysis predicts hematopoietic control mechanisms from genome-wide transcription factor binding data
    • Joshi A., Hannah R., Diamanti E., Gottgens B. Gene set control analysis predicts hematopoietic control mechanisms from genome-wide transcription factor binding data. Exp Hematol 2013, 41:354-366.e14.
    • (2013) Exp Hematol , vol.41
    • Joshi, A.1    Hannah, R.2    Diamanti, E.3    Gottgens, B.4
  • 88
    • 84864255882 scopus 로고    scopus 로고
    • The origin and evolution of mutations in acute myeloid leukemia
    • Welch J.S., Ley T.J., Link D.C., et al. The origin and evolution of mutations in acute myeloid leukemia. Cell 2012, 150:264-278.
    • (2012) Cell , vol.150 , pp. 264-278
    • Welch, J.S.1    Ley, T.J.2    Link, D.C.3
  • 89
    • 84865827060 scopus 로고    scopus 로고
    • Clonal evolution of preleukemic hematopoietic stem cells precedes human acute myeloid leukemia
    • 149ra18
    • Jan M., Snyder T.M., Corces-Zimmerman M.R., et al. Clonal evolution of preleukemic hematopoietic stem cells precedes human acute myeloid leukemia. Sci Transl Med 2012, 4:149ra18.
    • (2012) Sci Transl Med , vol.4
    • Jan, M.1    Snyder, T.M.2    Corces-Zimmerman, M.R.3
  • 90
    • 84862776906 scopus 로고    scopus 로고
    • Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing
    • Ding L., Ley T.J., Larson D.E., et al. Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing. Nature 2012, 481:506-510.
    • (2012) Nature , vol.481 , pp. 506-510
    • Ding, L.1    Ley, T.J.2    Larson, D.E.3
  • 91
    • 69449096005 scopus 로고    scopus 로고
    • Heterogeneity in cancer: cancer stem cells versus clonal evolution
    • Shackleton M., Quintana E., Fearon E.R., Morrison S.J. Heterogeneity in cancer: cancer stem cells versus clonal evolution. Cell 2009, 138:822-829.
    • (2009) Cell , vol.138 , pp. 822-829
    • Shackleton, M.1    Quintana, E.2    Fearon, E.R.3    Morrison, S.J.4
  • 92
    • 84863697677 scopus 로고    scopus 로고
    • From single cells to deep phenotypes in cancer
    • Bendall S.C., Nolan G.P. From single cells to deep phenotypes in cancer. Nat Biotechnol 2012, 30:639-647.
    • (2012) Nat Biotechnol , vol.30 , pp. 639-647
    • Bendall, S.C.1    Nolan, G.P.2
  • 93
    • 84876471008 scopus 로고    scopus 로고
    • Characterization of transcriptional networks in blood stem and progenitor cells using high-throughput single-cell gene expression analysis
    • Moignard V., Macaulay I.C., Swiers G., et al. Characterization of transcriptional networks in blood stem and progenitor cells using high-throughput single-cell gene expression analysis. Nat Cell Biol 2013, 15:363-372.
    • (2013) Nat Cell Biol , vol.15 , pp. 363-372
    • Moignard, V.1    Macaulay, I.C.2    Swiers, G.3
  • 94
    • 84885172419 scopus 로고    scopus 로고
    • Mapping cellular hierarchy by single-cell analysis of the cell surface repertoire
    • Guo G., Luc S., Marco E., et al. Mapping cellular hierarchy by single-cell analysis of the cell surface repertoire. Cell Stem Cell 2013, 13:492-505.
    • (2013) Cell Stem Cell , vol.13 , pp. 492-505
    • Guo, G.1    Luc, S.2    Marco, E.3
  • 95
    • 80054119730 scopus 로고    scopus 로고
    • Low expression of MN1 associates with better treatment response in older patients with de novo cytogenetically normal acute myeloid leukemia
    • Schwind S., Marcucci G., Kohlschmidt J., et al. Low expression of MN1 associates with better treatment response in older patients with de novo cytogenetically normal acute myeloid leukemia. Blood 2011, 118:4188-4198.
    • (2011) Blood , vol.118 , pp. 4188-4198
    • Schwind, S.1    Marcucci, G.2    Kohlschmidt, J.3
  • 96
    • 78650426052 scopus 로고    scopus 로고
    • BAALC and ERG expression levels are associated with outcome and distinct gene and microRNA expression profiles in older patients with de novo cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study
    • Schwind S., Marcucci G., Maharry K., et al. BAALC and ERG expression levels are associated with outcome and distinct gene and microRNA expression profiles in older patients with de novo cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study. Blood 2010, 116:5660-5669.
    • (2010) Blood , vol.116 , pp. 5660-5669
    • Schwind, S.1    Marcucci, G.2    Maharry, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.