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Volumn 13, Issue 12, 2007, Pages 2287-2299

Alternately spliced WT1 antisense transcripts interact with WT1 sense RNA and show epigenetic and splicing defects in cancer

Author keywords

Antisense; Epigenetics; Heteroduplex; RNA; Splicing; WT1

Indexed keywords

COMPLEMENTARY RNA; WT1 PROTEIN;

EID: 36249026230     PISSN: 13558382     EISSN: 14699001     Source Type: Journal    
DOI: 10.1261/rna.562907     Document Type: Article
Times cited : (70)

References (61)
  • 2
    • 0030878615 scopus 로고    scopus 로고
    • Serum-dependent and cell cycle-dependent expression from a cytomegalovirus-based mammalian expression vector
    • Brightwell, G., Poirier, V., Cole, E., Ivins, S., and Brown, K.W. 1997. Serum-dependent and cell cycle-dependent expression from a cytomegalovirus-based mammalian expression vector. Gene 194: 115-123.
    • (1997) Gene , vol.194 , pp. 115-123
    • Brightwell, G.1    Poirier, V.2    Cole, E.3    Ivins, S.4    Brown, K.W.5
  • 3
    • 0026606320 scopus 로고
    • Inactivation of the remaining allele of the WT1 gene in a Wilms' tumour from a WAGR patient
    • Brown, K.W., Watson, J.E., Poirier, V., Mott, M.G., Berry, P.J., and Maitland, N.J. 1992. Inactivation of the remaining allele of the WT1 gene in a Wilms' tumour from a WAGR patient. Oncogene 7: 763-768.
    • (1992) Oncogene , vol.7 , pp. 763-768
    • Brown, K.W.1    Watson, J.E.2    Poirier, V.3    Mott, M.G.4    Berry, P.J.5    Maitland, N.J.6
  • 6
    • 0036534129 scopus 로고    scopus 로고
    • Alternative splicing: Multiple control mechanisms and involvement in human disease
    • Caceres, J.F. and Kornblihtt, A.R. 2002. Alternative splicing: Multiple control mechanisms and involvement in human disease. Trends Genet. 18: 186-193.
    • (2002) Trends Genet , vol.18 , pp. 186-193
    • Caceres, J.F.1    Kornblihtt, A.R.2
  • 9
    • 19444386412 scopus 로고    scopus 로고
    • Genome-wide analysis of coordinate expression and evolution of human cis-encoded sense-antisense transcripts
    • Chen, J., Sun, M., Hurst, L.D., Carmichael, G.G., and Rowley, J.D. 2005. Genome-wide analysis of coordinate expression and evolution of human cis-encoded sense-antisense transcripts. Trends Genet. 21: 326-329.
    • (2005) Trends Genet , vol.21 , pp. 326-329
    • Chen, J.1    Sun, M.2    Hurst, L.D.3    Carmichael, G.G.4    Rowley, J.D.5
  • 10
    • 0034598919 scopus 로고    scopus 로고
    • Secondary structure of vertebrate telomerase RNA
    • Chen, J.L., Blasco, M.A., and Greider, C.W. 2000. Secondary structure of vertebrate telomerase RNA. Cell 100: 503-514.
    • (2000) Cell , vol.100 , pp. 503-514
    • Chen, J.L.1    Blasco, M.A.2    Greider, C.W.3
  • 11
    • 16244392766 scopus 로고    scopus 로고
    • Sense and antisense Foxl2 transcripts in mouse
    • Cocquet, J., Pannetier, M., Fellous, M., and Veitia, R.A. 2005. Sense and antisense Foxl2 transcripts in mouse. Genomics 85: 531-541.
    • (2005) Genomics , vol.85 , pp. 531-541
    • Cocquet, J.1    Pannetier, M.2    Fellous, M.3    Veitia, R.A.4
  • 13
    • 1242285636 scopus 로고    scopus 로고
    • Genomic imprinting at the WT1 gene involves a novel coding transcript (AWT1) that shows deregulation in Wilms' tumours
    • Dallosso, A.R., Hancock, A.L., Brown, K.W., Williams, A.C., Jackson, S., and Malik, K. 2004. Genomic imprinting at the WT1 gene involves a novel coding transcript (AWT1) that shows deregulation in Wilms' tumours. Hum. Mol. Genet. 13: 405-415.
    • (2004) Hum. Mol. Genet , vol.13 , pp. 405-415
    • Dallosso, A.R.1    Hancock, A.L.2    Brown, K.W.3    Williams, A.C.4    Jackson, S.5    Malik, K.6
  • 14
    • 0028356524 scopus 로고
    • Cloning of novel Wilms' tumor gene (WT1) cDNAs: Evidence for antisense transcription of WT1
    • Eccles, M.R., Grubb, G., Ogawa, O., Szeto, J., and Reeve, A.E. 1994. Cloning of novel Wilms' tumor gene (WT1) cDNAs: Evidence for antisense transcription of WT1. Oncogene 9: 2059-2063.
    • (1994) Oncogene , vol.9 , pp. 2059-2063
    • Eccles, M.R.1    Grubb, G.2    Ogawa, O.3    Szeto, J.4    Reeve, A.E.5
  • 15
    • 0028206250 scopus 로고
    • Transcriptional regulation of the human Wilms' tumor gene (WT1). Cell type-specific enhancer and promiscuous promoter
    • Fraizer, G.C., Wu, Y.J., Hewitt, S.M., Maity, T., Ton, C.C.T., Huff, V., and Saunders, G.F. 1994. Transcriptional regulation of the human Wilms' tumor gene (WT1). Cell type-specific enhancer and promiscuous promoter. J. Biol. Chem. 269: 8892-8900.
    • (1994) J. Biol. Chem , vol.269 , pp. 8892-8900
    • Fraizer, G.C.1    Wu, Y.J.2    Hewitt, S.M.3    Maity, T.4    Ton, C.C.T.5    Huff, V.6    Saunders, G.F.7
  • 16
    • 0027202419 scopus 로고
    • Sequence of the WT1 upstream region including the Wit-1 gene
    • Gessler, M. and Bruns, G.A.P. 1993. Sequence of the WT1 upstream region including the Wit-1 gene. Genomics 17: 499-501.
    • (1993) Genomics , vol.17 , pp. 499-501
    • Gessler, M.1    Bruns, G.A.P.2
  • 17
    • 0035965761 scopus 로고    scopus 로고
    • The murine Wilms' tumor suppressor gene (wt1) locus
    • Gong, Y., Eggert, H., and Englert, C. 2001. The murine Wilms' tumor suppressor gene (wt1) locus. Gene 279: 119-126.
    • (2001) Gene , vol.279 , pp. 119-126
    • Gong, Y.1    Eggert, H.2    Englert, C.3
  • 19
    • 0027384740 scopus 로고
    • Characterization of the transcriptional regulatory region of the human WT1 gene
    • Hofmann, W., Royer, H.D., Drechsler, M., Schneider, S., and Royerpokora, B. 1993. Characterization of the transcriptional regulatory region of the human WT1 gene. Oncogene 8: 3123-3132.
    • (1993) Oncogene , vol.8 , pp. 3123-3132
    • Hofmann, W.1    Royer, H.D.2    Drechsler, M.3    Schneider, S.4    Royerpokora, B.5
  • 20
    • 33749031535 scopus 로고    scopus 로고
    • The many facets of the Wilms' tumour gene, WT1
    • doi: 10.1093/hmg/ddi196
    • Hohenstein, P. and Hastie, N.D. 2006. The many facets of the Wilms' tumour gene, WT1. Hum. Mol. Genet. 15: R196-R201. doi: 10.1093/hmg/ddi196.
    • (2006) Hum. Mol. Genet , vol.15
    • Hohenstein, P.1    Hastie, N.D.2
  • 22
    • 0030888263 scopus 로고    scopus 로고
    • Identification of DNA methylation markers for human breast carcinomas using the methylation-sensitive restriction fingerprinting technique
    • Huang, T.H.-M., Laux, D.E., Hamlin, B.C., Tran, P., Tran, H., and Lubahn, D.B. 1997. Identification of DNA methylation markers for human breast carcinomas using the methylation-sensitive restriction fingerprinting technique. Cancer Res. 57: 1030-1034.
    • (1997) Cancer Res , vol.57 , pp. 1030-1034
    • Huang, T.H.-M.1    Laux, D.E.2    Hamlin, B.C.3    Tran, P.4    Tran, H.5    Lubahn, D.B.6
  • 23
    • 33847185603 scopus 로고    scopus 로고
    • A screen for nuclear transcripts identifies two linked noncoding RNAs associated with SC35 splicing domains
    • Hutchinson, J.N., Ensminger, A.W., Clemson, C.M., Lynch, C.R., Lawrence, J.B., and Chess, A. 2007. A screen for nuclear transcripts identifies two linked noncoding RNAs associated with SC35 splicing domains. BMC Genomics 8: 39.
    • (2007) BMC Genomics , vol.8 , pp. 39
    • Hutchinson, J.N.1    Ensminger, A.W.2    Clemson, C.M.3    Lynch, C.R.4    Lawrence, J.B.5    Chess, A.6
  • 25
    • 0034160084 scopus 로고    scopus 로고
    • Evidence for evolutionarily conserved secondary structure in the H19 tumor suppressor RNA
    • Juan, V., Crain, C., and Wilson, C. 2000. Evidence for evolutionarily conserved secondary structure in the H19 tumor suppressor RNA. Nucleic Acids Res. 28: 1221-1227.
    • (2000) Nucleic Acids Res , vol.28 , pp. 1221-1227
    • Juan, V.1    Crain, C.2    Wilson, C.3
  • 28
    • 0032104205 scopus 로고    scopus 로고
    • Molecular cloning of the human p120ctn catenin gene (CTNND1): Expression of multiple alternatively spliced isoforms
    • Keirsebilck, A., Bonne, S., Staes, K., van Hengel, J., Nollet, F., Reynolds, A., and van Roy, F. 1998. Molecular cloning of the human p120ctn catenin gene (CTNND1): Expression of multiple alternatively spliced isoforms. Genomics 50: 129-146.
    • (1998) Genomics , vol.50 , pp. 129-146
    • Keirsebilck, A.1    Bonne, S.2    Staes, K.3    van Hengel, J.4    Nollet, F.5    Reynolds, A.6    van Roy, F.7
  • 29
    • 0034730317 scopus 로고    scopus 로고
    • Noncoding RNA genes in dosage compensation and imprinting
    • Kelley, R.L. and Kuroda, M.I. 2000. Noncoding RNA genes in dosage compensation and imprinting. Cell 103: 9-12.
    • (2000) Cell , vol.103 , pp. 9-12
    • Kelley, R.L.1    Kuroda, M.I.2
  • 31
    • 3042718509 scopus 로고    scopus 로고
    • Dlx5, the mouse homologue of the human-imprinted DLX5 gene, is biallelically expressed in the mouse brain
    • Kimura, M.I., Kazuki, Y., Kashiwagi, A., Kai, Y., Abe, S., Barbieri, O., Levi, G., and Oshimura, M. 2004. Dlx5, the mouse homologue of the human-imprinted DLX5 gene, is biallelically expressed in the mouse brain. J. Hum. Genet. 49: 273-277.
    • (2004) J. Hum. Genet , vol.49 , pp. 273-277
    • Kimura, M.I.1    Kazuki, Y.2    Kashiwagi, A.3    Kai, Y.4    Abe, S.5    Barbieri, O.6    Levi, G.7    Oshimura, M.8
  • 32
    • 0029921478 scopus 로고    scopus 로고
    • Mutations in the Wilms' tumor gene WT1 in leukemias
    • King-Underwood, L., Renshaw, J., and Pritchardjones, K. 1996. Mutations in the Wilms' tumor gene WT1 in leukemias. Blood 87: 2171-2179.
    • (1996) Blood , vol.87 , pp. 2171-2179
    • King-Underwood, L.1    Renshaw, J.2    Pritchardjones, K.3
  • 33
    • 0032522974 scopus 로고    scopus 로고
    • Wilms' tumor (WT1) gene mutations occur mainly in acute myeloid leukemia and may confer drug resistance
    • King-Underwood, L. and Pritchard-Jones, K. 1998. Wilms' tumor (WT1) gene mutations occur mainly in acute myeloid leukemia and may confer drug resistance. Blood 91: 2961-2968.
    • (1998) Blood , vol.91 , pp. 2961-2968
    • King-Underwood, L.1    Pritchard-Jones, K.2
  • 34
    • 0032510113 scopus 로고    scopus 로고
    • Identification of a tumor-specific methylation site in the Wilms' tumor suppressor gene
    • Kleymenova, E.V., Yuan, X., LaBate, M.E., and Walker, C.L. 1998. Identification of a tumor-specific methylation site in the Wilms' tumor suppressor gene. Oncogene 16: 713-720.
    • (1998) Oncogene , vol.16 , pp. 713-720
    • Kleymenova, E.V.1    Yuan, X.2    LaBate, M.E.3    Walker, C.L.4
  • 35
    • 0025288707 scopus 로고
    • N-myc mRNA forms an RNA-RNA duplex with endogenous antisense transcripts
    • Krystal, G.W., Armstrong, B.C., and Battey, J.F. 1990. N-myc mRNA forms an RNA-RNA duplex with endogenous antisense transcripts. Mol. Cell. Biol. 10: 4180-4191.
    • (1990) Mol. Cell. Biol , vol.10 , pp. 4180-4191
    • Krystal, G.W.1    Armstrong, B.C.2    Battey, J.F.3
  • 38
    • 0030891372 scopus 로고    scopus 로고
    • A clinical overview of WT1 gene mutations
    • Little, M. and Wells, C. 1997. A clinical overview of WT1 gene mutations. Hum. Mutat. 9: 209-225.
    • (1997) Hum. Mutat , vol.9 , pp. 209-225
    • Little, M.1    Wells, C.2
  • 40
    • 22344440797 scopus 로고    scopus 로고
    • Genome-wide prediction of imprinted murine genes
    • Luedi, P.P., Hartemink, A.J., and Jirtle, R.L. 2005. Genome-wide prediction of imprinted murine genes. Genome Res. 15: 875-884.
    • (2005) Genome Res , vol.15 , pp. 875-884
    • Luedi, P.P.1    Hartemink, A.J.2    Jirtle, R.L.3
  • 41
    • 0034194238 scopus 로고    scopus 로고
    • Identification of differential methylation of the WT1 antisense regulatory region and relaxation of imprinting in Wilms' tumor
    • Malik, K., Salpekar, A., Hancock, A., Moorwood, K., Jackson, S., Charles, A., and Brown, K.W. 2000. Identification of differential methylation of the WT1 antisense regulatory region and relaxation of imprinting in Wilms' tumor. Cancer Res. 60: 2356-2360.
    • (2000) Cancer Res , vol.60 , pp. 2356-2360
    • Malik, K.1    Salpekar, A.2    Hancock, A.3    Moorwood, K.4    Jackson, S.5    Charles, A.6    Brown, K.W.7
  • 42
    • 0028803438 scopus 로고
    • Identification of an antisense WT1 promoter in intron 1: Implications for WT1 gene regulation
    • Malik, K.T., Wallace, J.I., Ivins, S.M., and Brown, K.W. 1995. Identification of an antisense WT1 promoter in intron 1: Implications for WT1 gene regulation. Oncogene 11: 1589-1595.
    • (1995) Oncogene , vol.11 , pp. 1589-1595
    • Malik, K.T.1    Wallace, J.I.2    Ivins, S.M.3    Brown, K.W.4
  • 43
    • 0031816558 scopus 로고    scopus 로고
    • Antisense WT1 transcription parallels sense mRNA and protein expression in fetal kidney and can elevate protein levels in vitro
    • Moorwood, K., Charles, A.K., Salpekar, A., Wallace, J.I., Brown, K.W., and Malik, K. 1998. Antisense WT1 transcription parallels sense mRNA and protein expression in fetal kidney and can elevate protein levels in vitro. J. Pathol. 185: 352-359.
    • (1998) J. Pathol , vol.185 , pp. 352-359
    • Moorwood, K.1    Charles, A.K.2    Salpekar, A.3    Wallace, J.I.4    Brown, K.W.5    Malik, K.6
  • 45
    • 17444410031 scopus 로고    scopus 로고
    • The influence of noncoding RNAs on allele-specific gene expression in mammals
    • doi: 10.1093/hmg/ddi108
    • O'Neill, M.J. 2005. The influence of noncoding RNAs on allele-specific gene expression in mammals. Hum. Mol. Genet. (Suppl. 1) 14: R113-R120. doi: 10.1093/hmg/ddi108.
    • (2005) Hum. Mol. Genet , vol.14 , Issue.SUPPL. 1
    • O'Neill, M.J.1
  • 47
    • 0033587010 scopus 로고    scopus 로고
    • Restriction landmark genome scanning for aberrant methylation in primary refractory and relapsed acute myeloid leukemia; involvement of the WIT-1 gene
    • Plass, C., Yu, F., Yu, L., Strout, M.P., El Rifai, W., Elonen, E., Knuutila, S., Marcucci, G., Young, D.C., Held, W.A., et al. 1999. Restriction landmark genome scanning for aberrant methylation in primary refractory and relapsed acute myeloid leukemia; involvement of the WIT-1 gene. Oncogene 18: 3159-3165.
    • (1999) Oncogene , vol.18 , pp. 3159-3165
    • Plass, C.1    Yu, F.2    Yu, L.3    Strout, M.P.4    El Rifai, W.5    Elonen, E.6    Knuutila, S.7    Marcucci, G.8    Young, D.C.9    Held, W.A.10
  • 50
    • 24344478550 scopus 로고    scopus 로고
    • Transcriptional regulation by WT1 in development
    • Roberts, S.G. 2005. Transcriptional regulation by WT1 in development. Curr. Opin. Genet. Dev. 15: 542-547.
    • (2005) Curr. Opin. Genet. Dev , vol.15 , pp. 542-547
    • Roberts, S.G.1
  • 51
    • 24944494948 scopus 로고    scopus 로고
    • Evidence that public database records for many cancer-associated genes reflect a splice form found in tumors and lack normal splice forms
    • doi: 10.1093/nar/gki792
    • Roy, M., Xu, Q., and Lee, C. 2005. Evidence that public database records for many cancer-associated genes reflect a splice form found in tumors and lack normal splice forms. Nucleic Acids Res. 33: 5026-5033. doi: 10.1093/nar/gki792.
    • (2005) Nucleic Acids Res , vol.33 , pp. 5026-5033
    • Roy, M.1    Xu, Q.2    Lee, C.3
  • 52
    • 0035827923 scopus 로고    scopus 로고
    • WT1 proteins: Functions in growth and differentiation
    • Scharnhorst, V., Van der Eb, A.J., and Jochemsen, A.G. 2001. WT1 proteins: Functions in growth and differentiation. Gene 273: 141-161.
    • (2001) Gene , vol.273 , pp. 141-161
    • Scharnhorst, V.1    Van der Eb, A.J.2    Jochemsen, A.G.3
  • 53
    • 33747603960 scopus 로고    scopus 로고
    • The imprinted Air ncRNA is an atypical RNAPII transcript that evades splicing and escapes nuclear export
    • Seidl, C.I., Stricker, S.H., and Barlow, D.P. 2006. The imprinted Air ncRNA is an atypical RNAPII transcript that evades splicing and escapes nuclear export. EMBO J. 25: 3565-3575.
    • (2006) EMBO J , vol.25 , pp. 3565-3575
    • Seidl, C.I.1    Stricker, S.H.2    Barlow, D.P.3
  • 54
    • 0037075032 scopus 로고    scopus 로고
    • The noncoding Air RNA is required for silencing autosomal imprinted genes
    • Sleutels, F., Zwart, R., and Barlow, D.P. 2002. The noncoding Air RNA is required for silencing autosomal imprinted genes. Nature 415: 810-813.
    • (2002) Nature , vol.415 , pp. 810-813
    • Sleutels, F.1    Zwart, R.2    Barlow, D.P.3
  • 56
    • 33847034967 scopus 로고    scopus 로고
    • Does everything now make (anti)sense?
    • Timmons, J.A. and Good, L. 2006. Does everything now make (anti)sense? Biochem. Soc. Trans. 34: 1148-1150.
    • (2006) Biochem. Soc. Trans , vol.34 , pp. 1148-1150
    • Timmons, J.A.1    Good, L.2
  • 57
    • 0345269100 scopus 로고    scopus 로고
    • Loss of imprinting of IGF2 sense and antisense transcripts in Wilms' tumor
    • Vu, T.H., Chuyen, N.V., Li, T., and Hoffman, A.R. 2003. Loss of imprinting of IGF2 sense and antisense transcripts in Wilms' tumor. Cancer Res. 63: 1900-1905.
    • (2003) Cancer Res , vol.63 , pp. 1900-1905
    • Vu, T.H.1    Chuyen, N.V.2    Li, T.3    Hoffman, A.R.4
  • 58
    • 0036146828 scopus 로고    scopus 로고
    • Alternative non-coding splice variants of Nespas, an imprinted gene antisense to Nesp in the Gnas imprinting cluster
    • Williamson, C.M., Skinner, J.A., Kelsey, G., and Peters, J. 2002. Alternative non-coding splice variants of Nespas, an imprinted gene antisense to Nesp in the Gnas imprinting cluster. Mamm. Genome 13: 74-79.
    • (2002) Mamm. Genome , vol.13 , pp. 74-79
    • Williamson, C.M.1    Skinner, J.A.2    Kelsey, G.3    Peters, J.4
  • 59
    • 0029853390 scopus 로고    scopus 로고
    • Regulation of WT1 by phosphorylation: Inhibition of DNA binding, alteration of transcriptional activity and cellular translocation
    • Ye, Y., Raychaudhuri, B., Gurney, A., Campbell, C.E., and Williams, B.R.G. 1996. Regulation of WT1 by phosphorylation: Inhibition of DNA binding, alteration of transcriptional activity and cellular translocation. EMBO J. 15: 5606-5615.
    • (1996) EMBO J , vol.15 , pp. 5606-5615
    • Ye, Y.1    Raychaudhuri, B.2    Gurney, A.3    Campbell, C.E.4    Williams, B.R.G.5


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